Gene: TNFSF13

8741
APRIL|CD256|TALL-2|TALL2|TNLG7B|TRDL-1|UNQ383/PRO715|ZTNF2
TNF superfamily member 13
protein-coding
17p13.1
Ensembl:ENSG00000161955 MIM:604472 Vega:OTTHUMG00000108145 UniprotKB:O75888
NG_029949.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.926e-2 (AD)  6.108e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH4A10.907
PBXIP10.905
TP53BP20.904
MLC10.898
SLC25A180.898
SOX90.896
CDC42EP40.895
PLEKHO20.893
GPR1430.892
RGS200.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL12RB2-0.474
SAMD5-0.471
ZNF860-0.469
TYRP1-0.468
ARHGEF28-0.467
SYNPO2-0.464
CCDC68-0.464
KCNK2-0.457
OSBPL10-0.455
COL19A1-0.45

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of TNFSF13 mRNA"19162173
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of TNFSF13 mRNA28522335
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TNFSF13 mRNA"23196670
D000082Acetaminophen[Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of TNFSF13 mRNA17093179
D000082AcetaminophenAcetaminophen affects the expression of TNFSF13 mRNA17562736
D020106AcrylamideAcrylamide affects the expression of TNFSF13 mRNA28959563
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of TNFSF13 mRNA28522335
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TNFSF13 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of TNFSF13 mRNA15761015
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNFSF13 mRNA19152381
D001564Benzo(a)pyrenechlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNFSF13 mRNA]19152381
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNFSF13 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of TNFSF13 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of TNFSF13 mRNA18958704
C018475butyraldehydebutyraldehyde results in decreased expression of TNFSF13 mRNA26079696
D002104CadmiumCadmium results in decreased expression of TNFSF13 mRNA21120746
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TNFSF13 mRNA17484886
C062876cetrorelixcetrorelix results in decreased expression of TNFSF13 mRNA21062912
C007020chlorophyllinchlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNFSF13 mRNA]19152381
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFSF13 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of TNFSF13 mRNA19376846
D003471CuprizoneCuprizone results in decreased expression of TNFSF13 mRNA27523638
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TNFSF13 mRNA23640034
C014347decitabinedecitabine affects the expression of TNFSF13 mRNA17145863
D002945CisplatinCisplatin results in decreased expression of TNFSF13 mRNA18423122
D004040Dietary Carbohydrates[Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of TNFSF13 mRNA17093179
D002117CalcitriolCalcitriol results in increased expression of TNFSF13 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TNFSF13 mRNA21592394
D004237DiuronDiuron results in decreased expression of TNFSF13 mRNA25152437
D005472FluorouracilFluorouracil results in increased expression of TNFSF13 mRNA18423122|2000333
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFSF13 mRNA20938992
C039281furanfuran results in decreased expression of TNFSF13 mRNA26194646
D005665FurosemideFurosemide affects the expression of TNFSF13 mRNA17497460
C004312glycidolglycidol results in decreased expression of TNFSF13 mRNA24915197
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFSF13 mRNA25613284
D007530IsofluraneIsoflurane results in decreased expression of TNFSF13 mRNA16978161
D007854LeadLead results in decreased expression of TNFSF13 mRNA19921347
C045463leflunomideleflunomide results in decreased expression of TNFSF13 mRNA19751817
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNFSF13 mRNA21131560
D008070LipopolysaccharidesTetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of TNFSF13 mRNA]21131560
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFSF13 mRNA20938992
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TNFSF13 mRNA25729387
D017239PaclitaxelPaclitaxel results in increased expression of TNFSF13 mRNA18058816
D010424PentobarbitalPentobarbital results in decreased expression of TNFSF13 mRNA16978161
D010862PilocarpinePilocarpine results in decreased expression of TNFSF13 mRNA17971868
D011441PropylthiouracilPropylthiouracil results in decreased expression of TNFSF13 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TNFSF13 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TNFSF13 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of TNFSF13 mRNA22431001
D012999SomanSoman results in increased expression of TNFSF13 mRNA19281266
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TNFSF13 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TNFSF13 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of TNFSF13 mRNA]21131560
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TNFSF13 mRNA21131560
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNFSF13 mRNA21131560
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TNFSF13 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFSF13 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TNFSF13 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TNFSF13 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TNFSF13 mRNA"26179874
C029297vinylidene chloridevinylidene chloride results in increased expression of TNFSF13 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS9743536  
GO:0005125cytokine activity-IEA-  
GO:0005164tumor necrosis factor receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-IEA-  
GO:0007165signal transduction-TAS9743536  
GO:0008284positive regulation of cell proliferation-TAS9743536  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0043488regulation of mRNA stability-TAS-  
GO:0048298positive regulation of isotype switching to IgA isotypes-IDA14988498  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA19828625  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04672Intestinal immune network for IgA production
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-450520HuR (ELAVL1) binds and stabilizes mRNATAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23118916Genome-wide scan identifies variant in TNFSF13 associated with serum IgM in a healthy Chinese male population. (2012)Yang MPLoS One
23919740Comparison of circulating tumour necrosis factor superfamily cytokines in periodontitis patients undergoing supportive therapy: a case-controlled cross-sectional study comparing smokers and non-smokers in health and disease. (2013 Sep)Nile CJJ Clin Periodontol