Gene: SGPL1

8879
NPHS14|S1PL|SPL
sphingosine-1-phosphate lyase 1
protein-coding
10q22.1
Ensembl:ENSG00000166224 MIM:603729 Vega:OTTHUMG00000018421 UniprotKB:O95470
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.906e-1 (AD)  4.591e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTDSP20.884
PHF20.871
KHNYN0.86
ABL10.843
MACF10.841
ARAF0.839
PPFIA10.835
PHF21A0.833
WWC30.833
ATF70.827

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.594
OR4F5-0.589
CRH-0.338
NMU-0.315
BHLHA9-0.295
MYOZ3-0.277
SMIM18-0.274
PPEF1-0.274
PPP1R17-0.271
FBLN7-0.268

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SGPL1 mRNA"21354444|2269881
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SGPL1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SGPL1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SGPL1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SGPL1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of SGPL1 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SGPL1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SGPL1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of SGPL1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SGPL1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SGPL1 mRNA16483693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of SGPL1 mRNA21632023
D004958Estradiol[Estradiol co-treated with EGF protein] results in decreased expression of SGPL1 mRNA24758408
D004958EstradiolEstradiol results in decreased expression of SGPL1 mRNA22467019
C006780bisphenol Abisphenol A affects the expression of SGPL1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SGPL1 mRNA25181051
C022990chromic chloridechromic chloride results in increased expression of SGPL1 mRNA12128095
C093628cyproconazolecyproconazole results in increased expression of SGPL1 mRNA22334560
D003976DiazinonDiazinon affects the expression of SGPL1 mRNA22546817
C016366dibenzothiophenedibenzothiophene results in decreased expression of SGPL1 mRNA23656968
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SGPL1 mRNA26924002
D004026DieldrinDieldrin affects the expression of SGPL1 mRNA22546817
D004041Dietary FatsDietary Fats results in decreased expression of SGPL1 mRNA18042831
C024629dimethyl phthalatedimethyl phthalate affects the expression of SGPL1 mRNA26924002
C109476epoxiconazoleepoxiconazole results in increased expression of SGPL1 mRNA22334560
C024565ethylene dichlorideethylene dichloride results in increased expression of SGPL1 mRNA28189721
C082360fipronilfipronil results in increased expression of SGPL1 mRNA23962444
D005839GentamicinsGentamicins results in increased expression of SGPL1 mRNA22061828
C492448ICG 001ICG 001 results in increased expression of SGPL1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SGPL1 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SGPL1 mRNA25613284
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of SGPL1 mRNA24694518
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SGPL1 mRNA26924002
C523799MRK 003SGPL1 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SGPL1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SGPL1 mRNA"25554681
C018620oleoresinsoleoresins results in increased expression of SGPL1 mRNA20008804
C053238onapristoneonapristone results in increased expression of SGPL1 mRNA17164439
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SGPL1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of SGPL1 mRNA24236059
D000073878Palm OilPalm Oil results in decreased expression of SGPL1 mRNA18042831
D010634PhenobarbitalPhenobarbital results in increased expression of SGPL1 mRNA19270015|1948288
D010936Plant ExtractsPlant Extracts results in increased expression of SGPL1 mRNA23557933
C045950propiconazolepropiconazole results in increased expression of SGPL1 mRNA21278054|2233456
C030984pyrenepyrene results in decreased expression of SGPL1 mRNA23656968
D012402RotenoneRotenone results in increased expression of SGPL1 mRNA23186747
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of SGPL1 mRNA21632023
C016104sodium bichromatesodium bichromate results in decreased expression of SGPL1 mRNA17685462
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SGPL1 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SGPL1 mRNA25975270
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of SGPL1 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SGPL1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SGPL1 mRNA25613284
D013849ThimerosalThimerosal results in increased expression of SGPL1 mRNA24675092
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SGPL1 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of SGPL1 mRNA28973697
C406224valdecoxibvaldecoxib results in increased expression of SGPL1 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SGPL1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SGPL1 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of SGPL1 mRNA26272509
C066075vanadium pentoxidevanadium pentoxide affects the expression of SGPL1 mRNA26210822
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SGPL1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21903422  
GO:0008117sphinganine-1-phosphate aldolase activity-IBA21873635  
GO:0008117sphinganine-1-phosphate aldolase activity-IDA14570870  24809814  
GO:0008117sphinganine-1-phosphate aldolase activity-IMP28165339  
GO:0008117sphinganine-1-phosphate aldolase activity-NAS11018465  
GO:0008117sphinganine-1-phosphate aldolase activity-TAS-  
GO:0016829lyase activity-IBA21873635  
GO:0016831carboxy-lyase activity-IEA-  
GO:0030170pyridoxal phosphate binding-IBA21873635  
GO:0030170pyridoxal phosphate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001553luteinization-IEA-  
GO:0001570vasculogenesis-IEA-  
GO:0001667ameboidal-type cell migration-IBA21873635  
GO:0001822kidney development-IEA-  
GO:0006631fatty acid metabolic process-IDA24809814  
GO:0006665sphingolipid metabolic process-IBA21873635  
GO:0006672ceramide metabolic process-IDA14570870  
GO:0007283spermatogenesis-IEA-  
GO:0008209androgen metabolic process-IEA-  
GO:0008210estrogen metabolic process-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0010761fibroblast migration-IEA-  
GO:0030097hemopoiesis-IEA-  
GO:0030148sphingolipid biosynthetic process-TAS-  
GO:0030149sphingolipid catabolic process-IBA21873635  
GO:0030149sphingolipid catabolic process-IDA24809814  
GO:0030149sphingolipid catabolic process-IMP28165339  
GO:0030149sphingolipid catabolic process-NAS11018465  
GO:0033327Leydig cell differentiation-IEA-  
GO:0040014regulation of multicellular organism growth-IEA-  
GO:0048008platelet-derived growth factor receptor signaling pathway-IEA-  
GO:0048705skeletal system morphogenesis-IEA-  
GO:0060021roof of mouth development-IEA-  
GO:0060325face morphogenesis-IEA-  
GO:0097190apoptotic signaling pathway-IDA14570870  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA14570870  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0030176integral component of endoplasmic reticulum membrane-NAS11018465  
KEGG ID KEGG Term
hsa00600Sphingolipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1660661Sphingolipid de novo biosynthesisTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26485657Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). (2015)Barnawi JPLoS One