Gene: SOCS2

8835
CIS2|Cish2|SOCS-2|SSI-2|SSI2|STATI2
suppressor of cytokine signaling 2
protein-coding
12q22
Ensembl:ENSG00000120833 MIM:605117 Vega:OTTHUMG00000170160 UniprotKB:O14508
NC_000012.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.092e-1 (AD)  3.035e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17021323chr12:93579094 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GBE10.725
ELL20.718
RBMS10.715
NAA380.698
CD550.683
PIK3R30.681
USP150.677
GCA0.676
SEC24D0.669
AKAP20.665

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.424
NWD1-0.385
WNT7B-0.354
ARSF-0.345
PYGM-0.338
DIO2-0.337
C16orf74-0.334
SOX21-0.329
SALL3-0.328
BTBD17-0.325

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of SOCS2 mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SOCS2 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SOCS2 mRNA"21354444
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS2 mRNA"25510870
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of SOCS2 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SOCS2 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of SOCS2 mRNA"18343893
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SOCS2 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of SOCS2 mRNA"24680724
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS2 mRNA"25510870
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of SOCS2 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of SOCS2 mRNA]28655636
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SOCS2 mRNA"19692669
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SOCS2 mRNA"15371557
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SOCS2 mRNA16788091
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of SOCS2 mRNA22841810
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of SOCS2 mRNA18544908
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SOCS2 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of SOCS2 mRNA15982314
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SOCS2 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of SOCS2 mRNA21420995
D000082AcetaminophenAcetaminophen results in decreased expression of SOCS2 mRNA18544908
D000082AcetaminophenAcetaminophen results in increased expression of SOCS2 mRNA11264010
D020106AcrylamideAcrylamide results in increased expression of SOCS2 mRNA28959563
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of SOCS2 mRNA19920212
C016601afimoxifeneafimoxifene results in increased expression of SOCS2 mRNA23373633
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SOCS2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SOCS2 mRNA27153756
D000393Air PollutantsAir Pollutants analog results in increased expression of SOCS2 mRNA21757418
C103303alitretinoinalitretinoin results in increased expression of SOCS2 mRNA15982314
D000638AmiodaroneAmiodarone affects the expression of SOCS2 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SOCS2 mRNA16483693
D000941AntigensAntigens results in increased expression of SOCS2 mRNA28935500
D000941Antigensdeoxynivalenol inhibits the reaction [Antigens results in increased expression of SOCS2 mRNA]28935500
D000941Antigensochratoxin A inhibits the reaction [Antigens results in increased expression of SOCS2 mRNA]28935500
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SOCS2 mRNA"18687144
D001241AspirinAspirin results in increased expression of SOCS2 mRNA16415877
D001241Aspirinbutyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [Aspirin results in increased expression of SOCS2 mRNA]16415877
D001241AspirinSOCS2 affects the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]16415877
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of SOCS2 mRNA15371557
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOCS2 mRNA20106945|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SOCS2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOCS2 mRNA21569818
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SOCS2 mRNA20660070
D004958EstradiolEstradiol results in increased expression of SOCS2 mRNA17272397|2179573
D004958EstradiolEstradiol results in increased expression of SOCS2 mRNA19484750|2521013
C006780bisphenol Abisphenol A results in decreased expression of SOCS2 mRNA16029874
C006780bisphenol Abisphenol A results in decreased expression of SOCS2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SOCS2 gene28505145
C033373butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalaninebutyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [Aspirin results in increased expression of SOCS2 mRNA]16415877
C033373butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalaninebutyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA]16415877
D002104CadmiumCadmium results in increased expression of SOCS2 mRNA21120746
D000074262Canola OilCanola Oil metabolite results in increased expression of SOCS2 mRNA27363782
D000074262Canola OilStarch analog inhibits the reaction [Canola Oil metabolite results in increased expression of SOCS2 mRNA]27363782
D002220CarbamazepineCarbamazepine affects the expression of SOCS2 mRNA25979313
D002746ChlorpromazineChlorpromazine affects the expression of SOCS2 mRNA25064622
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SOCS220938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOCS2 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SOCS2 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of SOCS2 mRNA18353800
D003010ClorgylineClorgyline results in increased expression of SOCS2 mRNA19691856
D019327Copper SulfateCopper Sulfate results in increased expression of SOCS2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SOCS2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of SOCS2 mRNA19167446
D003513CycloheximideCycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS2 mRNA]15371557
D003513CycloheximideCycloheximide results in increased expression of SOCS2 mRNA23237828
D016572CyclosporineCyclosporine affects the expression of SOCS2 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of SOCS2 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of SOCS2 mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of SOCS2 mRNA23300844
D003703DemecolcineDemecolcine results in increased expression of SOCS2 mRNA23649840
C007262deoxynivalenoldeoxynivalenol inhibits the reaction [Antigens results in increased expression of SOCS2 mRNA]28935500
C007262deoxynivalenoldeoxynivalenol results in increased expression of SOCS2 mRNA19625342
D003907DexamethasoneDexamethasone results in increased expression of SOCS2 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SOCS2 mRNA17361019|2126653
D002945CisplatinCisplatin affects the expression of SOCS2 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of SOCS2 mRNA27392435
D002945CisplatinSOCS2 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin results in decreased expression of SOCS2 mRNA22023808
C000944dicrotophosdicrotophos results in decreased expression of SOCS2 mRNA28302478
D004041Dietary Fats[Dietary Fats co-treated with sodium arsenite] results in decreased expression of SOCS2 mRNA28283972
D004041Dietary FatsDietary Fats results in decreased expression of SOCS2 mRNA28283972
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SOCS2 mRNA21318169
D004052Diethylnitrosamine[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of SOCS2 mRNA27048571
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SOCS2 mRNA25242112
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of SOCS2 mRNA15171707
D002117CalcitriolCalcitriol results in decreased expression of SOCS2 mRNA16002434
D002117CalcitriolCalcitriol results in increased expression of SOCS2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SOCS2 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of SOCS2 mRNA25380136
C521792DMU-212[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of SOCS2 mRNA27048571
C521792DMU-212DMU-212 results in increased expression of SOCS2 mRNA27048571
C118739entinostatentinostat results in increased expression of SOCS2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
D000431EthanolEthanol results in decreased expression of SOCS2 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SOCS2 mRNA25064622
D005485FlutamideFlutamide results in decreased expression of SOCS2 mRNA24136188|2479361
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SOCS220938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOCS2 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SOCS2 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of SOCS2 mRNA28937961
D005557FormaldehydeFormaldehyde results in increased expression of SOCS2 mRNA23649840
C546771gardiquimodgardiquimod results in increased expression of SOCS2 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SOCS2 mRNA]28003376
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of SOCS2 mRNA24680724
D006581HexachlorobenzeneHexachlorobenzene affects the expression of SOCS2 mRNA15159207
C000625835HFPO2 compoundHFPO2 compound results in decreased expression of SOCS2 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in decreased expression of SOCS2 mRNA27553808
D017313FenretinideFenretinide results in decreased expression of SOCS2 mRNA28973697
D017313FenretinideFenretinide results in increased expression of SOCS2 mRNA28973697
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in increased expression of SOCS2 mRNA"15371557
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of SOCS2 mRNA15182950
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS2 mRNA]25725100
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SOCS2 mRNA23086925|2675264
C045463leflunomideleflunomide results in increased expression of SOCS2 mRNA28988120
C045463leflunomideleflunomide results in increased expression of SOCS2 mRNA19751817
D001556LindaneLindane results in decreased expression of SOCS2 mRNA17785943
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOCS2 mRNA"18930950
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS2 mRNA]25725100
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SOCS2 mRNA25725100
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SOCS2 mRNA12057914|2216911
D008070LipopolysaccharidesSOCS2 affects the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]16415877
C040527lipoxin A4AHR affects the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA]16415877
C040527lipoxin A4butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA]16415877
C040527lipoxin A4lipoxin A4 results in increased expression of SOCS2 mRNA16415877
C040527lipoxin A4lipoxin A4 results in increased expression of SOCS2 protein16415877
C545385MequindoxMequindox results in increased expression of SOCS2 mRNA21146578
C042720mercuric bromidemercuric bromide results in increased expression of SOCS2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
D008701MethapyrileneMethapyrilene results in increased expression of SOCS2 mRNA22484513
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SOCS220938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOCS2 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SOCS2 mRNA20938992
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of SOCS2 mRNA"25926378
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SOCS2 mRNA28001369
C030957methylmercury IImethylmercury II results in increased expression of SOCS2 mRNA17905399
D015741MetriboloneMetribolone results in increased expression of SOCS2 mRNA16751804
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of SOCS2 mRNA"25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SOCS2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SOCS2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SOCS2 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of SOCS2 mRNA24136188
D009532NickelNickel results in increased expression of SOCS2 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of SOCS2 mRNA19167457
C464660obeticholic acidobeticholic acid results in decreased expression of SOCS2 mRNA27939613
C025589ochratoxin Aochratoxin A inhibits the reaction [Antigens results in increased expression of SOCS2 mRNA]28935500
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SOCS2 mRNA26272509
D010269ParaquatParaquat affects the expression of SOCS2 mRNA25064622
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of SOCS2 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of SOCS2 mRNA28655636
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SOCS2 mRNA"25510870
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SOCS2 mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SOCS2 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SOCS2 mRNA19162173|2131816
D010634PhenobarbitalPhenobarbital affects the expression of SOCS2 mRNA19159669
D010634Phenobarbital[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of SOCS2 mRNA27048571
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SOCS2 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SOCS2 mRNA11798191|1742611
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of SOCS2 mRNA]20059764
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SOCS2 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of SOCS2 mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SOCS2 mRNA20660070
D011374Progesterone[Progesterone co-treated with TGFB1 protein] results in decreased expression of SOCS2 mRNA21768398
D011374ProgesteroneProgesterone results in decreased expression of SOCS2 mRNA21768398
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SOCS2 mRNA]28003376
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of SOCS2 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of SOCS2 mRNA19371625
D015474IsotretinoinIsotretinoin results in increased expression of SOCS2 mRNA15982314
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of SOCS2 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SOCS2 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of SOCS2 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of SOCS2 mRNA25493608
C017947sodium arsenitesodium arsenite results in increased expression of SOCS2 mRNA21281968
C017947sodium arsenite[Dietary Fats co-treated with sodium arsenite] results in decreased expression of SOCS2 mRNA28283972
C017947sodium arsenitesodium arsenite results in decreased expression of SOCS2 mRNA28283972
C016104sodium bichromatesodium bichromate results in increased expression of SOCS2 mRNA25993096
D013213StarchStarch analog inhibits the reaction [Canola Oil metabolite results in increased expression of SOCS2 mRNA]27363782
D013629TamoxifenTamoxifen affects the expression of SOCS2 mRNA20937368
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SOCS2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SOCS2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of SOCS2 mRNA15788153
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOCS2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SOCS2 mRNA19692669|2010694
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS2 mRNA]15371557
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS2 protein]15371557
D013749TetrachlorodibenzodioxinCycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS2 mRNA]15371557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOCS2 mRNA18343893|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOCS2 mRNA18372398|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SOCS2 mRNA15371557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SOCS2 protein15371557
D013752TetracyclineTetracycline affects the expression of SOCS2 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of SOCS2 mRNA16979875
D013853ThioacetamideThioacetamide affects the expression of SOCS2 mRNA25064622
D013853ThioacetamideThioacetamide results in decreased expression of SOCS2 mRNA23411599
D014212TretinoinTretinoin metabolite results in increased expression of SOCS2 mRNA15982314
D014212TretinoinTretinoin results in increased expression of SOCS2 mRNA15982314|2193413
D014212TretinoinTretinoin results in decreased expression of SOCS2 mRNA16788091
D014241TrichloroethyleneTrichloroethylene results in increased expression of SOCS2 mRNA28973375
C012589trichostatin Atrichostatin A results in increased expression of SOCS2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SOCS2 mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOCS2 mRNA"18930950
C080163trovafloxacintrovafloxacin results in increased expression of SOCS2 mRNA24136188
D014415TunicamycinTunicamycin results in decreased expression of SOCS2 mRNA17127020
D014520UrethaneUrethane results in decreased expression of SOCS2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SOCS2 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of SOCS2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SOCS2 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of SOCS2 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of SOCS2 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of SOCS2 mRNA21318169
D014640VancomycinVancomycin results in decreased expression of SOCS2 mRNA18930951
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of SOCS2 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of SOCS2 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SOCS2 gene25560391
C025643vinclozolinvinclozolin affects the expression of SOCS2 mRNA19015723
D014800VitalliumVitallium analog results in increased expression of SOCS2 mRNA23825117
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SOCS2 mRNA18593933
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of SOCS2 mRNA16979875
D015032ZincZinc deficiency results in decreased expression of SOCS2 mRNA22171008
D019287Zinc SulfateZinc Sulfate results in increased expression of SOCS2 mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005070SH3/SH2 adaptor activity-TAS9344848  
GO:0005131growth hormone receptor binding-NAS12135564  
GO:0005159insulin-like growth factor receptor binding-IPI9727029  
GO:0005515protein binding-IPI11781573  16643902  19159283  24728074  
GO:0008269JAK pathway signal transduction adaptor activity-IEA-  
GO:00469351-phosphatidylinositol-3-kinase regulator activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-NAS9727029  
GO:0007259JAK-STAT cascade-TAS9266833  
GO:0007595lactation-IEA-  
GO:0009966regulation of signal transduction-NAS9727029  
GO:0009967positive regulation of signal transduction-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0032355response to estradiol-IDA12552091  
GO:0032870cellular response to hormone stimulus-IDA12552091  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0040015negative regulation of multicellular organism growth-IEA-  
GO:0043066negative regulation of apoptotic process-TAS9266833  
GO:0043687post-translational protein modification-TAS-  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0046627negative regulation of insulin receptor signaling pathway-IBA21873635  
GO:0046854phosphatidylinositol phosphorylation-IBA21873635  
GO:0060396growth hormone receptor signaling pathway-IDA12552091  
GO:0060749mammary gland alveolus development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-NAS9727029  
GO:0005829cytosol-TAS-  
GO:0005942phosphatidylinositol 3-kinase complex-IBA21873635  
KEGG ID KEGG Term
hsa04630Jak-STAT signaling pathway
hsa04910Insulin signaling pathway
hsa04930Type II diabetes mellitus
Reactome ID Reactome Term Evidence
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-982772Growth hormone receptor signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25104439Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. (2014 Aug)Slattery MLBreast Cancer Res Treat
22121102JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)Slattery MLMol Carcinog