Gene: FGF18

8817
FGF-18|ZFGF5
fibroblast growth factor 18
protein-coding
5q35.1
Ensembl:ENSG00000156427 MIM:603726 Vega:OTTHUMG00000130464 UniprotKB:O76093
NG_029158.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.086e-1 (AD)  6.687e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24698211chr5:170877540FGF189.800e-8Smoking27651444
cg15699524chr5:170845610FGF184.130e-9Alcohol consumption der day27843151
cg24698211chr5:170877540FGF182.290e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSPAN90.635
COL5A10.627
HS3ST10.622
ATP8B10.622
CDC42EP30.615
SLC6A200.606
FHL20.605
DCBLD20.595
NUDT40.593
SGCG0.593

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STON2-0.368
HOGA1-0.362
RIBC1-0.348
ZFHX4-AS1-0.341
ABHD1-0.34
DIAPH3-0.339
LRAT-0.338
S100A1-0.335
PDE11A-0.331
TPPP2-0.331

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of FGF18 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FGF18 mRNA19933214
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in decreased expression of FGF18 mRNA16014739
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF18 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF18 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF18 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FGF18 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGF18 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGF18 mRNA21569818
D004958EstradiolEstradiol affects the expression of FGF18 mRNA25321415
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of FGF18 mRNA17404688
C006780bisphenol Abisphenol A affects the expression of FGF18 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of FGF18 mRNA27022677
C006780bisphenol Abisphenol A results in decreased expression of FGF18 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of FGF18 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of FGF18 mRNA25979313
D002737ChloropreneChloroprene results in decreased expression of FGF18 mRNA23125180
D004390ChlorpyrifosChlorpyrifos affects the expression of FGF18 mRNA18502319
D002809Chondroitin SulfatesChondroitin Sulfates analog binds to FGF18 protein12221095
D002809Chondroitin Sulfates[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein15385557
D002809Chondroitin Sulfates[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein14699094
D002994ClofibrateClofibrate results in increased expression of FGF18 mRNA16081524
D019327Copper SulfateCopper Sulfate affects the expression of FGF18 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of FGF18 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of FGF18 mRNA22147139
D016572CyclosporineCyclosporine results in decreased methylation of FGF18 promoter27989131
D003871Dermatan Sulfate[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein15385557
D003871Dermatan Sulfate[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein14699094
D002945CisplatinCisplatin results in increased expression of FGF18 mRNA27392435
C058705diethyl malatediethyl malate affects the expression of FGF18 mRNA24814887
C058705diethyl malateS-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA]24814887
D004237DiuronDiuron results in decreased expression of FGF18 mRNA25152437
C118739entinostatentinostat results in increased expression of FGF18 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF18 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of FGF18 mRNA22079256
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of FGF18 mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of FGF18 mRNA28329830
D006497Heparitin SulfateHeparitin Sulfate analog binds to FGF18 protein14707131
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of FGF18 mRNA26752646
C008261lead acetatelead acetate results in decreased expression of FGF18 mRNA22609695
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FGF18 mRNA23519560
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FGF18 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride affects the expression of FGF18 mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of FGF18 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FGF18 mRNA"25554681
D009532NickelNickel results in decreased expression of FGF18 mRNA19130878
C007350nitrofennitrofen results in decreased expression of FGF18 mRNA23979401
C007350nitrofennitrofen results in decreased expression of FGF18 protein23979401
C025589ochratoxin Aochratoxin A results in increased expression of FGF18 mRNA22124623
C025589ochratoxin Aochratoxin A results in increased expression of FGF18 mRNA22124623
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF18 mRNA"27188386
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of FGF18 mRNA26705709
C046012pentanalpentanal results in increased expression of FGF18 mRNA26079696
D010656PhenylephrinePhenylephrine results in increased expression of FGF18 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF18 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FGF18 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of FGF18 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of FGF18 mRNA22079256
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of FGF18 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of FGF18 mRNA18037150
D011794QuercetinQuercetin results in increased expression of FGF18 mRNA21632981
C042431S-ethyl glutathioneS-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA]24814887
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FGF18 mRNA23806026
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of FGF18 mRNA"26680231
D014284TriiodothyronineTriiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK1 protein]16150908
D014284TriiodothyronineTriiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK3 protein]16150908
C003377taxifolintaxifolin results in decreased expression of FGF18 mRNA17541156
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FGF18 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FGF18 mRNA23519560
D014212TretinoinTretinoin results in increased expression of FGF18 mRNA21934132
D014212TretinoinTretinoin results in increased expression of FGF18 mRNA20488242
C012589trichostatin Atrichostatin A results in increased expression of FGF18 mRNA24935251
D014520UrethaneUrethane results in increased expression of FGF18 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of FGF18 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FGF18 mRNA24383497|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FGF18 gene25560391
C111237vorinostatvorinostat results in decreased expression of FGF18 mRNA27188386
C111237vorinostatvorinostat results in increased expression of FGF18 mRNA18769122
C088658zoledronic acidzoledronic acid results in increased expression of FGF18 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005105type 1 fibroblast growth factor receptor binding-IDA16384934  
GO:0005111type 2 fibroblast growth factor receptor binding-IDA16384934  
GO:0008083growth factor activity-IEA-  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001525angiogenesis-IEA-  
GO:0001936regulation of endothelial cell proliferationNOTIDA16756958  
GO:0001957intramembranous ossification-IEA-  
GO:0001958endochondral ossification-IEA-  
GO:0002063chondrocyte development-IEA-  
GO:0007165signal transduction-TAS9742123  
GO:0007267cell-cell signaling-TAS9742123  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0008543fibroblast growth factor receptor signaling pathway-TAS-  
GO:0009653anatomical structure morphogenesis-TAS9742123  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030324lung development-IEA-  
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway-IEA-  
GO:0032332positive regulation of chondrocyte differentiation-IEA-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0043406positive regulation of MAP kinase activity-IDA16756958  
GO:0043536positive regulation of blood vessel endothelial cell migration-IGI25449503  
GO:0045766positive regulation of angiogenesis-IGI25449503  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO:1903670regulation of sprouting angiogenesisNOTIDA16756958  
GO:2000546positive regulation of endothelial cell chemotaxis to fibroblast growth factor-IDA16756958  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-TAS9742123  
GO:0005730nucleolus-IDA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1839126FGFR2 mutant receptor activationTAS
R-HSA-1839130Signaling by activated point mutants of FGFR3TAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-190239FGFR3 ligand binding and activationTAS
R-HSA-190241FGFR2 ligand binding and activationTAS
R-HSA-190322FGFR4 ligand binding and activationTAS
R-HSA-190371FGFR3b ligand binding and activationTAS
R-HSA-190372FGFR3c ligand binding and activationTAS
R-HSA-190375FGFR2c ligand binding and activationTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2033514FGFR3 mutant receptor activationTAS
R-HSA-2033519Activated point mutants of FGFR2TAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-5654221Phospholipase C-mediated cascade; FGFR2TAS
R-HSA-5654227Phospholipase C-mediated cascade; FGFR3TAS
R-HSA-5654228Phospholipase C-mediated cascade; FGFR4TAS
R-HSA-5654695PI-3K cascade:FGFR2TAS
R-HSA-5654696Downstream signaling of activated FGFR2TAS
R-HSA-5654699SHC-mediated cascade:FGFR2TAS
R-HSA-5654700FRS-mediated FGFR2 signalingTAS
R-HSA-5654704SHC-mediated cascade:FGFR3TAS
R-HSA-5654706FRS-mediated FGFR3 signalingTAS
R-HSA-5654708Downstream signaling of activated FGFR3TAS
R-HSA-5654710PI-3K cascade:FGFR3TAS
R-HSA-5654712FRS-mediated FGFR4 signalingTAS
R-HSA-5654716Downstream signaling of activated FGFR4TAS
R-HSA-5654719SHC-mediated cascade:FGFR4TAS
R-HSA-5654720PI-3K cascade:FGFR4TAS
R-HSA-5654727Negative regulation of FGFR2 signalingTAS
R-HSA-5654732Negative regulation of FGFR3 signalingTAS
R-HSA-5654733Negative regulation of FGFR4 signalingTAS
R-HSA-5654736Signaling by FGFR1TAS
R-HSA-5654738Signaling by FGFR2TAS
R-HSA-5654741Signaling by FGFR3TAS
R-HSA-5654743Signaling by FGFR4TAS
R-HSA-5655253Signaling by FGFR2 in diseaseTAS
R-HSA-5655332Signaling by FGFR3 in diseaseTAS
R-HSA-5658623FGFRL1 modulation of FGFR1 signalingTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-8853338Signaling by FGFR3 point mutants in cancerTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26683928Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection. (2015 Dec)Rhie AMedicine (Baltimore)
22074045The FGF and FGFR Gene Family and Risk of Cleft Lip With or Without Cleft Palate. (2013 Jan)Wang HCleft Palate Craniofac J