Gene: CBS

875
HIP4
cystathionine-beta-synthase
protein-coding
21q22.3
Ensembl:ENSG00000160200 MIM:613381 Vega:OTTHUMG00000086834 UniprotKB:P35520
NG_008938.1
PubMed
0   ANCO-SNPs
ND|AD
19   
7.847e-1 (AD)  7.301e-1 (ND)   (Frontal_Cortex)
9.531e-1 (AD)  6.251e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPT20.838
ZFAND30.829
SLC44A20.822
PGM10.822
ALDH20.82
LRRC8A0.818
BBS20.814
CLU0.813
CYB5R30.811
IDH20.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.661
OR4F29-0.614
OR6C74-0.283
CETP-0.262
SCARA5-0.24
KLK9-0.227
CD244-0.225
WDR72-0.217
TSHR-0.214
DKK2-0.214

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00118AdemetionineSmall Molecule29908-03-0Approved|Investigational|NutraceuticalTarget
DB00133SerineSmall Molecule56-45-1Approved|NutraceuticalTarget
DB00151L-CysteineSmall Molecule52-90-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CBS mRNA"28903501
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of CBS mRNA20566314
C0326681-nitropyrene1-nitropyrene results in increased expression of CBS mRNA19041380
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CBS mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CBS mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
C0080704-hydroxyphenylacetic acid4-hydroxyphenylacetic acid inhibits the reaction [Peroxynitrous Acid results in decreased activity of CBS protein]19733148
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CBS mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of CBS mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of CBS mRNA25499718
D000082AcetaminophenCBS gene mutant form results in increased susceptibility to Acetaminophen25499718
D000082Acetaminophen[CBS gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of GPT protein25499718
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Rotenone results in decreased expression of CBS protein]25086357
D012436S-AdenosylmethionineS-Adenosylmethionine results in increased activity of CBS protein23665415
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CBS mRNA19770486
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of CBS protein17854288
D006710HomocysteineCBS protein affects the abundance of Homocysteine23024785
D006710HomocysteineCBS protein affects the abundance of Homocysteine metabolite19204075
D006710HomocysteineCBS protein results in increased metabolism of Homocysteine23665415
D006710Homocysteine[CBS protein results in increased metabolism of Homocysteine] which results in increased chemical synthesis of Cystathionine23665415
D001151ArsenicArsenic affects the methylation of CBS gene25304211
D001151ArsenicArsenic results in increased expression of CBS mRNA18487201
D001151ArsenicCBS gene polymorphism affects the metabolism of Arsenic20670920
D001151ArsenicCBS gene polymorphism affects the susceptibility to Arsenic20670920
D001151ArsenicCBS gene SNP affects the metabolism of Arsenic20600216
D001205Ascorbic AcidAscorbic Acid results in decreased expression of CBS mRNA19197388
C547126AZM551248AZM551248 results in decreased expression of CBS mRNA22323515
C028559bathocuproine sulfonatebathocuproine sulfonate results in decreased expression of CBS mRNA16973896
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of CBS mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of CBS mRNA20678512
C006780bisphenol Abisphenol A results in decreased expression of CBS mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of CBS protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CBS mRNA15336504|2750901
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased methylation of CBS gene27509014
C584509C646 compoundC646 compound results in increased expression of CBS mRNA26191083
D002104CadmiumCBS protein results in decreased susceptibility to Cadmium28115653
D002104CadmiumCadmium results in increased expression of CBS mRNA24603357
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CBS mRNA18804290
D002220CarbamazepineCarbamazepine affects the expression of CBS mRNA24752500
D002254CarbonatesCarbonates analog results in decreased activity of CBS protein19733148
D002518CeramidesCBS protein affects the abundance of Ceramides23024785
D002518CeramidesSMPD1 protein affects the reaction [CBS protein affects the abundance of Ceramides]23024785
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CBS mRNA18804290
D002794Choline[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of CBS mRNA23439872
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CBS mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of CBS mRNA24386269
C018021cobaltous chloridecobaltous chloride results in decreased expression of CBS protein21998720|2438626
D003300CopperCopper results in decreased expression of CBS mRNA24603357
D003300CopperCopper results in decreased expression of CBS mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of CBS mRNA19549813
D003471CuprizoneCuprizone results in increased expression of CBS mRNA27523638
D016572CyclosporineCyclosporine affects the expression of CBS mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of CBS mRNA20106945|2163298
D003540Cystathionine[CBS protein results in increased metabolism of Homocysteine] which results in increased chemical synthesis of Cystathionine23665415
D003545CysteineCysteine inhibits the reaction [[CBS protein co-treated with Methylmercury Compounds] results in increased chemical synthesis of methylmercury sulfide]21951228
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CBS mRNA27392435
D002945CisplatinCisplatin results in increased expression of CBS mRNA27594783
D004008DiclofenacDiclofenac affects the expression of CBS mRNA24752500
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CBS mRNA19245819
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CBS mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CBS mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CBS mRNA19638242
D004147DioxinsDioxins affects the expression of CBS mRNA20463971
C118739entinostatentinostat results in increased expression of CBS mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of CBS mRNA20064776
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CBS protein23301498
D000431EthanolEthanol results in decreased expression of CBS mRNA28986285
D000431Ethanol[Ethanol co-treated with Folic Acid deficiency] results in increased activity of CBS protein16792574
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of CBS mRNA]15016801
D005492Folic Acid[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of CBS mRNA23439872
D005492Folic AcidFolic Acid results in increased expression of CBS mRNA22959928
D005492Folic Acid[Ethanol co-treated with Folic Acid deficiency] results in increased activity of CBS protein16792574
D005492Folic AcidFolic Acid deficiency results in increased activity of CBS protein16792574
D005557FormaldehydeFormaldehyde results in increased expression of CBS mRNA27664576
D005557FormaldehydeFormaldehyde results in increased expression of CBS protein27664576
D005557FormaldehydeCBS protein affects the reaction [Formaldehyde results in increased abundance of Hydrogen Sulfide]23359814
D005557FormaldehydeCBS protein affects the reaction [Formaldehyde results in increased abundance of Reactive Oxygen Species]23359814
D005557FormaldehydeFormaldehyde results in decreased expression of CBS protein23359814
D005557Formaldehyde[Formaldehyde results in decreased expression of CBS protein] which results in decreased abundance of Hydrogen Sulfide23359814
D019833GenisteinGenistein results in decreased expression of CBS mRNA28988043
D005947GlucoseGlucose results in increased expression of CBS mRNA17178593
D005978GlutathioneCBS gene mutant form results in decreased abundance of Glutathione15016621
C529376GYY 4137"GYY 4137 inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of CBS protein]"28185984
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of CBS mRNA20566314
D006862Hydrogen SulfideCBS protein results in increased chemical synthesis of Hydrogen Sulfide21951228
D006862Hydrogen Sulfide[CBS protein results in increased chemical synthesis of Hydrogen Sulfide] which results in decreased susceptibility to Methylmercury Compounds21951228
D006862Hydrogen SulfideCBS protein results in increased abundance of Hydrogen Sulfide25086357
D006862Hydrogen SulfideCBS protein affects the reaction [Formaldehyde results in increased abundance of Hydrogen Sulfide]23359814
D006862Hydrogen SulfideCBS protein results in increased abundance of Hydrogen Sulfide23359814
D006862Hydrogen Sulfide[Formaldehyde results in decreased expression of CBS protein] which results in decreased abundance of Hydrogen Sulfide23359814
D006862Hydrogen SulfideCBS results in increased chemical synthesis of Hydrogen Sulfide25205294
D019811Hydroxylamine"Hydroxylamine promotes the reaction [Sodium Chloride, Dietary results in decreased expression of CBS protein]"28185984
C492448ICG 001ICG 001 results in increased expression of CBS mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of CBS mRNA17401462
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CBS mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CBS mRNA27392435
C544151jinfukangjinfukang results in increased expression of CBS mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CBS mRNA24796395|2675264
C410337K 7174K 7174 results in increased expression of CBS mRNA24086573
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CBS mRNA25613284
D008701MethapyrileneMethapyrilene results in decreased expression of CBS mRNA16393664
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of CBS mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CBS mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CBS mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
D008767Methylmercury CompoundsCBS protein results in decreased susceptibility to Methylmercury Compounds21951228
D008767Methylmercury Compounds[CBS protein results in increased chemical synthesis of Hydrogen Sulfide] which results in decreased susceptibility to Methylmercury Compounds21951228
D008767Methylmercury CompoundsCysteine inhibits the reaction [[CBS protein co-treated with Methylmercury Compounds] results in increased chemical synthesis of methylmercury sulfide]21951228
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of CBS mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of CBS mRNA21664453
C108833methylmercury sulfideCysteine inhibits the reaction [[CBS protein co-treated with Methylmercury Compounds] results in increased chemical synthesis of methylmercury sulfide]21951228
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CBS mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CBS mRNA24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CBS protein24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CBS protein21748658
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of CBS mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of CBS mRNA21195148
C500085muraglitazarmuraglitazar results in increased expression of CBS mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CBS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CBS mRNA"25554681
C022838nickel chloridenickel chloride affects the expression of CBS mRNA22110744
D017672Nitrogen Compounds[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds18224302
D017672Nitrogen CompoundsSimvastatin inhibits the reaction [[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds]18224302
D009585Nitrogen DioxideNitrogen Dioxide results in decreased activity of CBS protein19733148
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of CBS mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of CBS protein19716841
D010100OxygenOxygen results in increased expression of CBS protein27273718
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CBS mRNA26705709
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of CBS mRNA18281256
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CBS mRNA18804290
D030421Peroxynitrous Acid4-hydroxyphenylacetic acid inhibits the reaction [Peroxynitrous Acid results in decreased activity of CBS protein]19733148
D030421Peroxynitrous AcidPeroxynitrous Acid results in decreased activity of CBS protein19733148
D015232DinoprostoneCBS protein inhibits the reaction [Rotenone results in increased abundance of Dinoprostone]25086357
C031181phenanthrenephenanthrene results in increased expression of CBS mRNA19457238
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CBS mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of CBS mRNA19270015|1948288
D010634PhenobarbitalPhenobarbital results in increased expression of CBS mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of CBS mRNA23811191
C006253pirinixic acidpirinixic acid results in decreased expression of CBS mRNA17164430
D010936Plant ExtractsPlant Extracts results in decreased expression of CBS mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of CBS mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of CBS mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of CBS mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of CBS mRNA22238285
C045950propiconazolepropiconazole results in decreased expression of CBS mRNA21278054
C015586propiverinepropiverine binds to CBS protein29273565
D011794QuercetinQuercetin results in decreased expression of CBS mRNA21632981
D017382Reactive Oxygen SpeciesCBS protein affects the reaction [Formaldehyde results in increased abundance of Reactive Oxygen Species]23359814
C089730rosiglitazonerosiglitazone results in decreased expression of CBS mRNA25572481
C089730rosiglitazonerosiglitazone results in increased expression of CBS mRNA21515302
D012402RotenoneRotenone results in increased expression of CBS mRNA24810058
D012402RotenoneAcetylcysteine inhibits the reaction [Rotenone results in decreased expression of CBS protein]25086357
D012402RotenoneCBS protein inhibits the reaction [Rotenone results in decreased expression of IL10 mRNA]25086357
D012402RotenoneCBS protein inhibits the reaction [Rotenone results in increased abundance of Dinoprostone]25086357
D012402RotenoneCBS protein inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]25086357
D012402RotenoneCBS protein inhibits the reaction [Rotenone results in increased expression of TNF mRNA]25086357
D012402RotenoneRotenone results in decreased expression of CBS mRNA25086357
D012402RotenoneRotenone results in decreased expression of CBS protein25086357
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CBS mRNA25351596
D019821SimvastatinSimvastatin inhibits the reaction [[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds]18224302
D019821SimvastatinSimvastatin promotes the reaction [[APOA4 protein co-treated with CBS protein] affects the expression of CAV1 protein]18224302
C017947sodium arsenitesodium arsenite results in decreased expression of CBS protein24866292
C017947sodium arsenitesodium arsenite results in decreased expression of CBS protein24866292
D017673Sodium Chloride, Dietary"GYY 4137 inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of CBS protein]"28185984
D017673Sodium Chloride, Dietary"Hydroxylamine promotes the reaction [Sodium Chloride, Dietary results in decreased expression of CBS protein]"28185984
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in decreased expression of CBS protein"28185984
D018038Sodium SeleniteSodium Selenite results in increased expression of CBS mRNA24383545
D013481SuperoxidesCBS protein affects the abundance of Superoxides23024785
D013481SuperoxidesSMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides]23024785
D014284TriiodothyronineTriiodothyronine results in increased expression of CBS mRNA22281776
C501413tesaglitazartesaglitazar results in increased expression of CBS mRNA21515302
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of CBS mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CBS mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CBS mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of CBS mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CBS mRNA19770486|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CBS mRNA21215274|2172422
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of CBS mRNA28973375
D013752TetracyclineTetracycline results in decreased expression of CBS mRNA24489787
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CBS mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CBS mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of CBS mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CBS mRNA28065790
D014212TretinoinTretinoin results in decreased expression of CBS mRNA19960509|2372400
D014212TretinoinTretinoin results in decreased expression of CBS protein19960509
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CBS mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CBS mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of CBS mRNA21515302
C005460uranyl acetateuranyl acetate results in decreased expression of CBS protein26523793|2699101
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CBS mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CBS mRNA23179753|2438349
D014640VancomycinVancomycin results in increased expression of CBS mRNA18930951
C088658zoledronic acidzoledronic acid results in decreased expression of CBS mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004122cystathionine beta-synthase activity-IDA7929220  18776696  19010420  22985361  23981774  24416422  
GO:0004122cystathionine beta-synthase activity-TAS-  
GO:0004124cysteine synthase activity-IBA21873635  
GO:0005515protein binding-IPI17087506  25416956  27107014  
GO:0019825oxygen binding-IDA24515102  
GO:0019899enzyme binding-IPI17087506  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IDA7929220  24515102  
GO:0020037heme binding-IMP18776696  
GO:0030170pyridoxal phosphate binding-IBA21873635  
GO:0030170pyridoxal phosphate binding-IDA7929220  18776696  
GO:0031625ubiquitin protein ligase binding-IPI17087506  
GO:0042802identical protein binding-IPI16189514  19447967  21900206  25416956  
GO:0042803protein homodimerization activity-IDA11483494  
GO:0046872metal ion binding-IEA-  
GO:0050421nitrite reductase (NO-forming) activity-IDA24416422  
GO:0070025carbon monoxide binding-IDA24515102  
GO:0070026nitric oxide binding-IDA24416422  24515102  
GO:0072341modified amino acid binding-IDA20031578  
GO:1904047S-adenosyl-L-methionine binding-IDA22985361  
GO ID GO Term Qualifier Evidence PubMed
GO:0006535cysteine biosynthetic process from serine-IBA21873635  
GO:0006535cysteine biosynthetic process from serine-IEA-  
GO:0006563L-serine metabolic process-IDA19010420  
GO:0006565L-serine catabolic process-IDA18776696  
GO:0019343cysteine biosynthetic process via cystathionine-IEA-  
GO:0019344cysteine biosynthetic process-IDA24416422  
GO:0019346transsulfuration-TAS-  
GO:0019448L-cysteine catabolic process-IDA15520012  
GO:0042262DNA protection-IMP24534463  
GO:0043418homocysteine catabolic process-IDA18776696  24416422  
GO:0050667homocysteine metabolic process-IDA19010420  20031578  23981774  
GO:0055114oxidation-reduction process-IEA-  
GO:0070814hydrogen sulfide biosynthetic process-IDA15520012  24416422  
GO:0070814hydrogen sulfide biosynthetic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA17087506  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA23981774  
GO:0005829cytosol-HDA16780588  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00260Glycine, serine and threonine metabolism
hsa00270Cysteine and methionine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1614603Cysteine formation from homocysteineTAS
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-2408508Metabolism of ingested SeMet, Sec, MeSec into H2SeIEA
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24278388One-carbon metabolism pathway gene variants and risk of clear cell renal cell carcinoma in a Chinese population. (2013)Zhang LPLoS One
12439143Genetic risk factors in young adults with 'cryptogenic' ischemic cerebrovascular disease. (2002 Oct)Grossmann RBlood Coagul Fibrinolysis
11575217[APOC3, CETP, beta-fibrinogen and MTHFR are genetic determinants of carotid intim-media thickness (Stanislas cohort)]. (2001 Aug)Pallaud CArch Mal Coeur Vaiss
15313378Cigarette smoke increases intimal hyperplasia and homocysteine in a rat carotid endarterectomy. (2004 Sep)Davis JAJ Surg Res
9848890Carotid and femoral artery wall thickness and stiffness in patients at risk for cardiovascular disease, with special emphasis on hyperhomocysteinemia. (1998 Dec)Smilde TJArterioscler Thromb Vasc Biol
26536970[Serum cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE ) and cytochrome c oxidase (COX) in copper mine miners potentially expose d to hydrogen sulfide]. (2015)Skoczynska AMed Pr
14966476Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims. (2004 Feb)Hungund BLMol Psychiatry
15503105Plasma homocysteine, MTHFR C677T, CBS 844ins68bp, and MTHFD1 G1958A polymorphisms in spontaneous cervical artery dissections. (2004 Oct)Konrad CJ Neurol
21104445Mutations in methylenetetrahydrofolate reductase and in cysthationine beta synthase: is there a link to homocysteine levels in peripheral arterial disease? (2011 Jun)Santos MEMol Biol Rep
15726099Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer. (2005 Mar 14)Pufulete MBr J Cancer
11204591Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men. (2001 Jan)Dekou VThromb Haemost
29743070The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide. (2018 May 9)Perry MMRespir Res
11359462APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas cohort). (2001 May)Pallaud CClin Genet
15830093Hyperhomocysteinemia and atherosclerosis. (2005 Apr 25)Yang FSheng Li Xue Bao
25702197Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: results from the German Investigation on Neurobiology in Alcoholism (GINA). (2015 Mar)Semmler AAlcohol
23372658Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer. (2013)Swartz MDPLoS One
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet
17109677Rimonabant: endocannabinoid inhibition for the metabolic syndrome. (2006 Dec)Wierzbicki ASInt J Clin Pract
15181872[Hyperhomocysteinemia and pregnancy complications]. (2004 Apr)Sztenc SGinekol Pol