Gene info: ID 8864

Gene: PER2

GENE ID: 8864

Synonyms: FASPS|FASPS1

Description: period circadian regulator 2

Gene type: protein-coding

Location: 2q37.3

dbXrefs: Ensembl:ENSG00000132326 MIM:603426 Vega:OTTHUMG00000152884 UniprotKB:O15055

RefSeq: NG_012146.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 14

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.982e-2 (AD) 6.838e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DUSP4	0.755
SPRED2	0.725
DUSP6	0.72
ETV5	0.719
SLC20A1	0.679
OSBPL3	0.679
ZBTB21	0.671
SLC25A25	0.658
FRMD4A	0.652
TRIB2	0.65

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.402
OR4F29	-0.355
S100A4	-0.325
CTNNA3	-0.32
TNFRSF10C	-0.315
AZGP1	-0.309
NFE2	-0.308
CCR2	-0.305
MYL3	-0.295
CSAG1	-0.291

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of PER2 mRNA"	26377693
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of PER2 mRNA"	19162173
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PER2 mRNA"	21354444\|2890350
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of PER2 mRNA	28329830
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PER2 mRNA"	20056577
C061282	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in decreased expression of PER2 mRNA	22923002
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER2 mRNA"	28433925
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of PER2 mRNA"	20406850
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of PER2 mRNA"	20206263
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PER2 mRNA]"	19467301
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER2 mRNA"	27188386
C043877	acamprosate	PER2 affects the susceptibility to acamprosate	21697518
D000082	Acetaminophen	Acetaminophen results in decreased expression of PER2 mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of PER2 mRNA	17562736
D020106	Acrylamide	Acrylamide results in decreased expression of PER2 mRNA	28606764
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of PER2 mRNA	21757418
D000447	Aldehydes	Aldehydes results in decreased expression of PER2 mRNA	25014914
D000602	Amino Acids, Peptides, and Proteins	"PER2 affects the uptake of Amino Acids, Peptides, and Proteins"	15608650
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PER2 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of PER2 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of PER2 mRNA	20458559\|2670570
D001280	Atrazine	Atrazine results in decreased expression of PER2 mRNA	25929836
D001507	Beclomethasone	Beclomethasone results in increased expression of PER2 mRNA	23656298
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of PER2 mRNA	26377693
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER2 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER2 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of PER2 mRNA	26377693
C041512	benzo(b)fluorene	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of PER2 mRNA	22120849
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PER2 mRNA	18164116
D053119	Benzophenanthridines	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of PER2 mRNA	22120849
D053119	Benzophenanthridines	Benzophenanthridines analog results in increased expression of PER2 mRNA	22120849
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the splicing of PER2 exon	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PER2 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PER2 mRNA	22209252
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER2 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PER2 mRNA	20127859
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PER2 mRNA	21569818\|2261060
D004958	Estradiol	Estradiol results in decreased expression of PER2 mRNA	18728223
D004958	Estradiol	Estradiol results in increased expression of PER2 mRNA	19484750
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of PER2 mRNA	20096720
D004958	Estradiol	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of PER2 mRNA]	18728223
C095105	bexarotene	bexarotene results in decreased expression of PER2 mRNA	17178900
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PER2 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of PER2 mRNA	21786754
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PER2 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of PER2 mRNA	24726801
C006780	bisphenol A	bisphenol A results in increased expression of PER2 mRNA	21932408\|2559470
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER2 mRNA"	28433925
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in decreased expression of PER2 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of PER2 mRNA	25181051
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in increased expression of PER2 mRNA	19925653
C018475	butyraldehyde	butyraldehyde results in decreased expression of PER2 mRNA	26079696
D002104	Cadmium	Cadmium results in decreased expression of PER2 mRNA	24284285
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of PER2	23085516
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of PER2 mRNA	20107868\|2144200
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PER2 mRNA	17590544\|2599309
D019256	Cadmium Chloride	Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER2 mRNA]	17590544
D002211	Capsaicin	Capsaicin results in increased expression of PER2 mRNA	24746025
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of PER2 mRNA	17484886
D002737	Chloroprene	Chloroprene results in increased expression of PER2 mRNA	23125180
D002737	Chloroprene	Chloroprene results in increased expression of PER2 mRNA	23125180
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of PER2 mRNA	21356183
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER2 mRNA	27858113
D003033	Coal Tar	Coal Tar results in decreased expression of PER2 mRNA	27858113
D003042	Cocaine	Cocaine affects the expression of PER2 mRNA	15994025
D003042	Cocaine	Cocaine promotes the reaction [NPAS2 protein binds to PER2 promoter]	23776671
D003042	Cocaine	Cocaine results in increased expression of PER2 mRNA	20056891\|2377667
D003042	Cocaine	Cocaine results in increased expression of PER2 protein	23776671
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of PER2 mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of PER2 mRNA	27523638
D003474	Curcumin	Curcumin results in increased expression of PER2 mRNA	17198877
D016572	Cyclosporine	Cyclosporine results in decreased methylation of PER2 promoter	27989131
D016047	Zalcitabine	"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of PER2 mRNA"	18606552
D013759	Dronabinol	Dronabinol results in increased expression of PER2 mRNA	16616335
D003907	Dexamethasone	Dexamethasone affects the expression of PER2 mRNA	23251369
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PER2 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PER2 mRNA	28628672
D003907	Dexamethasone	Dexamethasone affects the expression of PER2 mRNA	18787022
D003907	Dexamethasone	Dexamethasone results in increased expression of PER2 mRNA	22733784
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PER2 mRNA	21266533
C000944	dicrotophos	dicrotophos results in increased expression of PER2 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of PER2 mRNA	26924002
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PER2 mRNA]"	19467301
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of PER2 mRNA	28433925
D004041	Dietary Fats	Dietary Fats results in increased expression of PER2 mRNA	19467301
D004041	Dietary Fats	Dietary Fats results in increased expression of PER2 mRNA	23537522
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of PER2 mRNA	28433925
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER2 mRNA"	28433925
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of PER2 mRNA	28871463
C014476	diethyl maleate	diethyl maleate results in decreased expression of PER2 mRNA	21161181
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PER2 mRNA	18164116
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of PER2 mRNA	19638242
D002117	Calcitriol	Calcitriol results in increased expression of PER2 mRNA	26485663
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of PER2 mRNA	26924002
D004237	Diuron	Diuron metabolite results in decreased expression of PER2 mRNA	24172598
C118739	entinostat	entinostat results in decreased expression of PER2 mRNA	27188386
C062669	epicatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER2 mRNA]	29061316
C045651	epigallocatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER2 mRNA]	29061316
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PER2 mRNA	22079256
D000431	Ethanol	PER2 gene SNP affects the susceptibility to Ethanol	23533602
D000431	Ethanol	Ethanol results in increased expression of PER2 mRNA	29018328
C000499	ferric oxide	ferric oxide analog results in increased expression of PER2 mRNA	25086211
D005419	Flavonoids	Flavonoids results in decreased expression of PER2 mRNA	18035473
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of PER2 mRNA	28329830
D005472	Fluorouracil	Fluorouracil results in decreased expression of PER2 mRNA	18329632
D005473	Fluoxetine	Fluoxetine affects the expression of PER2 mRNA	15994025
D005557	Formaldehyde	Formaldehyde results in decreased expression of PER2 mRNA	20655997
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of PER2 mRNA	20846436
C069837	fullerene C60	fullerene C60 results in increased expression of PER2 mRNA	19167457
C408042	fullerol C60(OH)24	fullerol C60(OH)24 results in decreased expression of PER2 mRNA	21513982
C039281	furan	furan results in decreased expression of PER2 mRNA	26194646
C039281	furan	furan results in increased expression of PER2 mRNA	25539665
D005707	Gallic Acid	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER2 mRNA]	29061316
C057580	gallocatechol	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER2 mRNA]	29061316
D005839	Gentamicins	Gentamicins results in decreased expression of PER2 mRNA	22061828
C514793	gp120 protein, Human immunodeficiency virus 1	"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of PER2 mRNA"	18606552
D017313	Fenretinide	Fenretinide results in decreased expression of PER2 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of PER2 mRNA	26846883
D006861	Hydrogen Peroxide	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER2 mRNA]	29061316
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PER2 mRNA	20044591\|2906131
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PER2 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PER2 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PER2 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PER2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PER2 mRNA	28628672
C045463	leflunomide	leflunomide results in increased expression of PER2 mRNA	24136188
D001556	Lindane	Lindane results in decreased expression of PER2 mRNA	17785943
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles results in increased expression of PER2 mRNA	24525745
C025340	manganese chloride	manganese chloride results in decreased expression of PER2 mRNA	28511934
D008550	Melatonin	Melatonin affects the expression of PER2 mRNA	21442002
D008550	Melatonin	Melatonin affects the reaction [Rotenone affects the expression of PER2 mRNA]	25430725
D008550	Melatonin	Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER2 mRNA]	17590544
D008694	Methamphetamine	Methamphetamine results in increased expression of PER2 mRNA	15542705\|1595075
D008694	Methamphetamine	Methamphetamine results in increased expression of PER2 protein	15542705\|1595075
D008694	Methamphetamine	Methamphetamine results in increased expression of PER2 mRNA	19564919
D008727	Methotrexate	PER2 protein affects the susceptibility to Methotrexate	16217747
D008727	Methotrexate	Methotrexate affects the expression of PER2 mRNA	18502557
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of PER2 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PER2 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PER2 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PER2 mRNA"	20188158
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of PER2 mRNA	24128854
C059539	midostaurin	midostaurin results in decreased expression of PER2 mRNA	20980353
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of PER2 mRNA	22401849
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of PER2 mRNA	26924002
D009020	Morphine	PER2 protein affects the susceptibility to Morphine	20434889
D009020	Morphine	Morphine affects the expression of PER2 mRNA	19383088
C554954	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of PER2 mRNA	28174063
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PER2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PER2 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PER2 mRNA"	25554681\|2562005
D009638	Norepinephrine	Norepinephrine results in increased expression of PER2 mRNA	12729908
D009966	Orphenadrine	Orphenadrine affects the expression of PER2 mRNA	23665939
D010126	Ozone	Ozone results in increased expression of PER2 mRNA	17095637\|2154328
D052638	Particulate Matter	Particulate Matter results in decreased expression of PER2 mRNA	22178795
C046012	pentanal	pentanal results in decreased expression of PER2 mRNA	26079696
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PER2 mRNA	19162173
D010634	Phenobarbital	Phenobarbital affects the expression of PER2 mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in increased expression of PER2 mRNA	19084549
D010634	Phenobarbital	Phenobarbital results in decreased expression of PER2 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of PER2 mRNA	19270015
D010634	Phenobarbital	Phenobarbital results in decreased expression of PER2 mRNA	19162173
D019800	Phenol	Phenol results in increased expression of PER2 mRNA	17547211
D010656	Phenylephrine	U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER2 mRNA]	12729908
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of PER2 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in decreased expression of PER2 mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of PER2 mRNA	20813756\|2381119
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PER2 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of PER2 mRNA	22079256
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of PER2 mRNA	23608068
D011239	Prednisolone	Prednisolone results in decreased expression of PER2 mRNA	16269518
D011239	Prednisolone	Prednisolone results in decreased expression of PER2 mRNA	16269518
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of PER2 mRNA	28903501
D011374	Progesterone	Progesterone results in increased expression of PER2 mRNA	20096720
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of PER2 mRNA	20096720
D011374	Progesterone	Progesterone results in decreased expression of PER2 mRNA	20726854
C005556	propionaldehyde	propionaldehyde results in decreased expression of PER2 mRNA	26079696
D011794	Quercetin	Quercetin results in decreased expression of PER2 mRNA	18095365
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of PER2 mRNA]	18728223
C447880	retene	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of PER2 mRNA	22120849
D012402	Rotenone	Melatonin affects the reaction [Rotenone affects the expression of PER2 mRNA]	25430725
D012402	Rotenone	Rotenone affects the expression of PER2 mRNA	25430725
C002979	selenomethylselenocysteine	selenomethylselenocysteine results in increased expression of PER2 mRNA	19122877
C009250	sevoflurane	sevoflurane affects the expression of PER2 mRNA	15967596
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of PER2 mRNA	25895662
D012906	Smoke	Smoke results in decreased expression of PER2 mRNA	21095227
D012906	Smoke	Smoke affects the expression of PER2 mRNA	23693141
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary deficiency affects the reaction [[PER2 protein co-treated with PER1 protein co-treated with PER3 protein] affects the expression of REN mRNA]"	26781276
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary deficiency affects the reaction [[PER2 protein co-treated with PER1 protein co-treated with PER3 protein] affects the expression of REN protein]"	26781276
D018038	Sodium Selenite	Sodium Selenite results in increased expression of PER2 mRNA	18175754
D012999	Soman	Soman results in decreased expression of PER2 mRNA	19281266
D053260	Soot	Soot results in decreased expression of PER2 mRNA	26551751
D020058	Styrene	Styrene results in increased expression of PER2 mRNA	28951217
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of PER2 mRNA	22281776
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in decreased expression of PER2 mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PER2 mRNA	20055451
D013749	Tetrachlorodibenzodioxin	PER2 affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]	20371273
D013749	Tetrachlorodibenzodioxin	PER2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]	19038280
D013749	Tetrachlorodibenzodioxin	PER2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]	19038280
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PER2 mRNA	21182907\|2157046
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PER2 protein	21182907
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER2 mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PER2 mRNA	16556773
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PER2 mRNA	18295293\|1977048
D013749	Tetrachlorodibenzodioxin	AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in increased expression of PER2 mRNA]	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PER2 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PER2 mRNA	15358164\|1605489
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of PER2 mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PER2 mRNA	25613284
D013792	Thalidomide	Thalidomide results in increased expression of PER2 mRNA	28892372
D019284	Thapsigargin	Thapsigargin results in increased expression of PER2 mRNA	12729908
C009495	titanium dioxide	titanium dioxide results in decreased expression of PER2 mRNA	21513982
C009495	titanium dioxide	titanium dioxide results in decreased expression of PER2 mRNA	23557971
C483909	torcetrapib	torcetrapib results in increased expression of PER2 mRNA	23228038
D014212	Tretinoin	Tretinoin results in increased expression of PER2 mRNA	20530235
D014212	Tretinoin	Tretinoin results in increased expression of PER2 mRNA	17069763
C012589	trichostatin A	trichostatin A results in decreased expression of PER2 mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PER2 mRNA"	26179874
C113580	U 0126	U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER2 mRNA]	12729908
C406224	valdecoxib	valdecoxib results in decreased expression of PER2 mRNA	24136188
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of PER2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of PER2 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid affects the expression of PER2 mRNA	17292431\|1796380
D014635	Valproic Acid	Valproic Acid results in increased expression of PER2 mRNA	29229235
D014638	Vanadates	Vanadates results in increased expression of PER2 mRNA	22714537
C025643	vinclozolin	vinclozolin results in decreased expression of PER2 mRNA	23034163
D024483	Vitamin K 3	Vitamin K 3 affects the expression of PER2 mRNA	20044591
C111237	vorinostat	vorinostat results in decreased expression of PER2 mRNA	27188386
C111237	vorinostat	vorinostat affects the expression of PER2 mRNA	29229235
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of PER2 mRNA"	24525044

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000976	transcription regulatory region sequence-specific DNA binding	-	IBA	21873635
GO:0000976	transcription regulatory region sequence-specific DNA binding	-	ISS	-
GO:0000989	transcription factor activity, transcription factor binding	-	IBA	21873635
GO:0001222	transcription corepressor binding	-	IBA	21873635
GO:0003713	transcription coactivator activity	-	ISS	-
GO:0005515	protein binding	-	IPI	16790549 17218255 21179498 22274616
GO:0008134	transcription factor binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0002931	response to ischemia	-	ISS	-
GO:0005978	glycogen biosynthetic process	-	ISS	-
GO:0006094	gluconeogenesis	-	ISS	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006631	fatty acid metabolic process	-	ISS	-
GO:0007623	circadian rhythm	-	TAS	9427249
GO:0009416	response to light stimulus	-	IBA	21873635
GO:0019229	regulation of vasoconstriction	-	ISS	-
GO:0019249	lactate biosynthetic process	-	ISS	-
GO:0031397	negative regulation of protein ubiquitination	-	ISS	-
GO:0032922	circadian regulation of gene expression	-	IBA	21873635
GO:0032922	circadian regulation of gene expression	-	ISS	-
GO:0042752	regulation of circadian rhythm	-	ISS	-
GO:0042754	negative regulation of circadian rhythm	-	ISS	-
GO:0043153	entrainment of circadian clock by photoperiod	-	IBA	21873635
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	-
GO:0050767	regulation of neurogenesis	-	ISS	-
GO:0050796	regulation of insulin secretion	-	ISS	-
GO:0050872	white fat cell differentiation	-	ISS	-
GO:0051726	regulation of cell cycle	-	ISS	-
GO:0051946	regulation of glutamate uptake involved in transmission of nerve impulse	-	ISS	-
GO:0070345	negative regulation of fat cell proliferation	-	ISS	-
GO:0070932	histone H3 deacetylation	-	ISS	-
GO:0097167	circadian regulation of translation	-	ISS	-
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	-
GO:2000678	negative regulation of transcription regulatory region DNA binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	22274616
GO:0005634	nucleus	-	ISS	-
GO:0005730	nucleolus	-	IEA	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0048471	perinuclear region of cytoplasm	-	IEA	-

KEGG ID	KEGG Term
hsa04710	Circadian rhythm

Reactome ID	Reactome Term	Evidence
R-HSA-400253	Circadian Clock	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21929298	Circadian and acamprosate modulation of elevated ethanol drinking in mPer2 clock gene mutant mice. (2011 Oct)	Brager AJ	Chronobiol Int
26512752	Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV. (2015)	Lee KA	Chronobiol Int
20205566	Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. (2010 Jan)	Ando H	Chronobiol Int
25677407	Clock genes in human alcohol abuse and comorbid conditions. (2015 Jun)	Partonen T	Alcohol
29144171	Circadian gene methylation in rotating-shift nurses: a cross-sectional study. (2018 Jan)	Reszka E	Chronobiol Int
28296937	Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)	Lin E	PLoS One
17992597	Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction. (2007 Aug)	Esquifino AI	Endocrine
17106427	Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. (2006 Dec)	Malison RT	Psychiatr Genet
28776866	Prenatal androgen receptor activation determines adult alcohol and water drinking in a sex-specific way. (2018 May)	Huber SE	Addict Biol
22832851	Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. (2012 Mar 6)	Shumay E	Transl Psychiatry
23550834	Circadian clock period inversely correlates with illness severity in cells from patients with alcohol use disorders. (2013 Aug)	McCarthy MJ	Alcohol Clin Exp Res
27070740	The effect of chronic morphine or methadone exposure and withdrawal on clock gene expression in the rat suprachiasmatic nucleus and AA-NAT activity in the pineal gland. (2016 Jul 18)	Pacesova D	Physiol Res
22832735	A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. (2012 Jan 31)	Wang X	Transl Psychiatry
21130813	Protracted cocaine withdrawal produces circadian rhythmic alterations of phosphorylated GSK-3beta in reward-related brain areas in rats. (2011 Mar 17)	Wei YM	Behav Brain Res