Gene: CBR1

873
CBR|SDR21C1|hCBR1
carbonyl reductase 1
protein-coding
21q22.12
Ensembl:ENSG00000159228 MIM:114830 Vega:OTTHUMG00000086618 UniprotKB:P16152
NC_000021.9
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.551e-1 (AD)  7.015e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFT2D10.873
FBXO70.861
MARCKSL10.859
MAL0.856
SLC48A10.851
TALDO10.846
TMEM1890.838
RNH10.838
CYP27A10.83
DAD10.828

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.629
OR4F29-0.602
FER1L6-0.342
MXRA5-0.281
AVPR2-0.261
HS6ST3-0.246
TRHR-0.245
FCER2-0.245
IBSP-0.241
GADL1-0.24

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01698RutinSmall Molecule153-18-4Experimental|InvestigationalTarget
DB02709ResveratrolSmall Molecule501-36-0Approved|Experimental|InvestigationalTarget
DB035562-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400Small MoleculeExperimentalTarget
DB04216QuercetinSmall Molecule117-39-5Experimental|InvestigationalTarget
DB044633-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)PhenolSmall MoleculeExperimentalTarget
DB11672CurcuminSmall Molecule458-37-7Approved|InvestigationalTarget
DB00414AcetohexamideSmall Molecule968-81-0Approved|Investigational|WithdrawnEnzyme
DB00502HaloperidolSmall Molecule52-86-8ApprovedEnzyme
DB00997DoxorubicinSmall Molecule23214-92-8Approved|InvestigationalEnzyme
DB01046LubiprostoneSmall Molecule136790-76-6Approved|InvestigationalEnzyme
DB035562-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400Small MoleculeExperimentalEnzyme
DB044633-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)PhenolSmall MoleculeExperimentalEnzyme
DB04844TetrabenazineSmall Molecule58-46-8Approved|InvestigationalEnzyme
DB05197SofalconeSmall Molecule64506-49-6InvestigationalEnzyme
DB06263AmrubicinSmall Molecule110267-81-7Approved|InvestigationalEnzyme
DB12161DeutetrabenazineSmall Molecule1392826-25-3Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0407561,2-naphthoquinone"[S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 1,2-naphthoquinone]"23295225
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CBR1 mRNA"27413110|2890350
C0353421,4-naphthoquinone"[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 1,4-naphthoquinone]"23295225
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CBR1 mRNA19933214
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of CBR1 mRNA"21920950
C0432312,3-hexanedione"CBR1 protein results in increased reduction of 2,3-hexanedione"25541467
C0432312,3-hexanedione"Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]"25541467
C0432312,3-hexanedione"Quercetin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]"25541467
C0432312,3-hexanedione"[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 2,3-hexanedione]"23295225
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CBR1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CBR1 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CBR1 mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of CBR1 mRNA"20702594
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in increased expression of CBR1 protein"22649188
C4390243,5-dihydroxy-4'-methoxystilbene"3,5-dihydroxy-4'-methoxystilbene inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 protein]"24975222
C4390243,5-dihydroxy-4'-methoxystilbene"3,5-dihydroxy-4'-methoxystilbene results in decreased activity of CBR1 protein"24064738
C0312853-xylene3-xylene results in increased expression of CBR1 mRNA12815608
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBR1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of CBR1 mRNA"21346803
C0667384-benzoylpyridine[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 4-benzoylpyridine]23295225
C0306014-hydroxymercuribenzoate4-hydroxymercuribenzoate results in decreased activity of CBR1 protein15145449
C0306014-hydroxymercuribenzoateNADP inhibits the reaction [4-hydroxymercuribenzoate results in decreased activity of CBR1 protein]15145449
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone11306090
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneEthacrynic Acid inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]11306090
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneQuercetin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]11306090
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneRutin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]11306090
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneVitamin K 3 inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]11306090
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCBR1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone28257955
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBR1 mRNA"27188386
C5294318-2 fluorotelomer alcohol8-2 fluorotelomer alcohol results in increased expression of CBR1 mRNA21984479
C0053999,10-phenanthrenequinone"[CBR1 protein co-treated with NADP] results in increased reduction of and affects the activity of 9,10-phenanthrenequinone"21910479
C0053999,10-phenanthrenequinone"CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone"29108775
C0053999,10-phenanthrenequinone"[S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone]"23295225
D000082AcetaminophenAcetaminophen results in decreased expression of CBR1 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of CBR1 mRNA18246545
D000082AcetaminophenAcetaminophen results in decreased expression of CBR1 mRNA18246545
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of CBR1 mRNA19920212
C010013adriamycinol[CBR1 protein results in increased reduction of Doxorubicin] which results in increased abundance of adriamycinol24064738
D000638AmiodaroneAmiodarone affects the expression of CBR1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CBR1 mRNA16483693
D000728AndrogensAndrogens affects the expression of CBR1 mRNA16457595
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR1 mRNA19737545
D018943AnthracyclinesCBR1 protein results in increased metabolism of Anthracyclines23247010
C006632arsenic trioxidearsenic trioxide results in increased expression of CBR1 mRNA22719067
C006632arsenic trioxideCBR1 protein results in decreased susceptibility to arsenic trioxide22719067
D001280AtrazineAtrazine results in decreased expression of CBR1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of CBR1 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of CBR1 mRNA19483382
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of CBR1 mRNA17569794|1973760
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR1 mRNA19737545
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CBR1 mRNA22531821
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CBR1 protein22531821
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CBR1 mRNA19770486|2590861
D001564Benzo(a)pyrene"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of CBR1 mRNA"28987381
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CBR1 mRNA26496021
C095105bexarotenebexarotene results in increased expression of CBR1 mRNA16648578
C006780bisphenol Abisphenol A affects the expression of CBR1 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CBR1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of CBR1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of CBR1 mRNA25181051
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of CBR1 mRNA23247010
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of CBR1 protein23247010
D002083Butylated Hydroxyanisole[Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] promotes the reaction [[NFE2L2 protein binds to CBR1 promoter] which results in increased expression of CBR1 mRNA]23247010|2324701
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CBR1 mRNA18804290
D002220CarbamazepineCarbamazepine affects the expression of CBR1 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CBR1 mRNA27339419
D002737ChloropreneChloroprene results in increased expression of CBR1 mRNA23125180
D002911Chrysenes[CBR1 protein co-treated with NADP] results in increased reduction of and affects the activity of Chrysenes21910479
C019304ciprofibrateciprofibrate results in increased expression of CBR1 mRNA12771043
D002994ClofibrateClofibrate affects the expression of CBR1 mRNA19483382
D009249NADP"[CBR1 protein co-treated with NADP] results in increased reduction of and affects the activity of 9,10-phenanthrenequinone"21910479
D009249NADP[CBR1 protein co-treated with NADP] results in increased reduction of and affects the activity of Chrysenes21910479
D009249NADP[CBR1 protein co-treated with NADP] results in increased reduction of and affects the activity of Dihydroxydihydrobenzopyrenes21910479
D009249NADP[CBR1 protein co-treated with NADP] results in increased reduction of and affects the activity of Naphthalenes21910479
D009249NADPCurcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein]25541467
D009249NADP[Genistein co-treated with NADP] binds to CBR1 protein25526675
D009249NADPNADP binds to and results in increased activity of CBR1 protein25526675
D009249NADPNADP metabolite binds to and results in increased activity of CBR1 protein25541467
D009249NADP[Quercetin co-treated with NADP] binds to CBR1 protein25526675
D009249NADP[Triclosan co-treated with NADP] binds to CBR1 protein25526675
D009249NADPNADP binds to CBR1 protein15145449
D009249NADPNADP inhibits the reaction [4-hydroxymercuribenzoate results in decreased activity of CBR1 protein]15145449
C030123coumarincoumarin results in increased expression of CBR1 mRNA18480146
D003375CoumestrolCoumestrol results in increased expression of CBR1 mRNA19167446
D003407CreosoteCreosote results in increased expression of CBR1 mRNA19389177
D003471CuprizoneCuprizone results in increased expression of CBR1 mRNA26577399
D003474CurcuminCurcumin binds to and results in decreased activity of CBR1 protein25541467
D003474Curcumin[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin25541467
D003474Curcumin[[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol25541467
D003474Curcumin"Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]"25541467
D003474CurcuminCurcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein]25541467
C057862cyanoginosin LRcyanoginosin LR results in increased expression of CBR1 mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of CBR1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of CBR1 mRNA19770486
D003630DaunorubicinCBR1 gene SNP results in decreased metabolism of Daunorubicin19204081
D003630DaunorubicinCBR1 protein results in increased reduction of Daunorubicin18579125|2554146
D003630Daunorubicin[CBR1 protein results in increased reduction of Daunorubicin] which results in increased chemical synthesis of daunorubicinol25541467
D003630DaunorubicinCBR1 results in increased metabolism of Daunorubicin20670211
D003630Daunorubicin[CBR1 results in increased metabolism of Daunorubicin] which results in increased chemical synthesis of daunorubicinol20670211
D003630Daunorubicin[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin25541467
D003630Daunorubicin[[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol25541467
D003630Daunorubicin[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]23295225
D003630DaunorubicinDaunorubicin results in increased activity of CBR1 protein15588138
C000847daunorubicinol[CBR1 protein results in increased reduction of Daunorubicin] which results in increased chemical synthesis of daunorubicinol25541467
C000847daunorubicinol[CBR1 results in increased metabolism of Daunorubicin] which results in increased chemical synthesis of daunorubicinol20670211
C000847daunorubicinol[[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol25541467
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CBR1 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of CBR1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CBR1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CBR1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CBR1 mRNA27392435
D004008DiclofenacDiclofenac affects the expression of CBR1 mRNA24752500
C014476diethyl maleatediethyl maleate results in increased expression of CBR1 mRNA25270620
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CBR1 mRNA12771043|2160768
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CBR1 mRNA19638242
D004101Dihydroxydihydrobenzopyrenes[CBR1 protein co-treated with NADP] results in increased reduction of and affects the activity of Dihydroxydihydrobenzopyrenes21910479
D004229DithiothreitolDithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]]21256830
D004237DiuronDiuron results in decreased expression of CBR1 mRNA21551480
D004317DoxorubicinCBR1 gene SNP results in decreased metabolism of Doxorubicin19204081
D004317DoxorubicinCBR1 protein affects the reduction of Doxorubicin18635746
D004317DoxorubicinCBR1 protein results in increased reduction of Doxorubicin18755171
D004317DoxorubicinDoxorubicin results in increased expression of CBR1 protein18755171
D004317Doxorubicin[resveratrol results in decreased activity of CBR1 protein] which affects the susceptibility to Doxorubicin24064738
D004317DoxorubicinCBR1 protein results in increased susceptibility to Doxorubicin11016643|1458345
D004317DoxorubicinCBR1 protein results in increased metabolism of Doxorubicin24975222
D004317DoxorubicinCBR1 protein results in increased reduction of Doxorubicin24064738
D004317Doxorubicin[CBR1 protein results in increased reduction of Doxorubicin] which results in increased abundance of adriamycinol24064738
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CBR1 mRNA"23262642
D004976Ethacrynic AcidEthacrynic Acid inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]11306090
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CBR1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CBR1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CBR1 mRNA17942748
D005001EthionineEthionine affects the expression of CBR1 mRNA19483382
C006012fenofibric acidCBR1 protein results in increased reduction of fenofibric acid27599626
D047309FlavonesFlavones affects the activity of CBR1 protein28274719
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of CBR1 mRNA21607683
D005485FlutamideFlutamide results in increased expression of CBR1 mRNA24136188
C039281furanfuran results in increased expression of CBR1 mRNA24183702
C039281furanfuran results in increased expression of CBR1 mRNA25539665
D019833Genistein[Genistein co-treated with NADP] binds to CBR1 protein25526675
D019833GenisteinGenistein results in increased expression of CBR1 mRNA16705744
C071834glycidamideglycidamide results in increased expression of CBR1 mRNA17822822
D006118GriseofulvinGriseofulvin affects the expression of CBR1 mRNA12735108
C029424hydrazinehydrazine results in increased expression of CBR1 mRNA15282401
D007213IndomethacinIndomethacin results in increased expression of CBR1 mRNA18299717
D007510Isatin[S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin]23295225
D007510IsatinCBR1 protein results in increased metabolism of Isatin23247010
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CBR1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of CBR1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of CBR1 protein17337753
D007654KetoconazoleKetoconazole results in increased expression of CBR1 mRNA17517826
C045463leflunomideleflunomide results in increased expression of CBR1 mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of CBR1 mRNA"28987381
D008070LipopolysaccharidesCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]25818598
D008070LipopolysaccharidesCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]25818598
D008070LipopolysaccharidesCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]25818598
D008070LipopolysaccharidesCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]25818598
D008070LipopolysaccharidesCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]25818598
D008070LipopolysaccharidesCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]25818598
D008070LipopolysaccharidesCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]25818598
D008070LipopolysaccharidesCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]25818598
D008070LipopolysaccharidesCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]25818598
D008070LipopolysaccharidesCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]25818598
D008070LipopolysaccharidesCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]25818598
D008694MethamphetamineMethamphetamine results in decreased expression of CBR1 mRNA15644446
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CBR1 mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CBR1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CBR1 mRNA27188386
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of CBR1 mRNA16525678
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CBR1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CBR1 mRNA"25554681
D009281Naphthalenes[CBR1 protein co-treated with NADP] results in increased reduction of and affects the activity of Naphthalenes21910479
D009281NaphthalenesNaphthalenes results in increased expression of CBR1 protein17337753
C051752nefazodonenefazodone results in increased expression of CBR1 mRNA24136188
C012655nimesulidenimesulide results in increased expression of CBR1 mRNA24136188
D026422S-NitrosoglutathioneCBR1 protein results in increased reduction of S-Nitrosoglutathione21256830
D026422S-NitrosoglutathioneDithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]]21256830
D026422S-NitrosoglutathioneS-Nitrosoglutathione binds to and results in decreased activity of CBR1 protein23295225
D026422S-NitrosoglutathioneS-Nitrosoglutathione binds to and results in increased activity of CBR1 protein23295225
D026422S-Nitrosoglutathione"[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 1,4-naphthoquinone]"23295225
D026422S-Nitrosoglutathione"[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 2,3-hexanedione]"23295225
D026422S-Nitrosoglutathione[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 4-benzoylpyridine]23295225
D026422S-Nitrosoglutathione[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]23295225
D026422S-Nitrosoglutathione[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Vitamin K 3]23295225
D026422S-Nitrosoglutathione"[S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 1,2-naphthoquinone]"23295225
D026422S-Nitrosoglutathione"[S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone]"23295225
D026422S-Nitrosoglutathione[S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin]23295225
D026422S-NitrosoglutathioneS-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]21256830
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of CBR1 mRNA19716841
C025256nonylphenolnonylphenol results in increased expression of CBR1 mRNA22982499
D009853OmeprazoleOmeprazole affects the expression of CBR1 mRNA19483382
C103439oracineCBR1 protein results in increased reduction of oracine18755171
C103439oracineoracine results in increased expression of CBR1 protein18755171
C103439oracineoracine binds to CBR1 protein25595226
C036006oxcarbazepineCBR1 protein results in increased reduction of oxcarbazepine25063510
D010100OxygenOxygen deficiency results in decreased expression of CBR1 mRNA19579223
D010100Oxygen"3,5-dihydroxy-4'-methoxystilbene inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 protein]"24975222
D010100OxygenHIF1A mutant form inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 protein]24975222
D010100OxygenOxygen deficiency results in increased expression of CBR1 mRNA24975222
D010100OxygenOxygen deficiency results in increased expression of CBR1 protein24975222
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 mRNA]24975222
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 protein]24975222
D010100OxygenHIF1A mutant form inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 mRNA]24975222
D010100OxygenHIF1A mutant form inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 protein]24975222
C016030pantogabpantogab results in decreased expression of CBR1 mRNA17379144
D010416PentachlorophenolPentachlorophenol results in increased expression of CBR1 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CBR1 mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CBR1 mRNA18709148
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CBR1 mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CBR1 mRNA19162173
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of CBR1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of CBR1 mRNA19482888|2309116
C018637phoronephorone affects the expression of CBR1 mRNA18198479
C522997pinostilbenepinostilbene results in decreased activity of CBR1 protein24064738
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CBR1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CBR1 mRNA18301758|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of CBR1 mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of CBR1 mRNA19483382
C006253pirinixic acidpirinixic acid results in increased expression of CBR1 mRNA19162173|2248451
D010936Plant ExtractsPlant Extracts results in increased expression of CBR1 mRNA23262642
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CBR1 mRNA22714537
C045362prochlorazprochloraz results in increased expression of CBR1 mRNA20805220
C045950propiconazolepropiconazole results in increased expression of CBR1 mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of CBR1 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of CBR1 mRNA24780913
D011453ProstaglandinsCBR1 protein results in increased metabolism of Prostaglandins23247010
D011794QuercetinQuercetin binds to and results in decreased activity of CBR1 protein25541467
D011794Quercetin[Quercetin co-treated with NADP] binds to CBR1 protein25526675
D011794QuercetinQuercetin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]11306090
D011794Quercetin"Quercetin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]"25541467
C052785rebamipiderebamipide results in increased expression of CBR1 mRNA18299717
C059514resveratrolCBR1 protein binds to resveratrol24064738
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 mRNA]24975222
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 protein]24975222
C059514resveratrol[resveratrol results in decreased activity of CBR1 protein] which affects the susceptibility to Doxorubicin24064738
C059514resveratrolresveratrol results in decreased activity of CBR1 protein24064738
D012431RutinRutin binds to and results in decreased activity of CBR1 protein18579125
D012431RutinRutin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]11306090
D012834SilverSilver analog results in increased expression of CBR1 mRNA22727896
D012835Silver NitrateSilver Nitrate results in increased expression of CBR1 mRNA22727896
D012906SmokeSmoke results in increased expression of CBR1 mRNA22531821
D012906SmokeSmoke results in increased expression of CBR1 protein22531821
C017947sodium arsenitesodium arsenite results in increased expression of CBR1 mRNA20308225
C017947sodium arsenitesodium arsenite results in increased expression of CBR1 mRNA28595984
C016104sodium bichromatesodium bichromate results in decreased expression of CBR1 mRNA22155349
D013311StreptozocinStreptozocin results in decreased activity of CBR1 protein11057757
D013605T-2 ToxinT-2 Toxin affects the expression of CBR1 protein26141394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of CBR1 mRNA26496021
C004648testosterone enanthatetestosterone enanthate affects the expression of CBR1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CBR1 mRNA15716485
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CBR1 mRNA20702594|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CBR1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CBR1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CBR1 mRNA18796159|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CBR1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CBR1 protein19492234
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of CBR1 mRNA28973375
D013755Tetradecanoylphorbol AcetateCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B mRNA]25818598
D013755Tetradecanoylphorbol AcetateCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]25818598
D013755Tetradecanoylphorbol AcetateCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]25818598
D013755Tetradecanoylphorbol AcetateCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]25818598
D013755Tetradecanoylphorbol AcetateCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]25818598
D013755Tetradecanoylphorbol AcetateCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein]25818598
D013755Tetradecanoylphorbol AcetateCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]25818598
D013755Tetradecanoylphorbol AcetateCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]25818598
D013755Tetradecanoylphorbol AcetateCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein]25818598
D013755Tetradecanoylphorbol AcetateCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]25818598
D013755Tetradecanoylphorbol AcetateCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]25818598
D013792ThalidomideThalidomide results in decreased expression of CBR1 mRNA26217789
D013853ThioacetamideThioacetamide affects the expression of CBR1 mRNA19483382
D013853ThioacetamideThioacetamide results in increased expression of CBR1 mRNA23411599
C021270tiaprofenic acidCBR1 protein results in increased reduction of tiaprofenic acid28322780
C009495titanium dioxidetitanium dioxide results in increased expression of CBR1 mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CBR1 protein22595367
D014260Triclosan[Triclosan co-treated with NADP] binds to CBR1 protein25526675
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CBR1 mRNA"26179874
C022884undecaneundecane results in increased expression of CBR1 protein17337753
C406224valdecoxibvaldecoxib results in increased expression of CBR1 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBR1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CBR1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of CBR1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CBR1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of CBR1 mRNA17292431
D014640VancomycinVancomycin results in increased expression of CBR1 mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of CBR1 mRNA17517826
D024483Vitamin K 3CBR1 protein results in increased metabolism of Vitamin K 319061875
D024483Vitamin K 3[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Vitamin K 3]23295225
D024483Vitamin K 3Vitamin K 3 inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]11306090
C088658zoledronic acidzoledronic acid results in decreased expression of CBR1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004090carbonyl reductase (NADPH) activity-IBA21873635  
GO:0004090carbonyl reductase (NADPH) activity-IDA18449627  
GO:0005515protein binding-IPI17353931  20562859  
GO:0016655oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor-IDA19442656  
GO:004702115-hydroxyprostaglandin dehydrogenase (NADP+) activity-IEA-  
GO:0050221prostaglandin-E2 9-reductase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0017144drug metabolic process-IDA18449627  
GO:0019371cyclooxygenase pathway-TAS-  
GO:0030855epithelial cell differentiation-IEP21492153  
GO:0042373vitamin K metabolic process-IDA18449627  
GO:0055114oxidation-reduction process-IDA19442656  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-2162123Synthesis of Prostaglandins (PG) and Thromboxanes (TX)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24088726Deeper insight into the reducing biotransformation of bupropion in the human liver. (2014)Skarydova LDrug Metab Pharmacokinet
28743530Different inhibitory potential of sex hormones on NNK detoxification in vitro: A possible explanation for gender-specific lung cancer risk. (2017 Oct 1)Stapelfeld CCancer Lett