Gene: RIPK2

8767
CARD3|CARDIAK|CCK|GIG30|RICK|RIP2
receptor interacting serine/threonine kinase 2
protein-coding
8q21.3
Ensembl:ENSG00000104312 MIM:603455 Vega:OTTHUMG00000163809 UniprotKB:O43353
NG_033016.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.508e-1 (AD)  9.162e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRY10.801
ARFGAP30.801
BTG30.784
ZNF2740.77
XBP10.76
NFIL30.749
WTAP0.748
PPIL40.741
LAP30.74
FEM1C0.74

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.422
OR4F29-0.398
HES5-0.257
PTGDR2-0.24
LYPD8-0.217
RERGL-0.212
GPR17-0.196
RNASE8-0.181
LRRC38-0.179
CRYBA2-0.173

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of RIPK2 mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RIPK2 mRNA"27589474
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RIPK2 mRNA"18648102
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of RIPK2 mRNA]"26546572
C5805985-OH-BDE-475-OH-BDE-47 results in decreased expression of RIPK2 mRNA27589474
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of RIPK2 mRNA]"19477266
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of RIPK2 mRNA27589474
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of RIPK2 mRNA]19477266
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of RIPK2 mRNA"24160326
D001280AtrazineAtrazine results in increased expression of RIPK2 mRNA25929836
D001374AzacitidineAzacitidine results in increased expression of RIPK2 mRNA15547111
D001379AzathioprineAzathioprine results in decreased expression of RIPK2 mRNA19192274
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RIPK2 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RIPK2 mRNA22228805
D004958EstradiolEstradiol affects the expression of RIPK2 mRNA14699072
D004958EstradiolEstradiol inhibits the reaction [Etoposide results in increased expression of RIPK2 mRNA]19426747
C044887beta-methylcholinebeta-methylcholine affects the expression of RIPK2 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of RIPK2 mRNA20678512|2927551
C006780bisphenol Abisphenol A results in increased expression of RIPK2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of RIPK2 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RIPK2 mRNA25993096
D002211CapsaicinCapsaicin results in increased expression of RIPK2 mRNA19502594
C023676chloroquine diphosphatechloroquine diphosphate results in decreased expression of RIPK2 mRNA19192274
D002784Cholesterol"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of RIPK2 mRNA]"19477266
D002784CholesterolAcetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of RIPK2 mRNA]19477266
D002784CholesterolCholesterol analog results in increased expression of RIPK2 mRNA19477266
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of RIPK2 mRNA18078969
D019327Copper SulfateCopper Sulfate results in increased expression of RIPK2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of RIPK2 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of RIPK2 mRNA20106945|2556210
C007262deoxynivalenoldeoxynivalenol results in increased expression of RIPK2 mRNA22968694
D002945CisplatinCisplatin results in decreased expression of RIPK2 mRNA27392435
D002945Cisplatin"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of RIPK2 mRNA]"26546572
D002945CisplatinCisplatin results in increased expression of RIPK2 mRNA26546572
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene affects the expression of RIPK2 mRNA24576310
C000944dicrotophosdicrotophos results in decreased expression of RIPK2 mRNA28302478
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of RIPK2 mRNA15784690
D004026DieldrinDieldrin affects the expression of RIPK2 mRNA22546817
D002117CalcitriolCalcitriol results in increased expression of RIPK2 mRNA16002434
D004147DioxinsDioxins affects the expression of RIPK2 mRNA20463971
D004317DoxorubicinRIPK2 protein affects the susceptibility to Doxorubicin16217747
D004391DustDust results in increased expression of RIPK2 mRNA17805423
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of RIPK2 mRNA19118595
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RIPK2 protein23301498
D005047EtoposideEstradiol inhibits the reaction [Etoposide results in increased expression of RIPK2 mRNA]19426747
D005047EtoposideEtoposide results in increased expression of RIPK2 mRNA19426747
C082360fipronilfipronil results in decreased expression of RIPK2 mRNA23962444
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of RIPK2 mRNA28329830
D005485FlutamideFlutamide results in decreased expression of RIPK2 mRNA24793618
C039281furanfuran results in increased expression of RIPK2 mRNA22079235
D005839GentamicinsGentamicins results in increased expression of RIPK2 mRNA22061828
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of RIPK2 mRNA19192274
D017313FenretinideFenretinide results in increased expression of RIPK2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RIPK2 mRNA25613284
C410337K 7174K 7174 results in increased expression of RIPK2 mRNA24086573
D007854LeadLead affects the expression of RIPK2 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RIPK2 mRNA20423518|2405697
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of RIPK2 mRNA]24056979
D008070Lipopolysaccharidesphenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of RIPK2 mRNA]20423518
D008727MethotrexateMethotrexate results in decreased expression of RIPK2 mRNA19192274
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of RIPK2 mRNA]24056979
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RIPK2 mRNA28001369
D008775MethylprednisoloneMethylprednisolone results in decreased expression of RIPK2 mRNA19192274
C022838nickel chloridenickel chloride results in increased expression of RIPK2 mRNA17312168
C029938nickel sulfatenickel sulfate results in increased expression of RIPK2 mRNA22714537
C025589ochratoxin Aochratoxin A results in decreased acetylation of RIPK2 promoter29098329
C025589ochratoxin A[ochratoxin A results in decreased acetylation of RIPK2 promoter] which results in decreased expression of RIPK2 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in decreased expression of RIPK2 mRNA29098329
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of RIPK2 mRNA"22937105
C016340o,p'-DDT"o,p'-DDT results in increased expression of RIPK2 mRNA"22937105
D008939MitotaneMitotane results in increased expression of RIPK2 mRNA23485034
D010269ParaquatParaquat results in increased expression of RIPK2 mRNA18836921
C058305phenethyl isothiocyanatephenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of RIPK2 mRNA]20423518
D010634PhenobarbitalPhenobarbital affects the expression of RIPK2 mRNA19159669
C006253pirinixic acidpirinixic acid inhibits the reaction [IL1B protein results in increased expression of RIPK2 mRNA]19693652
C006253pirinixic acidpirinixic acid inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA]19693652
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RIPK2 mRNA19710929
D010894PiroxicamPiroxicam results in decreased expression of RIPK2 mRNA19192274
D011239PrednisolonePrednisolone results in decreased expression of RIPK2 mRNA19192274
D011794QuercetinQuercetin results in increased expression of RIPK2 mRNA21632981
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of RIPK2 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide results in increased expression of RIPK2 mRNA23221170
C017947sodium arseniteCHEK2 protein affects the reaction [sodium arsenite results in increased expression of RIPK2 mRNA modified form]24865968
C017947sodium arseniteELAVL1 protein affects the reaction [sodium arsenite results in increased expression of RIPK2 mRNA modified form]24865968
C017947sodium arsenitesodium arsenite results in increased expression of RIPK2 mRNA24865968
C017947sodium arsenitesodium arsenite results in increased expression of RIPK2 mRNA modified form24865968
D012999SomanSoman results in increased expression of RIPK2 mRNA19281266
D012460SulfasalazineSulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA]19693652
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RIPK2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RIPK2 mRNA19520675
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RIPK2 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of RIPK2 protein24648495
D013853ThioacetamideThioacetamide results in increased expression of RIPK2 mRNA23411599
D019772TopotecanRIPK2 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in increased expression of RIPK2 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RIPK2 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of RIPK2 mRNA19140230
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of RIPK2 mRNA18078969
D014415TunicamycinTunicamycin results in increased expression of RIPK2 mRNA22378314
D014520UrethaneUrethane results in increased expression of RIPK2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of RIPK2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of RIPK2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of RIPK2 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RIPK2 gene25560391
D014750VincristineVincristine results in increased expression of RIPK2 mRNA23649840
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of RIPK2 mRNA15784690
C088658zoledronic acidzoledronic acid results in increased expression of RIPK2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004706JUN kinase kinase kinase activity-IBA21873635  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IEA-  
GO:0005102signaling receptor binding-IPI24790089  
GO:0005515protein binding-IPI9705938  10329646  11087742  11432859  11536016  15383541  
16418290  17054981  19337385  19667203  21887730  21903422  
21931591  22829933  23333941  25416956  28436939  
GO:0005524ATP binding-IEA-  
GO:0030274LIM domain binding-IPI15657077  
GO:0042802identical protein binding-IPI14743216  25416956  
GO:0042803protein homodimerization activity-IDA19337385  
GO:0050700CARD domain binding-IDA10329646  
GO:0050700CARD domain binding-IPI11087742  
GO:0089720caspase binding-IPI11432859  11536016  15383541  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0000187activation of MAPK activity-TAS-  
GO:0001961positive regulation of cytokine-mediated signaling pathway-IEA-  
GO:0002250adaptive immune response-IBA21873635  
GO:0002250adaptive immune response-ISS-  
GO:0002819regulation of adaptive immune response-IBA21873635  
GO:0006915apoptotic process-IEA-  
GO:0006954inflammatory response-TAS9705938  
GO:0007165signal transduction-TAS9642260  
GO:0007249I-kappaB kinase/NF-kappaB signaling-ISS-  
GO:0007254JNK cascade-TAS-  
GO:0007257activation of JUN kinase activity-IBA21873635  
GO:0010800positive regulation of peptidyl-threonine phosphorylation-IDA21887730  
GO:0010942positive regulation of cell death-IDA16920334  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0031398positive regulation of protein ubiquitination-IMP15620648  
GO:0031398positive regulation of protein ubiquitination-NAS22412986  
GO:0031663lipopolysaccharide-mediated signaling pathway-IEA-  
GO:0032092positive regulation of protein binding-IMP11432859  
GO:0032722positive regulation of chemokine production-IEA-  
GO:0032727positive regulation of interferon-alpha production-NAS22412986  
GO:0032728positive regulation of interferon-beta production-NAS22412986  
GO:0032729positive regulation of interferon-gamma production-IEA-  
GO:0032735positive regulation of interleukin-12 production-NAS22412986  
GO:0032743positive regulation of interleukin-2 production-IEA-  
GO:0032755positive regulation of interleukin-6 production-IEA-  
GO:0032760positive regulation of tumor necrosis factor production-IEA-  
GO:0033091positive regulation of immature T cell proliferation-IEA-  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IDA21887730  
GO:0034134toll-like receptor 2 signaling pathway-IDA11894098  
GO:0034142toll-like receptor 4 signaling pathway-IEA-  
GO:0042098T cell proliferation-IEA-  
GO:0043029T cell homeostasis-IBA21873635  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043066negative regulation of apoptotic process-TAS-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA10329646  
GO:0043330response to exogenous dsRNA-IEA-  
GO:0045087innate immune response-IBA21873635  
GO:0045087innate immune response-IDA23806334  
GO:0045087innate immune response-ISS-  
GO:0045627positive regulation of T-helper 1 cell differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-NAS22412986  
GO:0046330positive regulation of JNK cascade-IEA-  
GO:0046641positive regulation of alpha-beta T cell proliferation-IEA-  
GO:0050718positive regulation of interleukin-1 beta secretion-IDA11432859  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA21887730  
GO:0050830defense response to Gram-positive bacterium-IEA-  
GO:0050852T cell receptor signaling pathway-ISS-  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IBA21873635  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA11821383  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IMP21887730  21931591  
GO:0051092positive regulation of NF-kappaB transcription factor activity-TAS-  
GO:0070266necroptotic process-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway-TAS-  
GO:0070427nucleotide-binding oligomerization domain containing 1 signaling pathway-IEA-  
GO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathway-IDA23806334  
GO:0070498interleukin-1-mediated signaling pathway-TAS-  
GO:0070671response to interleukin-12-IEA-  
GO:0070673response to interleukin-18-IEA-  
GO:0071223cellular response to lipoteichoic acid-IEA-  
GO:0071224cellular response to peptidoglycan-IEA-  
GO:0071225cellular response to muramyl dipeptide-IDA21887730  
GO:0097202activation of cysteine-type endopeptidase activity-IDA11821383  
GO:1904417positive regulation of xenophagy-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA21887730  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IDA21887730  
GO:0031982vesicle-IDA21887730  
GO:0032991protein-containing complex-IDA11536016  15383541  21887730  
GO:0032991protein-containing complex-IMP11432859  
KEGG ID KEGG Term
hsa04621NOD-like receptor signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05131Shigellosis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168638NOD1/2 Signaling PathwayTAS
R-HSA-168638NOD1/2 Signaling PathwayIEA
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysTAS
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysIEA
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-193639p75NTR signals via NF-kBTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-209543p75NTR recruits signalling complexesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complexTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450294MAP kinase activationTAS
R-HSA-450302activated TAK1 mediates p38 MAPK activationTAS
R-HSA-450321JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1TAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689896Ovarian tumor domain proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-9020702Interleukin-1 signalingTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21931826Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells. (2011)Aldhous MCPLoS One