Gene: ST3GAL5

8869
SATI|SIAT9|SIATGM3S|SPDRS|ST3Gal V|ST3GalV
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
protein-coding
2p11.2
Ensembl:ENSG00000115525 MIM:604402 Vega:OTTHUMG00000130171 UniprotKB:Q9UNP4
NG_012807.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.396e-1 (AD)  1.423e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OCIAD10.947
ATP6V1E10.945
PITHD10.945
YWHAZ0.945
DDX10.943
VDAC30.943
GSTA40.941
COPS30.941
REEP50.94
TOMM200.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.696
OR4F29-0.65
RUNX3-0.325
EVC2-0.319
CSAG1-0.318
CXCR2-0.313
MAGEA12-0.312
WDR38-0.312
CNN2-0.308
KCNJ15-0.308

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB0586799mTc-14 F7 MabBiotechDrug-InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ST3GAL5 mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ST3GAL5 mRNA19933214
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of ST3GAL5 mRNA28522335
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ST3GAL5 mRNA]"19467301
D000082AcetaminophenAcetaminophen results in decreased expression of ST3GAL5 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of ST3GAL5 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of ST3GAL5 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ST3GAL5 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ST3GAL5 mRNA19770486
D000452AldrinAldrin results in decreased expression of ST3GAL5 mRNA18579281
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ST3GAL5 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ST3GAL5 mRNA16483693
D001151ArsenicArsenic affects the methylation of ST3GAL5 gene25304211
C015001arsenitearsenite results in increased methylation of ST3GAL5 promoter23974009
D001554BenzeneBenzene results in increased expression of ST3GAL5 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ST3GAL5 mRNA19770486
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ST3GAL5 mRNA20660070
C006780bisphenol Abisphenol A affects the expression of ST3GAL5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ST3GAL5 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ST3GAL5 mRNA25181051
D002087ButyratesButyrates results in increased expression of ST3GAL5 mRNA15541394
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ST3GAL5 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ST3GAL5 mRNA27339419
D002922CiguatoxinsCiguatoxins affects the expression of ST3GAL5 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of ST3GAL5 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of ST3GAL5 mRNA18579281
D016572CyclosporineCyclosporine results in decreased expression of ST3GAL5 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of ST3GAL5 mRNA19770486
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ST3GAL5 mRNA26924002
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ST3GAL5 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of ST3GAL5 mRNA19467301|2803146
D002117CalcitriolCalcitriol results in decreased expression of ST3GAL5 mRNA26485663
C024629dimethyl phthalatedimethyl phthalate affects the expression of ST3GAL5 mRNA26924002
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased expression of ST3GAL5 mRNA19805517
D004281Docosahexaenoic AcidsPPARD protein promotes the reaction [Docosahexaenoic Acids results in increased expression of ST3GAL5 mRNA]19805517
D004317DoxorubicinST3GAL5 protein results in decreased susceptibility to Doxorubicin16571667
D005047EtoposideST3GAL5 protein results in decreased susceptibility to Etoposide16571667
D005230Fatty Acids, Nonesterified"Fatty Acids, Nonesterified promotes the reaction [PPARD protein binds to ST3GAL5 enhancer]"19805517
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of ST3GAL5 protein6331524
D005679G(M3) GangliosideST3GAL5 protein results in increased chemical synthesis of G(M3) Ganglioside16571667
C412815GW 4064GW 4064 results in increased expression of ST3GAL5 mRNA26655953
D017313FenretinideFenretinide results in increased expression of ST3GAL5 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of ST3GAL5 mRNA26191083
D007213IndomethacinIndomethacin results in decreased expression of ST3GAL5 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ST3GAL5 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ST3GAL5 mRNA24796395
C410337K 7174K 7174 results in increased expression of ST3GAL5 mRNA24086573
D007854LeadLead affects the expression of ST3GAL5 mRNA28903495
C045463leflunomideleflunomide results in increased expression of ST3GAL5 mRNA24136188
D008727MethotrexateMethotrexate affects the expression of ST3GAL5 mRNA18502557
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ST3GAL5 mRNA26924002
C523799MRK 003ST3GAL5 results in increased susceptibility to MRK 00319903844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of ST3GAL5 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ST3GAL5 mRNA"25102311
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ST3GAL5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ST3GAL5 mRNA"25620056
C025589ochratoxin Aochratoxin A results in increased acetylation of ST3GAL5 promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of ST3GAL5 promoter] which results in increased expression of ST3GAL5 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of ST3GAL5 mRNA29098329
C016030pantogabpantogab results in increased expression of ST3GAL5 mRNA17379144
D010416PentachlorophenolPentachlorophenol results in increased expression of ST3GAL5 mRNA23892564
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of ST3GAL5 mRNA28558994
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of ST3GAL5 mRNA28558994
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ST3GAL5 mRNA17681415|2855899
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ST3GAL5 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ST3GAL5 mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ST3GAL5 mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ST3GAL5 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ST3GAL5 mRNA18301758|1844570
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ST3GAL5 mRNA28903501
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ST3GAL5 mRNA20660070
C045950propiconazolepropiconazole results in decreased expression of ST3GAL5 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of ST3GAL5 mRNA26079696
C089730rosiglitazonerosiglitazone results in increased expression of ST3GAL5 mRNA21515302
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ST3GAL5 mRNA21427059
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of ST3GAL5 mRNA"24160326
D012999SomanSoman results in decreased expression of ST3GAL5 mRNA19281266
D013311StreptozocinStreptozocin results in increased expression of ST3GAL5 mRNA16684804
D013311Streptozocinvanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of ST3GAL5 mRNA]16684804
D013629TamoxifenTamoxifen affects the expression of ST3GAL5 mRNA20937368
C501413tesaglitazartesaglitazar results in increased expression of ST3GAL5 mRNA21515302
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of ST3GAL5 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ST3GAL5 mRNA19770486|1993321
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ST3GAL5 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ST3GAL5 mRNA28065790
D014212TretinoinTretinoin results in increased expression of ST3GAL5 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of ST3GAL5 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of ST3GAL5 mRNA28542535
C057693troglitazonetroglitazone results in increased expression of ST3GAL5 mRNA21515302
D014415TunicamycinTunicamycin results in decreased expression of ST3GAL5 mRNA22378314
D014635Valproic AcidValproic Acid results in increased expression of ST3GAL5 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of ST3GAL5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ST3GAL5 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased expression of ST3GAL5 mRNA21427059
D014638VanadatesVanadates results in increased expression of ST3GAL5 mRNA22714537
C034028vanadyl sulfatevanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of ST3GAL5 mRNA]16684804
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of ST3GAL5 mRNA19165385
C025643vinclozolinvinclozolin results in increased expression of ST3GAL5 mRNA23869203
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of ST3GAL5 mRNA18579281
C029297vinylidene chloridevinylidene chloride results in increased expression of ST3GAL5 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-IBA21873635  
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-TAS-  
GO:0004513neolactotetraosylceramide alpha-2,3-sialyltransferase activity-TAS9822625  
GO:0008373sialyltransferase activity-TAS10092602  
GO:0047291lactosylceramide alpha-2,3-sialyltransferase activity-IBA21873635  
GO:0047291lactosylceramide alpha-2,3-sialyltransferase activity-IDA9822625  
GO ID GO Term Qualifier Evidence PubMed
GO:0001574ganglioside biosynthetic process-NAS9822625  
GO:0005975carbohydrate metabolic process-TAS9822625  
GO:0006688glycosphingolipid biosynthetic process-TAS10092602  
GO:0097503sialylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-NAS9822625  
GO:0000139Golgi membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9822625  
GO:0016021integral component of membrane-TAS10092602  
KEGG ID KEGG Term
hsa00604Glycosphingolipid biosynthesis - ganglio series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4085001Sialic acid metabolismTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27704662Cigarette smoking alters sialylation in the Fallopian tube of women, with implications for the pathogenesis of ectopic pregnancy. (2016 Dec)Nio-Kobayashi JMol Reprod Dev