Gene info: ID 8737

Gene: RIPK1

GENE ID: 8737

Synonyms: RIP|RIP-1|RIP1

Description: receptor interacting serine/threonine kinase 1

Gene type: protein-coding

Location: 6p25.2

dbXrefs: Ensembl:ENSG00000137275 MIM:603453 Vega:OTTHUMG00000014134 UniprotKB:Q13546

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : 1.140e-1 (AD) 7.668e-3 (ND) (Frontal_Cortex)

Pascal p-value : 2.652e-1 (AD) 4.374e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HDAC7	0.847
NUP188	0.842
CCNL1	0.834
B4GALT4	0.819
FNBP4	0.803
SLC8B1	0.801
ZNF700	0.797
SMC5	0.795
CEP95	0.794
MAML1	0.791

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.474
OR4F29	-0.458
CRH	-0.243
NMU	-0.219
ZNF804B	-0.211
PRLHR	-0.203
KRT83	-0.202
KCNG1	-0.198
SPRR2A	-0.191
NKX2-8	-0.188

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of RIPK1 mRNA"	27589474
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of RIPK1 mRNA"	21346803
C003898	2-anisidine	2-anisidine results in increased expression of RIPK1 mRNA	28089782
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]"	23452621
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of RIPK1 mRNA"	18648102
C549066	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine	"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of RIPK1 protein]"	26546572
C580598	5-OH-BDE-47	5-OH-BDE-47 results in decreased expression of RIPK1 mRNA	27589474
C580599	6-OH-BDE-47	6-OH-BDE-47 results in decreased expression of RIPK1 mRNA	27589474
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of RIPK1 mRNA"	19936915
D000082	Acetaminophen	Acetaminophen results in increased expression of RIPK1 mRNA	25704631
D000082	Acetaminophen	Acetaminophen inhibits the reaction [Acetaminophen results in increased expression of RIPK1 protein]	24440347
D000082	Acetaminophen	Acetaminophen results in increased expression of RIPK1 protein	24440347
D000171	Acrolein	[ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK1 protein	24847785
D020106	Acrylamide	Acrylamide results in decreased expression of RIPK1 mRNA	28959563
D000241	Adenosine	[Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein	24224954
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of RIPK1 mRNA	19770486
D006710	Homocysteine	[Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein	24224954
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of RIPK1 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in increased cleavage of RIPK1 protein	15314284
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RIPK1 mRNA	22316170
C517629	benzyloxycarbonyl-valyl-alanyl-aspartic acid	benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[vorinostat co-treated with TNFSF10 protein] affects the localization of RIPK1 protein]	19643600
C517629	benzyloxycarbonyl-valyl-alanyl-aspartic acid	benzyloxycarbonyl-valyl-alanyl-aspartic acid analog promotes the reaction [TNF protein results in increased expression of RIPK1 protein]	23000518
C517629	benzyloxycarbonyl-valyl-alanyl-aspartic acid	RIPK1 protein results in increased susceptibility to benzyloxycarbonyl-valyl-alanyl-aspartic acid analog	21853090
D004958	Estradiol	Estradiol results in decreased expression of RIPK1 mRNA	23373633
C006780	bisphenol A	bisphenol A results in increased expression of RIPK1 mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of RIPK1 mRNA	25181051
D000069286	Bortezomib	Bortezomib results in decreased expression of RIPK1 mRNA	20471514
D000069286	Bortezomib	Bortezomib results in increased expression of RIPK1 protein	26769846
D002108	Ceruletide	Ceruletide results in increased cleavage of RIPK1 protein	16339139
D003042	Cocaine	Cocaine results in decreased expression of RIPK1 mRNA	17898221
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of RIPK1 mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]	23452621
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of RIPK1 mRNA	21266533
D002945	Cisplatin	"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of RIPK1 protein]"	26546572
D002945	Cisplatin	Cisplatin results in increased expression of RIPK1 mRNA	21151649
D002945	Cisplatin	Cisplatin results in increased expression of RIPK1 protein	26546572
C002302	dimethoxon	dimethoxon results in decreased expression of RIPK1 mRNA	26688254
D004785	Environmental Pollutants	Environmental Pollutants affects the expression of RIPK1 mRNA	19118595
D000431	Ethanol	Ethanol results in decreased expression of RIPK1 mRNA	26769846
D000431	Ethanol	Ethanol results in decreased expression of RIPK1 protein	26769846
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of RIPK1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RIPK1 mRNA	17942748
C000499	ferric oxide	[ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK1 protein	24847785
D000068876	Fingolimod Hydrochloride	Fingolimod Hydrochloride results in increased expression of RIPK1 protein	25939952
D000068876	Fingolimod Hydrochloride	necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of RIPK1 protein]	25939952
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in decreased expression of RIPK1 mRNA	22584684
D005665	Furosemide	Furosemide affects the expression of RIPK1 mRNA	17497460
D019833	Genistein	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]	23452621
D005839	Gentamicins	Gentamicins results in increased expression of RIPK1 mRNA	22061828
D006146	Guanidines	Guanidines analog results in increased expression of and results in increased cleavage of RIPK1 protein	23147571
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of RIPK1 mRNA	17183730
C492448	ICG 001	ICG 001 results in increased expression of RIPK1 mRNA	26191083
C045463	leflunomide	leflunomide results in decreased expression of RIPK1 mRNA	28988120
D008344	Maneb	[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA	23963992
D008344	Maneb	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA]	23963992
C013592	mangiferin	mangiferin results in decreased expression of RIPK1 mRNA	15135318
D008549	Melarsoprol	Melarsoprol results in decreased expression of and results in increased cleavage of RIPK1 protein	15314284
C014655	methamidophos	methamidophos results in decreased expression of RIPK1 mRNA	26688254
D008701	Methapyrilene	Methapyrilene results in decreased expression of RIPK1 mRNA	22584684
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of RIPK1 mRNA	20864626
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of RIPK1 mRNA	23649840
D008743	Methyl Parathion	Methyl Parathion results in decreased expression of RIPK1 mRNA	26688254
C455139	myrtucommulone A	myrtucommulone A results in decreased expression of RIPK1 mRNA	26032814
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of RIPK1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of RIPK1 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of RIPK1 mRNA	15913567
D015058	1-Naphthylisothiocyanate	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RIPK1 mRNA]"	15913567
C507699	necrostatin-1	necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of RIPK1 protein]	25939952
C507699	necrostatin-1	necrostatin-1 inhibits the reaction [TNF protein results in increased expression of RIPK1 protein]	23000518
C507699	necrostatin-1	necrostatin-1 binds to and results in decreased activity of RIPK1 protein	23147571
D009532	Nickel	Nickel results in increased expression of RIPK1 mRNA	25583101
C107010	O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RIPK1 mRNA]"	15913567
D010100	Oxygen	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]"	23452621
D010100	Oxygen	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]	23452621
D010100	Oxygen	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]	23452621
D010100	Oxygen	Oxygen deficiency results in increased expression of RIPK1 mRNA	23452621
D010100	Oxygen	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]	23452621
D010100	Oxygen	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]	23452621
D010269	Paraquat	[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA	23963992
D010269	Paraquat	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA]	23963992
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of RIPK1 mRNA	23892564
C006253	pirinixic acid	pirinixic acid results in decreased expression of RIPK1 mRNA	23811191
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]	23452621
D010936	Plant Extracts	Plant Extracts results in increased expression of RIPK1 mRNA	23557933
D011070	Poly I-C	Poly I-C results in decreased expression of RIPK1 mRNA	19563882
C059514	resveratrol	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]	23452621
C059514	resveratrol	resveratrol analog results in decreased expression of RIPK1 protein	15652768
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of RIPK1 mRNA	21427059
C016101	shikonin	shikonin promotes the reaction [RIPK1 protein binds to RIPK3 protein]	23261677
D012834	Silver	Silver analog results in decreased expression of RIPK1 mRNA	24462830
D012838	Silymarin	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA]	23963992
C025026	sodium sulfite	sodium sulfite results in increased expression of RIPK1 protein	23973939
D012999	Soman	Soman results in increased expression of RIPK1 mRNA	19281266
D053260	Soot	Soot results in increased expression of RIPK1 mRNA	26551751
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RIPK1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RIPK1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RIPK1 mRNA	12167310\|1532836
D014520	Urethane	Urethane results in increased expression of RIPK1 mRNA	28818685
D014580	Ursodeoxycholic Acid	RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]	21362627
D014580	Ursodeoxycholic Acid	RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]	21362627
D014580	Ursodeoxycholic Acid	RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]	21362627
D014580	Ursodeoxycholic Acid	RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]	21362627
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of RIPK1 mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of RIPK1 mRNA	17963808
D014635	Valproic Acid	Valproic Acid results in decreased expression of RIPK1 mRNA	21427059
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of RIPK1 gene	25560391
C111237	vorinostat	benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[vorinostat co-treated with TNFSF10 protein] affects the localization of RIPK1 protein]	19643600
C111237	vorinostat	[vorinostat co-treated with TNFSF10 protein] affects the localization of RIPK1 protein	19643600

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004672	protein kinase activity	-	IDA	15001576 22265413
GO:0004672	protein kinase activity	-	IMP	22817896
GO:0004674	protein serine/threonine kinase activity	-	IBA	21873635
GO:0004674	protein serine/threonine kinase activity	-	IDA	8612133 23473668
GO:0004706	JUN kinase kinase kinase activity	-	IBA	21873635
GO:0005123	death receptor binding	-	IPI	7538908
GO:0005515	protein binding	-	IPI	8612133 10356400 10880512 11854271 12884866 12887920 14653779 14743216 16127453 16611992 17047155 17389591 17449468 18022363 18029035 18067272 18485876 19060883 19524512 19524513 19781631 21383699 21458669 21525013 21810480 21887730 21931591 22173242 22265413 22265414 22274400 22817896 22939624 23104095 23313255 23955153 24025841 25402006 25416956 25736436 25911380 26559832
GO:0005524	ATP binding	-	IEA	-
GO:0031625	ubiquitin protein ligase binding	-	IPI	18450452
GO:0042802	identical protein binding	-	IPI	14743216 22817896 23473668 25416956
GO:0044877	protein-containing complex binding	-	IDA	22265414
GO:0070513	death domain binding	-	IPI	8612133 9044836

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	IBA	21873635
GO:0001934	positive regulation of protein phosphorylation	-	IMP	17389591
GO:0002756	MyD88-independent toll-like receptor signaling pathway	-	TAS	-
GO:0006915	apoptotic process	-	IMP	21737330 22891283
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	TAS	-
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	TAS	-
GO:0007257	activation of JUN kinase activity	-	IBA	21873635
GO:0007257	activation of JUN kinase activity	-	TAS	17979836
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	-	TAS	-
GO:0010940	positive regulation of necrotic cell death	-	IMP	20550618
GO:0016032	viral process	-	IEA	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0032757	positive regulation of interleukin-8 production	-	IDA	16127453
GO:0032760	positive regulation of tumor necrosis factor production	-	IDA	16127453
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	IC	8612133
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	-
GO:0034138	toll-like receptor 3 signaling pathway	-	TAS	-
GO:0034612	response to tumor necrosis factor	-	IMP	10521396
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	-	TAS	-
GO:0036289	peptidyl-serine autophosphorylation	-	IDA	23473668
GO:0043065	positive regulation of apoptotic process	-	IDA	8612133 17389591
GO:0043065	positive regulation of apoptotic process	-	IMP	22173242
GO:0043068	positive regulation of programmed cell death	-	IMP	16611992
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IDA	17389591
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IEP	12761501
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	-	IMP	17047155
GO:0044257	cellular protein catabolic process	-	IDA	17389591
GO:0045651	positive regulation of macrophage differentiation	-	IMP	17047155
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	16127453 17389591
GO:0046330	positive regulation of JNK cascade	-	IDA	17389591
GO:0046777	protein autophosphorylation	-	IDA	8612133
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IMP	8612133 10521396 21931591
GO:0051260	protein homooligomerization	-	IDA	22817896
GO:0051291	protein heterooligomerization	-	IMP	22817896
GO:0060545	positive regulation of necroptotic process	-	IMP	22028622 22274400 22817896
GO:0070231	T cell apoptotic process	-	ISS	-
GO:0070266	necroptotic process	-	IMP	21737330 22265413 22265414
GO:0070266	necroptotic process	-	TAS	-
GO:0070926	regulation of ATP:ADP antiporter activity	-	IMP	16507998
GO:0071356	cellular response to tumor necrosis factor	-	IDA	17389591
GO:0071363	cellular response to growth factor stimulus	-	IEA	-
GO:0071550	death-inducing signaling complex assembly	-	TAS	-
GO:0097190	apoptotic signaling pathway	-	TAS	-
GO:0097191	extrinsic apoptotic signaling pathway	-	IDA	7538908
GO:0097191	extrinsic apoptotic signaling pathway	-	IMP	8612133 10521396
GO:0097343	ripoptosome assembly	-	IMP	21737330
GO:0097527	necroptotic signaling pathway	-	IMP	11101870 16507998
GO:0097527	necroptotic signaling pathway	-	ISS	-
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	TAS	-
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	TAS	-
GO:1905206	positive regulation of hydrogen peroxide-induced cell death	-	IMP	20550618
GO:1990000	amyloid fibril formation	-	IMP	22817896
GO:2000379	positive regulation of reactive oxygen species metabolic process	-	TAS	17979836
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	-	IMP	21525013
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	-	IMP	21525013 22274400
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IDA	16507998
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0010008	endosome membrane	-	TAS	-
GO:0031264	death-inducing signaling complex	-	IDA	11101870
GO:0043235	receptor complex	-	IDA	8612133
GO:0045121	membrane raft	-	IEA	-
GO:0097342	ripoptosome	-	IDA	21737330

KEGG ID	KEGG Term
hsa04210	Apoptosis
hsa04620	Toll-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway
hsa05160	Hepatitis C

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-140534	Ligand-dependent caspase activation	TAS
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	TAS
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	TAS
R-HSA-2562578	TRIF-mediated programmed cell death	TAS
R-HSA-2672351	Stimuli-sensing channels	TAS
R-HSA-3295583	TRP channels	TAS
R-HSA-3371378	Regulation by c-FLIP	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5213460	RIPK1-mediated regulated necrosis	TAS
R-HSA-5218859	Regulated Necrosis	TAS
R-HSA-5218900	CASP8 activity is inhibited	TAS
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalling pathway	TAS
R-HSA-5357786	TNFR1-induced proapoptotic signaling	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-5357905	Regulation of TNFR1 signaling	TAS
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	TAS
R-HSA-5675482	Regulation of necroptotic cell death	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-5689896	Ovarian tumor domain proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-69416	Dimerization of procaspase-8	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-75893	TNF signaling	TAS
R-HSA-9013957	TLR3-mediated TICAM1-dependent programmed cell death	TAS
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	TAS
R-HSA-937041	IKK complex recruitment mediated by RIP1	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-983712	Ion channel transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26202054	Interaction between smoking history and gene expression levels impacts survival of breast cancer patients. (2015 Aug)	Andres SA	Breast Cancer Res Treat
23908141	Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk. (2013 Nov)	Jang JH	Mol Carcinog