Gene: DLK1

8788
DLK|DLK-1|Delta1|FA1|PREF1|Pref-1|ZOG|pG2
delta like non-canonical Notch ligand 1
protein-coding
14q32.2
Ensembl:ENSG00000185559 MIM:176290 Vega:OTTHUMG00000171600 UniprotKB:P80370
NG_016863.2
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.001e-1 (AD)  4.752e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18392604chr14:101192386DLK11.620e-14Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HMX30.845
HCRT0.838
OTP0.834
SIM10.834
FOXB10.832
LHX50.826
HMX20.824
FEZF10.814
SIX60.811
C22orf420.808

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LZTS1-0.305
SLC17A7-0.296
TESPA1-0.288
MGAT5B-0.279
TNNT2-0.278
SHANK3-0.276
MGLL-0.275
KCNS1-0.272
RGS5-0.271
MPPED1-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DLK1 mRNA19933214
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane results in decreased expression of DLK1 mRNA"22763116
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane results in decreased expression of DLK1 mRNA"22763116
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DLK1 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DLK1 mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of DLK1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DLK1 mRNA19770486
D001151ArsenicArsenic affects the expression of DLK1 protein24675094
D001151ArsenicArsenic affects the methylation of DLK1 gene25304211
C006632arsenic trioxideDLK1 protein affects the susceptibility to arsenic trioxide18575777
D001280AtrazineAtrazine results in increased expression of DLK1 mRNA22378314
D001374AzacitidineAzacitidine results in decreased methylation of DLK1 promoter19194470
C006680baicaleinbaicalein results in increased expression of DLK1 mRNA24560969
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DLK1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DLK1 mRNA20127859|2222880
D004958EstradiolEstradiol results in decreased expression of DLK1 mRNA23094148
D004958EstradiolIGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of DLK1 mRNA]23094148
C044887beta-methylcholinebeta-methylcholine affects the expression of DLK1 mRNA21179406
D001629BezafibrateBezafibrate results in increased expression of DLK1 mRNA11473052
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of DLK1 mRNA28938450
C006780bisphenol Abisphenol A results in decreased expression of DLK1 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of DLK1 mRNA28079927|2893845
C006780bisphenol Abisphenol A results in decreased expression of DLK1 mRNA25181051
D001761BleomycinBleomycin results in increased expression of DLK1 protein29175452
D002220CarbamazepineCarbamazepine affects the expression of DLK1 mRNA25979313
D002251Carbon Tetrachloride[Tetrachlorodibenzodioxin co-treated with Carbon Tetrachloride] results in increased expression of DLK1 mRNA27693115
C007095cobaltiprotoporphyrincobaltiprotoporphyrin affects the expression of DLK1 protein23497794
D003300CopperCopper deficiency results in increased expression of DLK1 mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of DLK1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of DLK1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of DLK1 mRNA25562108
C014347decitabinedecitabine affects the expression of DLK1 mRNA23300844
C014347decitabinedecitabine results in decreased methylation of DLK1 promoter19194470
C014347decitabinedecitabine results in increased expression of DLK1 mRNA19194470
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of DLK1 mRNA25559859
D003907DexamethasoneDexamethasone results in decreased expression of DLK1 mRNA25851902
D003907Dexamethasonesilybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of DLK1 mRNA]25559859
D003907DexamethasoneDexamethasone results in increased expression of DLK1 mRNA23166830
D002945CisplatinCisplatin affects the expression of DLK1 mRNA23300844
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of DLK1 mRNA28085963
D004143Dioctyl Sulfosuccinic AcidDioctyl Sulfosuccinic Acid results in decreased expression of DLK1 mRNA26135921
C118739entinostatentinostat results in decreased expression of DLK1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DLK1 mRNA17557909
C082360fipronilfipronil results in increased expression of DLK1 mRNA23962444
D005419FlavonoidsFlavonoids results in increased expression of DLK1 mRNA18035473
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of DLK1 mRNA15567716|1718741
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of DLK1 protein17538966
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of DLK1 mRNA]15016801
D005492Folic Acid[Folic Acid co-treated with sodium arsenite] results in decreased methylation of DLK1 mRNA22959928
D019833GenisteinGenistein results in increased expression of DLK1 mRNA18359623
C001293glucosamine 6-phosphateglucosamine 6-phosphate results in decreased expression of DLK1 mRNA19427183
C004312glycidolglycidol results in increased expression of DLK1 mRNA24915197
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of DLK1 mRNA25559859
D0150561-Methyl-3-isobutylxanthinesilybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of DLK1 mRNA]25559859
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of DLK1 mRNA12057914
C025340manganese chloridemanganese chloride results in decreased expression of DLK1 mRNA27913844
C025340manganese chloridemanganese chloride results in increased methylation of DLK1 gene27913844
C000600817mercaptosteroid 6mercaptosteroid 6 results in decreased expression of DLK1 mRNA25851902
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of DLK1 mRNA26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of DLK1 mRNA24810058
C028007nickel monoxidenickel monoxide affects the expression of DLK1 mRNA19167457
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of DLK1 mRNA26272509
C046012pentanalpentanal results in increased expression of DLK1 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of DLK1 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of DLK1 mRNA23557933
C513428pyrachlostrobinpyrachlostrobin results in increased expression of DLK1 mRNA27029645
C089730rosiglitazonerosiglitazone results in decreased expression of DLK1 mRNA22763116
C089730rosiglitazonerosiglitazone results in decreased expression of DLK1 mRNA22763116|2308666
D012524SarinSarin results in decreased expression of DLK1 mRNA19522546
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DLK1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of DLK1 mRNA22431001
C440975silybinsilybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of DLK1 mRNA]25559859
C017947sodium arsenite[Folic Acid co-treated with sodium arsenite] results in decreased methylation of DLK1 mRNA22959928
C017947sodium arsenitesodium arsenite affects the expression of DLK1 mRNA28206643
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the methylation of DLK1 5' UTR28011154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the methylation of DLK1 exon28011154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DLK1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DLK1 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Carbon Tetrachloride] results in increased expression of DLK1 mRNA27693115
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DLK1 mRNA19933214
D013755Tetradecanoylphorbol AcetateDLK1 protein affects the susceptibility to Tetradecanoylphorbol Acetate18575777
D013792ThalidomideThalidomide results in decreased expression of DLK1 mRNA26217789
D019284ThapsigarginThapsigargin results in decreased expression of DLK1 mRNA22378314
D014118Toxins, Biological"Toxins, Biological affects the expression of DLK1 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of DLK1 mRNA16012519|2193413
D014212TretinoinTretinoin results in increased expression of DLK1 mRNA16604517
C011559tributyltintributyltin results in decreased expression of DLK1 mRNA23322813|2451344
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of DLK1 mRNA24935251|2627250
C053549triflumizoltriflumizol results in decreased expression of DLK1 mRNA23086663
D017973Tungsten CompoundsTungsten Compounds results in increased expression of DLK1 mRNA28666766
D014415TunicamycinTunicamycin results in decreased expression of DLK1 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of DLK1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DLK1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of DLK1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of DLK1 mRNA24896083
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLK1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of DLK1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0030154cell differentiation-IEA-  
GO:0045746negative regulation of Notch signaling pathway-IBA21873635  
GO:0045746negative regulation of Notch signaling pathway-IDA25093684  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA7925474  25093684  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29435111Impact of DLK1-DIO3 imprinted cluster hypomethylation in smoker patients with lung cancer. (2018 Jan 12)Molina-Pinelo SOncotarget
23116464Beckwith Wiedemann imprinting defect found in leucocyte but not buccal DNA in a child born small for gestational age. (2012 Nov 1)Murphy RBMC Med Genet
22677950Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. (2012 Jul)Liu YEpigenetics