Gene: IL18RAP

8807
ACPL|CD218b|CDw218b|IL-18R-beta|IL-18RAcP|IL-18Rbeta|IL-1R-7|IL-1R7|IL-1RAcPL|IL18RB
interleukin 18 receptor accessory protein
protein-coding
2q12.1
Ensembl:ENSG00000115607 MIM:604509 Vega:OTTHUMG00000130777 UniprotKB:O95256
NG_011481.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.066e-1 (AD)  6.282e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21282997chr2:103035835IL18RAPPromoter1.129e-4Alcohol use disorders26763658
cg11335172chr2:103033799IL18RAP7.770e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXCR10.854
CST70.837
VNN20.816
CXCR20.81
LILRA50.802
KCNJ150.798
LILRB20.786
FCGR3B0.783
CEACAM30.783
FFAR20.775

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.595
ZNF835-0.588
SVOP-0.57
LRTM2-0.567
CORT-0.567
CYP46A1-0.564
BCL11A-0.564
ANKRD34A-0.564
CHRNA4-0.561
FAM57B-0.559

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of IL18RAP mRNA19933214
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IL18RAP mRNA19191707
D020106AcrylamideAcrylamide results in decreased expression of IL18RAP mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL18RAP mRNA24449571
D001151ArsenicArsenic affects the expression of IL18RAP mRNA28793237
D001151Arsenic[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of IL18RAP mRNA28793237
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IL18RAP mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of IL18RAP mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of IL18RAP mRNA26079696
D002101Cacodylic Acid[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of IL18RAP mRNA28793237
C007262deoxynivalenoldeoxynivalenol results in decreased expression of IL18RAP mRNA22968694
D017313FenretinideFenretinide results in decreased expression of IL18RAP mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of IL18RAP mRNA18996434
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL18RAP mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL18RAP mRNA25982114
C008261lead acetatelead acetate results in increased expression of IL18RAP mRNA21829687
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]18192897
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IL18RAP mRNA21641980
D008727MethotrexateMethotrexate results in decreased expression of IL18RAP mRNA17400583
D008748MethylcholanthreneMethylcholanthrene results in increased expression of IL18RAP mRNA20713471
C568376MT19c compoundMT19c compound results in increased expression of IL18RAP mRNA21781307
C500085muraglitazarmuraglitazar results in decreased expression of IL18RAP mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IL18RAP mRNA"25554681
D009532NickelNickel results in increased expression of IL18RAP mRNA25583101
C006253pirinixic acidpirinixic acid results in increased expression of IL18RAP mRNA20813756
C089730rosiglitazonerosiglitazone results in decreased expression of IL18RAP mRNA21515302
D000068718Rosuvastatin CalciumLipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]18192897
D000068718Rosuvastatin CalciumRosuvastatin Calcium results in decreased expression of IL18RAP mRNA18192897
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IL18RAP mRNA23806026
D012969Sodium FluorideSodium Fluoride results in increased expression of IL18RAP mRNA27862939
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IL18RAP mRNA21641980
C016766sulforafansulforafan results in increased expression of IL18RAP mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL18RAP mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL18RAP mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL18RAP mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL18RAP mRNA25613284
C057693troglitazonetroglitazone results in decreased expression of IL18RAP mRNA21515302

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0038023signaling receptor activity-TAS9792649  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-TAS9792649  
GO:0006955immune response-TAS9792649  
GO:0007166cell surface receptor signaling pathway-TAS9792649  
GO:0008283cell proliferation-IEA-  
GO:0032609interferon-gamma production-IEA-  
GO:0032635interleukin-6 production-IEA-  
GO:0035655interleukin-18-mediated signaling pathway-IDA25500532  
GO:0035655interleukin-18-mediated signaling pathway-TAS-  
GO:0035744T-helper 1 cell cytokine production-IEA-  
GO:0042119neutrophil activation-IEA-  
GO:0045954positive regulation of natural killer cell mediated cytotoxicity-IEA-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA25500532  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-9012546Interleukin-18 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19473509Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. (2009 May 27)Grisoni MLBMC Med Genet