Gene: IQGAP1

8826
HUMORFA01|SAR1|p195
IQ motif containing GTPase activating protein 1
protein-coding
15q26.1
Ensembl:ENSG00000140575 MIM:603379 Vega:OTTHUMG00000149832 UniprotKB:P46940
NG_052946.1
PubMed
0   ANCO-SNPs
AD
1   
2.524e-1 (AD)  7.504e-1 (ND)   (Frontal_Cortex)
8.892e-1 (AD)  5.199e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LBR0.869
ELF10.868
MTUS10.865
PAK20.846
SH3BP40.845
TANC10.844
ATL30.844
ITGB10.841
SP10.841
PARP40.84

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.458
GSG1-0.419
ADRA1D-0.398
MARCH4-0.391
SPEF1-0.387
FBLN7-0.383
OR4F29-0.381
ABCC12-0.377
BHLHA9-0.375
KCNK3-0.371

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of IQGAP1 mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of IQGAP1 mRNA]"19414516
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of IQGAP1 mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IQGAP1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of IQGAP1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of IQGAP1 mRNA28959563
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of IQGAP1 mRNA]"19414516
C016601afimoxifeneafimoxifene results in decreased expression of IQGAP1 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IQGAP1 protein20106945
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of IQGAP1 mRNA28522335
D034341Aristolochic AcidsAristolochic Acids results in increased expression of IQGAP1 mRNA19717638
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of IQGAP1 mRNA"17331233
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IQGAP1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IQGAP1 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IQGAP1 mRNA"20018196
D004958EstradiolEstradiol results in increased expression of IQGAP1 mRNA16514628
C018475butyraldehydebutyraldehyde results in decreased expression of IQGAP1 mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of IQGAP1 mRNA26191083
D002104CadmiumCadmium results in decreased expression of IQGAP1 mRNA21679763
D002104CadmiumCadmium results in decreased expression of IQGAP1 protein21679763
D002118CalciumCalcium promotes the reaction [PAFAH1B1 protein binds to IQGAP1 protein binds to CDC42 protein]16369480
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IQGAP1 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IQGAP1 mRNA20938992
C030973cupric oxidecupric oxide results in increased expression of IQGAP1 protein25470785
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IQGAP1 mRNA]11007951
D016572CyclosporineCyclosporine results in increased expression of IQGAP1 mRNA20106945|2556210
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of IQGAP1 mRNA"25908611
D004026DieldrinDieldrin results in increased expression of IQGAP1 mRNA20438755
D004041Dietary FatsDietary Fats results in increased expression of IQGAP1 mRNA15238619|1903023
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of IQGAP1 mRNA]19030233
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of IQGAP1 mRNA26464624
C039060dihydroartemisinindihydroartemisinin analog binds to IQGAP1 protein modified form26340163
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of IQGAP1 mRNA25380136
C118739entinostatentinostat results in increased expression of IQGAP1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
D000431EthanolEthanol results in decreased expression of IQGAP1 protein20829428
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IQGAP1 mRNA20938992
C070081fulvestrantfulvestrant results in decreased expression of IQGAP1 mRNA16514628
C001277geldanamycingeldanamycin results in increased expression of IQGAP1 mRNA26705709
C056507gemcitabinegemcitabine results in increased expression of IQGAP1 mRNA17039268
D005839GentamicinsGentamicins results in increased expression of IQGAP1 mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of IQGAP1 mRNA22634610
D006118GriseofulvinGriseofulvin affects the expression of IQGAP1 mRNA12735108
C492448ICG 001ICG 001 results in decreased expression of IQGAP1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IQGAP1 mRNA25613284
C410337K 7174K 7174 results in increased expression of IQGAP1 mRNA24086573
D048628KetolidesKetolides analog results in increased expression of IQGAP1 mRNA24967691
C008261lead acetatelead acetate results in decreased expression of IQGAP1 mRNA21891863
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IQGAP1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of IQGAP1 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IQGAP1 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IQGAP1 mRNA26272509|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IQGAP1 mRNA26011545
D008942MitoxantroneIQGAP1 protein affects the susceptibility to Mitoxantrone16217747
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of IQGAP1 mRNA25380136
C028007nickel monoxidenickel monoxide results in increased expression of IQGAP1 mRNA19167457
C025589ochratoxin Aochratoxin A results in increased expression of IQGAP1 mRNA19717638
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of IQGAP1 mRNA26272509
D010634PhenobarbitalPhenobarbital affects the expression of IQGAP1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of IQGAP1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IQGAP1 mRNA19710929
D011748PyrogallolPyrogallol results in increased expression of IQGAP1 mRNA20362636
D011794QuercetinQuercetin inhibits the reaction [IQGAP1 protein binds to MAPK1 protein binds to MAPK3 protein]24397597
D011794QuercetinQuercetin results in decreased expression of IQGAP1 mRNA19207037|2439759
D011794QuercetinQuercetin results in decreased expression of IQGAP1 protein19207037|2439759
D011794QuercetinQuercetin results in increased expression of IQGAP1 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of IQGAP1 mRNA16514628
C089032rimonabantrimonabant affects the expression of IQGAP1 mRNA19030233
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of IQGAP1 mRNA]19030233
D012524SarinSarin results in decreased expression of IQGAP1 mRNA19522546
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of IQGAP1 mRNA"16251409
D012822Silicon DioxideSilicon Dioxide results in increased expression of IQGAP1 mRNA22431001
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IQGAP1 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IQGAP1 mRNA11007951|1237799
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IQGAP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IQGAP1 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IQGAP1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of IQGAP1 protein24648495
D013849ThimerosalThimerosal results in decreased expression of IQGAP1 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IQGAP1 mRNA28111298
D014050TolueneToluene results in increased expression of IQGAP1 mRNA22967744
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of IQGAP1 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of IQGAP1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of IQGAP1 mRNA23179753|2627250
D014640VancomycinVancomycin results in decreased expression of IQGAP1 mRNA18930951
C025643vinclozolinvinclozolin affects the expression of IQGAP1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of IQGAP1 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of IQGAP1 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of IQGAP1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005095GTPase inhibitor activity-TAS8670801  
GO:0005096GTPase activator activity-TAS8051149  
GO:0005509calcium ion binding-TAS18567582  
GO:0005515protein binding-IPI8670801  8702968  8798539  9368021  10793131  12745076  
17563371  17620407  17853893  18567582  20875083  21349850  
21724847  22662192  23982733  25074804  25554515  26496610  
27173435  28007913  29033352  
GO:0005516calmodulin binding-IDA18567582  
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding-IDA22493426  
GO:0019901protein kinase binding-IPI17563371  
GO:0019903protein phosphatase binding-IPI16380380  
GO:0019904protein domain specific binding-IPI25554515  
GO:0043539protein serine/threonine kinase activator activity-IDA17563371  
GO:0044548S100 protein binding-IPI25554515  
GO:0044877protein-containing complex binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO:0048365Rac GTPase binding-IEA-  
GO:0051019mitogen-activated protein kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001817regulation of cytokine production-IEA-  
GO:0007165signal transduction-TAS8051149  
GO:0007173epidermal growth factor receptor signaling pathway-IMP17563371  
GO:0007346regulation of mitotic cell cycle-IMP20883816  
GO:0008543fibroblast growth factor receptor signaling pathway-IEA-  
GO:0034260negative regulation of GTPase activity-IEA-  
GO:0035305negative regulation of dephosphorylation-IEA-  
GO:0036120cellular response to platelet-derived growth factor stimulus-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0043406positive regulation of MAP kinase activity-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0045860positive regulation of protein kinase activity-IMP17563371  
GO:0048008platelet-derived growth factor receptor signaling pathway-IEA-  
GO:0051894positive regulation of focal adhesion assembly-IEA-  
GO:0071277cellular response to calcium ion-IDA18567582  
GO:0071364cellular response to epidermal growth factor stimulus-IMP17563371  
GO:0072015glomerular visceral epithelial cell development-ISS-  
GO:1900006positive regulation of dendrite development-IEA-  
GO:1900086positive regulation of peptidyl-tyrosine autophosphorylation-IEA-  
GO:1903829positive regulation of cellular protein localization-IEA-  
GO:1904754positive regulation of vascular associated smooth muscle cell migration-IEA-  
GO:1990138neuron projection extension-IMP15695813  
GO:1990776response to angiotensin-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IDA25554515  
GO:0005634nucleus-IDA20883816  29033352  
GO:0005737cytoplasm-IDA25554515  29033352  
GO:0005829cytosol-TAS-  
GO:0005874microtubule-IDA21525035  
GO:0005884actin filament-TAS8670801  
GO:0005886plasma membrane-IDA29033352  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0015629actin cytoskeletoncolocalizes_withISS-  
GO:0015630microtubule cytoskeletoncolocalizes_withISS-  
GO:0016328lateral plasma membrane-IEA-  
GO:0030424axon-ISS-  
GO:0030426growth cone-ISS-  
GO:0030496midbody-IDA15166316  
GO:0030667secretory granule membrane-TAS-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IDA22493426  
GO:0036057slit diaphragm-ISS-  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA15121898  
GO:0043005neuron projection-ISS-  
GO:0045121membrane raft-IEA-  
GO:0070062extracellular exosome-HDA19056867  19199708  20458337  23533145  
KEGG ID KEGG Term
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-163685Integration of energy metabolismIEA
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-373753Nephrin family interactionsTAS
R-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretionIEA
R-HSA-422356Regulation of insulin secretionIEA
R-HSA-5626467RHO GTPases activate IQGAPsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23974104High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors. (2013 Sep 15)Robinson TJCell Cycle