Gene: CDK5R1

8851
CDK5P35|CDK5R|NCK5A|p23|p25|p35|p35nck5a
cyclin dependent kinase 5 regulatory subunit 1
protein-coding
17q11.2
Ensembl:ENSG00000176749 MIM:603460 Vega:OTTHUMG00000132814 UniprotKB:Q15078
NC_000017.11
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.844e-1 (AD)  9.815e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNAP910.976
SLC12A50.975
RTN10.975
RAB6B0.974
NPTN0.972
INA0.972
NSF0.971
CAP20.971
SULT4A10.971
SERPINI10.969

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.559
CSAG1-0.522
TFPI2-0.517
OR4F29-0.511
KCNJ15-0.488
RAI14-0.485
CNN2-0.484
FZD10-0.481
REST-0.479
IL18RAP-0.476

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02052Indirubin-3'-MonoximeSmall MoleculeExperimentalTarget
DB073646-PHENYL[5H]PYRROLO[2,3-B]PYRAZINESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of CDK5R1 mRNA"20453058
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK5R1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDK5R1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK5R1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK5R1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK5R1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDK5R1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK5R1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK5R1 mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDK5R1 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased cleavage of CDK5R1 protein18991853
D003913DextroamphetamineDextroamphetamine results in increased expression of CDK5R1 protein18991853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CDK5R1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of CDK5R1 mRNA24641850
C006632arsenic trioxidearsenic trioxide results in increased expression of CDK5R1 protein modified form24641850
C015001arsenitearsenite metabolite results in increased cleavage of CDK5R1 protein18242949
C015001arsenitearsenite metabolite results in increased expression of CDK5R1 mRNA18242949
C015001arsenitearsenite metabolite results in increased expression of CDK5R1 protein18242949
C015001arsenitecalpeptin inhibits the reaction [arsenite metabolite results in increased cleavage of CDK5R1 protein]18242949
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in decreased expression of CDK5R1 mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDK5R1 mRNA19146932
D004958EstradiolEstradiol inhibits the reaction [ESR2 protein affects the expression of CDK5R1 mRNA]20404318
C006780bisphenol Abisphenol A results in decreased expression of CDK5R1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of CDK5R1 mRNA29097150
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of CDK5R1 mRNA26314263
D002118CalciumCalcium results in increased cleavage of CDK5R1 protein18242949
D002118Calciumcalpeptin inhibits the reaction [Calcium results in increased cleavage of CDK5R1 protein]18242949
C071482calpeptincalpeptin inhibits the reaction [arsenite metabolite results in increased cleavage of CDK5R1 protein]18242949
C071482calpeptincalpeptin inhibits the reaction [Calcium results in increased cleavage of CDK5R1 protein]18242949
D003024ClozapineClozapine results in increased expression of CDK5R1 mRNA17266109
C018021cobaltous chloridecobaltous chloride results in decreased expression of CDK5R1 mRNA26314263
D003042CocaineCDK5R1 protein inhibits the reaction [Cocaine affects the expression of FOS mRNA]15665076
D003042CocaineCDK5R1 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]15665076
D003042CocaineCDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]15665076
D003042CocaineCDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K1 protein]15665076
D003042CocaineCDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K2 protein]15665076
D003042CocaineCDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK1 protein]15665076
D003042CocaineCDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK3 protein]15665076
D003042CocaineCDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]15665076
D003042CocaineCocaine results in decreased expression of CDK5R1 protein16263094
D003042CocaineCocaine results in increased expression of CDK5R1 mRNA11268215
D003042CocaineCocaine results in increased expression of CDK5R1 protein11268215
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of CDK5R1 mRNA24690739
D013759DronabinolDronabinol results in increased expression of CDK5R1 protein29082320
D013759Dronabinol[Dronabinol results in increased susceptibility to Dronabinol] which results in increased expression of CDK5R1 protein29082320
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of CDK5R1 mRNA24690739
D004317DoxorubicinDoxorubicin affects the expression of CDK5R1 mRNA15205334
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CDK5R1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDK5R1 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CDK5R1 mRNA23649840
D005472FluorouracilFluorouracil affects the expression of CDK5R1 mRNA15205334
D005557FormaldehydeFormaldehyde results in decreased expression of CDK5R1 mRNA20655997|2364984
D017313FenretinideFenretinide results in decreased expression of CDK5R1 mRNA16570282
D007455IodineIodine deficiency results in decreased expression of CDK5R1 protein22987596
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDK5R1 mRNA25613284
D015759IonomycinIonomycin promotes the reaction [CAMK2A protein binds to CDK5R1 protein]19217379
D007657Ketone BodiesKetone Bodies results in decreased expression of CDK5R1 mRNA16807920
C008261lead acetatelead acetate results in decreased expression of and results in increased cleavage of CDK5R1 protein23973560
C008261lead acetatelead acetate affects the reaction [MAPT protein affects the abundance of CDK5R1 protein modified form]29203278
C008261lead acetatelead acetate results in decreased expression of and results in increased cleavage of CDK5R1 protein24954411
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CDK5R1 mRNA25613284
D008344Maneb[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA23017109
D008628MercuryMercury results in increased expression of CDK5R1 mRNA16823088
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CDK5R1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK5R1 mRNA"27188386
C030957methylmercury IImethylmercury II results in decreased expression of CDK5R1 mRNA26314263
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CDK5R1 mRNA23649840
D008770MethylnitrosoureaMethylnitrosourea results in increased cleavage of CDK5R1 protein17069801
D008774MethylphenidateMethylphenidate results in increased expression of CDK5R1 mRNA22470460
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDK5R1 mRNA"15329391
D009532NickelNickel results in increased expression of CDK5R1 mRNA25583101
C025589ochratoxin Aochratoxin A metabolite results in decreased expression of CDK5R1 mRNA26314263
C025589ochratoxin Aochratoxin A results in decreased expression of CDK5R1 mRNA26314263
D010269Paraquat[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA23017109
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CDK5R1 mRNA18593933
D010575PesticidesPesticides results in decreased methylation of CDK5R1 gene28396702
D010622PhencyclidinePhencyclidine results in increased expression of CDK5R1 mRNA17266109
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDK5R1 mRNA"27188386
C006253pirinixic acidpirinixic acid results in increased expression of CDK5R1 mRNA20813756
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CDK5R1 mRNA24583197
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CDK5R1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CDK5R1 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in decreased expression of CDK5R1 protein22987596
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [resveratrol results in decreased expression of CDK5R1 mRNA]21736731
D011794QuercetinQuercetin results in increased expression of CDK5R1 mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CDK5R1 mRNA19059307
C059514resveratrolpyrazolanthrone inhibits the reaction [resveratrol results in decreased expression of CDK5R1 mRNA]21736731
C059514resveratrolresveratrol inhibits the reaction [CDK5R1 protein results in increased cleavage of CASP3 protein]17581637
C059514resveratrolresveratrol inhibits the reaction [CDK5R1 protein results in increased expression of and results in increased acetylation of TRP53 protein]17581637
C059514resveratrolresveratrol inhibits the reaction [CDK5R1 protein results in increased expression of GFAP protein]17581637
C059514resveratrolresveratrol inhibits the reaction [TNF protein results in increased expression of CDK5R1 mRNA]21736731
C059514resveratrolresveratrol results in decreased expression of CDK5R1 mRNA21736731
C059514resveratrolSB 203580 inhibits the reaction [resveratrol results in decreased expression of CDK5R1 mRNA]21736731
C059514resveratrol[U 0126 co-treated with resveratrol] results in decreased expression of CDK5R1 mRNA21736731
C059514resveratrolresveratrol results in decreased expression of CDK5R1 mRNA21736731
C059514resveratrolresveratrol results in decreased expression of CDK5R1 protein21736731
C059514resveratrol[resveratrol results in decreased expression of CDK5R1 protein] which results in decreased activity of CDK5 protein21736731
C093642SB 203580SB 203580 inhibits the reaction [resveratrol results in decreased expression of CDK5R1 mRNA]21736731
D012834SilverSilver results in increased expression of CDK5R1 mRNA26014281
D018038Sodium SeleniteSodium Selenite results in increased expression of CDK5R1 mRNA16705456
C473643sulphoraphenesulphoraphene results in decreased expression of CDK5R1 mRNA29247643
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CDK5R1 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDK5R1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDK5R1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CDK5R1 mRNA28065790
D024505TocopherolsTocopherols results in increased expression of CDK5R1 mRNA17654050
D014212TretinoinTretinoin results in increased expression of CDK5R1 mRNA17045167
C011559tributyltintributyltin results in decreased expression of CDK5R1 mRNA26314263
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in increased expression of CDK5R1 protein]15363585
D014241TrichloroethyleneTrichloroethylene results in increased expression of CDK5R1 mRNA15363585
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK5R1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CDK5R1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CDK5R1 mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of CDK5R1 mRNA22378314
C113580U 0126[U 0126 co-treated with resveratrol] results in decreased expression of CDK5R1 mRNA21736731
C113580U 0126U 0126 results in decreased expression of CDK5R1 mRNA21736731
D014635Valproic AcidValproic Acid results in increased methylation of CDK5R1 gene29154799
D014638VanadatesVanadates results in decreased expression of CDK5R1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CDK5R1 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK5R1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of CDK5R1 mRNA26272509
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CDK5R1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IEA-  
GO:0004672protein kinase activity-TAS7592934  
GO:0005509calcium ion binding-ISS-  
GO:0005515protein binding-IPI10721722  12223541  14521924  15689152  20133653  21220307  
23602568  25416956  
GO:0016301kinase activity-ISS-  
GO:0016534cyclin-dependent protein kinase 5 activator activity-TAS17491008  
GO:0019901protein kinase binding-IPI12832520  
GO:0035255ionotropic glutamate receptor binding-IEA-  
GO:0043014alpha-tubulin binding-ISS-  
GO:0043539protein serine/threonine kinase activator activity-IDA12832520  
GO:0043539protein serine/threonine kinase activator activity-ISS-  
GO:0045296cadherin binding-ISS-  
GO:0046875ephrin receptor binding-IEA-  
GO:0048487beta-tubulin binding-ISS-  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-TAS7592934  
GO:0000226microtubule cytoskeleton organization-TAS17491008  
GO:0001764neuron migration-ISS-  
GO:0007158neuron cell-cell adhesion-ISS-  
GO:0007213G-protein coupled acetylcholine receptor signaling pathway-ISS-  
GO:0007411axon guidance-ISS-  
GO:0007413axonal fasciculation-ISS-  
GO:0007420brain development-ISS-  
GO:0007420brain development-NAS10915792  
GO:0008283cell proliferation-TAS8090221  
GO:0009792embryo development ending in birth or egg hatching-IEA-  
GO:0016241regulation of macroautophagy-NAS21499257  
GO:0018105peptidyl-serine phosphorylation-IDA12832520  
GO:0018107peptidyl-threonine phosphorylation-IDA12832520  
GO:0021549cerebellum development-IEA-  
GO:0021722superior olivary nucleus maturation-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0021819layer formation in cerebral cortex-IEA-  
GO:0030182neuron differentiation-ISS-  
GO:0030517negative regulation of axon extension-IEA-  
GO:0031116positive regulation of microtubule polymerization-ISS-  
GO:0031175neuron projection development-ISS-  
GO:0031175neuron projection development-TAS17491008  
GO:0032956regulation of actin cytoskeleton organization-IEA-  
GO:0035235ionotropic glutamate receptor signaling pathway-ISS-  
GO:0042501serine phosphorylation of STAT protein-IEA-  
GO:0043525positive regulation of neuron apoptotic process-ISS-  
GO:0045664regulation of neuron differentiation-NAS10721722  
GO:0045892negative regulation of transcription, DNA-templated-IMP20357208  
GO:0048013ephrin receptor signaling pathway-ISS-  
GO:0048511rhythmic process-IEA-  
GO:0061001regulation of dendritic spine morphogenesis-ISS-  
GO:0071158positive regulation of cell cycle arrest-IEA-  
GO:0071902positive regulation of protein serine/threonine kinase activity-IEA-  
GO:0090314positive regulation of protein targeting to membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-TAS-  
GO:0005874microtubulecolocalizes_withISS-  
GO:0005886plasma membrane-TAS-  
GO:0014069postsynaptic density-ISS-  
GO:0016020membrane-ISS-  
GO:0016533protein kinase 5 complex-IEA-  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0030426growth cone-ISS-  
GO:0031594neuromuscular junction-ISS-  
GO:0043005neuron projection-ISS-  
GO:0043025neuronal cell body-ISS-  
GO:0043197dendritic spine-ISS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0043292contractile fiber-ISS-  
GO:0048471perinuclear region of cytoplasm-IDA12832520  
KEGG ID KEGG Term
hsa05010Alzheimer's disease
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseIEA
R-HSA-1643685DiseaseTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-373755Semaphorin interactionsTAS
R-HSA-373755Semaphorin interactionsIEA
R-HSA-399956CRMPs in Sema3A signalingTAS
R-HSA-399956CRMPs in Sema3A signalingIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsIEA
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsTAS
R-HSA-8863678Neurodegenerative DiseasesIEA
R-HSA-8863678Neurodegenerative DiseasesTAS
R-HSA-9006115Signaling by NTRK2 (TRKB)IEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9032845Activated NTRK2 signals through CDK5IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26384852Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry. (2015 Nov)Levran OCNS Neurosci Ther