Gene: RGS9

8787
PERRS|RGS9L
regulator of G protein signaling 9
protein-coding
17q24.1
Ensembl:ENSG00000108370 MIM:604067 Vega:OTTHUMG00000179349 UniprotKB:O75916
NG_013021.1
PubMed
0   ANCO-SNPs
OD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.178e-1 (AD)  3.955e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTLL90.708
C10orf1050.686
C50.674
IGSF10.673
GSN0.671
CARHSP10.666
ACAP10.648
C14orf930.648
HOGA10.645
ZNF5990.642

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCERG1L-0.377
PLS1-0.374
KCNH5-0.365
SERTM1-0.36
BEAN1-0.358
FGF5-0.355
FAM162B-0.352
KCNK9-0.351
MCHR1-0.349
CUX2-0.345

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RGS9 mRNA"25510870
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of RGS9 mRNA"18343893
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RGS9 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RGS9 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RGS9 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RGS9 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RGS9 mRNA"23994337
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS9 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RGS9 gene27153756
D000447AldehydesAldehydes results in increased expression of RGS9 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RGS9 mRNA16483693
D000661Amphetamine[Amphetamine co-treated with diarylpropionitrile] results in decreased expression of RGS9 mRNA17493623
D000661Amphetamine[Amphetamine co-treated with Estradiol] affects the expression of RGS9 mRNA17493623
D000661Amphetamine[Amphetamine co-treated with Estradiol] affects the expression of RGS9 protein17493623
D000661AmphetamineAmphetamine results in decreased expression of RGS9 mRNA17318883
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RGS9 mRNA24449571
D001058ApomorphineRGS9 affects the susceptibility to Apomorphine15728856
D001151ArsenicArsenic results in increased methylation of RGS9 promoter21291286
C015001arsenitearsenite results in decreased expression of RGS9 protein21344382
D001280AtrazineAtrazine results in increased expression of RGS9 mRNA22378314
C005177benserazide, levodopa drug combination"RGS9 affects the susceptibility to benserazide, levodopa drug combination"18160641
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of RGS9 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of RGS9 mRNA26377693
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of RGS9 mRNA23994337
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of RGS9 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RGS9 mRNA21839799
D004958Estradiol[Amphetamine co-treated with Estradiol] affects the expression of RGS9 mRNA17493623
D004958Estradiol[Amphetamine co-treated with Estradiol] affects the expression of RGS9 protein17493623
D004958EstradiolEstradiol results in decreased expression of RGS9 mRNA15640770
D004958EstradiolEstradiol results in increased expression of RGS9 mRNA20068009
C006780bisphenol Abisphenol A affects the methylation of RGS9 promoter27334623
C006780bisphenol Abisphenol A affects the expression of RGS9 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of RGS9 protein24552547
C018475butyraldehydebutyraldehyde results in increased expression of RGS9 mRNA26079696
D003042CocaineCocaine affects the expression of RGS9 mRNA20187946
D003471CuprizoneCuprizone results in increased expression of RGS9 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of RGS9 mRNA27989131
D016572CyclosporineCyclosporine results in decreased methylation of RGS9 promoter27989131
C492519diarylpropionitrile[Amphetamine co-treated with diarylpropionitrile] results in decreased expression of RGS9 mRNA17493623
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of RGS9 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RGS9 mRNA27392435
D006220HaloperidolRGS9 affects the susceptibility to Haloperidol15728856
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of RGS9 mRNA17183730
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of RGS9 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RGS9 mRNA26752646
D007649KetamineKetamine results in increased expression of RGS9 mRNA20080153
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RGS9 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RGS9 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of RGS9 mRNA22714537
D019319Okadaic AcidOkadaic Acid results in decreased expression of RGS9 mRNA25270620
D010100OxygenOxygen deficiency results in increased expression of RGS9 mRNA26516004
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RGS9 mRNA"25510870
C046012pentanalpentanal results in increased expression of RGS9 mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of RGS9 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS9 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RGS9 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RGS9 mRNA19710929
C005556propionaldehydepropionaldehyde results in increased expression of RGS9 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of RGS9 mRNA24780913
D019257QuinpiroleRGS9 affects the susceptibility to Quinpirole15728856
D012110ReserpineRGS9 affects the susceptibility to Reserpine15728856
D012110ReserpineReserpine results in decreased expression of RGS9 mRNA14505795
D012822Silicon DioxideSilicon Dioxide analog affects the expression of RGS9 mRNA25895662
D013629TamoxifenTamoxifen results in decreased expression of RGS9 mRNA15590111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RGS9 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RGS9 mRNA18343893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RGS9 mRNA23994337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RGS9 mRNA22298810
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of RGS9 mRNA19042947
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of RGS9 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of RGS9 mRNA28001369|2915479
D014635Valproic AcidValproic Acid results in increased expression of RGS9 mRNA23665938

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0044877protein-containing complex binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006457protein folding-TAS-  
GO:0007212dopamine receptor signaling pathway-IEA-  
GO:0007399nervous system development-IEA-  
GO:0007601visual perception-IEA-  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-IEA-  
GO:0009968negative regulation of signal transduction-IEA-  
GO:0035556intracellular signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0043627response to estrogen-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001917photoreceptor inner segment-IEA-  
GO:0005634nucleus-IEA-  
GO:0097381photoreceptor disc membrane-TAS-  
KEGG ID KEGG Term
hsa04744Phototransduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-2187338Visual phototransductionTAS
R-HSA-2187338Visual phototransductionIEA
R-HSA-2514856The phototransduction cascadeTAS
R-HSA-2514856The phototransduction cascadeIEA
R-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascadeTAS
R-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascadeIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-390466Chaperonin-mediated protein foldingTAS
R-HSA-391251Protein foldingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-6814122Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22056472Differential regulation of RGS proteins in the prefrontal cortex of short- and long-term human opiate abusers. (2012 Feb)Rivero GNeuropharmacology
24561386Nucleus accumbens-specific interventions in RGS9-2 activity modulate responses to morphine. (2014 Jul)Gaspari SNeuropsychopharmacology
17880927A role of RGS proteins in drug addiction. (2008 Jan 1)Hooks SBBiochem Pharmacol