Gene: PER3

8863
FASPS3|GIG13
period circadian regulator 3
protein-coding
1p36.23
Ensembl:ENSG00000049246 MIM:603427 Vega:OTTHUMG00000001216 UniprotKB:P56645
NG_046850.1
PubMed
0   ANCO-SNPs
ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.979e-1 (AD)  6.064e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08764927chr1:7844895PER3Promoter1.246e-5Alcohol use disorders26763658
cg25514503chr1:7845070PER3Gene body2.729e-4Alcohol use disorders26763658
cg24454741chr1:7845237PER3Gene body5.585e-4Alcohol use disorders26763658
cg11978441chr1:7902772PER33.570e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLITRK20.75
ABLIM10.749
NADK20.741
WASF30.734
KDM3B0.734
BBS20.734
ZHX30.732
ALDH5A10.731
ADH50.727
ADCYAP1R10.724

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.579
OR4F29-0.563
FCER2-0.361
DCSTAMP-0.307
PPBP-0.307
TMEM236-0.28
SCP2D1-0.278
OR5D18-0.278
GSDMA-0.274
IL1F10-0.273

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PER3 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of PER3 mRNA"28903501
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of PER3 mRNA"21920950
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER3 mRNA"28433925
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PER3 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PER3 mRNA"23196670
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of PER3 mRNA18544908
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PER3 mRNA21420995
D000082AcetaminophenAcetaminophen results in decreased expression of PER3 mRNA18544908
D020106AcrylamideAcrylamide results in decreased expression of PER3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PER3 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PER3 mRNA23630614
D000447AldehydesAldehydes results in decreased expression of PER3 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PER3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PER3 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of PER3 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of PER3 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER3 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER3 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PER3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PER3 mRNA26001963
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER3 mRNA27858113
C006780bisphenol Abisphenol A affects the expression of PER3 mRNA21786754
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER3 mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of PER3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PER3 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of PER3 mRNA26079696
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PER3 mRNA20360939
C026690cerous chloridecerous chloride results in increased expression of PER3 mRNA23573234
D002737ChloropreneChloroprene results in increased expression of PER3 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PER3 mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER3 mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of PER3 mRNA27858113
D003042CocaineCocaine affects the expression of PER3 mRNA17622340
D003042CocaineMelatonin affects the reaction [Cocaine affects the expression of PER3 mRNA]17622340
D003042CocaineCocaine promotes the reaction [NPAS2 protein binds to PER3 promoter]23776671
D003042CocaineCocaine results in increased expression of PER3 mRNA15994025|2377667
D003042CocaineCocaine results in increased expression of PER3 protein23776671
D003471CuprizoneCuprizone results in increased expression of PER3 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of PER3 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PER3 mRNA17361019|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PER3 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PER3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PER3 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of PER3 mRNA28302478
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PER3 mRNA]"19467301
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of PER3 mRNA28433925
D004041Dietary FatsDietary Fats results in increased expression of PER3 mRNA19467301
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of PER3 mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER3 mRNA"28433925
C014476diethyl maleatediethyl maleate results in decreased expression of PER3 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PER3 mRNA20360939
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PER3 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of PER3 mRNA19167457
C039281furanfuran results in increased expression of PER3 mRNA25539665
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of PER3 mRNA19695318
D017313FenretinideFenretinide results in decreased expression of PER3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PER3 mRNA26846883
D007545IsoproterenolIsoproterenol results in decreased expression of PER3 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PER3 mRNA27392435
D007854LeadLead results in decreased expression of PER3 mRNA19921347
D008550MelatoninMelatonin affects the reaction [Cocaine affects the expression of PER3 mRNA]17622340
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PER3 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of PER3 mRNA24449571
D008752Methylene ChlorideMethylene Chloride results in increased expression of PER3 mRNA28392392
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PER3 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of PER3 mRNA22129749
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PER3 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PER3 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of PER3 promoter"26251327
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of PER3 mRNA22401849
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PER3 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PER3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PER3 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of PER3 mRNA25583101
C005290oxybenzoneoxybenzone results in decreased expression of PER3 mRNA22721600
C046012pentanalpentanal results in decreased expression of PER3 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PER3 mRNA17560707
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of PER3 mRNA26678675
D010634PhenobarbitalPhenobarbital results in increased expression of PER3 mRNA19084549
D010634PhenobarbitalPhenobarbital affects the expression of PER3 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PER3 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of PER3 mRNA17426115
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of PER3 mRNA23147375
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of PER3 mRNA19695318
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PER3 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PER3 mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of PER3 mRNA21795739
C005556propionaldehydepropionaldehyde results in decreased expression of PER3 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of PER3 mRNA24780913
D012312RitodrineRitodrine results in increased expression of PER3 mRNA23370008
D012643SeleniumSelenium results in decreased expression of PER3 mRNA19244175
C002979selenomethylselenocysteineselenomethylselenocysteine results in increased expression of PER3 mRNA19122877
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PER3 mRNA25895662
D012834SilverSilver results in increased expression of PER3 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of PER3 mRNA21795629
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary deficiency affects the reaction [[PER2 protein co-treated with PER1 protein co-treated with PER3 protein] affects the expression of REN mRNA]"26781276
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary deficiency affects the reaction [[PER2 protein co-treated with PER1 protein co-treated with PER3 protein] affects the expression of REN protein]"26781276
D018038Sodium SeleniteSodium Selenite results in decreased expression of PER3 mRNA18175754
D053260SootSoot results in decreased expression of PER3 mRNA26551751
D020058StyreneStyrene results in increased expression of PER3 mRNA28951217
D013739TestosteroneTestosterone results in decreased expression of PER3 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PER3 mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER3 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PER3 mRNA21215274|2280813
D013853ThioacetamideThioacetamide results in increased expression of PER3 mRNA23411599
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of PER3 mRNA24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PER3 mRNA20133372
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PER3 gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PER3 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PER3 mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of PER3 mRNA22378314
D014520UrethaneUrethane results in decreased expression of PER3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PER3 mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of PER3 mRNA17963808
D014638VanadatesVanadates results in increased expression of PER3 mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of PER3 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of PER3 mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of PER3 mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of PER3 mRNA"24525044
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of PER3 mRNA"23246600
D015032ZincZinc deficiency results in decreased expression of PER3 mRNA18356318
D019287Zinc SulfateZinc Sulfate results in decreased expression of PER3 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000989transcription factor activity, transcription factor binding-IBA21873635  
GO:0001222transcription corepressor binding-IBA21873635  
GO:0005515protein binding-IPI21070773  
GO:0008134transcription factor binding-IBA21873635  
GO:0019900kinase binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IDA26903630  
GO:0006351transcription, DNA-templated-IEA-  
GO:0009416response to light stimulus-IBA21873635  
GO:0032922circadian regulation of gene expression-IBA21873635  
GO:0032922circadian regulation of gene expression-IEA-  
GO:0043153entrainment of circadian clock by photoperiod-IBA21873635  
GO:0045187regulation of circadian sleep/wake cycle, sleep-IMP17346965  19716732  24439663  24577121  26903630  
GO:0050821protein stabilization-IMP26903630  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA26903630  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA26903630  
KEGG ID KEGG Term
hsa04710Circadian rhythm
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26512752Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV. (2015)Lee KAChronobiol Int
29144171Circadian gene methylation in rotating-shift nurses: a cross-sectional study. (2018 Jan)Reszka EChronobiol Int
25187986Nightshift work and genome-wide DNA methylation. (2015 Feb)Bhatti PChronobiol Int
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One
17992597Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction. (2007 Aug)Esquifino AIEndocrine
22467995PER3 polymorphism and insomnia severity in alcohol dependence. (2012 Apr 1)Brower KJSleep
20205566Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. (2010 Jan)Ando HChronobiol Int
22832735A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. (2012 Jan 31)Wang XTransl Psychiatry