Gene: NAPA

8775
SNAPA
NSF attachment protein alpha
protein-coding
19q13.32-q13.33
Ensembl:ENSG00000105402 MIM:603215 Vega:OTTHUMG00000183294 UniprotKB:P54920
NC_000019.10
PubMed
0   ANCO-SNPs
CD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.147e-1 (AD)  6.227e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTUB10.962
GPI0.961
RNPS10.96
GDI10.957
ARF50.957
C6orf1360.956
PRKACA0.956
TMEM59L0.956
MLF20.954
GSK3A0.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.737
OR4F29-0.698
TFPI2-0.363
CXCR2-0.346
REST-0.346
KCNJ15-0.344
ASB4-0.34
MBNL3-0.338
RAI14-0.328
MTRNR2L9-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of NAPA protein"21673325
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NAPA mRNA"25614096
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NAPA mRNA]12710931
C0112692,5-hexanedione"2,5-hexanedione results in decreased expression of NAPA protein"19033394
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NAPA mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of NAPA mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NAPA mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NAPA mRNA22228805
C095105bexarotenebexarotene results in increased expression of NAPA mRNA16648578
C006780bisphenol Abisphenol A affects the expression of NAPA mRNA21786754
C006780bisphenol Abisphenol A promotes the reaction [NAPA protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A results in increased expression of NAPA mRNA26063408
C006780bisphenol Abisphenol A affects the expression of NAPA mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of NAPA mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NAPA gene20938992
D003042CocaineCocaine affects the expression of NAPA mRNA20187946
D003300CopperCopper deficiency results in decreased expression of NAPA protein25150618
D003976DiazinonDiazinon results in increased methylation of NAPA gene22964155
D002945CisplatinNAPA results in decreased susceptibility to Cisplatin21945668
D004041Dietary FatsDietary Fats results in decreased expression of NAPA mRNA25016146
D004147DioxinsDioxins affects the expression of NAPA mRNA20463971
D004178DiquatDiquat affects the expression of NAPA mRNA22814884
D000431EthanolEthanol results in decreased expression of NAPA protein23702218
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NAPA mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NAPA mRNA17555576
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NAPA gene20938992
D019833GenisteinGenistein results in decreased expression of NAPA mRNA16705744
D005947GlucoseGlucose deficiency results in decreased expression of NAPA protein22314686
D007657Ketone BodiesKetone Bodies results in increased expression of NAPA mRNA16807920
D008627Mercuric ChlorideMercuric Chloride affects the expression of NAPA mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NAPA gene20938992
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of NAPA protein26558463
D0156551-Methyl-4-phenylpyridinium2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NAPA mRNA]12710931
D015741MetriboloneMetribolone results in increased expression of NAPA protein17152098
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NAPA protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of NAPA protein26879310
D011441PropylthiouracilPropylthiouracil results in decreased expression of NAPA mRNA24780913
D012643SeleniumSelenium results in increased expression of NAPA mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NAPA mRNA25895662
D012999SomanSoman results in decreased expression of NAPA mRNA19281266
D013629TamoxifenTamoxifen affects the expression of NAPA mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NAPA mRNA21570461
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of NAPA protein"25852303
D014635Valproic AcidValproic Acid results in increased expression of NAPA mRNA23179753|2915479
D014635Valproic AcidValproic Acid results in increased methylation of NAPA gene29154799
D014635Valproic AcidValproic Acid affects the expression of NAPA mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of NAPA mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-ISS-  
GO:0005483soluble NSF attachment protein activity-IBA21873635  
GO:0005515protein binding-IPI15029241  15272311  15322554  16189514  16354670  20562859  
GO:0019905syntaxin binding-IBA21873635  
GO:0044877protein-containing complex binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-TAS-  
GO:0006891intra-Golgi vesicle-mediated transport-TAS8455721  
GO:0007420brain development-IEA-  
GO:0010807regulation of synaptic vesicle priming-IBA21873635  
GO:0010807regulation of synaptic vesicle priming-IEA-  
GO:0030182neuron differentiation-IEA-  
GO:0032781positive regulation of ATPase activity-IEA-  
GO:0035249synaptic transmission, glutamatergic-IBA21873635  
GO:0035249synaptic transmission, glutamatergic-IEA-  
GO:0035494SNARE complex disassembly-IBA21873635  
GO:0045176apical protein localization-IEA-  
GO:0048208COPII vesicle coating-TAS-  
GO:0061025membrane fusion-TAS8455721  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0016020membrane-HDA19946888  
GO:0031201SNARE complex-IBA21873635  
GO:0043195terminal bouton-IBA21873635  
GO:0043209myelin sheath-IEA-  
GO:0043679axon terminus-IBA21873635  
GO:0070044synaptobrevin 2-SNAP-25-syntaxin-1a complex-IBA21873635  
GO:0070044synaptobrevin 2-SNAP-25-syntaxin-1a complex-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-199992trans-Golgi Network Vesicle BuddingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-421837Clathrin derived vesicle buddingTAS
R-HSA-432722Golgi Associated Vesicle BiogenesisTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807878COPI-mediated anterograde transportTAS
R-HSA-6811434COPI-dependent Golgi-to-ER retrograde trafficTAS
R-HSA-6811438Intra-Golgi trafficTAS
R-HSA-6811440Retrograde transport at the Trans-Golgi-NetworkTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21426264Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)Fernandez-Castillo NWorld J Biol Psychiatry