Gene: GALR2

8811
GAL2-R|GALNR2|GALR-2
galanin receptor 2
protein-coding
17q25.1
Ensembl:ENSG00000182687 MIM:603691 Vega:OTTHUMG00000167479 UniprotKB:O43603
NC_000017.11
PubMed
0   ANCO-SNPs
OD|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.107e-2 (AD)  5.208e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2G2E0.565
SLC6A30.549
CALCB0.529
OR5K30.523
GPX20.514
DEFB1150.509
GCM10.508
POU4F20.508
TMEM950.501
LRRC260.496

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
P2RY14-0.356
ITIH5-0.301
GPR17-0.258
ABCG2-0.251
PDGFRA-0.251
COL20A1-0.249
NXPE2-0.244
DPEP2-0.242
CYSLTR2-0.232
GJC1-0.231

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GALR2 mRNA"27291303
C552254(9H-fluoren-9-yl)methyl(1-((6-(tert-butoxycarbonyl)amino-1-((4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)amino)-1-oxohexan-2-yl)amino)-3-cyclohexyl-1-oxopropan-2-yl)carbamate"(9H-fluoren-9-yl)methyl(1-((6-(tert-butoxycarbonyl)amino-1-((4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)amino)-1-oxohexan-2-yl)amino)-3-cyclohexyl-1-oxopropan-2-yl)carbamate promotes the reaction [GAL protein results in increased activity of GALR2 protein]"20660766
D000079AcetaldehydeAcetaldehyde affects the expression of GALR2 mRNA22634333
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GALR2 mRNA16483693
C015001arsenitearsenite results in decreased expression of GALR2 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of GALR2 mRNA]18929588
D001280AtrazineAtrazine results in decreased expression of GALR2 mRNA25929836
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of GALR2 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GALR2 mRNA21632981
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GALR2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of GALR2 mRNA19619570|2118537
C095105bexarotenebexarotene results in increased expression of GALR2 mRNA16648578
C006780bisphenol Abisphenol A results in decreased expression of GALR2 mRNA19371625
C006780bisphenol Abisphenol A results in decreased expression of GALR2 mRNA15518916|2518105
C006780bisphenol Abisphenol A results in decreased methylation of GALR2 gene28505145
C006780bisphenol Abisphenol A results in increased methylation of GALR2 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of GALR2 mRNA26079696
D002211CapsaicinCapsaicin results in increased expression of GALR2 mRNA18553211
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GALR2 mRNA23640034
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GALR2 mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GALR2 mRNA15620428
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of GALR2 mRNA15620428
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GALR2 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of GALR2 mRNA18721800
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GALR2 mRNA15620428
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of GALR2 mRNA19371625
D015025ZearalenoneZearalenone results in decreased expression of GALR2 mRNA19371625
C061365flusilazoleflusilazole affects the expression of GALR2 mRNA22634333
D005557FormaldehydeFormaldehyde results in increased expression of GALR2 mRNA23649840
C039281furanfuran results in increased expression of GALR2 mRNA27387713
D019833GenisteinGenistein results in decreased expression of GALR2 mRNA19371625
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of GALR2 mRNA21782745
C544151jinfukangjinfukang results in decreased expression of GALR2 mRNA27392435
D007649KetamineKetamine results in decreased expression of GALR2 mRNA20080153
C008261lead acetatelead acetate results in increased expression of GALR2 mRNA22609695
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of GALR2 mRNA"24972896
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of GALR2 mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GALR2 mRNA21385734
C028007nickel monoxidenickel monoxide results in increased expression of GALR2 mRNA19167457
C025256nonylphenolnonylphenol results in decreased expression of GALR2 mRNA15518916|1562042
D016627OxidopamineOxidopamine results in decreased expression of GALR2 mRNA15518916
D016627OxidopamineOxidopamine results in increased expression of GALR2 mRNA15303306
C016340o,p'-DDT"o,p'-DDT results in decreased expression of GALR2 mRNA"19371625
D010795Phthalic AcidsPhthalic Acids results in decreased expression of GALR2 mRNA15518916
D011441PropylthiouracilPropylthiouracil results in decreased expression of GALR2 mRNA24780913
D011794QuercetinQuercetin results in increased expression of GALR2 mRNA21632981
C009277sodium arsenatesodium arsenate results in decreased expression of GALR2 mRNA21795629
D012999SomanSoman results in increased expression of GALR2 mRNA19281266
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GALR2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GALR2 mRNA19619570|2010694
C011559tributyltintributyltin results in increased expression of GALR2 mRNA21683754
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GALR2 mRNA"26179874
D014520UrethaneUrethane results in increased expression of GALR2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of GALR2 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of GALR2 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of GALR2 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004966galanin receptor activity-IBA21873635  
GO:0004966galanin receptor activity-IDA9832121  24517231  
GO:0005515protein binding-IPI23597562  25691535  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO:0017046peptide hormone binding-IDA24517231  
GO:0017046peptide hormone binding-IPI9832121  
GO:0042923neuropeptide binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS9480833  
GO:0007166cell surface receptor signaling pathway-TAS9480833  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-TAS9685625  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0007194negative regulation of adenylate cyclase activity-IEA-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IDA9832121  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007275multicellular organism development-TAS9480833  
GO:0007611learning or memory-TAS9480833  
GO:0007631feeding behavior-TAS9480833  
GO:0031175neuron projection development-IEA-  
GO:0043647inositol phosphate metabolic process-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA24517231  
GO:0046488phosphatidylinositol metabolic process-IEA-  
GO:0090663galanin-activated signaling pathway-IDA9832121  
GO:1902608positive regulation of large conductance calcium-activated potassium channel activity-IMP24602615  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-TAS9480833  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21955024Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala. (2012 Jul)Bajo MAddict Biol
17083333Alcoholism is associated with GALR3 but not two other galanin receptor genes. (2007 Jul)Belfer IGenes Brain Behav
21969124Galanin negatively modulates opiate withdrawal via galanin receptor 1. (2012 Apr)Holmes FEPsychopharmacology (Berl)
23639882The role of galanin system in modulating depression, anxiety, and addiction-like behaviors after chronic restraint stress. (2013 Aug 29)Zhao XNeuroscience