Gene info: ID 8772

Gene: FADD

GENE ID: 8772

Synonyms: GIG3|MORT1

Description: Fas associated via death domain

Gene type: protein-coding

Location: 11q13.3

dbXrefs: Ensembl:ENSG00000168040 MIM:602457 Vega:OTTHUMG00000167264 UniprotKB:Q13158

RefSeq: NG_027966.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND

# Publications: 8

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.918e-2 (AD) 9.715e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PRELID1	0.767
MESP1	0.724
DHRS13	0.723
FEM1A	0.715
GET4	0.713
PDF	0.712
IRF2BPL	0.703
CTU1	0.697
ENDOG	0.691
NTMT1	0.689

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
P2RY14	-0.389
MTRNR2L6	-0.356
XIRP2	-0.343
OR4F5	-0.339
MTRNR2L10	-0.327
MTRNR2L9	-0.324
OR4F29	-0.296
LMOD2	-0.292
CTNNA3	-0.286
AMPD1	-0.283

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C554291	10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one	"10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one inhibits the reaction [FADD protein binds to CASP8 protein]"	20833157
C504897	12-(3-adamantan-1-ylureido)dodecanoic acid	12-(3-adamantan-1-ylureido)dodecanoic acid results in increased expression of FADD mRNA	19435785
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl affects the expression of FADD mRNA"	21703328
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether affects the expression of FADD mRNA"	27589474
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FADD mRNA"	19114083
C416653	2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone	2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone results in increased expression of FADD protein	23523585
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of FADD mRNA"	21346803
C003898	2-anisidine	2-anisidine affects the expression of FADD mRNA	28089782
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein]	21138480
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]"	23452621
C580598	5-OH-BDE-47	5-OH-BDE-47 results in decreased expression of FADD mRNA	27589474
C496492	abrine	abrine results in increased expression of FADD protein	23788630
C496492	abrine	abrine results in increased expression of FADD protein	23788630
D000082	Acetaminophen	Acetaminophen results in decreased expression of FADD mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of FADD mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of FADD mRNA	12540782
D000082	Acetaminophen	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of FADD mRNA]"	12540782
D000111	Acetylcysteine	[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased expression of FADD protein]	20946910
D017255	Acitretin	Acitretin results in increased expression of FADD	18624760
D000171	Acrolein	Acrolein affects the localization of FADD protein	17320762
D000241	Adenosine	Adenosine results in decreased expression of FADD mRNA	17303086
D000241	Adenosine	Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA]	17303086
C518327	aloe emodin	aloe emodin results in increased expression of and affects the localization of FADD protein	19928967
D000622	Aminolevulinic Acid	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein]	21138480
D000622	Aminolevulinic Acid	Aminolevulinic Acid analog results in increased phosphorylation of FADD protein	21138480
D000622	Aminolevulinic Acid	FADD mutant form inhibits the reaction [Aminolevulinic Acid analog results in increased cleavage of PARP1 protein]	21138480
D000622	Aminolevulinic Acid	pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein]	21138480
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FADD mRNA	16483693
D016718	Arachidonic Acid	FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP3 protein]	19720122
D016718	Arachidonic Acid	FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP8 protein]	19720122
D016718	Arachidonic Acid	FADD protein promotes the reaction [Arachidonic Acid results in increased cleavage of BID protein]	19720122
D000069059	Atorvastatin Calcium	[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased expression of FADD protein]	20946910
D001280	Atrazine	Atrazine results in decreased expression of FADD mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of FADD mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FADD mRNA"	20382639
D004958	Estradiol	Estradiol affects the expression of FADD mRNA	22574217
C044887	beta-methylcholine	beta-methylcholine affects the expression of FADD mRNA	21179406
C026609	beta-solamarine	beta-solamarine results in increased expression of FADD protein	17619073
C006780	bisphenol A	bisphenol A results in decreased expression of FADD protein	21277958
C006780	bisphenol A	bisphenol A results in decreased expression of FADD mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of FADD protein	16421179
D019256	Cadmium Chloride	[Mercuric Chloride co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased expression of FADD protein	16421179
C034939	cadmium sulfide	cadmium sulfide results in increased expression of FADD mRNA	27866839
D002211	Capsaicin	Capsaicin results in increased expression of FADD protein	22150557
D002211	Capsaicin	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein]	22150557
D002211	Capsaicin	Naproxen inhibits the reaction [Capsaicin results in increased expression of FADD protein]	22150557
D002211	Capsaicin	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FADD protein]	22150557
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of FADD mRNA	26062544
D002251	Carbon Tetrachloride	Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of FADD mRNA]	26062544
C054133	casticin	casticin results in increased expression of FADD protein	27862857
D000068579	Celecoxib	Celecoxib promotes the reaction [FAS protein binds to FADD protein]	15197583
D000068579	Celecoxib	FADD affects the susceptibility to Celecoxib	15572759
D000068579	Celecoxib	FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]	15572759
D000068579	Celecoxib	FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]	15572759
D000068579	Celecoxib	FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]	15572759
D000068579	Celecoxib	FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]	15572759
D002784	Cholesterol	Cholesterol promotes the reaction [Hydrogen Peroxide results in increased expression of FADD protein]	20946910
D002784	Cholesterol	Cholesterol results in increased expression of FADD protein	20946910
D002784	Cholesterol	Hydrogen Peroxide promotes the reaction [Cholesterol results in increased expression of FADD protein]	20946910
D003042	Cocaine	Cocaine affects the expression of FADD mRNA	18580876
D003042	Cocaine	Cocaine results in decreased expression of FADD protein modified form	18580876
D003042	Cocaine	Raclopride affects the reaction [Cocaine affects the expression of FADD protein]	18580876
C024989	coenzyme Q10	coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FADD protein]	27087047
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of FADD mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]	23452621
D016572	Cyclosporine	Cyclosporine results in increased expression of FADD mRNA	20106945
D003609	Dactinomycin	Dactinomycin results in decreased expression of FADD mRNA	16001973
C014347	decitabine	decitabine results in increased expression of FADD mRNA	27915011
C040424	destruxin B	destruxin B results in increased activity of FADD protein	23751424
D003976	Diazinon	Diazinon results in decreased expression of FADD mRNA	27920530
D003976	Diazinon	Magnesium Oxide promotes the reaction [Diazinon results in decreased expression of FADD mRNA]	27920530
D003976	Diazinon	[Selenium analog co-treated with Magnesium Oxide analog] promotes the reaction [Diazinon results in decreased expression of FADD mRNA]	27920530
D003976	Diazinon	Selenium analog inhibits the reaction [Diazinon results in decreased expression of FADD mRNA]	27920530
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of FADD mRNA	17361019\|2126653
D002945	Cisplatin	Cisplatin results in increased expression of FADD mRNA	26546572
D004026	Dieldrin	Dieldrin affects the expression of FADD mRNA	22546817
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of FADD mRNA	22467019
D004176	Dipyridamole	Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA]	17303086
D004176	Dipyridamole	Dipyridamole results in increased expression of FADD mRNA	17303086
D004317	Doxorubicin	Doxorubicin affects the expression of FADD mRNA	16705698
D004317	Doxorubicin	[Doxorubicin co-treated with Selenium] promotes the reaction [FADD protein binds to CASP8 protein]	17970047
D004317	Doxorubicin	Doxorubicin results in increased expression of FADD mRNA	16001973
D004317	Doxorubicin	coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FADD protein]	27087047
D004317	Doxorubicin	Doxorubicin results in increased expression of FADD protein	27087047
D004726	Endosulfan	Endosulfan results in increased expression of FADD mRNA	26722802
D004785	Environmental Pollutants	Environmental Pollutants affects the expression of FADD mRNA	19118595
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FADD protein	23301498
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FADD mRNA	22079256
D000431	Ethanol	Ethanol promotes the reaction [RIPK3 protein binds to FADD protein]	24946281
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of FADD mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FADD mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of FADD mRNA	23550701
C002994	ethylene dimethanesulfonate	ethylene dimethanesulfonate results in decreased expression of FADD mRNA	22711419
D005557	Formaldehyde	Formaldehyde results in decreased expression of FADD mRNA	20655997
D005620	Freund's Adjuvant	[Urethane co-treated with Freund's Adjuvant] results in decreased expression of FADD mRNA	12400877
D005665	Furosemide	Furosemide affects the expression of FADD mRNA	17497460
D019833	Genistein	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]	23452621
D019833	Genistein	Genistein results in increased expression of FADD protein	24299158
D006861	Hydrogen Peroxide	Cholesterol promotes the reaction [Hydrogen Peroxide results in increased expression of FADD protein]	20946910
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [Cholesterol results in increased expression of FADD protein]	20946910
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of FADD protein	20946910
C031927	hydroquinone	hydroquinone results in decreased expression of FADD mRNA	15452088
D000068877	Imatinib Mesylate	[tetraarsenic tetrasulfide co-treated with Imatinib Mesylate] results in increased expression of FADD mRNA	19208803
C428264	indioside D	indioside D results in increased expression of FADD protein	18376857
D007530	Isoflurane	Isoflurane results in decreased expression of FADD mRNA	16978161
C045463	leflunomide	leflunomide results in decreased expression of FADD mRNA	28988120
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in decreased expression of FADD mRNA"	23090859
D008277	Magnesium Oxide	Magnesium Oxide promotes the reaction [Diazinon results in decreased expression of FADD mRNA]	27920530
D008277	Magnesium Oxide	[Selenium analog co-treated with Magnesium Oxide analog] promotes the reaction [Diazinon results in decreased expression of FADD mRNA]	27920530
D008627	Mercuric Chloride	[Mercuric Chloride co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased expression of FADD protein	16421179
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of FADD protein	16421179
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of FADD protein"	26068050
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of FADD mRNA"	25406165
C070571	ML 7	FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]	16723733
C056218	ML 9	FADD protein affects the reaction [[ML 9 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]	16723733
C008548	morin	morin results in increased expression of FADD mRNA	28689916
C437683	motexafin gadolinium	motexafin gadolinium results in decreased expression of FADD mRNA	16357179
C437683	motexafin gadolinium	[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FADD mRNA	16357179
D009151	Mustard Gas	FADD protein affects the reaction [Mustard Gas promotes the reaction [CASP6 protein results in increased cleavage of LMNA protein]]	12482751
D009151	Mustard Gas	FADD protein affects the reaction [Mustard Gas results in increased cleavage of CASP3 protein]	12482751
D009151	Mustard Gas	FADD protein affects the reaction [Mustard Gas results in increased cleavage of CASP7 protein]	12482751
D009151	Mustard Gas	FADD protein affects the reaction [Mustard Gas results in increased cleavage of CASP8 protein]	12482751
D009151	Mustard Gas	FADD protein affects the reaction [Mustard Gas results in increased cleavage of PARP1 protein]	12482751
D009151	Mustard Gas	Mustard Gas results in increased expression of FADD protein	19748996
C455139	myrtucommulone A	myrtucommulone A results in decreased expression of FADD mRNA	26032814
D009288	Naproxen	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein]	22150557
D009288	Naproxen	Naproxen inhibits the reaction [Capsaicin results in increased expression of FADD protein]	22150557
C005274	naringin	naringin results in increased expression of FADD mRNA	22847135
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of FADD mRNA"	12756304
D009761	Nystatin	Nystatin inhibits the reaction [resveratrol affects the localization of FADD protein]	12902349
C107010	O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of FADD mRNA]"	12540782
C464660	obeticholic acid	obeticholic acid results in increased expression of FADD mRNA	27939613
C025589	ochratoxin A	ochratoxin A results in decreased expression of FADD mRNA	17316727
C018620	oleoresins	oleoresins results in decreased expression of FADD mRNA	20008804
C000594117	ON123300	ON123300 results in decreased expression of FADD mRNA	26873845
C016340	o,p'-DDT	"o,p'-DDT analog results in decreased expression of FADD mRNA"	22937105
D010100	Oxygen	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]"	23452621
D010100	Oxygen	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]	23452621
D010100	Oxygen	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]	23452621
D010100	Oxygen	Oxygen deficiency results in increased expression of FADD mRNA	23452621
D010100	Oxygen	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]	23452621
D010100	Oxygen	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]	23452621
D017239	Paclitaxel	Paclitaxel results in increased expression of FADD mRNA	18058816
D017239	Paclitaxel	Paclitaxel results in increased phosphorylation of FADD protein	16450001
D017239	Paclitaxel	pyrazolanthrone inhibits the reaction [Paclitaxel results in increased phosphorylation of FADD protein]	16450001
C482884	panduratin A	panduratin A results in increased expression of FADD protein	16497706
D010269	Paraquat	Paraquat results in decreased expression of FADD mRNA	18836921
C005435	phenylmethylpyrazolone	phenylmethylpyrazolone results in decreased expression of FADD mRNA	17967739
C005435	phenylmethylpyrazolone	phenylmethylpyrazolone results in decreased expression of FADD protein	17967739
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]	23452621
D010936	Plant Extracts	Plant Extracts results in increased expression of FADD protein	24534064
C472086	polyphenon E	polyphenon E results in increased phosphorylation of FADD protein	23285096
C472086	polyphenon E	pyrazolanthrone inhibits the reaction [polyphenon E results in increased phosphorylation of FADD protein]	23285096
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FADD mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of FADD mRNA	22079256
D011339	Probenecid	"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of FADD mRNA"	25406165
D011374	Progesterone	Progesterone results in increased expression of FADD mRNA	21549006
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein]	21138480
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Paclitaxel results in increased phosphorylation of FADD protein]	16450001
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [polyphenon E results in increased phosphorylation of FADD protein]	23285096
C432165	pyrazolanthrone	pyrazolanthrone results in decreased phosphorylation of FADD protein	16450001
D011794	Quercetin	Quercetin affects the localization of FADD protein	17876056
D011794	Quercetin	Quercetin promotes the reaction [TNFSF10 protein affects the localization of FADD protein]	17876056
D011794	Quercetin	Quercetin results in decreased expression of FADD mRNA	20361964
D011794	Quercetin	Quercetin results in increased expression of FADD protein	24299158
D020891	Raclopride	Raclopride affects the reaction [Cocaine affects the expression of FADD protein]	18580876
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FADD mRNA	19059307
C059514	resveratrol	FADD protein results in increased susceptibility to resveratrol	19561642
C059514	resveratrol	Nystatin inhibits the reaction [resveratrol affects the localization of FADD protein]	12902349
C059514	resveratrol	resveratrol affects the localization of FADD protein	12902349
C059514	resveratrol	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]	23452621
C059514	resveratrol	resveratrol promotes the reaction [FAS protein binds to FADD protein]	12902349
C059514	resveratrol	resveratrol results in increased expression of FADD protein	24299158
C059514	resveratrol	resveratrol results in increased localization of FADD protein	19561642
D012431	Rutin	Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of FADD mRNA]	26062544
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of FADD mRNA"	16678137
C534628	SCH 23390	SCH 23390 results in increased expression of FADD protein	18580876
D012643	Selenium	[Doxorubicin co-treated with Selenium] promotes the reaction [FADD protein binds to CASP8 protein]	17970047
D012643	Selenium	[Selenium analog co-treated with Magnesium Oxide analog] promotes the reaction [Diazinon results in decreased expression of FADD mRNA]	27920530
D012643	Selenium	Selenium analog inhibits the reaction [Diazinon results in decreased expression of FADD mRNA]	27920530
D012643	Selenium	Selenium results in increased expression of FADD protein	17970047
C017947	sodium arsenite	sodium arsenite results in increased expression of FADD mRNA	12016162
C017947	sodium arsenite	[Mercuric Chloride co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased expression of FADD protein	16421179
C017947	sodium arsenite	sodium arsenite results in decreased expression of FADD mRNA	16014739
C017947	sodium arsenite	sodium arsenite results in increased expression of FADD protein	16421179
C017947	sodium arsenite	[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased expression of FADD protein]	20946910
C017947	sodium arsenite	sodium arsenite results in increased expression of FADD protein	20946910
C471405	sorafenib	EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to FADD protein binds to CASP8 protein]]	18787411
C471405	sorafenib	FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]	18787411
C471405	sorafenib	FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] results in decreased expression of ATG5 protein]	18787411
C471405	sorafenib	FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2AK3 protein]	18787411
C471405	sorafenib	FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2A protein]	18787411
C471405	sorafenib	[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to FAS protein binds to FADD protein]	18787411
C061636	suillin	suillin results in increased expression of FADD protein	19616521
D018170	Sumatriptan	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein]	22150557
D018170	Sumatriptan	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FADD protein]	22150557
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in decreased expression of FADD mRNA	19059307
D013629	Tamoxifen	Tamoxifen results in increased phosphorylation of FADD protein	16450001
D013739	Testosterone	FADD protein promotes the reaction [Testosterone results in increased expression of CASP8]	16845445
C534735	tetraarsenic tetrasulfide	[tetraarsenic tetrasulfide co-treated with Imatinib Mesylate] results in increased expression of FADD mRNA	19208803
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone promotes the reaction [TNFRSF10B protein binds to FADD protein binds to CASP8 protein]	27484784
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FADD mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FADD mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FADD mRNA	19520675\|2121527
C009495	titanium dioxide	titanium dioxide results in decreased expression of FADD mRNA	19695317
C518838	Titanocene Y	FADD protein affects the susceptibility to Titanocene Y	21986259
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of FADD mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of FADD protein	16137721
D014212	Tretinoin	[Tretinoin co-treated with zoledronic acid] results in increased expression of FADD protein	20349282
D014222	Triamcinolone Acetonide	Triamcinolone Acetonide results in increased expression of FADD protein	15987869
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of FADD mRNA	15363585
D014520	Urethane	[Urethane co-treated with Freund's Adjuvant] results in decreased expression of FADD mRNA	12400877
D014580	Ursodeoxycholic Acid	FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]	21362627
D014580	Ursodeoxycholic Acid	FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]	21362627
D014580	Ursodeoxycholic Acid	FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]	21362627
D014580	Ursodeoxycholic Acid	FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]	21362627
C025643	vinclozolin	vinclozolin results in decreased expression of FADD mRNA	18220299
C111237	vorinostat	EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to FADD protein binds to CASP8 protein]]	18787411
C111237	vorinostat	FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]	18787411
C111237	vorinostat	FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] results in decreased expression of ATG5 protein]	18787411
C111237	vorinostat	FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2AK3 protein]	18787411
C111237	vorinostat	FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2A protein]	18787411
C111237	vorinostat	[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to FAS protein binds to FADD protein]	18787411
D019345	Zinc Acetate	[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FADD mRNA	16357179
D019345	Zinc Acetate	Zinc Acetate results in decreased expression of FADD mRNA	16357179
C088658	zoledronic acid	[Tretinoin co-treated with zoledronic acid] results in increased expression of FADD protein	20349282

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IPI	9208847 21785459
GO:0005123	death receptor binding	-	IEA	-
GO:0005164	tumor necrosis factor receptor binding	-	IEA	-
GO:0005515	protein binding	-	IPI	7536190 7538907 8681376 9045686 9208847 9343261 10442631 10880445 11112409 11717445 12702765 12887920 14612908 15069192 15073179 15688372 16127453 16498403 17047155 17159907 18328427 18485876 19060883 19118384 19176810 19524512 19524513 20103630 20890306 20935634 21382479 21458669 21525013 21625644 21713032 21785459 21803845 21988832 22173242 22274400 22510408 23955153 24025841 25043603 25241761 25911380 26942442
GO:0032813	tumor necrosis factor receptor superfamily binding	-	IPI	21109225
GO:0033612	receptor serine/threonine kinase binding	-	IEA	-
GO:0035877	death effector domain binding	-	IPI	11717445
GO:0042802	identical protein binding	-	IPI	7536190 8681376
GO:0044877	protein-containing complex binding	-	IEA	-
GO:0089720	caspase binding	-	IPI	9343261

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001916	positive regulation of T cell mediated cytotoxicity	-	ISS	-
GO:0002821	positive regulation of adaptive immune response	-	ISS	-
GO:0006915	apoptotic process	-	IMP	22891283
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	TAS	-
GO:0007166	cell surface receptor signaling pathway	-	TAS	-
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	-	TAS	7538907
GO:0016032	viral process	-	IEA	-
GO:0032729	positive regulation of interferon-gamma production	-	ISS	-
GO:0032757	positive regulation of interleukin-8 production	-	IDA	16127453
GO:0032760	positive regulation of tumor necrosis factor production	-	IDA	16127453
GO:0033077	T cell differentiation in thymus	-	ISS	-
GO:0034138	toll-like receptor 3 signaling pathway	-	TAS	-
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	-	TAS	-
GO:0036462	TRAIL-activated apoptotic signaling pathway	-	IDA	21785459
GO:0042104	positive regulation of activated T cell proliferation	-	ISS	-
GO:0043029	T cell homeostasis	-	ISS	-
GO:0043065	positive regulation of apoptotic process	-	IDA	11821383
GO:0043065	positive regulation of apoptotic process	-	IMP	20935634
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IEP	12761501
GO:0043278	response to morphine	-	IEA	-
GO:0045087	innate immune response	-	IEA	-
GO:0045651	positive regulation of macrophage differentiation	-	IMP	17047155
GO:0045862	positive regulation of proteolysis	-	IDA	18387192
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	16127453
GO:0048148	behavioral response to cocaine	-	IEA	-
GO:0048535	lymph node development	-	ISS	-
GO:0048536	spleen development	-	ISS	-
GO:0048538	thymus development	-	ISS	-
GO:0051607	defense response to virus	-	IMP	21109225
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	-	IMP	21109225
GO:0060546	negative regulation of necroptotic process	-	IEA	-
GO:0070236	negative regulation of activation-induced cell death of T cells	-	ISS	-
GO:0071260	cellular response to mechanical stimulus	-	IEP	19593445
GO:0071550	death-inducing signaling complex assembly	-	TAS	-
GO:0097049	motor neuron apoptotic process	-	IEA	-
GO:0097190	apoptotic signaling pathway	-	IDA	11101870
GO:0097190	apoptotic signaling pathway	-	TAS	-
GO:0097191	extrinsic apoptotic signaling pathway	-	IDA	21785459
GO:0097191	extrinsic apoptotic signaling pathway	-	IMP	16611992
GO:0097191	extrinsic apoptotic signaling pathway	-	TAS	18309324
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	-	IEA	-
GO:0097202	activation of cysteine-type endopeptidase activity	-	IDA	18387192
GO:0097527	necroptotic signaling pathway	-	IMP	11101870
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	TAS	-
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	TAS	-
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	IEA	-
GO:2000454	positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	-	ISS	-
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	-	IMP	21525013

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	-	IDA	22510408
GO:0005829	cytosol	-	IDA	21785459
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	22510408
GO:0031264	death-inducing signaling complex	-	IDA	11101870 21803845
GO:0031264	death-inducing signaling complex	-	TAS	18309324
GO:0031265	CD95 death-inducing signaling complex	-	IDA	20935634
GO:0043005	neuron projection	-	IEA	-
GO:0044297	cell body	-	IEA	-
GO:0045121	membrane raft	-	IEA	-
GO:0097342	ripoptosome	-	IDA	21737330

KEGG ID	KEGG Term
hsa04210	Apoptosis
hsa04620	Toll-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa05010	Alzheimer's disease
hsa05142	Chagas disease (American trypanosomiasis)
hsa05200	Pathways in cancer

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-140534	Ligand-dependent caspase activation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-2562578	TRIF-mediated programmed cell death	TAS
R-HSA-3371378	Regulation by c-FLIP	TAS
R-HSA-5213460	RIPK1-mediated regulated necrosis	TAS
R-HSA-5218859	Regulated Necrosis	TAS
R-HSA-5218900	CASP8 activity is inhibited	TAS
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalling pathway	TAS
R-HSA-5357786	TNFR1-induced proapoptotic signaling	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-5675482	Regulation of necroptotic cell death	TAS
R-HSA-69416	Dimerization of procaspase-8	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-75157	FasL/ CD95L signaling	TAS
R-HSA-75158	TRAIL signaling	TAS
R-HSA-75893	TNF signaling	TAS
R-HSA-9013957	TLR3-mediated TICAM1-dependent programmed cell death	TAS
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18834930	Regulation of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of short- and long-term human opiate abusers. (2008 Nov 11)	Garcia-Fuster MJ	Neuroscience
21796105	Decreased proliferation of adult hippocampal stem cells during cocaine withdrawal: possible role of the cell fate regulator FADD. (2011 Oct)	Garcia-Fuster MJ	Neuropsychopharmacology
22741574	Substituting a long-acting dopamine uptake inhibitor for cocaine prevents relapse to cocaine seeking. (2013 Jul)	Velazquez-Sanchez C	Addict Biol
24278325	Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma. (2013)	Urashima M	PLoS One
24722570	Cardiac Fas-dependent and mitochondria-dependent apoptosis after chronic cocaine abuse. (2014 Apr 9)	Liou CM	Int J Mol Sci
19303913	Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 is increased in the prefrontal cortex of opiate abusers: relation to mitogen activated protein kinase, phosphoprotein enriched in astrocytes of 15 kDa, and Akt signaling pathways involved in neuroplasticity. (2009 Jun 16)	Ramos-Miguel A	Neuroscience
17030115	Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: a delta-opioid tone inhibits FADD. (2007 Apr)	Garcia-Fuster MJ	Eur Neuropsychopharmacol
21925237	Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats. (2011 Nov 24)	Alvaro-Bartolome M	Neuroscience