Gene: CCKAR

886
CCK-A|CCK1-R|CCK1R|CCKRA
cholecystokinin A receptor
protein-coding
4p15.2
Ensembl:ENSG00000163394 MIM:118444 Vega:OTTHUMG00000128567 UniprotKB:P32238
NG_012053.1
PubMed
0   ANCO-SNPs
AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.403e-1 (AD)  6.251e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARNTL20.522
RALGPS20.493
BCAT10.484
HTR70.481
MCTP20.479
TMEM2330.478
CDH70.477
TPH20.475
TLL10.47
CLMP0.469

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACOX2-0.397
PLIN4-0.395
FOXJ1-0.37
BBOX1-0.367
C16orf74-0.367
FAM181A-0.356
CLDN10-0.352
PHYHD1-0.351
SMO-0.351
CDKN2C-0.349

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00403CeruletideSmall Molecule17650-98-5ApprovedTarget
DB04856DexloxiglumideSmall Molecule119817-90-2InvestigationalTarget
DB04867LintitriptSmall Molecule136381-85-6InvestigationalTarget
DB08862CholecystokininSmall Molecule9011-97-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of CCKAR mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of CCKAR mRNA"19162173
C5684602-(2-((1H-indole-2-carbonyl)amino)benzoylamino)-4-phenylbutyric acid2-(2-((1H-indole-2-carbonyl)amino)benzoylamino)-4-phenylbutyric acid inhibits the reaction [Bolton Hunter-cholecystokinin nonapeptide binds to CCKAR protein]21728335
C5684602-(2-((1H-indole-2-carbonyl)amino)benzoylamino)-4-phenylbutyric acid2-(2-((1H-indole-2-carbonyl)amino)benzoylamino)-4-phenylbutyric acid binds to CCKAR protein21728335
C0115144-nitrobenzofurazan[Cholecystokinin analog binds to 4-nitrobenzofurazan] which binds to and results in increased activity of CCKAR protein16779661
C0005895965-benzo(1,3)dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazole-3-carbaldehyde"5-benzo(1,3)dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazole-3-carbaldehyde analog binds to and results in decreased activity of CCKAR protein"20977279
C0900198-sulfocholecystokinin octapeptide8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein24630973
C0900198-sulfocholecystokinin octapeptideGallic Acid inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]24630973
C0900198-sulfocholecystokinin octapeptidekaempferol inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]24630973
C0900198-sulfocholecystokinin octapeptidePlant Extracts inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]24630973
C0900198-sulfocholecystokinin octapeptideQuercetin inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]24630973
C0900198-sulfocholecystokinin octapeptideresveratrol inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]24630973
C0900198-sulfocholecystokinin octapeptide8-sulfocholecystokinin octapeptide binds to CCKAR protein21728335
C095427A 86929A 86929 binds to CCKAR protein8558425
C038518acrylodan[Cholecystokinin analog binds to acrylodan] which binds to and results in increased activity of CCKAR protein16779661
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of CCKAR mRNA19920212
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CCKAR mRNA16483693
D001151ArsenicArsenic affects the methylation of CCKAR gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCKAR mRNA22316170
D004958EstradiolEstradiol results in increased expression of CCKAR mRNA26789235|2770260
C006780bisphenol Abisphenol A results in increased expression of CCKAR mRNA26789235|2770260
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of CCKAR mRNA]26789235
C006780bisphenol Abisphenol A results in decreased expression of CCKAR mRNA25181051
D001761BleomycinBleomycin results in decreased expression of CCKAR mRNA15808516
C055121Bolton Hunter-cholecystokinin nonapeptide2-(2-((1H-indole-2-carbonyl)amino)benzoylamino)-4-phenylbutyric acid inhibits the reaction [Bolton Hunter-cholecystokinin nonapeptide binds to CCKAR protein]21728335
C055121Bolton Hunter-cholecystokinin nonapeptideBolton Hunter-cholecystokinin nonapeptide binds to CCKAR protein21728335
C055121Bolton Hunter-cholecystokinin nonapeptideVL-0395 inhibits the reaction [Bolton Hunter-cholecystokinin nonapeptide binds to CCKAR protein]21728335
C034532camostatcamostat results in increased expression of CCKAR mRNA10458643
D002766Cholecystokinin[Cholecystokinin analog binds to 4-nitrobenzofurazan] which binds to and results in increased activity of CCKAR protein16779661
D002766Cholecystokinin[Cholecystokinin analog binds to acrylodan] which binds to and results in increased activity of CCKAR protein16779661
D002766CholecystokininCholecystokinin binds to CCKAR protein18700727
C049128cholecystokinin pentapeptidecholecystokinin pentapeptide binds to and results in increased activity of CCKAR protein9922984
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of CCKAR mRNA26033743
D003300CopperCopper deficiency results in increased expression of CCKAR mRNA26033743
D016572CyclosporineCyclosporine results in increased methylation of CCKAR promoter27989131
D020109DevazepideDevazepide inhibits the reaction [CCKAR protein results in increased susceptibility to ]18003792
D020109DevazepideDevazepide binds to and results in decreased activity of CCKAR protein7524350
D020109DevazepideDevazepide binds to CCKAR protein21728335
C103490dexloxiglumidedexloxiglumide binds to and results in decreased activity of CCKAR protein17138722|1830307
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CCKAR mRNA15620428
D004041Dietary FatsDietary Fats results in increased expression of CCKAR mRNA18721800
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of CCKAR mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of CCKAR mRNA26033743
D005419FlavonoidsFlavonoids results in increased expression of CCKAR mRNA18035473
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of CCKAR mRNA]26789235
C070081fulvestrantfulvestrant inhibits the reaction [isoliquiritigenin results in increased expression of CCKAR mRNA]27702603
D005707Gallic AcidGallic Acid inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]24630973
C412815GW 4064GW 4064 results in increased expression of CCKAR mRNA26655953
C040920isoliquiritigeninfulvestrant inhibits the reaction [isoliquiritigenin results in increased expression of CCKAR mRNA]27702603
C040920isoliquiritigeninisoliquiritigenin results in increased expression of CCKAR mRNA27702603
C006552kaempferolkaempferol inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]24630973
C008261lead acetatelead acetate results in decreased expression of CCKAR mRNA22613225
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CCKAR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CCKAR mRNA"25554681
D010852PicrotoxinPicrotoxin results in increased expression of CCKAR mRNA15170462
C006253pirinixic acidpirinixic acid results in increased expression of CCKAR mRNA20813756
D010936Plant ExtractsPlant Extracts inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]24630973
D011794QuercetinQuercetin inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]24630973
C059514resveratrolresveratrol inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]24630973
C541923sandostatinLARsandostatinLAR results in decreased expression of CCKAR mRNA17210224
D053260SootSoot results in decreased expression of CCKAR mRNA26551751
C080460SR 27897SR 27897 binds to and results in decreased activity of CCKAR protein24385417
D013449SulfonamidesSulfonamides analog binds to and results in decreased activity of CCKAR protein19811913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CCKAR protein15716480
C009495titanium dioxidetitanium dioxide results in increased expression of CCKAR mRNA23557971
D014635Valproic AcidValproic Acid results in increased methylation of CCKAR gene29154799
D014635Valproic AcidValproic Acid affects the expression of CCKAR mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CCKAR gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of CCKAR mRNA26682919
C492564VL-0395VL-0395 inhibits the reaction [Bolton Hunter-cholecystokinin nonapeptide binds to CCKAR protein]21728335
C492564VL-0395VL-0395 binds to and results in decreased activity of CCKAR protein21728335

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004951cholecystokinin receptor activity-IBA21873635  
GO:0004951cholecystokinin receptor activity-IDA8503909  
GO:0017046peptide hormone binding-IPI8503909  
GO:0042277peptide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-TAS8343165  
GO:0007409axonogenesis-IEA-  
GO:0007631feeding behavior-IBA21873635  
GO:0030900forebrain development-IEA-  
GO:0032870cellular response to hormone stimulus-IBA21873635  
GO:0038188cholecystokinin signaling pathway-IDA8503909  
GO:0046883regulation of hormone secretion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8343165  
GO:0016020membrane-IDA8503909  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04972Pancreatic secretion
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12198366Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (2002 Aug)Okubo TAlcohol Clin Exp Res
11513220Polymorphisms of the CCK, CCKAR and CCKBR genes: an association with alcoholism study. (2001 Jul)Okubo TJ Stud Alcohol
26608796Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort. (2015 Dec)Norden-Krichmar TMTwin Res Hum Genet