Gene: NRP1

8829
BDCA4|CD304|NP1|NRP|VEGF165R
neuropilin 1
protein-coding
10p11.22
Ensembl:ENSG00000099250 MIM:602069 Vega:OTTHUMG00000019343 UniprotKB:O14786
NG_030328.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.690e-1 (AD)  3.192e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2243668chr10:33274965 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25713793chr10:33590732NRP1Gene body3.491e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJC30.743
MOB1A0.738
PTPN90.738
DCAF120.733
AFF10.732
SMAD10.729
STAT30.729
MR10.723
TRIM40.719
SORBS10.719

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.344
OR4F29-0.335
S1PR5-0.27
NKX2-8-0.246
GIPR-0.243
C5orf64-0.242
SULT2B1-0.237
KLRC3-0.236
MYCNOS-0.235
FIBCD1-0.229

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00039PaliferminBiotechDrug162394-19-6ApprovedTarget
DB04895PegaptanibBiotechDrug222716-86-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0636091,2-dimethyl-4-nitrobenzene"1,2-dimethyl-4-nitrobenzene results in increased expression of NRP1 mRNA"19784758
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of NRP1 mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NRP1 mRNA28986273
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NRP1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of NRP1 mRNA"19095052
C0192732,2-bis(4-glycidyloxyphenyl)propane"[2,2-bis(4-glycidyloxyphenyl)propane co-treated with Cytarabine] results in decreased expression of NRP1 mRNA"23264188
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NRP1 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of NRP1 mRNA"20406850
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of NRP1 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of NRP1 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C496492abrineabrine results in increased expression of NRP1 mRNA22595364
D000079AcetaldehydeAcetaldehyde affects the expression of NRP1 mRNA22634333
D000082AcetaminophenAcetaminophen results in decreased expression of NRP1 mRNA21420995|2906747
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of NRP1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NRP1 mRNA]17585979
D000082AcetaminophenAcetaminophen affects the expression of NRP1 mRNA19784758
D000082AcetaminophenAcetaminophen results in decreased expression of NRP1 mRNA19784758
D000082AcetaminophenAcetaminophen results in increased expression of NRP1 mRNA19784758
D020106AcrylamideAcrylamide results in decreased expression of NRP1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NRP1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NRP1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NRP1 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of NRP1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NRP1 mRNA16483693
D000968Antimycin AAntimycin A results in decreased expression of NRP1 mRNA19304788
C015001arsenitearsenite results in increased methylation of NRP1 promoter23974009
D001280AtrazineAtrazine results in decreased expression of NRP1 mRNA25929836
D001372Aza CompoundsAza Compounds results in decreased expression of NRP1 mRNA20521778
D001372Aza CompoundsAza Compounds results in increased expression of NRP1 mRNA20521778
C487081belinostatbelinostat results in increased expression of NRP1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NRP1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NRP1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NRP1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NRP1 mRNA"19150397|2038263
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of NRP1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of NRP1 mRNA14664709
C053541bicalutamidebicalutamide results in decreased expression of NRP1 mRNA15638997
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of NRP1 mRNA25912373
C006780bisphenol Abisphenol A affects the expression of NRP1 mRNA20170705
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NRP1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of NRP1 mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of NRP1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of NRP1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of NRP1 mRNA22079614
C018475butyraldehydebutyraldehyde results in decreased expression of NRP1 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of NRP1 mRNA26191083
D002110CaffeineCaffeine results in decreased expression of NRP1 mRNA26179615
C459604candoxincandoxin results in increased expression of NRP1 mRNA16309724
D000074262Canola OilCanola Oil metabolite results in decreased expression of NRP1 mRNA27363782
D002211CapsaicinCapsaicin results in increased expression of NRP1 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]22150557
D002220CarbamazepineCarbamazepine affects the expression of NRP1 mRNA22634333
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NRP1 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of NRP1 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of NRP1 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of NRP1 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of NRP1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NRP1 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of NRP1 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in decreased expression of NRP1 mRNA24386269
D003042CocaineCocaine results in increased expression of NRP1 mRNA15691709
D003300Copper[Disulfiram binds to Copper] which results in increased expression of NRP1 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of NRP1 mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of NRP1 mRNA15467011
D003520CyclophosphamideCyclophosphamide results in decreased expression of NRP1 mRNA15331540
D003520CyclophosphamideCyclophosphamide results in increased expression of NRP1 mRNA18632792
D016572CyclosporineCyclosporine affects the expression of NRP1 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of NRP1 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of NRP1 mRNA21632981
D003561Cytarabine"[2,2-bis(4-glycidyloxyphenyl)propane co-treated with Cytarabine] results in decreased expression of NRP1 mRNA"23264188
C014347decitabine[decitabine co-treated with Depsipeptides] results in decreased expression of NRP1 mRNA17064661
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of NRP1 mRNA]21095227
D003703DemecolcineDemecolcine results in increased expression of NRP1 mRNA23649840
D047630Depsipeptides[decitabine co-treated with Depsipeptides] results in decreased expression of NRP1 mRNA17064661
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NRP1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NRP1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NRP1 mRNA21266533
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of NRP1 mRNA21858171
D004008DiclofenacDiclofenac results in increased expression of NRP1 mRNA26934552
C000944dicrotophosdicrotophos results in decreased expression of NRP1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of NRP1 mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of NRP1 mRNA14664709
D002117CalcitriolCalcitriol results in decreased expression of NRP1 mRNA16002434
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of NRP1 mRNA24690739
D004317DoxorubicinNRP1 protein affects the susceptibility to Doxorubicin16217747
C118739entinostatentinostat results in increased expression of NRP1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
D000431EthanolEthanol results in decreased expression of NRP1 protein20621659
D000431EthanolEthanol affects the expression of NRP1 mRNA22198099
D000431EthanolEthanol results in decreased expression of NRP1 mRNA15353170
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NRP1 mRNA18936297
C000499ferric oxideferric oxide analog results in decreased expression of NRP1 mRNA25086211
D005411Flame RetardantsFlame Retardants results in increased expression of NRP1 mRNA27219277
D005419FlavonoidsFlavonoids results in increased expression of NRP1 mRNA18035473
D005472FluorouracilNRP1 protein results in decreased susceptibility to Fluorouracil15956974
D005492Folic AcidFolic Acid results in increased expression of NRP1 mRNA25006883
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of NRP1 mRNA20938992
C039281furanfuran results in increased methylation of NRP1 gene22079235
C056507gemcitabineNRP1 protein results in decreased susceptibility to gemcitabine15956974
D019833GenisteinGenistein affects the expression of NRP1 mRNA16399490
D005839GentamicinsGentamicins results in increased expression of NRP1 mRNA22061828
C010176halofuginonehalofuginone results in increased expression of NRP1 mRNA17180598
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in increased expression of NRP1 mRNA27219277
D017313FenretinideFenretinide results in increased expression of NRP1 mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of NRP1 mRNA19376150
C492448ICG 001ICG 001 results in decreased expression of NRP1 mRNA26191083
D007211IndolesIndoles results in decreased expression of NRP1 mRNA20521778
D007211IndolesIndoles results in increased expression of NRP1 mRNA20521778
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NRP1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of NRP1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NRP1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NRP1 mRNA24796395|2675264
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of NRP1 mRNA25119042
C045463leflunomideleflunomide results in increased expression of NRP1 mRNA28988120
C045463leflunomideleflunomide results in increased expression of NRP1 mRNA24136188
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NRP1 mRNA26378955
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NRP1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of NRP1 mRNA26378955
D008345ManganeseManganese results in increased expression of NRP1 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of NRP1 mRNA17175027
D008558MelphalanMelphalan results in decreased expression of NRP1 mRNA22363485
C042720mercuric bromidemercuric bromide results in increased expression of NRP1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of NRP1 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of NRP1 mRNA21678067
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of NRP1 mRNA21664453
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of NRP1 mRNA15120970
C064769N-acetylsphingosineN-acetylsphingosine results in decreased expression of NRP1 mRNA15741222
C064769N-acetylsphingosinesphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]15741222
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NRP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NRP1 mRNA"25620056
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]22150557
C022838nickel chloridenickel chloride results in decreased expression of NRP1 mRNA12839937
C028007nickel monoxidenickel monoxide results in decreased expression of NRP1 mRNA19167457
D009578NitrobenzenesNitrobenzenes analog results in increased expression of NRP1 mRNA19784758
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of NRP1 mRNA20971185
C030110oxaliplatinoxaliplatin results in increased expression of NRP1 protein18790786
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NRP1 mRNA25729387
D017239PaclitaxelPaclitaxel results in increased expression of NRP1 mRNA19682730
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of NRP1 mRNA26272509
C016030pantogabpantogab results in increased expression of NRP1 mRNA17379144
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of NRP1 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of NRP1 mRNA25119042
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of NRP1 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NRP1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of NRP1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NRP1 mRNA19162173
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of NRP1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of NRP1 mRNA19482888|2309116
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NRP1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of NRP1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of NRP1 mRNA18301758
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of NRP1 mRNA21858171
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of NRP1 mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of NRP1 mRNA20660070
C045950propiconazolepropiconazole results in decreased expression of NRP1 mRNA21278054
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of NRP1 mRNA23274088
D011794QuercetinQuercetin affects the expression of NRP1 mRNA21632981
C089730rosiglitazonerosiglitazone results in decreased expression of NRP1 mRNA17639046
D012402RotenoneRotenone results in decreased expression of NRP1 mRNA19304788
D012524SarinSarin results in decreased expression of NRP1 mRNA19522546
D012524SarinSarin results in increased expression of NRP1 mRNA19522546
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NRP1 mRNA19073995
D019821SimvastatinNRP1 SNP results in decreased susceptibility to Simvastatin21483694
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of NRP1 mRNA]21095227
C009277sodium arsenatesodium arsenate results in increased expression of NRP1 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of NRP1 mRNA21503876
C017947sodium arsenitesodium arsenite results in increased expression of NRP1 protein21503876
C016104sodium bichromatesodium bichromate results in decreased expression of NRP1 mRNA17685462
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of NRP1 mRNA23274088
D012999SomanSoman results in increased expression of NRP1 mRNA19281266
C060506sphingosine 1-phosphatesphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA]15741222
C060506sphingosine 1-phosphatesphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]15741222
C060506sphingosine 1-phosphatesphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA]15741222
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NRP1 mRNA26378955
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NRP1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of NRP1 mRNA26378955
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]22150557
D014284TriiodothyronineTriiodothyronine results in increased expression of NRP1 mRNA15953391
D013629TamoxifenTamoxifen affects the expression of NRP1 mRNA20937368
C501413tesaglitazartesaglitazar results in increased expression of NRP1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NRP1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NRP1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NRP1 mRNA19770486|1993321
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of NRP1 mRNA25613284
D013792Thalidomidesphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA]15741222
D013792ThalidomideThalidomide results in decreased expression of NRP1 mRNA15741222
D013792Thalidomidesphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA]15741222
D013853ThioacetamideThioacetamide results in increased expression of NRP1 mRNA19784758
C009495titanium dioxidetitanium dioxide results in decreased expression of NRP1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NRP1 mRNA28065790
D014050TolueneToluene results in decreased expression of NRP1 mRNA22166486
D014050TolueneToluene results in increased expression of NRP1 mRNA22166486|2296774
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of NRP1 protein"27103660
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NRP1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of NRP1 mRNA25729387
D014107Tosyllysine Chloromethyl KetoneTosyllysine Chloromethyl Ketone inhibits the reaction [FGF2 protein results in increased expression of NRP1 mRNA]16289960
D014212TretinoinTretinoin results in decreased expression of NRP1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of NRP1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of NRP1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of NRP1 mRNA16330548|2493525
C012589trichostatin Atrichostatin A results in increased expression of NRP1 protein16330548
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NRP1 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of NRP1 mRNA19140230|2557248
C057693troglitazonetroglitazone results in decreased expression of NRP1 mRNA28973697
C113580U 0126U 0126 inhibits the reaction [FGF2 protein results in increased expression of NRP1 mRNA]16289960
D014520UrethaneUrethane results in decreased expression of NRP1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRP1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of NRP1 mRNA28001369|2915479
D014635Valproic AcidValproic Acid results in increased expression of NRP1 mRNA24383497|2627250
D014638VanadatesVanadates results in increased expression of NRP1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NRP1 gene25560391
C025643vinclozolinvinclozolin affects the expression of NRP1 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of NRP1 mRNA26682919
D014800VitalliumVitallium analog results in decreased expression of NRP1 mRNA23825117
D015032ZincZinc deficiency results in decreased expression of NRP1 mRNA20857495

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005021vascular endothelial growth factor-activated receptor activity-ISS-  
GO:0005021vascular endothelial growth factor-activated receptor activity-NAS19909241  
GO:0005096GTPase activator activity-IMP26051942  
GO:0005515protein binding-IPI16763549  17222790  19175293  24021649  24863063  
GO:0008201heparin binding-IEA-  
GO:0015026coreceptor activity-TAS21245381  
GO:0017154semaphorin receptor activity-NAS19909241  
GO:0019838growth factor binding-IPI9529250  
GO:0019838growth factor binding-TAS21245381  
GO:0019901protein kinase binding-IEA-  
GO:0019955cytokine binding-NAS19909241  
GO:0038085vascular endothelial growth factor binding-IPI24401374  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IMP23639442  
GO:0001525angiogenesis-ISS24401374  
GO:0001569branching involved in blood vessel morphogenesis-ISS24401374  
GO:0001764neuron migration-ISS-  
GO:0001938positive regulation of endothelial cell proliferation-TAS21245381  
GO:0002040sprouting angiogenesis-ISS24401374  
GO:0002042cell migration involved in sprouting angiogenesis-ISS-  
GO:0003148outflow tract septum morphogenesis-ISS-  
GO:0006930substrate-dependent cell migration, cell extension-IMP24863063  
GO:0007165signal transduction-TAS9288753  
GO:0007229integrin-mediated signaling pathway-IMP24863063  26051942  
GO:0007267cell-cell signaling-TAS9288753  
GO:0007411axon guidance-NAS19909241  
GO:0007413axonal fasciculation-IEA-  
GO:0009611response to wounding-IEA-  
GO:0009887animal organ morphogenesis-TAS9529250  
GO:0010595positive regulation of endothelial cell migration-IMP24863063  
GO:0010595positive regulation of endothelial cell migration-TAS21245381  
GO:0014911positive regulation of smooth muscle cell migration-TAS21245381  
GO:0021612facial nerve structural organization-IEA-  
GO:0021637trigeminal nerve structural organization-IEA-  
GO:0021649vestibulocochlear nerve structural organization-IEA-  
GO:0021675nerve development-ISS-  
GO:0021785branchiomotor neuron axon guidance-IEA-  
GO:0021828gonadotrophin-releasing hormone neuronal migration to the hypothalamus-IEA-  
GO:0031290retinal ganglion cell axon guidance-ISS-  
GO:0031532actin cytoskeleton reorganization-IMP24863063  
GO:0032489regulation of Cdc42 protein signal transduction-IMP26051942  
GO:0034446substrate adhesion-dependent cell spreading-IMP24863063  
GO:0035729cellular response to hepatocyte growth factor stimulus-IMP21245381  
GO:0035767endothelial cell chemotaxis-IMP21245381  
GO:0035924cellular response to vascular endothelial growth factor stimulus-ISS24401374  
GO:0036486ventral trunk neural crest cell migration-IEA-  
GO:0038189neuropilin signaling pathway-IMP24863063  26051942  
GO:0038190VEGF-activated neuropilin signaling pathway-IMP24863063  
GO:0038190VEGF-activated neuropilin signaling pathway-ISS23639442  
GO:0042327positive regulation of phosphorylation-IMP24863063  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0043542endothelial cell migration-IMP24863063  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0048008platelet-derived growth factor receptor signaling pathway-IMP21245381  
GO:0048010vascular endothelial growth factor receptor signaling pathway-IMP21245381  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0048012hepatocyte growth factor receptor signaling pathway-IMP21245381  
GO:0048842positive regulation of axon extension involved in axon guidance-ISS-  
GO:0048843negative regulation of axon extension involved in axon guidance-IEA-  
GO:0048844artery morphogenesis-ISS23639442  24401374  
GO:0048846axon extension involved in axon guidance-ISS-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IMP21245381  
GO:0050918positive chemotaxis-ISS-  
GO:0051491positive regulation of filopodium assembly-IMP26051942  
GO:0051496positive regulation of stress fiber assembly-IMP26051942  
GO:0051894positive regulation of focal adhesion assembly-IDA24863063  
GO:0060301positive regulation of cytokine activity-TAS21245381  
GO:0060385axonogenesis involved in innervation-ISS-  
GO:0060627regulation of vesicle-mediated transport-TAS21245381  
GO:0060666dichotomous subdivision of terminal units involved in salivary gland branching-IEA-  
GO:0060978angiogenesis involved in coronary vascular morphogenesis-ISS24401374  
GO:0060982coronary artery morphogenesis-IEA-  
GO:0061299retina vasculature morphogenesis in camera-type eye-ISS24401374  
GO:0061441renal artery morphogenesis-IEA-  
GO:0061549sympathetic ganglion development-ISS-  
GO:0061551trigeminal ganglion development-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS23639442  
GO:0071526semaphorin-plexin signaling pathway-NAS19909241  
GO:0071679commissural neuron axon guidance-ISS-  
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis-IEA-  
GO:0090259regulation of retinal ganglion cell axon guidance-ISS-  
GO:0097102endothelial tip cell fate specification-ISS-  
GO:0097374sensory neuron axon guidance-IEA-  
GO:0097475motor neuron migration-ISS-  
GO:0097490sympathetic neuron projection extension-ISS-  
GO:0097491sympathetic neuron projection guidance-ISS-  
GO:0150018basal dendrite development-ISS22683681  
GO:0150020basal dendrite arborization-ISS22683681  
GO:1900026positive regulation of substrate adhesion-dependent cell spreading-IMP24863063  
GO:1901166neural crest cell migration involved in autonomic nervous system development-ISS-  
GO:1901998toxin transport-IEA-  
GO:1902285semaphorin-plexin signaling pathway involved in neuron projection guidance-ISS-  
GO:1902287semaphorin-plexin signaling pathway involved in axon guidance-IEA-  
GO:1902336positive regulation of retinal ganglion cell axon guidance-ISS-  
GO:1902378VEGF-activated neuropilin signaling pathway involved in axon guidance-IEA-  
GO:1902946protein localization to early endosome-ISS23639442  
GO:1903375facioacoustic ganglion development-IEA-  
GO:1904835dorsal root ganglion morphogenesis-IEA-  
GO:1905040otic placode development-IEA-  
GO:2000251positive regulation of actin cytoskeleton reorganization-IMP24863063  26051942  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002116semaphorin receptor complex-NAS19909241  
GO:0005615extracellular space-HDA16502470  
GO:0005769early endosome-ISS23639442  
GO:0005829cytosol-IDA21245381  
GO:0005883neurofilament-IEA-  
GO:0005886plasma membrane-IDA21245381  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA24863063  
GO:0009986cell surface-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030424axon-ISS-  
GO:0030426growth cone-IEA-  
GO:0031410cytoplasmic vesicle-TAS21245381  
GO:0043005neuron projection-ISS22683681  
GO:0043025neuronal cell body-IEA-  
GO:0043235receptor complex-TAS21245381  
GO:0097443sorting endosome-ISS23639442  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-194306Neurophilin interactions with VEGF and VEGFRTAS
R-HSA-373755Semaphorin interactionsTAS
R-HSA-373755Semaphorin interactionsIEA
R-HSA-373760L1CAM interactionsIEA
R-HSA-373760L1CAM interactionsTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-399954Sema3A PAK dependent Axon repulsionTAS
R-HSA-399955SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionIEA
R-HSA-399955SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionTAS
R-HSA-399956CRMPs in Sema3A signalingTAS
R-HSA-399956CRMPs in Sema3A signalingIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-445144Signal transduction by L1TAS
R-HSA-447041CHL1 interactionsIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal