Gene: TNFRSF11A

8792
CD265|FEO|LOH18CR1|ODFR|OFE|OPTB7|OSTS|PDB2|RANK|TRANCER
TNF receptor superfamily member 11a
protein-coding
18q21.33
Ensembl:ENSG00000141655 MIM:603499 Vega:OTTHUMG00000132779 UniprotKB:Q9Y6Q6
NG_008098.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.857e-1 (AD)  4.419e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RASSF50.846
TMEM2410.831
RASAL20.827
FHL20.826
LRRK10.826
ENTPD40.823
LNX10.821
ARHGEF30.821
DOPEY20.819
PAK10.817

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.559
MYOM1-0.542
COPZ2-0.53
AKR1C3-0.529
HVCN1-0.519
MYL3-0.512
RFTN2-0.503
STON2-0.502
ASB4-0.495
S100A1-0.492

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05959ENMD-1198Small Molecule864668-87-1InvestigationalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TNFRSF11A mRNA"21346803
C0038982-anisidine2-anisidine results in decreased expression of TNFRSF11A mRNA28089782
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TNFRSF11A mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF11A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF11A mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TNFRSF11A mRNA26690555|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TNFRSF11A gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TNFRSF11A mRNA24449571
D001151ArsenicArsenic affects the expression of TNFRSF11A protein24675094
C006632arsenic trioxidearsenic trioxide results in decreased expression of TNFRSF11A mRNA19769630
C006632arsenic trioxidearsenic trioxide results in increased expression of TNFRSF11A mRNA17530438|2252195
C006632arsenic trioxidearsenic trioxide results in decreased expression of TNFRSF11A mRNA19730151
D001205Ascorbic Acid[Ascorbic Acid co-treated with TNFSF11 protein] results in decreased expression of TNFRSF11A mRNA15730627
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNFRSF11A mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of TNFRSF11A gene25435355
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of TNFRSF11A mRNA20660070
D004958EstradiolEstradiol results in increased expression of TNFRSF11A mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of TNFRSF11A mRNA23900028
C006780bisphenol Abisphenol A results in decreased expression of TNFRSF11A mRNA25181051
D019256Cadmium Chloride[Cadmium Chloride co-treated with TNFSF11] results in increased expression of TNFRSF11A mRNA21723911
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFRSF11A mRNA20938992
D016572CyclosporineCyclosporine results in decreased expression of TNFRSF11A mRNA25562108
D002945CisplatinCisplatin results in decreased expression of TNFRSF11A mRNA27392435
D002945CisplatinCisplatin results in increased expression of TNFRSF11A mRNA21278888
D002945CisplatinCisplatin results in increased expression of TNFRSF11A protein21278888
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TNFRSF11A mRNA22129741
D004967EstrogensEstrogens results in decreased expression of TNFRSF11A mRNA16005483
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFRSF11A mRNA20938992
D005665FurosemideFurosemide affects the expression of TNFRSF11A mRNA17497460
D005839GentamicinsGentamicins results in decreased expression of TNFRSF11A mRNA22061828
C071834glycidamideglycidamide results in increased expression of TNFRSF11A mRNA17822822
C004312glycidolglycidol results in increased expression of TNFRSF11A mRNA24915197
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TNFRSF11A mRNA22129741
D007530IsofluraneIsoflurane results in decreased expression of TNFRSF11A mRNA16978161
C006552kaempferolkaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]16434028
C008261lead acetatelead acetate results in increased expression of TNFRSF11A mRNA22641619
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TNFRSF11A mRNA"24972896
D008070LipopolysaccharidesCSF1R affects the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A mRNA]22067001
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNFRSF11A mRNA22067001
C013592mangiferinmangiferin results in decreased expression of TNFRSF11A mRNA15135318
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFRSF11A mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNFRSF11A mRNA26011545
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of TNFRSF11A mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNFRSF11A mRNA"25554681
C005274naringinnaringin results in decreased expression of TNFRSF11A mRNA24376342
D052638Particulate MatterParticulate Matter results in increased expression of TNFRSF11A mRNA17450221
D010424PentobarbitalPentobarbital results in decreased expression of TNFRSF11A mRNA16978161
C006253pirinixic acidpirinixic acid results in decreased expression of TNFRSF11A mRNA17426115
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of TNFRSF11A mRNA20660070
D011441PropylthiouracilPropylthiouracil results in decreased expression of TNFRSF11A mRNA24780913
D011794QuercetinQuercetin results in increased expression of TNFRSF11A mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]16434028
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TNFRSF11A mRNA16005483
C059514resveratrolresveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TNFRSF11A mRNA]16267019
C059514resveratrolresveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TNFRSF11A protein]16267019
C089730rosiglitazonerosiglitazone inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]22286232
C089730rosiglitazonerosiglitazone inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A protein]22286232
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNFRSF11A mRNA20106945|2163298
D014025TitaniumTitanium results in increased expression of TNFRSF11A mRNA18449944
C009495titanium dioxidetitanium dioxide results in increased expression of TNFRSF11A mRNA23557971
D014212TretinoinTretinoin results in decreased expression of TNFRSF11A mRNA21934132
C012589trichostatin Atrichostatin A affects the expression of TNFRSF11A mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of TNFRSF11A mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF11A mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of TNFRSF11A mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TNFRSF11A gene25560391
D015032ZincZinc deficiency results in decreased expression of TNFRSF11A mRNA21893222
D015032ZincZinc deficiency results in decreased expression of TNFRSF11A protein21893222

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IDA9367155  
GO:0005031tumor necrosis factor-activated receptor activity-ISS19940926  
GO:0005515protein binding-IPI15750601  23333834  
GO:0019955cytokine binding-IPI9367155  
GO:0038023signaling receptor activity-TAS9367155  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-IEA-  
GO:0002250adaptive immune response-IMP18606301  
GO:0002548monocyte chemotaxis-NAS15248232  
GO:0007165signal transduction-TAS9367155  
GO:0007267cell-cell signaling-TAS9367155  
GO:0008284positive regulation of cell proliferation-TAS9367155  
GO:0009314response to radiation-IEA-  
GO:0030316osteoclast differentiation-IMP18606301  
GO:0032496response to lipopolysaccharide-ISS19940926  
GO:0033209tumor necrosis factor-mediated signaling pathway-ISS19940926  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0034097response to cytokine-IMP18606301  
GO:0034612response to tumor necrosis factor-ISS19940926  
GO:0043507positive regulation of JUN kinase activity-IMP12296995  
GO:0045780positive regulation of bone resorption-IEA-  
GO:0048535lymph node development-IEA-  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA12296995  
GO:0051091positive regulation of DNA-binding transcription factor activity-ISS19940926  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA9367155  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IMP12296995  
GO:0060086circadian temperature homeostasis-ISS19940926  
GO:0060749mammary gland alveolus development-IEA-  
GO:0070555response to interleukin-1-ISS19940926  
GO:0071812positive regulation of fever generation by positive regulation of prostaglandin secretion-ISS19940926  
GO:0071847TNFSF11-mediated signaling pathway-IMP18606301  
GO:0071848positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling-IMP18606301  
GO:0072674multinuclear osteoclast differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IDA9367155  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04380Osteoclast differentiation
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20531232TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women. (2010 Sep-Oct)Lu YMenopause