Gene: IL18R1

8809
CD218a|CDw218a|IL-1Rrp|IL18RA|IL1RRP
interleukin 18 receptor 1
protein-coding
2q12.1
Ensembl:ENSG00000115604 MIM:604494 Vega:OTTHUMG00000130780 UniprotKB:Q13478
NC_000002.12
PubMed
0   ANCO-SNPs
ND
4   
8.716e-1 (AD)  9.442e-1 (ND)   (Frontal_Cortex)
7.532e-1 (AD)  5.763e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL1RL10.892
IRAK30.812
IL4R0.775
NID10.747
ACSL50.735
IL1R10.734
CDK20.733
ITGA10.732
ZNF2170.721
CHSY10.72

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.489
DLX1-0.486
PIP5KL1-0.486
MARCH4-0.483
PRLHR-0.482
NEUROD6-0.481
RTN4R-0.473
KIT-0.47
KCNIP3-0.466
DLK2-0.462

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of IL18R1 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of IL18R1 mRNA"27291303
D000171AcroleinAcrolein affects the expression of IL18R1 mRNA18515264
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IL18R1 protein20106945
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of IL18R1 mRNA19962721
D001151ArsenicArsenic results in decreased expression of IL18R1 mRNA19962721
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of IL18R1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of IL18R1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of IL18R1 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of IL18R1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IL18R1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of IL18R1 gene25435355
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of IL18R1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IL18R1 mRNA25908611
C006780bisphenol Abisphenol A results in decreased expression of IL18R1 mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of IL18R1 mRNA27685785
C006780bisphenol Abisphenol A results in increased methylation of IL18R1 gene22576693
C006780bisphenol A[potassium bromate co-treated with bisphenol A] affects the expression of IL18R1 mRNA27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of IL18R1 mRNA]27082013
C006780bisphenol Abisphenol A results in decreased expression of IL18R1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of IL18R1 mRNA18958704
D000069286BortezomibBortezomib results in increased expression of IL18R1 mRNA17895889
D002104CadmiumCadmium results in decreased expression of IL18R1 mRNA23358151
D000001Calcimycin[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL18R1 protein14994387
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of IL18R1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of IL18R1 mRNA22202117
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of IL18R1 mRNA]22202117
D016572CyclosporineCyclosporine results in increased expression of IL18R1 mRNA20106945|2798913
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of IL18R1 mRNA23640034
D016264Dextran SulfateIL18R1 protein affects the susceptibility to Dextran Sulfate12940437
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of IL18R1 mRNA"25908611
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of IL18R1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of IL18R1 mRNA22023808
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of IL18R1 mRNA11708898
C118739entinostatentinostat results in increased expression of IL18R1 mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of IL18R1 mRNA23649840
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of IL18R1 mRNA19962721
D005459FluoridesFluorides results in decreased expression of IL18R1 mRNA19962721
D007213IndomethacinIndomethacin results in increased expression of IL18R1 mRNA18996434
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL18R1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of IL18R1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL18R1 mRNA26387944|2675264
C018091maduramicinmaduramicin results in decreased expression of IL18R1 mRNA29128925
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL18R1 mRNA"25926378
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IL18R1 mRNA23649840
C568376MT19c compoundMT19c compound results in increased expression of IL18R1 mRNA21781307
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL18R1 mRNA"25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IL18R1 mRNA"25554681
D009532NickelNickel results in increased expression of IL18R1 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in increased expression of IL18R1 mRNA17312168
C030110oxaliplatinoxaliplatin results in increased expression of IL18R1 mRNA25729387
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IL18R1 mRNA19710929
C019536potassium bromatepotassium bromate affects the expression of IL18R1 mRNA27082013
C019536potassium bromate[potassium bromate co-treated with bisphenol A] affects the expression of IL18R1 mRNA27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of IL18R1 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of IL18R1 mRNA]27082013
D011374ProgesteroneProgesterone results in decreased expression of IL18R1 mRNA22238285
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of IL18R1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IL18R1 mRNA23806026
D053260SootSoot results in decreased expression of IL18R1 mRNA26551751
C016766sulforafansulforafan results in increased expression of IL18R1 mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL18R1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL18R1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL18R1 protein14994387
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL18R1 mRNA25613284
C024746tobacco tartobacco tar results in decreased expression of IL18R1 mRNA19559774
D014118Toxins, Biological"Toxins, Biological affects the expression of IL18R1 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of IL18R1 mRNA21934132
D014635Valproic AcidValproic Acid results in increased expression of IL18R1 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of IL18R1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IL18R1 gene25560391
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of IL18R1 mRNA]22202117
C088658zoledronic acidzoledronic acid results in increased expression of IL18R1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004908interleukin-1 receptor activity-IEA-  
GO:0005515protein binding-IPI25261253  
GO:0038023signaling receptor activity-TAS9325300  
GO:0042007interleukin-18 binding-IDA14528293  25261253  25500532  
GO:0042008interleukin-18 receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-TAS9325300  
GO:0007165signal transduction-TAS9325300  
GO:0030101natural killer cell activation-IEA-  
GO:0032729positive regulation of interferon-gamma production-IDA10653850  
GO:0035655interleukin-18-mediated signaling pathway-IDA25500532  
GO:0035655interleukin-18-mediated signaling pathway-TAS-  
GO:0045063T-helper 1 cell differentiation-IEA-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA25500532  
GO:0071345cellular response to cytokine stimulus-TAS-  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IEA-  
GO:2000556positive regulation of T-helper 1 cell cytokine production-IDA10653850  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-9008059Interleukin-37 signalingTAS
R-HSA-9012546Interleukin-18 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23028483Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. (2012)Ramasamy APLoS One
16971411IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. (2006 Dec)Nadif REur Respir J
19473509Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. (2009 May 27)Grisoni MLBMC Med Genet
27058054Asthma susceptibility variants are more strongly associated with clinically similar subgroups. (2016 Nov)Lavoie-Charland EJ Asthma