Gene info: ID 8804

Gene: CREG1

GENE ID: 8804

Synonyms: CREG

Description: cellular repressor of E1A stimulated genes 1

Gene type: protein-coding

Location: 1q24.2

dbXrefs: Ensembl:ENSG00000143162 Vega:OTTHUMG00000034682 UniprotKB:O75629

RefSeq: NC_000001.11

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.961e-1 (AD) 9.170e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs1229430	chr1:167544181 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg17936236	chr1:167520305	CREG1		1.300e-10	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DDX5	0.892
CAPZA1	0.891
ERP44	0.886
C5orf15	0.885
UBE2A	0.881
ADPGK	0.879
UBE2J1	0.874
SDCBP	0.872
CD164	0.871
TMEM167B	0.87

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.681
OR4F29	-0.653
HES5	-0.174
HPSE2	-0.155
NXNL1	-0.137
PRDM14	-0.135
PRAMEF17	-0.135
SSX5	-0.13
PTGDR2	-0.127
OR10K1	-0.126

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of CREG1 mRNA"	27071940
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of CREG1 mRNA]"	27071940
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of CREG1 mRNA"	19162173
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of CREG1 mRNA"	18281256
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CREG1 mRNA"	28903501
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREG1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREG1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREG1 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of CREG1 mRNA	19191707
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREG1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREG1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREG1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of CREG1 mRNA	17562736
D001151	Arsenic	CREG1 mRNA results in increased susceptibility to Arsenic	17976673
D001280	Atrazine	Atrazine results in increased expression of CREG1 mRNA	22378314
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of CREG1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CREG1 mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CREG1 mRNA"	20382639
C038328	BEP protocol	BEP protocol results in increased expression of CREG1 mRNA	18987330
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of CREG1 mRNA	20660070
C006780	bisphenol A	bisphenol A results in decreased expression of CREG1 mRNA	26364221
C006780	bisphenol A	bisphenol A results in increased expression of CREG1 mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of CREG1 mRNA	25181051
D002104	Cadmium	Cadmium results in increased expression of CREG1 mRNA	23256528
D002104	Cadmium	Cadmium results in increased expression of CREG1 mRNA	24376830
C028031	cadmium acetate	cadmium acetate results in decreased expression of CREG1 mRNA	18155341
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CREG1 mRNA	17484886
D002737	Chloroprene	Chloroprene results in increased expression of CREG1 mRNA	23125180
D002994	Clofibrate	Clofibrate results in increased expression of CREG1 mRNA	23811191
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CREG1 mRNA	24386269
D016572	Cyclosporine	Cyclosporine results in decreased expression of CREG1 mRNA	25562108
C093628	cyproconazole	cyproconazole results in increased expression of CREG1 mRNA	22334560
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CREG1 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CREG1 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of CREG1 mRNA	28962523
D002945	Cisplatin	Cisplatin results in increased expression of CREG1 mRNA	22023808
C000944	dicrotophos	dicrotophos results in decreased expression of CREG1 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of CREG1 mRNA	18042831
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of CREG1 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of CREG1 mRNA]	19850644
D004317	Doxorubicin	CREG1 protein affects the susceptibility to Doxorubicin	16217747
C118739	entinostat	entinostat results in increased expression of CREG1 mRNA	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of CREG1 mRNA	20064776
C109476	epoxiconazole	epoxiconazole results in increased expression of CREG1 mRNA	22334560
D018120	Finasteride	Finasteride results in increased expression of CREG1 mRNA	24136188
D005485	Flutamide	Flutamide results in decreased expression of CREG1 mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of CREG1 mRNA	24136188
D005978	Glutathione	Glutathione deficiency results in increased expression of CREG1 mRNA	20621112
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CREG1 mRNA	25613284
D007649	Ketamine	Ketamine results in increased expression of CREG1 mRNA	20080153
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CREG1 mRNA	25613284
C042720	mercuric bromide	mercuric bromide results in increased expression of CREG1 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREG1 mRNA"	27188386
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of CREG1 mRNA	24810058
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of CREG1 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of CREG1 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of CREG1 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CREG1 mRNA"	25554681
C051752	nefazodone	nefazodone results in increased expression of CREG1 mRNA	24136188
C012655	nimesulide	nimesulide results in increased expression of CREG1 mRNA	24136188
D017239	Paclitaxel	CREG1 protein affects the susceptibility to Paclitaxel	16217747
D000073878	Palm Oil	Palm Oil results in decreased expression of CREG1 mRNA	18042831
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of CREG1 mRNA	23892564
D010615	Phenacetin	Phenacetin results in increased expression of CREG1 mRNA	17698508
C031181	phenanthrene	phenanthrene results in increased expression of CREG1 mRNA	19457238
D010634	Phenobarbital	Phenobarbital affects the expression of CREG1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of CREG1 mRNA	19162173
C030299	phenylhydrazine	phenylhydrazine results in increased expression of CREG1 mRNA	17698508
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREG1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of CREG1 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CREG1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of CREG1 mRNA	18301758\|2081375
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of CREG1 mRNA	19162173
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of CREG1 mRNA	20660070
C045950	propiconazole	propiconazole results in increased expression of CREG1 mRNA	21278054\|2233456
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of CREG1 mRNA"	16678137
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CREG1 mRNA	21427059
D012906	Smoke	Smoke results in decreased expression of CREG1 mRNA	21095227
D012999	Soman	Soman results in increased expression of CREG1 mRNA	19281266
C061133	tamibarotene	tamibarotene results in increased expression of CREG1 mRNA	15498508
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of CREG1 mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CREG1 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of CREG1 protein	24648495
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CREG1 mRNA	22363418
D019772	Topotecan	Topotecan results in decreased expression of CREG1 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of CREG1 mRNA	15498508\|1721838
D014241	Trichloroethylene	Trichloroethylene results in increased expression of CREG1 mRNA	19448997
C406224	valdecoxib	valdecoxib results in increased expression of CREG1 mRNA	24136188
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREG1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of CREG1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of CREG1 mRNA	19101580\|2317975
D014635	Valproic Acid	Valproic Acid results in increased expression of CREG1 mRNA	21427059
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CREG1 gene	25560391
D014747	Vinblastine	CREG1 protein affects the susceptibility to Vinblastine	16217747
C025643	vinclozolin	vinclozolin results in decreased expression of CREG1 mRNA	23034163
C025643	vinclozolin	vinclozolin results in increased expression of CREG1 mRNA	22570695
C029297	vinylidene chloride	vinylidene chloride results in increased expression of CREG1 mRNA	26682919
C111237	vorinostat	vorinostat results in increased expression of CREG1 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003714	transcription corepressor activity	-	TAS	9710587
GO:0008134	transcription factor binding	-	IEA	-
GO:0048037	cofactor binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006357	regulation of transcription by RNA polymerase II	-	TAS	9710587
GO:0007275	multicellular organism development	-	TAS	9710587
GO:0008283	cell proliferation	-	TAS	9710587
GO:0040008	regulation of growth	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:1903507	negative regulation of nucleic acid-templated transcription	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	25645918
GO:0005667	transcription factor complex	-	IEA	-
GO:0035578	azurophil granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal