Gene info: ID 885

Gene: CCK

GENE ID: 885

Synonyms: -

Description: cholecystokinin

Gene type: protein-coding

Location: 3p22.1

dbXrefs: Ensembl:ENSG00000187094 MIM:118440 Vega:OTTHUMG00000131796 UniprotKB:P06307

RefSeq: NC_000003.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 50

Sherlock p-value : NA (AD) 1.236e-1 (ND) (Frontal_Cortex)

Pascal p-value : 7.183e-1 (AD) 4.351e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LMO4	0.933
BASP1	0.933
OLFM1	0.932
ATP6V1G2	0.931
TOLLIP	0.929
NRGN	0.928
SYP	0.927
SYNGR3	0.927
DIRAS1	0.925
RAB3A	0.924

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.591
OR4F29	-0.559
REST	-0.487
C1orf87	-0.485
ARHGEF5	-0.462
CXCR2	-0.459
WWTR1	-0.456
ZIC4	-0.449
IL18RAP	-0.445
FCGR3B	-0.444

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C063609	1,2-dimethyl-4-nitrobenzene	"1,2-dimethyl-4-nitrobenzene results in increased expression of CCK mRNA"	19784758
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of CCK mRNA"	19162173
C074681	1-(4-bromophenylaminocarbonyl)-4,5-diphenyl-3-pyrazolidinone	"1-(4-bromophenylaminocarbonyl)-4,5-diphenyl-3-pyrazolidinone inhibits the reaction [CCK protein inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IGHG1 protein]]"	21664492
C046760	15-acetyldeoxynivalenol	15-acetyldeoxynivalenol results in increased expression of CCK protein	24385417
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]"	25787141
C582212	1NMPP1 compound	[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of CCK mRNA	27417517
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCK mRNA"	25510870
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CCK mRNA"	19114083
C038890	2,3,4,7,8-pentachlorodibenzofuran	"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of CCK protein alternative form"	10919282
C038890	2,3,4,7,8-pentachlorodibenzofuran	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Tetrachlorodibenzodioxin co-treated with 2,3,4,7,8-pentachlorodibenzofuran] results in decreased expression of CCK protein alternative form"	10919282
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCK mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCK mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of CCK protein alternative form"	10919282
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCK mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCK mRNA"	25510870
C411827	2,5-dihydro-2,4,5-trimethylthiazoline	"2,5-dihydro-2,4,5-trimethylthiazoline results in increased expression of CCK mRNA"	12431849
C538758	2-aminoethyl diphenylborinate	2-aminoethyl diphenylborinate inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]	25787141
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of CCK protein alternative form"	10919282
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Tetrachlorodibenzodioxin co-treated with 2,3,4,7,8-pentachlorodibenzofuran] results in decreased expression of CCK protein alternative form"	10919282
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CCK protein alternative form"	10919282
C043247	3-acetyldeoxynivalenol	3-acetyldeoxynivalenol results in increased expression of CCK protein	24385417
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCK mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCK mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCK mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCK mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of CCK mRNA	22230336
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CCK mRNA	22100608\|2715375
D000447	Aldehydes	Aldehydes results in increased expression of CCK mRNA	25014914
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CCK mRNA	16483693
D000701	Analgesics, Opioid	"[CCK protein alternative form results in increased activity of CCKBR protein] which results in decreased susceptibility to Analgesics, Opioid"	11880531
D001058	Apomorphine	CCK protein results in decreased activity of Apomorphine	3561887
D001058	Apomorphine	Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine]	3561887
D001058	Apomorphine	CCK protein alternative form results in decreased susceptibility to Apomorphine	3735805
C015001	arsenite	arsenite results in increased methylation of CCK promoter	23974009
D001280	Atrazine	Atrazine results in decreased expression of CCK mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CCK mRNA	23735875
D004958	Estradiol	Estradiol affects the expression of CCK mRNA	25321415
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of CCK mRNA	19693291
D004958	Estradiol	Estradiol results in increased expression of CCK mRNA	19693291
C006780	bisphenol A	bisphenol A results in decreased methylation of CCK promoter	27312807
C006780	bisphenol A	bisphenol A affects the expression of CCK mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of CCK mRNA	26079696
D020148	Butyric Acid	Butyric Acid results in increased expression of CCK mRNA	12431849
D002211	Capsaicin	[Capsaicin co-treated with CCK protein alternative form] results in increased expression of TAC1 protein	10683199
D002211	Capsaicin	Capsaicin inhibits the reaction [CCK protein alternative form results in decreased expression of NGF mRNA]	10683199
D002211	Capsaicin	Capsaicin promotes the reaction [CCK protein alternative form results in increased expression of NGF protein]	10683199
D002211	Capsaicin	Capsaicin inhibits the reaction [CCK protein results in increased phosphorylation of MAPK1 protein]	22508518
D002211	Capsaicin	Capsaicin inhibits the reaction [CCK protein results in increased phosphorylation of MAPK3 protein]	22508518
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CCK mRNA	17484886
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of CCK mRNA	20350560
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of CCK mRNA	20682304
D003024	Clozapine	Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]	16567023
D003024	Clozapine	Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]	16567023
D003024	Clozapine	Clozapine results in increased expression of CCK mRNA	10974607
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of CCK mRNA	24690739
D019327	Copper Sulfate	Copper Sulfate results in increased expression of CCK mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of CCK mRNA	26577399
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of CCK mRNA	24921660
C014347	decitabine	decitabine results in increased expression of CCK mRNA	19151715
D013759	Dronabinol	Dronabinol results in decreased expression of CCK mRNA	21955143
C007262	deoxynivalenol	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]"	25787141
C007262	deoxynivalenol	2-aminoethyl diphenylborinate inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]	25787141
C007262	deoxynivalenol	CASR affects the reaction [deoxynivalenol results in increased secretion of CCK protein]	25787141
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CCK protein	22903826\|2438541
C007262	deoxynivalenol	deoxynivalenol results in increased secretion of CCK protein	25787141
C007262	deoxynivalenol	Egtazic Acid inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]	25787141
C007262	deoxynivalenol	"[N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine co-treated with Ruthenium Red] inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]"	26979077
C007262	deoxynivalenol	"N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]"	26979077
C007262	deoxynivalenol	Nitrendipine inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]	25787141
C007262	deoxynivalenol	Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]	26979077
C007262	deoxynivalenol	triphenylphosphine oxide inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]	25787141
C007262	deoxynivalenol	TRPA1 affects the reaction [deoxynivalenol results in increased secretion of CCK protein]	25787141
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CCK mRNA	24893172
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of CCK mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in increased expression of CCK protein	19837920
D004041	Dietary Fats	Dietary Fats results in increased expression of CCK mRNA	18457598
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of CCK mRNA	26924002
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of CCK mRNA	28939011
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of CCK mRNA	24690739
D004221	Disulfiram	Disulfiram results in decreased expression of CCK protein alternative form	8246921
D016291	Dizocilpine Maleate	Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]	16567023
D016291	Dizocilpine Maleate	Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]	16567023
D016291	Dizocilpine Maleate	Dizocilpine Maleate results in decreased expression of CCK mRNA	16567023
D016291	Dizocilpine Maleate	Dizocilpine Maleate results in decreased expression of CCK protein	16567023
D004533	Egtazic Acid	Egtazic Acid inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]	25787141
D000431	Ethanol	Ethanol results in increased expression of CCK mRNA	21955143
D000431	Ethanol	CCK protein alternative form results in increased susceptibility to Ethanol	6281507
D000431	Ethanol	TRH protein inhibits the reaction [CCK protein alternative form results in increased susceptibility to Ethanol]	6281507
D005223	Fats	Fats results in increased secretion of CCK protein	18303078
D005223	Fats	orlistat inhibits the reaction [Fats results in increased secretion of CCK protein]	18303078
D005230	Fatty Acids, Nonesterified	"[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein"	11408251
C540355	fenamidone	fenamidone results in decreased expression of CCK mRNA	27029645
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in decreased expression of CCK mRNA	22584684
D005473	Fluoxetine	Fluoxetine results in decreased expression of CCK mRNA	17105902
D005473	Fluoxetine	Fluoxetine results in decreased expression of CCK mRNA	17033635
C002469	fusarenon-X	fusarenon-X results in increased expression of CCK protein	24385417
D006220	Haloperidol	Haloperidol results in increased expression of CCK mRNA	10974607
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CCK mRNA	20044591
C051890	irinotecan	irinotecan affects the expression of CCK mRNA	20097248
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CCK mRNA	26644586
D007608	Kainic Acid	Kainic Acid results in decreased expression of CCK protein	7774662
C440499	lipopolysaccharide, Escherichia coli O111 B4	"1-(4-bromophenylaminocarbonyl)-4,5-diphenyl-3-pyrazolidinone inhibits the reaction [CCK protein inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IGHG1 protein]]"	21664492
C440499	lipopolysaccharide, Escherichia coli O111 B4	"CCK protein inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IGHG1 protein]"	21664492
D008294	Malathion	Malathion results in increased expression of CCK mRNA	19784758
D008550	Melatonin	Melatonin results in increased secretion of CCK protein	15009505
D008694	Methamphetamine	CCK protein modified form inhibits the reaction [Methamphetamine promotes the reaction [NCF1 protein binds to CYBB protein]]	27565679
D008694	Methamphetamine	CCK protein modified form inhibits the reaction [Methamphetamine results in increased phosphorylation of NCF1 protein]	27565679
D008694	Methamphetamine	CCK protein alternative form results in decreased susceptibility to Methamphetamine	3735805\|6281507
D008694	Methamphetamine	CCK protein alternative form results in increased susceptibility to Methamphetamine	6281507
D008727	Methotrexate	Methotrexate results in increased expression of CCK mRNA	21678067
D008743	Methyl Parathion	Methyl Parathion affects the expression of CCK mRNA	19784758
D008743	Methyl Parathion	Methyl Parathion results in decreased expression of CCK mRNA	19784758
D008743	Methyl Parathion	Methyl Parathion results in increased expression of CCK mRNA	19784758
C008493	methylselenic acid	methylselenic acid results in increased expression of CCK mRNA	18548127
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of CCK mRNA	26924002
D009020	Morphine	Morphine results in decreased expression of CCK mRNA	21955143
D009151	Mustard Gas	Mustard Gas results in increased expression of CCK mRNA	25102026
C436740	N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine	"[N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine co-treated with Ruthenium Red] inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]"	26979077
C436740	N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine	"N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]"	26979077
D009270	Naloxone	Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine]	3561887
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CCK mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CCK mRNA"	25554681
D009538	Nicotine	Nicotine results in decreased expression of CCK mRNA	21955143
D009538	Nicotine	Nicotine results in increased susceptibility to CCK protein	18204935
D009568	Nitrendipine	Nitrendipine inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]	25787141
D009578	Nitrobenzenes	Nitrobenzenes analog results in increased expression of CCK mRNA	19784758
C038405	nivalenol	nivalenol results in increased expression of CCK protein	24385417
D015282	Octreotide	Octreotide results in decreased secretion of CCK protein	11148435\|1155291
D015282	Octreotide	Octreotide results in decreased susceptibility to CCK protein	2883060
C108709	oleoyl-estrone	oleoyl-estrone results in decreased expression of CCK protein	18848587
D000069463	Olive Oil	Olive Oil results in increased expression of CCK protein	19837920
D000069463	Olive Oil	Olive Oil results in increased secretion of CCK protein	17138722\|1830307
D000069463	Olive Oil	orlistat inhibits the reaction [Olive Oil results in increased secretion of CCK protein]	18303078
C055122	orlistat	orlistat inhibits the reaction [Fats results in increased secretion of CCK protein]	18303078
C055122	orlistat	orlistat inhibits the reaction [Olive Oil results in increased secretion of CCK protein]	18303078
C055122	orlistat	"[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein"	11408251
C055122	orlistat	orlistat results in decreased secretion of CCK protein	18647814
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in increased expression of CCK mRNA	24888373
C013173	osteum	osteum results in increased secretion of CCK protein	17138722\|1830307
D010278	Parathion	Parathion results in increased expression of CCK mRNA	19784758
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCK mRNA"	25510870
C046012	pentanal	pentanal results in increased expression of CCK mRNA	26079696
D010424	Pentobarbital	CCK protein alternative form results in increased susceptibility to Pentobarbital	6281507
D010424	Pentobarbital	TRH protein inhibits the reaction [CCK protein alternative form results in increased susceptibility to Pentobarbital]	6281507
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of CCK mRNA	23602845
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in increased expression of CCK mRNA	24888373
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of CCK mRNA	19693291
D011374	Progesterone	Progesterone results in decreased expression of CCK mRNA	22238285
C005556	propionaldehyde	propionaldehyde results in increased expression of CCK mRNA	26079696
C502851	quinocetone	quinocetone results in increased expression of CCK mRNA	27046791
C059514	resveratrol	resveratrol inhibits the reaction [CCK protein results in decreased activity of CAT protein]	16499907
D012430	Ruthenium Red	"[N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine co-treated with Ruthenium Red] inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]"	26979077
D012430	Ruthenium Red	Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]	26979077
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CCK mRNA	25895662
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CCK mRNA	27257137
D013448	Sulfobromophthalein	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form]	25106415
D013739	Testosterone	Testosterone results in decreased expression of CCK mRNA	19693291
D013739	Testosterone	Testosterone results in increased expression of CCK mRNA	19693291
D013749	Tetrachlorodibenzodioxin	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Tetrachlorodibenzodioxin co-treated with 2,3,4,7,8-pentachlorodibenzofuran] results in decreased expression of CCK protein alternative form"	10919282
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CCK mRNA	22808131
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CCK protein alternative form	10919282
D013853	Thioacetamide	Thioacetamide results in decreased expression of CCK mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in increased expression of CCK mRNA	27760801
D014118	Toxins, Biological	"Toxins, Biological affects the expression of CCK mRNA"	19682533
C012589	trichostatin A	trichostatin A results in decreased expression of CCK mRNA	24935251
D014280	Triglycerides	Triglycerides affects the susceptibility to CCK protein	20699090
C063888	triphenylphosphine oxide	triphenylphosphine oxide inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]	25787141
C113580	U 0126	U 0126 inhibits the reaction [CCK protein results in increased phosphorylation of TH protein]	19176891
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCK mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of CCK mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of CCK mRNA	26272509
D014635	Valproic Acid	Valproic Acid results in increased expression of CCK mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of CCK gene	29154799
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCK mRNA"	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005179	hormone activity	-	IBA	21873635
GO:0005179	hormone activity	-	TAS	10320330
GO:0005184	neuropeptide hormone activity	-	IBA	21873635
GO:0005184	neuropeptide hormone activity	-	ISS	15374756

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001662	behavioral fear response	-	IEA	-
GO:0001764	neuron migration	-	ISS	15152034
GO:0001836	release of cytochrome c from mitochondria	-	IEA	-
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	IEA	-
GO:0007165	signal transduction	-	TAS	10320330
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	-	IEA	-
GO:0007409	axonogenesis	-	ISS	15152034
GO:0007586	digestion	-	IBA	21873635
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0014049	positive regulation of glutamate secretion	-	IEA	-
GO:0032099	negative regulation of appetite	-	IEA	-
GO:0032461	positive regulation of protein oligomerization	-	IEA	-
GO:0042755	eating behavior	-	ISS	15374756
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0051901	positive regulation of mitochondrial depolarization	-	IEA	-
GO:0051930	regulation of sensory perception of pain	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IEA	-
GO:0030424	axon	-	IBA	21873635
GO:0030424	axon	-	ISS	15152034
GO:0030425	dendrite	-	IEA	-
GO:0043194	axon initial segment	-	IEA	-
GO:0043195	terminal bouton	-	IEA	-
GO:0043203	axon hillock	-	IEA	-
GO:0043204	perikaryon	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
8004452	The CCKA receptor antagonist devazepide does not modify opioid self-administration or drug discrimination: comparison with the dopamine antagonist haloperidol. (1994 Mar 21)	Higgins GA	Brain Res
11321513	Leptin, gastrointestinal and stress hormones in response to exercise in fasted or fed subjects and before or after blood donation. (2001 Mar)	Sliwowski Z	J Physiol Pharmacol
10464148	Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide. (1999 Sep)	Pandol SJ	Gastroenterology
9622381	A new genetic variant in the Sp1 binding cis-element of cholecystokinin gene promoter region and relationship to alcoholism. (1998 May)	Harada S	Alcohol Clin Exp Res
3378566	Enhancement of morphine analgesia and prevention of morphine tolerance in the rat by the cholecystokinin antagonist L-364,718. (1988 Mar 15)	Dourish CT	Eur J Pharmacol
793379	Evidences for duodenopancreatic reflexes and an anti-CCK factor with lidocaine infused intravenously and sprayed topically on pancreatic papilla in nonalcoholic and alcohol-fed dogs. (1976 Sep)	Tiscornia OM	Am J Gastroenterol
8090802	Effects induced by BC 264, a selective agonist of CCK-B receptors, on morphine-dependent rats. (1994 Jun)	Maldonado R	Pharmacol Biochem Behav
10757528	Cholecystokinin-B receptor antagonists attenuate morphine dependence and withdrawal in rats. (2000 Mar 20)	Lu L	Neuroreport
2311658	The selective CCK-B receptor antagonist L-365,260 enhances morphine analgesia and prevents morphine tolerance in the rat. (1990 Jan 25)	Dourish CT	Eur J Pharmacol
21056606	Pork, beef and chicken have similar effects on acute satiety and hormonal markers of appetite. (2011 Feb)	Charlton KE	Appetite
14576487	Mechanisms of alcoholic pancreatitis. Proceedings of a conference. Chicago, Illinois, USA, November 2002. (2003 Nov)	-	Pancreas
29515441	Autophagy Flux Contributes to Regulation of Components of Eclipta prostrata L. on Cigarette Smoking-Induced Injury of Bronchial Epithelial Cells. (2018)	Ding S	Front Pharmacol
26898612	Cigarette smoke extract exposure induces EGFR-TKI resistance in EGFR-mutated NSCLC via mediating Src activation and EMT. (2016 Mar)	Li D	Lung Cancer
8111629	Cholecystokinin in human cerebrospinal fluid: concentrations, dynamics, molecular forms and relationship to fasting and feeding in health, depression and alcoholism. (1993 Dec 3)	Geracioti TD Jr	Brain Res
16049839	International Narcotics Research--31st Conference. (2000 Oct)	Fowler C	IDrugs
8804049	The CCK-B antagonist LY288513 blocks the effects of nicotine withdrawal on auditory startle. (1996 Apr 10)	Rasmussen K	Neuroreport
29027939	Nicotine Component of Cigarette Smoke Extract (CSE) Decreases the Cytotoxicity of CSE in BEAS-2B Cells Stably Expressing Human Cytochrome P450 2A13. (2017 Oct 13)	Ji M	Int J Environ Res Public Health
15740988	Cholecystokinin (CCK) and the CCKA receptor gene polymorphism, and smoking behavior. (2005 Feb 28)	Takimoto T	Psychiatry Res
19570262	An exploratory study on the development of an animal model of acute pancreatitis following nicotine exposure. (2003 Sep 15)	Chowdhury P	Tob Induc Dis
520770	Analysis of pure pancreatic juice in patients with chronic alcoholism. (1979 Oct)	Harada H	Gastroenterol Jpn
15857316	Opioid-modulating peptides: mechanisms of action. (2005)	Mollereau C	Curr Top Med Chem
10220011	No association between C-45T polymorphism in the Sp1 binding site of the promoter region of the cholecystokinin gene and alcoholism. (1999 Feb 22)	Ishiguro H	Psychiatry Res
18336667	Individual susceptibility to alcoholic pancreatitis. (2008 Mar)	Apte MV	J Gastroenterol Hepatol
28521453	Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/beta-catenin and Wnt/PCP signaling pathways. (2017 May)	Wang C	Oncol Lett
8808434	Effects of ethanol on meal-stimulated secretion of pancreatic polypeptide and cholecystokinin: comparison of healthy volunteers, heavy drinkers, and patients with chronic pancreatitis. (1996 Feb)	Hirano H	J Gastroenterol
12198366	Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (2002 Aug)	Okubo T	Alcohol Clin Exp Res
10803770	Genetic polymorphism of the CCK gene in patients with alcohol withdrawal symptoms. (2000 Apr)	Okubo T	Alcohol Clin Exp Res
9398794	Differential responsiveness to contractile agents of isolated smooth muscle cells from human colons as a function of age and inflammation. (1997 Nov)	Boyer JC	Dig Dis Sci
19793020	A review of smoking behavior and smokers evidence (chemical modification, inducing nicotine metabolism, and individual variations by genotype: dopaminergic function and personality traits). (2009)	Iwahashi K	Drug Chem Toxicol
14691070	Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population. (2004 Jan-Feb)	Miyasaka K	Alcohol Alcohol
26608796	Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort. (2015 Dec)	Norden-Krichmar TM	Twin Res Hum Genet
24793809	alpha5 Nicotinic acetylcholine receptor mediates nicotine-induced HIF-1alpha and VEGF expression in non-small cell lung cancer. (2014 Jul 15)	Ma X	Toxicol Appl Pharmacol
11513220	Polymorphisms of the CCK, CCKAR and CCKBR genes: an association with alcoholism study. (2001 Jul)	Okubo T	J Stud Alcohol
14992428	Determinants of gallbladder kinetics in obesity. (2004 Jan)	Mathus-Vliegen EM	Dig Dis Sci
2417451	Acute continuous exposure to cigarette smoke produces discrete changes in cholecystokinin and substance P levels in the hypothalamus and preoptic area of the male rat. (1985 Nov)	Fuxe K	Acta Physiol Scand
11826132	Chronic morphine treatment modulates the extracellular levels of endogenous enkephalins in rat brain structures involved in opiate dependence: a microdialysis study. (2002 Feb 1)	Nieto MM	J Neurosci
26353468	Pancreatic polypeptide: a review of its involvement in neuro-endocrine reflexes, islet-acinar interactions and ethanol-evoked physiopatologic pancreatic gland changes. (2015 Jun)	Tiscornia OM	Acta Gastroenterol Latinoam
9922984	The role of cholecystokinin (CCK), CCK-A or CCK-B receptor antagonists in the spontaneous preference for drugs of abuse (alcohol or cocaine) in naive rats. (1998 Oct)	Crespi F	Methods Find Exp Clin Pharmacol
17365745	Cholecystokinin C-45T polymorphism and smoking cessation in women. (2007 Jan)	Ton TG	Nicotine Tob Res
1438498	Failure of cholecystokinin antagonists to modify the discriminative stimulus effects of cocaine. (1992 Oct)	Spealman RD	Pharmacol Biochem Behav
26419886	How does cigarette smoking cause acute pancreatitis? (2016 Mar-Apr)	Barreto SG	Pancreatology
28104585	RCAD/BiP pathway is necessary for the proper synthesis of digestive enzymes and secretory function of the exocrine pancreas. (2017 Mar 1)	Miller C	Am J Physiol Gastrointest Liver Physiol
8617406	Opioid and anti-opioid peptides. (1995)	Cesselin F	Fundam Clin Pharmacol
11368834	No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence. (2001 May 10)	Vanakoski J	Psychiatry Res
25523932	Histone acetyltransferase inhibitor II induces apoptosis in glioma cell lines via the p53 signaling pathway. (2014 Dec 19)	Xu LX	J Exp Clin Cancer Res
10207236	Long-term effects on the regulation of pancreatic secretion after gastric surgery. (1999)	Hedberg M	Dig Surg
15767271	Differences in ethanol ingestion between cholecystokinin-A receptor deficient and -B receptor deficient mice. (2005 May-Jun)	Miyasaka K	Alcohol Alcohol
11509018	Cholecystokinin (CCK) gene as a possible risk factor for smoking: a replication in two independent samples. (2001 Aug)	Comings DE	Mol Genet Metab
10889557	Function of the C-36 to T polymorphism in the human cholecystokinin gene promoter. (2000 Jul)	Hansen TV	Mol Psychiatry
2315297	Structural and functional effects of long-term alcohol administration on the dog exocrine pancreas submitted to two different diets. (1990 Mar)	Devaux MA	Pancreas