Gene: AKAP4

8852
AKAP 82|AKAP-4|AKAP82|CT99|FSC1|HI|PRKA4|hAKAP82|p82
A-kinase anchoring protein 4
protein-coding
Xp11.22
Ensembl:ENSG00000147081 MIM:300185 Vega:OTTHUMG00000021517 UniprotKB:Q5JQC9
NG_012552.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRM20.629
TNP10.608
PRM10.605
BOD1L20.578
TUBA3C0.558
UBQLN30.557
C3orf300.494
SPATA80.493
ACTL7A0.477
ORM10.455

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTRB2-0.206
C1QTNF9-0.203
HIST1H4K-0.201
RPSAP58-0.2
FGF6-0.196
PRSS1-0.191
CPA1-0.187
DIAPH2-0.187
REG1A-0.18
OR2T6-0.178

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AKAP4 mRNA"19114083
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AKAP4 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of AKAP4 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AKAP4 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of AKAP4 mRNA25181051
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKAP4 mRNA17942748
D017313FenretinideFenretinide results in decreased expression of AKAP4 mRNA28973697
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of AKAP4 protein19854247
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of AKAP4 mRNA19854247
D012969Sodium FluorideSodium Fluoride results in increased expression of AKAP4 protein28918527
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKAP4 mRNA17942748
D014635Valproic AcidValproic Acid results in decreased methylation of AKAP4 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of AKAP4 gene25560391
C025643vinclozolinvinclozolin results in increased expression of AKAP4 protein20616205

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0051018protein kinase A binding-IBA21873635  
GO:0051018protein kinase A binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS9822690  
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway-IEA-  
GO:0007338single fertilization-TAS9822690  
GO:0010738regulation of protein kinase A signaling-IBA21873635  
GO:0030317flagellated sperm motility-IMP9822690  
GO:0044458motile cilium assembly-IEA-  
GO:0045184establishment of protein localization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005737cytoplasm-IBA21873635  
GO:0005856cytoskeleton-TAS9822690  
GO:0005952cAMP-dependent protein kinase complex-NAS9822690  
GO:0030018Z disc-IEA-  
GO:0031514motile cilium-IDA9822690  
GO:0035686sperm fibrous sheath-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0097228sperm principal piece-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27148411Expression and clinical significance of A-kinase anchor protein 4 in lung adenocarcinoma tissue. (2016 Apr 26)Li HMThorac Cancer
26160834AKAP4 is a circulating biomarker for non-small cell lung cancer. (2015 Jul 10)Gumireddy KOncotarget