Gene: STK19

8859
D6S60|D6S60E|G11|HLA-RP1|RP1
serine/threonine kinase 19
protein-coding
6p21.33
Ensembl:ENSG00000204344 MIM:604977 Vega:OTTHUMG00000166424 UniprotKB:P49842
NC_000006.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs389883chr6:31979683 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs386480chr6:31979060 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MOGS0.891
DDX19A0.888
VCP0.884
KDM1A0.884
SEC24C0.883
TMUB20.883
PSMD30.882
ACAD80.882
HDAC30.881
NPLOC40.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.597
OR4F29-0.553
MTRNR2L9-0.396
MTRNR2L6-0.369
MTRNR2L10-0.348
KLRB1-0.308
MTRNR2L2-0.304
OR4F16-0.298
P2RY14-0.292
TTLL10-AS1-0.271

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of STK19 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of STK19 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of STK19 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of STK19 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of STK19 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STK19 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STK19 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of STK19 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of STK19 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of STK19 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of STK19 promoter22457795
D016572CyclosporineCyclosporine results in increased expression of STK19 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of STK19 mRNA19770486
C000944dicrotophosdicrotophos results in decreased expression of STK19 mRNA28302478
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of STK19 mRNA23649840
C410337K 7174K 7174 results in increased expression of STK19 mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of STK19 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of STK19 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of STK19 mRNA23649840
C029938nickel sulfatenickel sulfate results in increased expression of STK19 mRNA18651567
D010936Plant ExtractsPlant Extracts results in increased expression of STK19 mRNA23557933
D012822Silicon DioxideSilicon Dioxide results in increased expression of STK19 mRNA23221170
C017947sodium arsenitesodium arsenite results in increased expression of STK19 mRNA22714537
C016104sodium bichromatesodium bichromate results in increased expression of STK19 mRNA25993096
D014284TriiodothyronineTriiodothyronine results in increased expression of STK19 mRNA23397585
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STK19 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to STK19 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STK19 mRNA19770486
D019284ThapsigarginThapsigargin results in increased expression of STK19 mRNA22378314
C012589trichostatin Atrichostatin A results in increased expression of STK19 mRNA15901671
D014415TunicamycinTunicamycin results in increased expression of STK19 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of STK19 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of STK19 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of STK19 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of STK19 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of STK19 mRNA15901671
C025643vinclozolinvinclozolin results in increased expression of STK19 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-TAS9812991  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS9812991  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal