Gene info: ID 8764

Gene: TNFRSF14

GENE ID: 8764

Description: TNF receptor superfamily member 14

Gene type: protein-coding

Location: 1p36.32

dbXrefs: Ensembl:ENSG00000157873 MIM:602746 Vega:OTTHUMG00000000792 UniprotKB:Q92956

RefSeq: NG_047096.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.556e-1 (AD) 9.141e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EGFL7	0.759
C19orf66	0.757
LMF2	0.726
DENND3	0.724
RHOT2	0.715
DUS1L	0.71
RNPEP	0.71
DCAF15	0.707
RNF166	0.707
MAN2C1	0.704

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.487
OR4F5	-0.487
SLC27A6	-0.307
NKX2-1	-0.298
SLITRK6	-0.287
BTBD8	-0.264
KLHL1	-0.253
ISL1	-0.252
IRX2	-0.248
CRISP2	-0.247

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C024566	1,1,1-trichloroethane	"1,1,1-trichloroethane results in increased expression of TNFRSF14 mRNA"	25270620
C036423	1-aminomethylphosphonic acid	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of TNFRSF14 mRNA	20566314
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TNFRSF14 mRNA"	27291303
D000082	Acetaminophen	Acetaminophen results in decreased expression of TNFRSF14 mRNA	29067470
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TNFRSF14 mRNA	21641981
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of TNFRSF14 mRNA	24449571
D001151	Arsenic	[Arsenic co-treated with Fluorides] results in decreased expression of TNFRSF14 mRNA	19962721
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TNFRSF14 mRNA	17530438
C547126	AZM551248	AZM551248 results in increased expression of TNFRSF14 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TNFRSF14 mRNA	21632981\|2231617
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TNFRSF14 mRNA	25908611
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TNFRSF14 mRNA"	26238291
C006780	bisphenol A	bisphenol A results in increased expression of TNFRSF14 mRNA	27685785
C006780	bisphenol A	bisphenol A results in increased methylation of TNFRSF14 promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of TNFRSF14 mRNA	25181051
C584509	C646 compound	C646 compound results in increased expression of TNFRSF14 mRNA	26191083
D002746	Chlorpromazine	Chlorpromazine analog results in increased expression of TNFRSF14 mRNA	15924885
D003042	Cocaine	Cocaine results in increased expression of TNFRSF14 mRNA	20948987
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TNFRSF14 mRNA	19549813
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of TNFRSF14 mRNA	21527772
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in increased expression of TNFRSF14 mRNA]	27392435
D002945	Cisplatin	Cisplatin results in increased expression of TNFRSF14 mRNA	27594783
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in increased expression of TNFRSF14 mRNA]	27392435
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of TNFRSF14 mRNA	28085963
C014476	diethyl maleate	diethyl maleate results in decreased expression of TNFRSF14 mRNA	21161181
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNFRSF14 mRNA"	21527772
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of TNFRSF14 mRNA	23649840
D005047	Etoposide	Etoposide results in increased expression of TNFRSF14 mRNA	21527772
C056516	exemestane	exemestane results in increased expression of TNFRSF14 mRNA	17254854
D005459	Fluorides	[Arsenic co-treated with Fluorides] results in decreased expression of TNFRSF14 mRNA	19962721
D005459	Fluorides	Fluorides results in decreased expression of TNFRSF14 mRNA	19962721
D005492	Folic Acid	Folic Acid affects the expression of TNFRSF14 mRNA	16361273
D005620	Freund's Adjuvant	Freund's Adjuvant results in decreased expression of TNFRSF14 mRNA	20846436
D005839	Gentamicins	Gentamicins results in increased expression of TNFRSF14 mRNA	22061828
D006540	Herbicides	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of TNFRSF14 mRNA	20566314
C492448	ICG 001	ICG 001 results in increased expression of TNFRSF14 mRNA	26191083
C051890	irinotecan	irinotecan affects the expression of TNFRSF14 mRNA	20097248
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in increased expression of TNFRSF14 mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in increased expression of TNFRSF14 mRNA]	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TNFRSF14 mRNA	23086925
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TNFRSF14 mRNA	26582142
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TNFRSF14 mRNA	23649840
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of TNFRSF14 mRNA"	18204070
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of TNFRSF14 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of TNFRSF14 mRNA	25729387
D010634	Phenobarbital	Phenobarbital affects the expression of TNFRSF14 mRNA	19159669
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TNFRSF14 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of TNFRSF14 mRNA	17426115
C005556	propionaldehyde	propionaldehyde results in decreased expression of TNFRSF14 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of TNFRSF14 mRNA	24780913
D011794	Quercetin	Quercetin results in increased expression of TNFRSF14 mRNA	21632981
C061133	tamibarotene	tamibarotene results in increased expression of TNFRSF14 mRNA	15498508
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of TNFRSF14 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TNFRSF14 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TNFRSF14 mRNA	14718646\|2157046
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TNFRSF14 mRNA	22363418\|2806579
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of TNFRSF14 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of TNFRSF14 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of TNFRSF14 mRNA	15498508\|2383079
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of TNFRSF14 mRNA	21346803
D014520	Urethane	Urethane results in decreased expression of TNFRSF14 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased methylation of TNFRSF14 gene	29154799
C088658	zoledronic acid	zoledronic acid results in increased expression of TNFRSF14 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001618	virus receptor activity	-	IEA	-
GO:0005031	tumor necrosis factor-activated receptor activity	-	TAS	9153189
GO:0005515	protein binding	-	IPI	9153189 9162022 9462508 10318773 17353931 19332782 26977880
GO:0031625	ubiquitin protein ligase binding	-	IPI	11279055

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006955	immune response	-	TAS	9162022
GO:0007166	cell surface receptor signaling pathway	-	TAS	9153189
GO:0031295	T cell costimulation	-	TAS	-
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	-
GO:0046718	viral entry into host cell	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-388841	Costimulation by the CD28 family	IEA
R-HSA-388841	Costimulation by the CD28 family	TAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TAS
R-HSA-5669034	TNFs bind their physiological receptors	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20439292	Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)	van der Helm-van Mil AH	Ann Rheum Dis