Gene: CFLAR

8837
CASH|CASP8AP1|CLARP|Casper|FLAME|FLAME-1|FLAME1|FLIP|I-FLICE|MRIT|c-FLIP|c-FLIPL|c-FLIPR|c-FLIPS
CASP8 and FADD like apoptosis regulator
protein-coding
2q33.1
Ensembl:ENSG00000003402 MIM:603599 Vega:OTTHUMG00000132819 UniprotKB:O15519
NG_029005.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.221e-1 (AD)  4.715e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17777683chr2:201986522CFLAR6.800e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TEP10.883
ELF10.868
BNIP20.867
FAM111A0.865
ATP10D0.854
ZNF2170.851
RBMS20.847
PXN0.843
IRAK40.841
CD2AP0.834

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.514
CRH-0.512
ADRA1D-0.491
NEUROD6-0.472
RTN4R-0.464
MYADML2-0.461
GSG1-0.46
SMIM18-0.459
FBLN7-0.459
PIP5KL1-0.454

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of CFLAR mRNA"26377693
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CFLAR protein"15498850
C0479481'-acetoxychavicol acetate1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of CFLAR protein]15905586
C4779311L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate results in decreased expression of CFLAR protein12970779
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CFLAR mRNA"27589474
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CFLAR mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CFLAR mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CFLAR mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CFLAR protein12970779|2117323
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CFLAR protein alternative form16434995
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in decreased expression of CFLAR protein"18444175
C55788225-methoxyldammarane-3,12,20-triol"25-methoxyldammarane-3,12,20-triol affects the expression of CFLAR protein modified form"21924252
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of CFLAR mRNA16788091
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of CFLAR mRNA16174796|1638044
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of CFLAR protein16173963
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]"23452621
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of CFLAR mRNA22841810
C5546804-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide results in decreased expression of CFLAR mRNA20446019
C5546804-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide results in decreased expression of CFLAR protein20446019
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CFLAR mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CFLAR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CFLAR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CFLAR mRNA"27188386
C5805985-OH-BDE-475-OH-BDE-47 results in decreased expression of CFLAR mRNA27589474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CFLAR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CFLAR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CFLAR mRNA"27188386
C496492abrineabrine results in increased expression of CFLAR mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of CFLAR mRNA21420995|2776149
D000082AcetaminophenAcetaminophen affects the expression of CFLAR mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein]25034532
D000111AcetylcysteineAcetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]25619640
D020106AcrylamideAcrylamide results in decreased expression of CFLAR mRNA28959563
D000241AdenosineAdenosine results in decreased expression of CFLAR mRNA17303086
D000241AdenosineAdenosine results in decreased expression of CFLAR mRNA alternative form17303086
D000241AdenosineAdenosine results in decreased expression of CFLAR protein17303086
D000241AdenosineDipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA]17303086
D000241AdenosineDipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form]17303086
D000241AdenosineDipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein]17303086
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CFLAR gene28458013
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CFLAR mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of CFLAR mRNA"19936710
C077990alvocidibalvocidib affects the expression of CFLAR mRNA16951203
C077990alvocidibalvocidib results in decreased expression of CFLAR16820931
C077990alvocidibalvocidib results in decreased expression of CFLAR protein16951203
C077990alvocidibbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [alvocidib results in decreased expression of CFLAR protein]16951203
D000638AmiodaroneAmiodarone results in decreased expression of CFLAR protein21224497
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CFLAR mRNA16483693
C088115anacardic acidanacardic acid inhibits the reaction [TNF protein results in increased expression of CFLAR protein]18349320
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CFLAR mRNA17696278
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CFLAR mRNA24449571
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of CFLAR mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of CFLAR mRNA23912714
C006632arsenic trioxide[arsenic trioxide co-treated with TNF protein] results in decreased expression of CFLAR protein17673311
C006632arsenic trioxidearsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of CFLAR protein]23082001
C006632arsenic trioxidearsenic trioxide results in decreased expression of CFLAR mRNA16174796
C006632arsenic trioxidearsenic trioxide results in decreased expression of CFLAR protein16105982|1617479
C006632arsenic trioxidearsenic trioxide results in decreased expression of CFLAR protein alternative form16434995
C006632arsenic trioxidearsenic trioxide results in increased expression of CFLAR mRNA22521957
C006632arsenic trioxideBCL2 inhibits the reaction [[arsenic trioxide co-treated with TNF protein] results in decreased expression of CFLAR protein]17673311
C006632arsenic trioxideCFLAR protein results in decreased susceptibility to arsenic trioxide16105982
D001241AspirinAspirin results in increased expression of CFLAR mRNA20457246
D001241AspirinAspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein]25449198
D001397AzoxymethaneAspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein]25449198
D001397Azoxymethane[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein25449198
D001397AzoxymethaneCamptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein]25449198
D001397AzoxymethanePlant Extracts inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein]25449198
C006680baicaleinbaicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein]20850421
C012765bakuchiolbakuchiol results in decreased expression of CFLAR protein27033605
C004456beauvericinbeauvericin results in increased expression of CFLAR mRNA29203277
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of CFLAR mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CFLAR mRNA15034205
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the expression of CFLAR protein alternative form17510429
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [alvocidib results in decreased expression of CFLAR protein]16951203
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [(+)-JQ1 compound results in decreased expression of CFLAR protein]26415225
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Quercetin results in decreased expression of CFLAR protein alternative form]18980244
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [shogaol results in decreased expression of CFLAR protein modified form]25619640
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[vorinostat co-treated with TNFSF10 protein] affects the localization of CFLAR protein]19643600
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[vorinostat co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein]19643600
D019207beta Carotenebeta Carotene results in increased expression of CFLAR mRNA17034753
D004958EstradiolEstradiol affects the expression of CFLAR mRNA21826169
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CFLAR mRNA28628672
C006780bisphenol Abisphenol A affects the expression of CFLAR mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CFLAR mRNA21826169
C006780bisphenol Abisphenol A results in decreased expression of CFLAR mRNA20678512|2927551
C006780bisphenol Abisphenol A results in increased expression of CFLAR mRNA22687993
C006780bisphenol Abisphenol A affects the expression of CFLAR mRNA25181051
D000069286BortezomibBortezomib affects the expression of CFLAR protein17326159
D000069286Bortezomib[Bortezomib co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein19100720|2051594
D000069286BortezomibBortezomib results in decreased expression of CFLAR mRNA17659339
D000069286BortezomibBortezomib results in decreased expression of CFLAR protein17327374|1765933
D000069286BortezomibBortezomib results in increased expression of CFLAR protein19100720|2087677
D000069286BortezomibBortezomib results in increased expression of CFLAR protein alternative form17510429
D000069286BortezomibBortezomib results in increased expression of CFLAR protein modified form17351739
D000069286BortezomibCFLAR protein alternative form results in decreased susceptibility to Bortezomib17510429
D000069286BortezomibCFLAR results in decreased susceptibility to Bortezomib17510429
D000069286Bortezomib[romidepsin co-treated with Bortezomib] results in decreased expression of CFLAR protein18223231
D000069286BortezomibTNFSF10 protein promotes the reaction [Bortezomib results in decreased expression of CFLAR protein]17659339
D0151248-Bromo Cyclic Adenosine Monophosphate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CFLAR protein alternative form16709600
C018475butyraldehydebutyraldehyde results in decreased expression of CFLAR mRNA26079696
D002087ButyratesButyrates results in decreased expression of CFLAR mRNA16042588
C584509C646 compoundC646 compound results in increased expression of CFLAR mRNA26191083
C584509C646 compoundC646 compound results in increased expression of CFLAR mRNA26921506
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CFLAR mRNA19010381
C053400cafestolcafestol results in decreased expression of CFLAR protein21334318
D002166CamptothecinCamptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein]25449198
D002211CapsaicinCapsaicin results in decreased expression of CFLAR protein alternative form19939880
D002211CapsaicinCapsaicin results in increased expression of CFLAR mRNA19502594
D002220CarbamazepineCarbamazepine affects the expression of CFLAR mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CFLAR mRNA17484886
C038590cardanolcardanol results in decreased expression of CFLAR mRNA26694491
D000068579CelecoxibCelecoxib results in decreased expression of CFLAR17145853
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CFLAR gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of CFLAR mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of CFLAR mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of CFLAR mRNA25125499
C018021cobaltous chloridelysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of CFLAR mRNA]25125499
D003042CocaineCocaine affects the expression of CFLAR mRNA15681117
D003375CoumestrolCoumestrol results in decreased expression of CFLAR mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of CFLAR mRNA26577399
D003471CuprizoneCuprizone results in increased expression of CFLAR mRNA27523638
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]23452621
D003474CurcuminCurcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]16219905
D003474CurcuminCurcumin results in decreased expression of CFLAR protein16173963
D003513CycloheximideCycloheximide results in decreased expression of CFLAR protein12663669|1607719
D003513CycloheximideCycloheximide results in decreased expression of CFLAR protein alternative form15924153
D003513CycloheximideCycloheximide results in decreased expression of CFLAR protein modified form25619640
D003513Cycloheximideshogaol promotes the reaction [Cycloheximide results in decreased expression of CFLAR protein modified form]25619640
D003609DactinomycinDactinomycin results in decreased expression of CFLAR protein11234897|1460105
C014347decitabinedecitabine affects the expression of CFLAR protein18636160
C107676deguelindeguelin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]22623043
C107676deguelindeguelin results in decreased expression of CFLAR mRNA22623043
C464444dehydroxymethylepoxyquinomicin[dehydroxymethylepoxyquinomicin co-treated with TNF protein] results in decreased expression of CFLAR16211219
D003703DemecolcineDemecolcine results in increased expression of CFLAR mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of CFLAR21244764
D003907DexamethasoneDexamethasone results in increased expression of CFLAR mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CFLAR mRNA28628672
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of CFLAR]21244764
D016264Dextran SulfateAspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein]25449198
D016264Dextran Sulfate[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein25449198
D016264Dextran SulfateCamptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein]25449198
D016264Dextran SulfatePlant Extracts inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein]25449198
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CFLAR protein25205294
D003976DiazinonDiazinon results in increased expression of CFLAR mRNA27920530
D003976DiazinonMagnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CFLAR mRNA]27920530
D003976Diazinon[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of CFLAR mRNA]27920530
D003976DiazinonSelenium analog promotes the reaction [Diazinon results in increased expression of CFLAR mRNA]27920530
D002945CisplatinCisplatin results in decreased expression of CFLAR protein14601052|2087677
D002945Cisplatin[Cisplatin results in decreased expression of CFLAR protein] which results in increased susceptibility to TNFSF10 protein20876774
D002945CisplatinCFLAR protein results in decreased susceptibility to Cisplatin20683665
D002945CisplatinCisplatin results in decreased expression of CFLAR21877938
D004008DiclofenacDiclofenac affects the expression of CFLAR mRNA24752500
D004008Diclofenac[Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein20237495
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CFLAR mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CFLAR mRNA]19850644
C014476diethyl maleatediethyl maleate results in decreased expression of CFLAR mRNA21161181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of CFLAR mRNA"21294050
D0151279,10-Dimethyl-1,2-benzanthracene"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CFLAR mRNA]"21294050
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of CFLAR mRNA24834073
D004144DiosgeninDiosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]16331273
D004144DiosgeninDiosgenin results in decreased expression of CFLAR protein16331273
D004176DipyridamoleDipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA]17303086
D004176DipyridamoleDipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form]17303086
D004176DipyridamoleDipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein]17303086
D004237DiuronDiuron results in increased expression of CFLAR mRNA25152437
D004317DoxorubicinDoxorubicin results in decreased expression of CFLAR protein14601052|1589791
D004317DoxorubicinDoxorubicin results in decreased expression of CFLAR protein15703961
C118739entinostatentinostat results in decreased expression of CFLAR mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CFLAR mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CFLAR mRNA22079256
C078846epoxomicinepoxomicin affects the expression of CFLAR protein alternative form17510429
D004976Ethacrynic Acidarsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of CFLAR protein]23082001
D004976Ethacrynic AcidEthacrynic Acid results in decreased expression of CFLAR protein23082001
D000431EthanolEthanol results in increased expression of CFLAR protein19429258
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CFLAR mRNA23649840
D005047EtoposideEtoposide results in increased expression of CFLAR protein14601052
C049639evodiamineevodiamine inhibits the reaction [TNF protein results in increased expression of CFLAR protein]15710601
D005472FluorouracilCFLAR protein affects the susceptibility to Fluorouracil15548681|1621774
D005472FluorouracilCFLAR protein alternative form inhibits the reaction [Fluorouracil results in increased activity of TNFSF10 protein]16373718
D005472FluorouracilCFLAR protein inhibits the reaction [Fluorouracil results in increased susceptibility to TNFSF10 protein]20876774
D005472Fluorouracil[Fluorouracil co-treated with IFNA1 protein] results in decreased expression of CFLAR protein17045692
D005472FluorouracilFluorouracil results in decreased expression of CFLAR mRNA17045692|2087677
D005472FluorouracilFluorouracil results in decreased expression of CFLAR protein16373718|1704569
D005472Fluorouracil[Fluorouracil results in decreased expression of CFLAR protein] which results in increased susceptibility to TNFSF10 protein20876774
D005472FluorouracilFluorouracil results in increased expression of CFLAR mRNA15152939
D005472FluorouracilIFNA1 protein promotes the reaction [Fluorouracil results in decreased expression of CFLAR mRNA]17045692
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CFLAR gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of CFLAR mRNA23649840
D005688Galactosaminebaicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein]20850421
D005688Galactosamine[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein20850421
D005688GalactosamineSilymarin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein]20850421
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]23452621
C007845gingerolAcetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein]25034532
C007845gingerolgingerol results in decreased expression of CFLAR protein25034532
D005999Glycochenodeoxycholic AcidGlycochenodeoxycholic Acid results in decreased expression of and results in increased phosphorylation of CFLAR protein25125499
D005999Glycochenodeoxycholic AcidGlycochenodeoxycholic Acid promotes the reaction [lysophosphatidylethanolamine analog results in increased expression of CFLAR protein]25125499
D005999Glycochenodeoxycholic AcidGlycochenodeoxycholic Acid results in increased expression of CFLAR protein25125499
D005999Glycochenodeoxycholic Acidlysophosphatidylethanolamine analog promotes the reaction [Glycochenodeoxycholic Acid results in increased expression of CFLAR protein]25125499
C529376GYY 4137GYY 4137 results in decreased expression of CFLAR protein25205294
D017313FenretinideFenretinide inhibits the reaction [TNF protein results in increased expression of CFLAR protein]16230421
D017313FenretinideFenretinide results in decreased expression of CFLAR protein16230421
D006820Hyaluronic Acid[Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein20237495
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CFLAR protein18603805
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CFLAR protein16157298
D006886HydroxychloroquineHydroxychloroquine results in decreased expression of CFLAR mRNA16734620
D006886HydroxychloroquineHydroxychloroquine results in decreased expression of CFLAR protein16734620
C492448ICG 001ICG 001 results in increased expression of CFLAR mRNA26191083
D000068877Imatinib Mesylate[tetraarsenic tetrasulfide co-treated with Imatinib Mesylate] results in decreased expression of CFLAR mRNA19208803
C016517indole-3-carbinolindole-3-carbinol inhibits the reaction [TNF protein results in increased expression of CFLAR protein]15811958
C016517indole-3-carbinolindole-3-carbinol results in decreased expression of CFLAR16082211
D007213IndomethacinIndomethacin inhibits the reaction [LTA protein results in increased expression of CFLAR protein]17873517
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CFLAR mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of CFLAR mRNA25972201
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CFLAR mRNA25613284
C051890irinotecanCFLAR protein affects the susceptibility to irinotecan16373718
C051890irinotecanCFLAR protein alternative form inhibits the reaction [irinotecan results in increased activity of TNFSF10 protein]16373718
C051890irinotecanirinotecan results in decreased expression of CFLAR protein16373718
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CFLAR mRNA28628672
C477508jaceosidinCFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]27729209
C477508jaceosidinjaceosidin results in decreased expression of CFLAR mRNA27729209
C477508jaceosidinjaceosidin results in decreased expression of CFLAR protein27729209
C477508jaceosidinRELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]27729209
C477508jaceosidinSP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]27729209
C561695(+)-JQ1 compoundbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [(+)-JQ1 compound results in decreased expression of CFLAR protein]26415225
C561695(+)-JQ1 compoundCFLAR protein results in decreased susceptibility to [(+)-JQ1 compound co-treated with TNFSF10 protein]26415225
C561695(+)-JQ1 compound(+)-JQ1 compound analog results in decreased expression of CFLAR protein26415225
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CFLAR mRNA23086925|2479639
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CFLAR protein26415225
C046438kahweol acetateCFLAR protein inhibits the reaction [[TNFSF10 protein co-treated with kahweol acetate] results in increased activity of CASP8 protein]20403343
C046438kahweol acetate[TNFSF10 protein co-treated with kahweol acetate] results in decreased expression of CFLAR protein20403343
C046438kahweol acetateCFLAR protein results in decreased susceptibility to [TNFSF10 protein co-treated with kahweol acetate]20403343
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of CFLAR mRNA"23090859
D008070Lipopolysaccharidesbaicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein]20850421
D008070Lipopolysaccharides[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein20850421
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CFLAR mRNA10975854
D008070LipopolysaccharidesSilymarin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein]20850421
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CFLAR mRNA21645290
C115354lonafarniblonafarnib inhibits the reaction [TNF protein results in increased expression of CFLAR protein]15090542
C008301lysophosphatidylethanolaminelysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of CFLAR mRNA]25125499
C008301lysophosphatidylethanolaminelysophosphatidylethanolamine analog results in increased expression of CFLAR mRNA25125499
C008301lysophosphatidylethanolaminelysophosphatidylethanolamine analog results in increased expression of CFLAR protein25125499
C008301lysophosphatidylethanolamineGlycochenodeoxycholic Acid promotes the reaction [lysophosphatidylethanolamine analog results in increased expression of CFLAR protein]25125499
C008301lysophosphatidylethanolaminelysophosphatidylethanolamine analog promotes the reaction [Glycochenodeoxycholic Acid results in increased expression of CFLAR protein]25125499
C008301lysophosphatidylethanolaminelysophosphatidylethanolamine analog results in increased expression of CFLAR protein25125499
D008277Magnesium OxideMagnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CFLAR mRNA]27920530
D008277Magnesium Oxide[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of CFLAR mRNA]27920530
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CFLAR mRNA26378955
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CFLAR mRNA21641980
D017258Medroxyprogesterone Acetate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CFLAR protein alternative form16709600
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CFLAR gene20938992
D008727MethotrexateMethotrexate results in increased expression of CFLAR mRNA17696278|2167806
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CFLAR mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CFLAR mRNA"20188158
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CFLAR mRNA"15329391
C008493methylselenic acid"[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in decreased expression of CFLAR protein"18444175
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of CFLAR]21244764
D015735MifepristoneMifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased expression of CFLAR protein modified form]]12645856
D015735MifepristoneMifepristone results in decreased expression of CFLAR mRNA25972201
C016599mono-(2-ethylhexyl)phthalate[FASL affects the susceptibility to mono-(2-ethylhexyl)phthalate] which affects the expression of CFLAR protein20100735
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of CFLAR mRNA25177542
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of CFLAR mRNA20886546
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CFLAR mRNA"25554681|2562005
D009532NickelNickel results in increased expression of CFLAR mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of CFLAR mRNA22546817
C029938nickel sulfatenickel sulfate results in increased expression of CFLAR mRNA16780908
C558013NSC 689534NSC 689534 results in increased expression of CFLAR mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of CFLAR mRNA18417182
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of CFLAR mRNA"22937105
D008939MitotaneMitotane analog results in increased expression of CFLAR mRNA23485034
C030110oxaliplatinCFLAR protein affects the susceptibility to oxaliplatin16373718
C030110oxaliplatinCFLAR protein alternative form inhibits the reaction [oxaliplatin results in increased activity of TNFSF10 protein]16373718
C030110oxaliplatinoxaliplatin results in decreased expression of CFLAR protein16373718
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of CFLAR mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]23452621
D017239PaclitaxelCFLAR protein results in decreased susceptibility to Paclitaxel16080463
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CFLAR mRNA"27188386
C551803PCI 32765PCI 32765 results in decreased expression of CFLAR mRNA26254443
D000068437PemetrexedCFLAR results in decreased susceptibility to Pemetrexed21726997
C046012pentanalpentanal results in decreased expression of CFLAR mRNA26079696
D010431Pentoxifylline[Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein20804743
D010431PentoxifyllinePentoxifylline results in decreased expression of CFLAR protein18851957
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CFLAR mRNA25868421
C539933pevonedistatpevonedistat affects the expression of CFLAR mRNA24634471
C526145Phellinus linteus extractPhellinus linteus extract results in decreased expression of CFLAR protein alternative form16868541
D010634PhenobarbitalPhenobarbital affects the expression of CFLAR mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of CFLAR mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of CFLAR mRNA18445702|2381119
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]23452621
D010936Plant ExtractsPlant Extracts results in decreased expression of CFLAR protein25449198
D010936Plant ExtractsPlant Extracts inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein]25449198
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CFLAR mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CFLAR mRNA22079256
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]"15322087
D011374ProgesteroneProgesterone results in increased expression of CFLAR mRNA21770760
D011441PropylthiouracilPropylthiouracil results in increased expression of CFLAR mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors results in decreased expression of CFLAR protein21173233
D011794Quercetinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Quercetin results in decreased expression of CFLAR protein alternative form]18980244
D011794QuercetinQuercetin results in decreased expression of CFLAR mRNA23727915
D011794QuercetinQuercetin results in decreased expression of CFLAR protein alternative form18980244
D011794Quercetin"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CFLAR mRNA]"21294050
C059514resveratrol"[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in decreased expression of CFLAR protein"18444175
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]23452621
C059514resveratrolresveratrol results in decreased cleavage of CFLAR protein18222423
C059514resveratrolresveratrol results in decreased expression of CFLAR protein20097879
C059514resveratrolTNFSF10 protein promotes the reaction [resveratrol results in decreased expression of CFLAR protein]20097879
C059514resveratrolresveratrol results in decreased expression of CFLAR protein17872969
C059514resveratrolresveratrol results in increased expression of CFLAR mRNA16081268
C059514resveratrolresveratrol results in decreased expression of CFLAR protein18454317
D012293RifampinMifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased expression of CFLAR protein modified form]]12645856
D012293RifampinRifampin inhibits the reaction [FAS protein results in increased expression of CFLAR protein modified form]12645856
D012293RifampinRifampin results in increased expression of CFLAR protein11958592
C087123romidepsin[romidepsin co-treated with Bortezomib] results in decreased expression of CFLAR protein18223231
C089730rosiglitazonerosiglitazone results in decreased expression of CFLAR mRNA19467017|1973182
C089730rosiglitazonerosiglitazone results in decreased expression of CFLAR protein18164688
C089730rosiglitazoneTretinoin promotes the reaction [rosiglitazone results in decreased expression of CFLAR mRNA]19467017|1973182
C046245rubimaillinBCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein]19716835
C046245rubimaillinrubimaillin results in increased cleavage of CFLAR protein19716835
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of CFLAR mRNA21427059
D012524SarinSarin results in increased expression of CFLAR mRNA19522546
D012643Selenium[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of CFLAR mRNA]27920530
D012643SeleniumSelenium analog promotes the reaction [Diazinon results in increased expression of CFLAR mRNA]27920530
C042431S-ethyl glutathioneS-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]25619640
C040115shogaolAcetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]25619640
C040115shogaolbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [shogaol results in decreased expression of CFLAR protein modified form]25619640
C040115shogaolCFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]25619640
C040115shogaolS-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]25619640
C040115shogaolshogaol promotes the reaction [Cycloheximide results in decreased expression of CFLAR protein modified form]25619640
C040115shogaolshogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]25619640
C040115shogaolshogaol results in decreased expression of CFLAR protein modified form25619640
D012822Silicon DioxideSilicon Dioxide results in increased expression of CFLAR mRNA19073995
D012834SilverSilver results in decreased expression of CFLAR mRNA27131904
D012838SilymarinSilymarin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein]20850421
D019821SimvastatinSimvastatin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]17277159
D019821SimvastatinSimvastatin results in decreased expression of CFLAR protein18521906
D019821SimvastatinSimvastatin results in decreased expression of CFLAR protein alternative form21910007
D019821SimvastatinSimvastatin results in increased expression of CFLAR mRNA19262002
D019821SimvastatinSimvastatin results in increased expression of CFLAR protein19262002
C118258SN50 peptideSN50 peptide results in decreased expression of CFLAR protein12970779
C009277sodium arsenatesodium arsenate results in decreased expression of CFLAR mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of CFLAR mRNA12016162|2088654
C017947sodium arsenitesodium arsenite results in decreased expression of CFLAR mRNA19822182
C471405sorafenib[sorafenib co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein17909059
C471405sorafenibsorafenib results in decreased expression of CFLAR protein17909059
C471405sorafenib[sorafenib results in decreased expression of CFLAR protein] which results in increased susceptibility to TNFSF10 protein17909059
C471405sorafenibsorafenib results in increased degradation of CFLAR protein20071162
C471405sorafenib[sorafenib results in increased degradation of CFLAR protein] which results in increased susceptibility to TNFSF10 protein20071162
C471405sorafenib[sorafenib co-treated with vorinostat] results in decreased expression of CFLAR protein modified form18787411
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CFLAR mRNA26378955
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CFLAR mRNA21641980
C025462sulindac sulfidesulindac sulfide results in decreased expression of CFLAR protein11912124
D013629Tamoxifen[Tamoxifen co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein modified form17767197
C021751tanshinonetanshinone results in increased expression of CFLAR protein26203587
C534735tetraarsenic tetrasulfide[tetraarsenic tetrasulfide co-treated with Imatinib Mesylate] results in decreased expression of CFLAR mRNA19208803
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of CFLAR mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CFLAR mRNA18334599
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CFLAR protein18334599
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CFLAR mRNA12167310
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CFLAR mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CFLAR mRNA19520675
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CFLAR mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of CFLAR protein15986355
D013853ThioacetamideThioacetamide results in decreased expression of CFLAR mRNA23411599
D014118Toxins, Biological"Toxins, Biological affects the expression of CFLAR mRNA"19682533
D014212Tretinoin[Tretinoin co-treated with TGFB1 protein] results in increased expression of CFLAR protein16242776
D014212TretinoinTretinoin promotes the reaction [rosiglitazone results in decreased expression of CFLAR mRNA]19467017|1973182
D014212TretinoinTretinoin results in increased expression of CFLAR mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CFLAR mRNA19448997
C012589trichostatin Atrichostatin A results in decreased expression of CFLAR mRNA28542535
C046488trimethyltintrimethyltin results in increased expression of CFLAR mRNA21435392
C057693troglitazonetroglitazone results in decreased expression of CFLAR protein16820965
C057693troglitazonetroglitazone results in increased expression of CFLAR mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of CFLAR mRNA17127020
C004218tylophorinetylophorine analog results in increased expression of CFLAR mRNA19284764
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid analog results in increased expression of CFLAR protein21146893
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CFLAR mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CFLAR mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CFLAR mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased expression of CFLAR mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CFLAR gene25560391
C025643vinclozolinvinclozolin affects the expression of CFLAR mRNA19015723
D014750VincristineVincristine results in increased expression of CFLAR mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of CFLAR mRNA26682919
D014810Vitamin EVitamin E results in increased expression of CFLAR mRNA19244175
C111237vorinostatbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[vorinostat co-treated with TNFSF10 protein] affects the localization of CFLAR protein]19643600
C111237vorinostatbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[vorinostat co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein]19643600
C111237vorinostat[vorinostat co-treated with TNFSF10 protein] affects the localization of CFLAR protein19643600
C111237vorinostat[vorinostat co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein19643600
C111237vorinostatvorinostat inhibits the reaction [TNF protein results in increased expression of CFLAR protein]16377638
C111237vorinostatvorinostat results in decreased expression of CFLAR protein15897598|1964360
C111237vorinostatvorinostat results in decreased expression of CFLAR protein modified form17351739
C111237vorinostatvorinostat results in increased expression of CFLAR protein modified form17351739
C111237vorinostat[sorafenib co-treated with vorinostat] results in decreased expression of CFLAR protein modified form18787411
C403304zerumbonezerumbone results in decreased expression of CFLAR mRNA16007145
C088658zoledronic acidzoledronic acid results in increased expression of CFLAR mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI9208847  
GO:0005123death receptor binding-IEA-  
GO:0005515protein binding-IPI9208847  11741985  12887920  17047155  23541952  24438025  
25241761  25416956  
GO:0008047enzyme activator activity-IDA9208847  
GO:0016504peptidase activator activity-IEA-  
GO:0044877protein-containing complex binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0097153cysteine-type endopeptidase activity involved in apoptotic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0006915apoptotic process-IBA21873635  
GO:0006915apoptotic process-IMP21737330  
GO:0007519skeletal muscle tissue development-ISS-  
GO:0010667negative regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0010952positive regulation of peptidase activity-IEA-  
GO:0010976positive regulation of neuron projection development-IEA-  
GO:0014732skeletal muscle atrophy-ISS-  
GO:0014842regulation of skeletal muscle satellite cell proliferation-ISS-  
GO:0014866skeletal myofibril assembly-ISS-  
GO:0016032viral process-IEA-  
GO:0032869cellular response to insulin stimulus-IEA-  
GO:0033574response to testosterone-IEA-  
GO:0043066negative regulation of apoptotic process-TAS9217161  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEP12761501  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0043403skeletal muscle tissue regeneration-ISS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-ISS-  
GO:0060544regulation of necroptotic process-IDA21737330  
GO:0060546negative regulation of necroptotic process-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO:0071364cellular response to epidermal growth factor stimulus-IEA-  
GO:0071392cellular response to estradiol stimulus-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:0071549cellular response to dexamethasone stimulus-IEA-  
GO:0071732cellular response to nitric oxide-IEA-  
GO:0072126positive regulation of glomerular mesangial cell proliferation-IEA-  
GO:1901740negative regulation of myoblast fusion-ISS-  
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors-TAS-  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-IBA21873635  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-IDA26582200  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-IMP18202225  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-TAS-  
GO:1903055positive regulation of extracellular matrix organization-IEA-  
GO:1903427negative regulation of reactive oxygen species biosynthetic process-IEA-  
GO:1903845negative regulation of cellular response to transforming growth factor beta stimulus-IEA-  
GO:1903944negative regulation of hepatocyte apoptotic process-IEA-  
GO:2000347positive regulation of hepatocyte proliferation-IEA-  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IDA9208847  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IMP22266862  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA18073330  
GO:0005829cytosol-TAS-  
GO:0031264death-inducing signaling complex-IDA21803845  
GO:0031265CD95 death-inducing signaling complex-IEA-  
GO:0045121membrane raft-IEA-  
GO:0097342ripoptosome-IDA21737330  
KEGG ID KEGG Term
hsa04210Apoptosis
hsa05142Chagas disease (American trypanosomiasis)
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-140534Ligand-dependent caspase activationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-3371378Regulation by c-FLIPTAS
R-HSA-5213460RIPK1-mediated regulated necrosisTAS
R-HSA-5218859Regulated NecrosisTAS
R-HSA-5218900CASP8 activity is inhibitedTAS
R-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathwayTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5675482Regulation of necroptotic cell deathTAS
R-HSA-69416Dimerization of procaspase-8TAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-75158TRAIL signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28670784Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium. (2017 Nov 1)Barrdahl MInt J Cancer