Gene: TNFRSF10A

8797
APO2|CD261|DR4|TRAILR-1|TRAILR1
TNF receptor superfamily member 10a
protein-coding
8p21.3
Ensembl:ENSG00000104689 MIM:603611 Vega:OTTHUMG00000097843 UniprotKB:O00220
NG_032107.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.093e-1 (AD)  9.134e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
F11R0.873
B4GALT10.871
NOS30.86
TRIM380.856
ITGA50.854
CARD60.853
CASP40.847
MMRN20.846
CD930.844
RBMS20.842

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN1-0.469
DLK2-0.468
MARCH4-0.461
TMEM179-0.459
NEUROD6-0.455
KCNIP3-0.455
SLC7A4-0.454
SMIM18-0.453
MYADML2-0.453
DRD5-0.445

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5524201-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane"1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased expression of TNFRSF10A protein"20674558
C0908591-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole results in increased expression of TNFRSF10A protein15572759
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TNFRSF10A mRNA"27589474
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]24930757
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]24930757
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein inhibits the reaction [esculetin results in increased expression of TNFRSF10A protein]]]19786087
C4166532-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone results in increased expression of TNFRSF10A mRNA23523585
C4166532-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone results in increased expression of TNFRSF10A protein23523585
C5622542'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione"2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in increased expression of TNFRSF10A protein"21741372
C5622542'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione"Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in increased expression of TNFRSF10A protein]"21741372
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFRSF10A15942663
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFRSF10A protein21179458
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneresveratrol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFRSF10A protein]21179458
C0038982-anisidine2-anisidine results in increased expression of TNFRSF10A mRNA28089782
C4824923,4,5,4'-tetramethoxystilbene"3,4,5,4'-tetramethoxystilbene results in increased expression of TNFRSF10A mRNA"22687606
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]"23452621
C504089(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate"(3Z)-3-(1H-pyrrol-2-yl)-methyllidene)-1-(1-(piperidylmethyl)-1,3-dihydro-2H-indol-2-one mesylate affects the expression of TNFRSF10A protein"20495136
C4800304-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid results in increased expression of TNFRSF10A protein15930313
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]24930757
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]24930757
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF10A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF10A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF10A mRNA"27188386
C5805985-OH-BDE-475-OH-BDE-47 results in decreased expression of TNFRSF10A mRNA27589474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF10A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF10A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF10A mRNA"27188386
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of TNFRSF10A mRNA27589474
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in increased expression of TNFRSF10A protein]"21741372
D000111AcetylcysteineAcetylcysteine inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]24930757
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TNFRSF10A protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TNFRSF10A mRNA21632981|2164198
C103303alitretinoinalitretinoin results in increased expression of TNFRSF10A mRNA16449964
C077990alvocidibalvocidib results in increased expression of TNFRSF10A16820931
C006632arsenic trioxidearsenic trioxide results in increased expression of TNFRSF10A protein24377552
C006632arsenic trioxide[Bortezomib co-treated with arsenic trioxide] results in increased expression of TNFRSF10A protein24377552
C006632arsenic trioxide"arsenic trioxide promotes the reaction [Drugs, Chinese Herbal results in increased expression of TNFRSF10A protein]"28587418
C006632arsenic trioxidearsenic trioxide results in increased expression of TNFRSF10A protein28587418
C006632arsenic trioxide"Drugs, Chinese Herbal promotes the reaction [arsenic trioxide results in increased expression of TNFRSF10A protein]"28587418
C012765bakuchiolbakuchiol results in increased expression of TNFRSF10A protein27033605
C012765bakuchiolTNFRSF10A results in increased susceptibility to [TNFSF10 protein co-treated with bakuchiol]27033605
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in increased expression of TNFRSF10A mRNA24289642
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with resveratrol] results in increased expression of TNFRSF10A mRNA24289642
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of TNFRSF10A mRNA24289642
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNFRSF10A mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNFRSF10A mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TNFRSF10A mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TNFRSF10A protein16287099
D004958EstradiolEstradiol results in increased expression of TNFRSF10A mRNA20106945|2301914
D001688Biological ProductsBiological Products results in increased expression of TNFRSF10A mRNA22654482
C482801bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) results in increased localization of TNFRSF10A protein21037225
C006780bisphenol Abisphenol A results in decreased expression of TNFRSF10A mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of TNFRSF10A mRNA25181051
D000069286BortezomibBortezomib affects the expression of TNFRSF10A mRNA17327374
D000069286BortezomibBortezomib affects the expression of TNFRSF10A protein17510429
D000069286Bortezomib[Bortezomib co-treated with arsenic trioxide] results in increased expression of TNFRSF10A protein24377552
D000069286BortezomibBortezomib results in decreased expression of TNFRSF10A protein19922463
D000069286BortezomibBortezomib results in increased expression of TNFRSF10A protein12902978|1732737
D000069286BortezomibBortezomib results in increased localization of TNFRSF10A protein17326159
D000069286Bortezomib[Bortezomib results in increased localization of TNFRSF10A protein] promotes the reaction [Bortezomib results in increased susceptibility to and results in increased activity of TNFSF10 protein]17326159
D000069286BortezomibBrefeldin A inhibits the reaction [Bortezomib results in increased localization of TNFRSF10A protein]17326159
D020126Brefeldin ABrefeldin A inhibits the reaction [Bortezomib results in increased localization of TNFRSF10A protein]17326159
C546611brevetoxin 2brevetoxin 2 results in increased expression of TNFRSF10A mRNA20498034
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TNFRSF10A mRNA22079614
D016642BupropionBupropion results in increased expression of TNFRSF10A mRNA21354251
C006862butylphenbutylphen results in increased expression of TNFRSF10A protein15816839
C018475butyraldehydebutyraldehyde results in increased expression of TNFRSF10A mRNA26079696
C055494caffeic acid phenethyl ester[Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in increased expression of TNFRSF10A mRNA24289642
D002193CantharidinCantharidin results in increased expression of TNFRSF10A protein27113412
D002211CapsaicinCapsaicin results in increased expression of TNFRSF10A mRNA19502594
D002211CapsaicinCapsaicin results in increased expression of TNFRSF10A protein19846903
D002220CarbamazepineCarbamazepine affects the expression of TNFRSF10A mRNA25979313
C099555CD 437CD 437 results in increased expression of TNFRSF10A protein16024638
C099555CD 437helenalin inhibits the reaction [CD 437 results in increased expression of TNFRSF10A protein]16024638
C099555CD 437NFKBIA protein affects the reaction [CD 437 results in increased expression of TNFRSF10A protein]16024638
D000068579CelecoxibCelecoxib results in increased expression of TNFRSF10A mRNA15572759
D000068579CelecoxibCelecoxib results in increased expression of TNFRSF10A protein15572759
D002699ChlorambucilChlorambucil affects the expression of TNFRSF10A mRNA14614459
D002738ChloroquineChloroquine results in increased expression of TNFRSF10A protein27692344
D019327Copper SulfateCopper Sulfate results in increased expression of TNFRSF10A mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]23452621
D003474CurcuminCurcumin results in increased expression of TNFRSF10A protein18226269
D003474CurcuminTNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein]18226269
D003513CycloheximideCycloheximide inhibits the reaction [docetaxel results in increased expression of TNFRSF10A protein]11212279
D003513CycloheximideCycloheximide inhibits the reaction [Paclitaxel results in increased expression of TNFRSF10A protein]11212279
D016572CyclosporineCyclosporine results in increased expression of TNFRSF10A mRNA20106945|2556210
C089595cylindrospermopsincylindrospermopsin results in increased expression of TNFRSF10A mRNA23726867
D003630DaunorubicinDaunorubicin promotes the reaction [TNFSF10 results in increased expression of TNFRSF10A mRNA]17204177
C014347decitabinedecitabine affects the methylation of TNFRSF10A promoter17653094
D003976DiazinonDiazinon results in decreased expression of TNFRSF10A mRNA27920530
D003976DiazinonMagnesium Oxide analog promotes the reaction [Diazinon results in decreased expression of TNFRSF10A mRNA]27920530
D003976DiazinonSelenium analog inhibits the reaction [Diazinon results in decreased expression of TNFRSF10A mRNA]27920530
D002945CisplatinCisplatin results in increased expression of TNFRSF10A mRNA21532991|2739243
D002945CisplatinCisplatin results in increased localization of TNFRSF10A protein21037225
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of TNFRSF10A mRNA23999411
C521792DMU-212DMU-212 results in increased expression of TNFRSF10A mRNA22687606
C067311docetaxelCycloheximide inhibits the reaction [docetaxel results in increased expression of TNFRSF10A protein]11212279
C067311docetaxeldocetaxel results in increased expression of TNFRSF10A protein11212279
D004317DoxorubicinDoxorubicin results in increased expression of TNFRSF10A protein15897917|1743784
D004317DoxorubicinTNFRSF10A protein affects the reaction [Doxorubicin results in increased activity of CASP3 protein]17437844
D004317DoxorubicinTNFRSF10A protein affects the reaction [Doxorubicin results in increased activity of CASP6 protein]17437844
D004317DoxorubicinTNFRSF10A protein affects the reaction [Doxorubicin results in increased activity of CASP8 protein]17437844
D004317DoxorubicinTNFRSF10A protein affects the reaction [Doxorubicin results in increased activity of CASP9 protein]17437844
D004317DoxorubicinTNFRSF10A protein affects the susceptibility to Doxorubicin16098063|1743784
D004365Drugs, Chinese Herbal"arsenic trioxide promotes the reaction [Drugs, Chinese Herbal results in increased expression of TNFRSF10A protein]"28587418
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal promotes the reaction [arsenic trioxide results in increased expression of TNFRSF10A protein]"28587418
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of TNFRSF10A protein"28587418
C064874DuP 697DuP 697 results in increased expression of TNFRSF10A protein15572759
C010945embelinembelin results in increased expression of TNFRSF10A protein24694877
C007590emulphogene BC 720emulphogene BC 720 results in increased expression of TNFRSF10A mRNA25398874
C118739entinostatentinostat results in increased expression of TNFRSF10A mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF10A mRNA"27188386
C118739entinostatentinostat results in increased expression of TNFRSF10A protein21041383
C118739entinostatTNFSF10 protein promotes the reaction [entinostat results in increased expression of TNFRSF10A protein]21041383
D004811EpichlorohydrinEpichlorohydrin results in decreased expression of TNFRSF10A mRNA22723965
C007628esculetinesculetin results in increased expression of TNFRSF10A protein19786087
C007628esculetin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein inhibits the reaction [esculetin results in increased expression of TNFRSF10A protein]]]19786087
C007628esculetinBCL2 protein inhibits the reaction [esculetin results in increased expression of TNFRSF10A protein]19786087
C007628esculetinethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein inhibits the reaction [esculetin results in increased expression of TNFRSF10A protein]]19786087
C456800ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein inhibits the reaction [esculetin results in increased expression of TNFRSF10A protein]]]19786087
C456800ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylateethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein inhibits the reaction [esculetin results in increased expression of TNFRSF10A protein]]19786087
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TNFRSF10A mRNA23649840
C024352fludarabinefludarabine affects the expression of TNFRSF10A mRNA14614459
D005472FluorouracilFluorouracil results in increased expression of TNFRSF10A mRNA26544897
D005472FluorouracilFluorouracil results in increased expression of TNFRSF10A protein15585621
C065180fluvastatin[zoledronic acid co-treated with fluvastatin] results in increased expression of TNFRSF10A mRNA16996129
D005557FormaldehydeFormaldehyde results in increased expression of TNFRSF10A mRNA23649840
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]23452621
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF10A mRNA28433809
C001329helenalinhelenalin inhibits the reaction [CD 437 results in increased expression of TNFRSF10A protein]16024638
C538724HhAntag691[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein]22087285
C538724HhAntag691HhAntag691 results in increased expression of TNFRSF10A protein22087285
C501367hispanolonehispanolone analog results in increased expression of TNFRSF10A protein25930665
C501367hispanoloneTNFRSF10A protein affects the reaction [TNFSF10 protein promotes the reaction [hispanolone analog results in increased activity of CASP8 protein]]25930665
C501367hispanoloneTNFSF10 protein promotes the reaction [hispanolone analog results in increased expression of TNFRSF10A protein]25930665
D006918HydroxyureaHydroxyurea results in increased expression of TNFRSF10A mRNA27208086
C492448ICG 001ICG 001 results in increased expression of TNFRSF10A mRNA26191083
C467077ilimaquinone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]24930757
C467077ilimaquinone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]24930757
C467077ilimaquinone4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]24930757
C467077ilimaquinone4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]24930757
C467077ilimaquinoneAcetylcysteine inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]24930757
C467077ilimaquinoneilimaquinone results in increased expression of TNFRSF10A mRNA24930757
C467077ilimaquinoneilimaquinone results in increased expression of TNFRSF10A protein24930757
C551631isoangustone Aisoangustone A results in increased expression of TNFRSF10A protein20229524
C551631isoangustone ATNFRSF10A mRNA affects the susceptibility to isoangustone A20229524
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of TNFRSF10A protein27169980
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNFRSF10A protein26415225
C410337K 7174K 7174 results in increased expression of TNFRSF10A mRNA24086573
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of TNFRSF10A mRNA"23090859
D008277Magnesium OxideMagnesium Oxide analog promotes the reaction [Diazinon results in decreased expression of TNFRSF10A mRNA]27920530
D008555MelittenMelitten results in increased expression of TNFRSF10A mRNA22027265
D008555MelittenTNFRSF10A protein affects the reaction [Melitten results in decreased phosphorylation of STAT3 protein]22027265
D008555MelittenTNFRSF10A protein affects the susceptibility to Melitten22027265
C042720mercuric bromidemercuric bromide results in increased expression of TNFRSF10A mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF10A mRNA"27188386
D008727MethotrexateMethotrexate results in increased expression of TNFRSF10A mRNA21678067
D008727MethotrexateMethotrexate results in increased expression of TNFRSF10A protein17637740
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TNFRSF10A mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TNFRSF10A mRNA23649840
D009151Mustard GasIL10 protein affects the reaction [Mustard Gas affects the expression of TNFRSF10A mRNA]16173061
C058815N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamideN-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in increased expression of TNFRSF10A protein15520213
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of TNFRSF10A protein15572759
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TNFRSF10A mRNA"20800606
D009532NickelNickel results in increased expression of TNFRSF10A mRNA24768652
C010615Nonidet P-40Nonidet P-40 results in decreased expression of TNFRSF10A mRNA26552463
C570897NSC668394NSC668394 results in increased expression of TNFRSF10A mRNA27137931
D009761NystatinNystatin inhibits the reaction [Quercetin affects the localization of TNFRSF10A protein]17876056
D010081OxazoloneOxazolone results in increased expression of TNFRSF10A mRNA23999411
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of TNFRSF10A mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]23452621
D010126OzoneOzone results in increased expression of TNFRSF10A mRNA27206323
D017239PaclitaxelCycloheximide inhibits the reaction [Paclitaxel results in increased expression of TNFRSF10A protein]11212279
D017239PaclitaxelPaclitaxel results in increased expression of TNFRSF10A protein11212279
D010269ParaquatParaquat results in decreased expression of TNFRSF10A mRNA18836921
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of TNFRSF10A mRNA18593933
D010431PentoxifyllinePentoxifylline results in increased expression of TNFRSF10A protein20804743
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TNFRSF10A protein26879310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF10A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TNFRSF10A mRNA26272509
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]23452621
D010936Plant ExtractsPlant Extracts results in increased expression of TNFRSF10A protein18070620|2022952
D010936Plant ExtractsTNFRSF10A mRNA affects the susceptibility to Plant Extracts20229524
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF10A mRNA28433809
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of TNFRSF10A mRNA24583197
C005556propionaldehydepropionaldehyde results in increased expression of TNFRSF10A mRNA26079696
D011794QuercetinNystatin inhibits the reaction [Quercetin affects the localization of TNFRSF10A protein]17876056
D011794QuercetinQuercetin affects the localization of TNFRSF10A protein17876056
D011794QuercetinQuercetin promotes the reaction [TNFSF10 protein affects the localization of TNFRSF10A protein]17876056
D011794QuercetinQuercetin results in increased expression of TNFRSF10A mRNA21632981
D011794QuercetinQuercetin results in increased expression of TNFRSF10A protein17548900
D012116Resins, Plant"Resins, Plant results in increased expression of TNFRSF10A protein"27268964
C059514resveratrol[Benzo(a)pyrene co-treated with resveratrol] results in increased expression of TNFRSF10A mRNA24289642
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of TNFRSF10A protein]21179458
C059514resveratrolFOXO3 protein affects the reaction [resveratrol results in increased expression of TNFRSF10A protein]21179458
C059514resveratrolFOXO4 protein affects the reaction [resveratrol results in increased expression of TNFRSF10A protein]21179458
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]23452621
C059514resveratrolresveratrol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFRSF10A protein]21179458
C059514resveratrolresveratrol results in increased expression of TNFRSF10A mRNA22406996
C059514resveratrolresveratrol results in increased expression of TNFRSF10A protein17636462|1984690
C059514resveratrolresveratrol results in increased localization of TNFRSF10A protein19561642
C059514resveratrolresveratrol promotes the reaction [TNFSF10 protein results in increased expression of TNFRSF10A protein]21209944
C059514resveratrolTNFSF10 protein promotes the reaction [resveratrol results in increased expression of TNFRSF10A protein]21209944
C115461SC 560SC 560 results in increased expression of TNFRSF10A protein15572759
D012643SeleniumSelenium analog inhibits the reaction [Diazinon results in decreased expression of TNFRSF10A mRNA]27920530
D012717SesquiterpenesSesquiterpenes results in increased expression of TNFRSF10A protein18070620
C025462sulindac sulfidesulindac sulfide results in increased expression of TNFRSF10A mRNA15180942
C025462sulindac sulfidesulindac sulfide results in increased expression of TNFRSF10A protein15180942
D013792ThalidomideThalidomide results in decreased expression of TNFRSF10A protein16531263
C003466thymoquinone[Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of TNFRSF10A mRNA24289642
D014212TretinoinTretinoin results in decreased expression of TNFRSF10A protein16242776
C012589trichostatin Atrichostatin A affects the expression of TNFRSF10A mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of TNFRSF10A mRNA24935251
C050414tripterineTNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein]20605676
C050414tripterinetripterine results in increased expression of and results in increased localization of TNFRSF10A protein20605676
C050414tripterinetripterine results in increased expression of TNFRSF10A mRNA20605676
C001899triptolidetriptolide results in increased expression of TNFRSF10A protein26990902
C057693troglitazonetroglitazone results in increased expression of TNFRSF10A mRNA19140230
D017974Uranium CompoundsUranium Compounds results in increased expression of TNFRSF10A mRNA19654044
D014635Valproic AcidValproic Acid results in decreased expression of TNFRSF10A mRNA28001369
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of TNFRSF10A protein27169980
C111237vorinostatTNFSF10 protein promotes the reaction [vorinostat results in increased expression of TNFRSF10A protein]19509267
C111237vorinostatvorinostat results in increased expression of TNFRSF10A protein19509267|1973794
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of TNFRSF10A mRNA18593933
C088658zoledronic acid[zoledronic acid co-treated with fluvastatin] results in increased expression of TNFRSF10A mRNA16996129
C088658zoledronic acidzoledronic acid results in increased expression of TNFRSF10A mRNA19036117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI21785459  
GO:0005035death receptor activity-TAS9082980  
GO:0005515protein binding-IPI10894160  17047155  18165900  19427028  20103630  21785459  
GO:0008134transcription factor binding-IPI18165900  
GO:0038023signaling receptor activity-NAS9311998  
GO:0045569TRAIL binding-NAS9373179  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-NAS9311998  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-TAS-  
GO:0007165signal transduction-TAS9082980  
GO:0007166cell surface receptor signaling pathway-TAS-  
GO:0007250activation of NF-kappaB-inducing kinase activity-NAS9430227  11464292  
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors-NAS9311998  
GO:0033209tumor necrosis factor-mediated signaling pathway-IEA-  
GO:0036462TRAIL-activated apoptotic signaling pathway-IDA21785459  
GO:0042981regulation of apoptotic process-TAS-  
GO:0050900leukocyte migration-TAS-  
GO:0071260cellular response to mechanical stimulus-IEP19593445  
GO:0097191extrinsic apoptotic signaling pathway-IDA21785459  
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors-TAS-  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IDA22952982  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04210Apoptosis
hsa04650Natural killer cell mediated cytotoxicity
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-109582HemostasisTAS
R-HSA-140534Ligand-dependent caspase activationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3371378Regulation by c-FLIPTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5213460RIPK1-mediated regulated necrosisTAS
R-HSA-5218859Regulated NecrosisTAS
R-HSA-5218900CASP8 activity is inhibitedTAS
R-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathwayTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-5675482Regulation of necroptotic cell deathTAS
R-HSA-6803211TP53 Regulates Transcription of Death Receptors and LigandsTAS
R-HSA-69416Dimerization of procaspase-8TAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75158TRAIL signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19505916Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. (2009 Jun)Van Dyke ALCancer Epidemiol Biomarkers Prev