Gene: GGH

8836
GH
gamma-glutamyl hydrolase
protein-coding
8q12.3
Ensembl:ENSG00000137563 MIM:601509 Vega:OTTHUMG00000164365 UniprotKB:Q92820
NG_028126.1
PubMed
0   ANCO-SNPs
ND|AD
3   
2.560e-2 (AD)  1.936e-1 (ND)   (Frontal_Cortex)
3.341e-1 (AD)  4.991e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NKIRAS10.906
ATP6V1D0.905
CISD10.901
TMEM14A0.898
TMEM2420.896
ANKRD460.895
COPS40.893
CADM20.892
B3GALNT10.89
ELOVL40.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.512
OR4F5-0.498
IL18RAP-0.487
KLRB1-0.485
EBF1-0.474
TFPI2-0.47
FZD10-0.466
KCNJ15-0.465
FOLR3-0.464
MAGEA12-0.463

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00158Folic AcidSmall Molecule59-30-3Approved|NutraceuticalEnzyme
DB00563MethotrexateSmall Molecule59-05-2ApprovedEnzyme
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of GGH mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GGH mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GGH mRNA"19167446
C0306014-hydroxymercuribenzoate4-hydroxymercuribenzoate inhibits the reaction [GGH protein results in increased hydrolysis of Folic Acid]17449573
C0306014-hydroxymercuribenzoate4-hydroxymercuribenzoate results in decreased activity of GGH protein17449573
C0118647-hydroxymethotrexateGGH mRNA results in decreased susceptibility to 7-hydroxymethotrexate19426680
D000082AcetaminophenAcetaminophen results in increased expression of GGH mRNA22230336
D000638AmiodaroneAmiodarone affects the expression of GGH mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GGH mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of GGH mRNA25258189
D001379AzathioprineAzathioprine results in decreased expression of GGH mRNA22623647
D001553BenzbromaroneBenzbromarone affects the expression of GGH mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GGH mRNA17879257
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GGH mRNA19619570
D004958EstradiolEstradiol results in increased expression of GGH mRNA16474171|1916744
C044887beta-methylcholinebeta-methylcholine affects the expression of GGH mRNA21179406
C006780bisphenol Abisphenol A affects the expression of GGH mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of GGH mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of GGH mRNA16474171
C006780bisphenol Abisphenol A affects the expression of GGH mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GGH promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GGH mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GGH gene20938992
D002994ClofibrateClofibrate affects the expression of GGH mRNA19483382
D019327Copper SulfateCopper Sulfate results in decreased expression of GGH mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GGH mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of GGH mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of GGH mRNA19167446
C029892cupric chloridecupric chloride results in decreased expression of GGH mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of GGH mRNA20106945|2556210
D002945CisplatinCisplatin results in increased expression of GGH mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of GGH mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of GGH mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of GGH mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GGH mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GGH mRNA25380136
D004237DiuronDiuron results in increased expression of GGH mRNA21551480
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GGH protein23301498
D005001EthionineEthionine affects the expression of GGH mRNA19483382
D005492Folic AcidFolic Acid affects the expression of GGH mRNA17311948
D005492Folic AcidFolic Acid deficiency results in decreased expression of GGH mRNA18499665
D005492Folic AcidFolic Acid deficiency results in decreased expression of GGH protein18499665
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GGH gene20938992
D005492Folic Acid4-hydroxymercuribenzoate inhibits the reaction [GGH protein results in increased hydrolysis of Folic Acid]17449573
D005492Folic AcidGGH protein results in increased hydrolysis of Folic Acid17449573
D019833GenisteinGenistein results in increased expression of GGH mRNA16474171
D005839GentamicinsGentamicins results in increased expression of GGH mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of GGH mRNA21179406
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GGH mRNA25613284
C410337K 7174K 7174 results in decreased expression of GGH mRNA24086573
D048628KetolidesKetolides analog results in increased expression of GGH mRNA24967691
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GGH gene20938992
D008727MethotrexateGGH gene polymorphism affects the susceptibility to Methotrexate21219404
D008727MethotrexateMethotrexate results in decreased expression of GGH mRNA23897011
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GGH mRNA28001369
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of GGH mRNA22401849
C044361M-VAC protocol[DBI co-treated with GGH] results in increased susceptibility to M-VAC protocol19815704
C051752nefazodonenefazodone results in increased expression of GGH mRNA24136188
C012655nimesulidenimesulide results in increased expression of GGH mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of GGH mRNA19483382
D000068437PemetrexedGGH protein affects the susceptibility to Pemetrexed17575230
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GGH mRNA27153767
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GGH mRNA18692542
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of GGH mRNA17616710
D010634PhenobarbitalPhenobarbital affects the expression of GGH mRNA19159669
C006253pirinixic acidpirinixic acid affects the expression of GGH mRNA19483382
D010984PlatinumGGH gene polymorphism affects the susceptibility to Platinum18851872
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of GGH mRNA16474171
D011441PropylthiouracilPropylthiouracil affects the expression of GGH mRNA19483382
D011794QuercetinQuercetin results in increased expression of GGH mRNA26432773
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of GGH mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of GGH protein25895662
D012999SomanSoman results in decreased expression of GGH mRNA19281266
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of GGH mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of GGH mRNA21592394
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GGH mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GGH mRNA19619570|2010694
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GGH mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in increased expression of GGH protein20109541
D013853ThioacetamideThioacetamide affects the expression of GGH mRNA19483382
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of GGH mRNA29024780
D014415TunicamycinTunicamycin results in decreased expression of GGH mRNA22378314
C406224valdecoxibvaldecoxib results in increased expression of GGH mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of GGH mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GGH mRNA23179753|2718838
C111237vorinostatvorinostat results in increased expression of GGH mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008238exopeptidase activity-TAS8816764  
GO:0008242omega peptidase activity-TAS8816764  
GO:0034722gamma-glutamyl-peptidase activity-IBA21873635  
GO:0034722gamma-glutamyl-peptidase activity-IDA11005824  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0010043response to zinc ion-IEA-  
GO:0032868response to insulin-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045471response to ethanol-IEA-  
GO:0046900tetrahydrofolylpolyglutamate metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA25645918  
GO:0005634nucleus-HDA21630459  
GO:0005773vacuole-IBA21873635  
GO:0005829cytosol-IEA-  
GO:0035578azurophil granule lumen-TAS-  
GO:0035580specific granule lumen-TAS-  
GO:0042470melanosome-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:1904724tertiary granule lumen-TAS-  
KEGG ID KEGG Term
hsa00790Folate biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22147198Alcohol-associated folate disturbances result in altered methylation of folate-regulating genes. (2012 Apr)Wani NAMol Cell Biochem
21597034The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. (2011 Jun)Ye XPsychosom Med
22649255Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. (2012 Jul)Wernimont SMJ Nutr