Gene: WISP1

8840
CCN4|WISP1-OT1|WISP1-UT1|WISP1c|WISP1i|WISP1tc
WNT1 inducible signaling pathway protein 1
protein-coding
8q24.22
Ensembl:ENSG00000104415 MIM:603398 Vega:OTTHUMG00000164440 UniprotKB:O95388
NG_029529.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.645e-1 (AD)  2.073e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S1PR30.588
TRIOBP0.583
KDELC20.581
WWTR10.578
SLC43A30.573
SH2D2A0.568
WEE10.567
COL6A20.567
SLC26A20.566
LDLRAD30.564

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBLN7-0.409
SPEF1-0.408
ZMAT4-0.396
LRTM2-0.395
MARCH4-0.395
ADRA1D-0.395
LRRC73-0.387
CCNO-0.387
CDH22-0.383
KCNQ4-0.38

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of WISP1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of WISP1 mRNA"22698814|2890350
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of WISP1 mRNA"27291303
C0942102,2'-(hydroxynitrosohydrazono)bis-ethanamine"2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of WISP1 mRNA"19238344
C0942102,2'-(hydroxynitrosohydrazono)bis-ethanamine"2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of WISP1 protein"19238344
C0942102,2'-(hydroxynitrosohydrazono)bis-ethanamine"CREB1 mutant form inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of WISP1 mRNA]"19238344
C0942102,2'-(hydroxynitrosohydrazono)bis-ethanamine"CTNNB1 mutant form inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of WISP1 mRNA]"19238344
C0942102,2'-(hydroxynitrosohydrazono)bis-ethanamine"Cycloheximide inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of WISP1 mRNA]"19238344
C0942102,2'-(hydroxynitrosohydrazono)bis-ethanamine"Dactinomycin inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of WISP1 mRNA]"19238344
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of WISP1 mRNA"25710175
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of WISP1 mRNA"20406850
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of WISP1 mRNA"18648102
D006710HomocysteineHomocysteine results in decreased expression of WISP1 mRNA17320366
D000643Ammonium ChlorideAmmonium Chloride affects the expression of WISP1 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of WISP1 mRNA"22863853
D001151ArsenicArsenic affects the expression of WISP1 protein24675094
C006632arsenic trioxidearsenic trioxide results in decreased expression of WISP1 mRNA20458559|2670570
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of WISP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of WISP1 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of WISP1 mRNA21569818
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of WISP1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of WISP1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of WISP1 mRNA21457566
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of WISP1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of WISP1 mRNA27339419
D002330CarmustineWISP1 mRNA affects the susceptibility to Carmustine16365179
D002737ChloropreneChloroprene results in decreased expression of WISP1 mRNA23125180
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of WISP1 mRNA15467011
D003471CuprizoneCuprizone results in decreased expression of WISP1 mRNA26577399|2752363
D003513Cycloheximide"Cycloheximide inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of WISP1 mRNA]"19238344
D003609Dactinomycin"Dactinomycin inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of WISP1 mRNA]"19238344
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of WISP1 mRNA23640034
C014347decitabinedecitabine results in increased expression of WISP1 mRNA27915011
D003907DexamethasoneDexamethasone results in decreased expression of WISP1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of WISP1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of WISP1 mRNA21151649
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of WISP1 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of WISP1 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of WISP1 mRNA24535843
D002117CalcitriolCalcitriol results in decreased expression of WISP1 mRNA26485663
C024629dimethyl phthalatedimethyl phthalate affects the expression of WISP1 mRNA26924002
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of WISP1 mRNA"23262642
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of WISP1 mRNA17351261
D005492Folic AcidFolic Acid affects the expression of WISP1 mRNA17320366
D007213IndomethacinIndomethacin results in decreased expression of WISP1 mRNA17054584
D007213IndomethacinIndomethacin results in decreased expression of WISP1 protein17054584
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of WISP1 mRNA26644586
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of WISP1 mRNA"24972896
D008727MethotrexateMethotrexate results in decreased expression of WISP1 mRNA17320366
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of WISP1 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of WISP1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of WISP1 mRNA23179753
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of WISP1 mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of WISP1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of WISP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of WISP1 mRNA"25554681
D009599NitroprussideNitroprusside results in increased expression of WISP1 mRNA19238344
D009599NitroprussideNitroprusside results in increased expression of WISP1 protein19238344
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of WISP1 mRNA17616710
C025589ochratoxin Aochratoxin A analog results in increased expression of WISP1 mRNA27422291
C025589ochratoxin Aochratoxin A results in increased expression of WISP1 mRNA27422291
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of WISP1 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of WISP1 mRNA18042831
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of WISP1 mRNA24535843
D010634PhenobarbitalNR1I3 protein promotes the reaction [Phenobarbital results in increased expression of WISP1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of WISP1 mRNA19270015|1936314
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of WISP1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of WISP1 mRNA23262642
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of WISP1 protein29175452
C045950propiconazolepropiconazole results in increased expression of WISP1 mRNA21278054
C513428pyrachlostrobinpyrachlostrobin results in increased expression of WISP1 mRNA27029645
C059514resveratrolresveratrol results in increased expression of WISP1 mRNA23419489
D012834SilverSilver results in decreased expression of WISP1 mRNA27131904
D053260SootSoot results in increased expression of WISP1 mRNA26551751
C047246temozolomideWISP1 mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WISP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WISP1 mRNA15667827
C009495titanium dioxidetitanium dioxide results in increased expression of WISP1 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of WISP1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of WISP1 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of WISP1 mRNA19042947
D014302Trinitrobenzenesulfonic AcidNOS2 gene mutant form inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of WISP1 mRNA]19238344
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of WISP1 mRNA19238344
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of WISP1 mRNA23537331
C057693troglitazonetroglitazone results in decreased expression of WISP1 mRNA28934090
D017973Tungsten CompoundsTungsten Compounds results in decreased expression of WISP1 mRNA28666766
C113580U 0126U 0126 results in increased expression of WISP1 mRNA17320366
D014635Valproic AcidValproic Acid results in increased methylation of WISP1 gene29154799
D014640VancomycinVancomycin results in decreased expression of WISP1 mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IBA21873635  
GO:0005520insulin-like growth factor binding-IEA-  
GO:0008201heparin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-IEA-  
GO:0007155cell adhesion-IBA21873635  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-TAS9843955  
GO:0007267cell-cell signaling-TAS9843955  
GO:0016055Wnt signaling pathway-IEA-  
GO:0060548negative regulation of cell death-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-NAS9843955  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28426731Effect of genetic variation in microRNA binding site in WNT1-inducible signaling pathway protein 1 gene on oral squamous cell carcinoma susceptibility. (2017)Lau HKPLoS One