Gene: HRK

8739
DP5|HARAKIRI
harakiri, BCL2 interacting protein
protein-coding
12q24.22
Ensembl:ENSG00000135116 MIM:603447 Vega:OTTHUMG00000169328 UniprotKB:O00198
NC_000012.12
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.604e-1 (AD)  6.397e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XKR70.783
ARL4D0.775
ADRA2A0.769
GPR680.758
CCKBR0.755
GRM20.748
STX1A0.745
GALNT140.742
SSTR20.74
ABCC120.738

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASB4-0.558
PARD3B-0.515
PHEX-0.496
MYOM1-0.487
PON3-0.474
FXYD3-0.461
C10orf105-0.461
MBNL3-0.451
OLAH-0.447
ARHGAP19-0.446

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid results in decreased expression of HRK mRNA19435785
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of HRK mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HRK mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of HRK mRNA"19095052
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HRK"25697951
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HRK mRNA"21346803
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in increased expression of HRK mRNA"22514694
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
D000447AldehydesAldehydes results in increased expression of HRK mRNA25014914
D000638AmiodaroneAmiodarone results in increased expression of HRK mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HRK mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of HRK mRNA20471514|2434546
C006632arsenic trioxidearsenic trioxide results in increased expression of HRK mRNA19730151
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of HRK mRNA"17331233
D001374AzacitidineAzacitidine results in increased expression of HRK mRNA15547111
C006780bisphenol Abisphenol A affects the expression of HRK mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of HRK mRNA26079696
D002331CarnitineCarnitine inhibits the reaction [Gentamicins results in increased expression of HRK mRNA]16239342
D002331CarnitineCarnitine inhibits the reaction [Gentamicins results in increased expression of HRK protein]16239342
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of HRK mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HRK gene20938992
D002994ClofibrateClofibrate results in decreased expression of HRK mRNA17585979
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of HRK mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of HRK mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of HRK mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of HRK mRNA24834073
C014347decitabinedecitabine affects the expression of HRK mRNA23300844
D003976DiazinonDiazinon affects the expression of HRK mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HRK mRNA21266533
D002945CisplatinCisplatin affects the expression of HRK mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of HRK mRNA27392435
D002945CisplatinCisplatin results in decreased expression of HRK mRNA27392435
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene affects the expression of HRK mRNA24576310
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of HRK mRNA16931933
D004026DieldrinDieldrin affects the expression of HRK mRNA22546817
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of HRK mRNA24690739
C118739entinostatentinostat results in increased expression of HRK mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C082360fipronilfipronil results in increased expression of HRK mRNA23962444
D005419FlavonoidsFlavonoids results in increased expression of HRK mRNA18035473
D005492Folic AcidFolic Acid affects the expression of HRK mRNA16361273
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HRK gene20938992
C039281furanfuran results in increased expression of HRK mRNA20562052|2207923
D005665FurosemideFurosemide affects the expression of HRK mRNA17497460
D005839GentamicinsCarnitine inhibits the reaction [Gentamicins results in increased expression of HRK mRNA]16239342
D005839GentamicinsCarnitine inhibits the reaction [Gentamicins results in increased expression of HRK protein]16239342
D005839GentamicinsGentamicins results in increased expression of HRK mRNA16239342
D005839GentamicinsGentamicins results in increased expression of HRK protein16239342
D005839GentamicinsHRK affects the reaction [Gentamicins results in increased activity of CASP3 protein]16239342
C004312glycidolglycidol results in increased expression of HRK mRNA24915197
C010176halofuginonehalofuginone results in decreased expression of HRK mRNA17180598
C492448ICG 001ICG 001 results in increased expression of HRK mRNA26191083
D007530IsofluraneIsoflurane results in decreased expression of HRK mRNA16978161
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of HRK mRNA27392435
D007649KetamineKetamine results in increased expression of HRK mRNA20080153
D007854LeadLead results in decreased expression of HRK mRNA19921347
C045463leflunomideleflunomide results in increased expression of HRK mRNA28988120
C042720mercuric bromidemercuric bromide results in increased expression of HRK mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of HRK mRNA25290377
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HRK gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HRK mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA24399507
D0156551-Methyl-4-phenylpyridiniumsphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]24399507
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of HRK mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HRK mRNA16357179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HRK mRNA"15585362
C119536nickel acetateNFE2L2 protein inhibits the reaction [nickel acetate results in increased expression of HRK mRNA]23023193
C119536nickel acetatenickel acetate results in decreased expression of HRK mRNA23023193
C022838nickel chloridenickel chloride affects the expression of HRK mRNA22546817
C016340o,p'-DDT"o,p'-DDT results in increased expression of HRK mRNA"18204070
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of HRK mRNA"22937105
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of HRK mRNA24888373
D010126OzoneOzone results in increased expression of HRK mRNA25838073
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of HRK mRNA26272509
D010269ParaquatParaquat results in decreased expression of HRK mRNA18836921
C046012pentanalpentanal results in increased expression of HRK mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
D010862PilocarpinePilocarpine results in decreased expression of HRK mRNA17971868
C006253pirinixic acidpirinixic acid results in increased expression of HRK mRNA19162173
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of HRK mRNA24888373
D059808PolyphenolsPolyphenols results in decreased expression of HRK mRNA16293270
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of HRK mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of HRK mRNA22238285
C005556propionaldehydepropionaldehyde results in increased expression of HRK mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of HRK mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HRK mRNA25895662
D012906SmokeSmoke results in decreased expression of HRK mRNA21095227
C060506sphingosine 1-phosphatesphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]24399507
D013629TamoxifenTamoxifen affects the expression of HRK mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HRK mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HRK mRNA11879969|1471864
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HRK protein11879969
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HRK mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HRK mRNA21724226
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HRK mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of HRK mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HRK mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of HRK mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of HRK mRNA27188386
D014635Valproic AcidValproic Acid affects the expression of HRK mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HRK gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRK mRNA"27188386
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of HRK mRNA16931933
D015032ZincZinc deficiency results in decreased expression of HRK mRNA18356318
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HRK mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of HRK mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14596824  15031724  15694340  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0032464positive regulation of protein homooligomerization-IDA21041309  
GO:0043065positive regulation of apoptotic process-IBA21873635  
GO:0043065positive regulation of apoptotic process-IMP15031724  
GO:0090200positive regulation of release of cytochrome c from mitochondria-IDA21041309  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA15031724  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24186945Respiratory disease mortality among US coal miners; results after 37 years of follow-up. (2014 Jan)Graber JMOccup Environ Med
24847019In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. (2014 Jul)Fowler PAHum Reprod
16830233Embryonic loss due to exposure to polycyclic aromatic hydrocarbons is mediated by Bax. (2006 Aug)Detmar JApoptosis