Gene: ZPR1

8882
ZNF259
ZPR1 zinc finger
protein-coding
11q23.3
Ensembl:ENSG00000109917 MIM:603901 Vega:OTTHUMG00000046114 UniprotKB:O75312
NC_000011.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.877e-2 (AD)  7.484e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ZPR1 mRNA"22698814
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ZPR1 mRNA"25614096
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to ZPR1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ZPR1 protein]26598702
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ZPR1 gene27153756
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ZPR1 protein]26598702
D001280AtrazineAtrazine results in increased expression of ZPR1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZPR1 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of ZPR1 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZPR1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ZPR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ZPR1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ZPR1 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ZPR1 mRNA27339419
D002922CiguatoxinsCiguatoxins affects the expression of ZPR1 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in increased expression of ZPR1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of ZPR1 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of ZPR1 mRNA19789285
C029892cupric chloridecupric chloride results in increased expression of ZPR1 mRNA24650576
D016572CyclosporineCyclosporine results in increased expression of ZPR1 mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ZPR1 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZPR1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ZPR1 mRNA17361019
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ZPR1 mRNA21266533
C082360fipronilfipronil results in increased expression of ZPR1 mRNA23962444
D005485FlutamideFlutamide results in increased expression of ZPR1 mRNA24136188
C039281furanfuran results in increased expression of ZPR1 mRNA24183702
C039281furanfuran results in increased methylation of ZPR1 gene22079235
D005839GentamicinsGentamicins results in increased expression of ZPR1 mRNA22061828
C492448ICG 001ICG 001 results in increased expression of ZPR1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZPR1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZPR1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZPR1 mRNA28628672
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ZPR1 mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ZPR1 mRNA26924002
C051752nefazodonenefazodone results in increased expression of ZPR1 mRNA24136188
D009532NickelNickel results in increased expression of ZPR1 mRNA24768652
C012655nimesulidenimesulide results in increased expression of ZPR1 mRNA24136188
D010634PhenobarbitalPhenobarbital affects the expression of ZPR1 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of ZPR1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of ZPR1 mRNA19270015
C006253pirinixic acidpirinixic acid results in decreased expression of ZPR1 mRNA20813756|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of ZPR1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ZPR1 mRNA22714537
D012402RotenoneRotenone results in decreased expression of ZPR1 mRNA19013527
D012715Sesame OilSesame Oil results in increased expression of ZPR1 mRNA29191790
D012834SilverSilver results in decreased expression of ZPR1 mRNA27131904
D053260SootSoot results in increased expression of ZPR1 mRNA22461453
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZPR1 mRNA22903824
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZPR1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZPR1 mRNA25613284
D013893ThiramThiram results in increased expression of ZPR1 mRNA20530235
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZPR1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of ZPR1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZPR1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of ZPR1 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11283611  
GO:0008270zinc ion binding-IEA-  
GO:0030971receptor tyrosine kinase binding-IEA-  
GO:0031369translation initiation factor binding-IBA21873635  
GO:0031369translation initiation factor binding-IPI9852145  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-ISS-  
GO:0001833inner cell mass cell proliferation-IEA-  
GO:0001834trophectodermal cell proliferation-ISS-  
GO:0006397mRNA processing-IEA-  
GO:0007165signal transduction-TAS8650580  
GO:0008283cell proliferation-IBA21873635  
GO:0008283cell proliferation-TAS9763455  
GO:0008380RNA splicing-IEA-  
GO:0010628positive regulation of gene expression-IBA21873635  
GO:0010628positive regulation of gene expression-IMP22422766  
GO:0021510spinal cord development-ISS-  
GO:0030576Cajal body organization-IBA21873635  
GO:0030576Cajal body organization-IMP17068332  
GO:0030576Cajal body organization-ISS-  
GO:0031641regulation of myelination-ISS-  
GO:0033120positive regulation of RNA splicing-IMP11283611  
GO:0042023DNA endoreduplication-ISS-  
GO:0042307positive regulation of protein import into nucleus-IBA21873635  
GO:0042307positive regulation of protein import into nucleus-IDA11283611  
GO:0045927positive regulation of growth-ISS-  
GO:0061564axon development-IBA21873635  
GO:0061564axon development-IMP22422766  
GO:0061564axon development-ISS-  
GO:0071364cellular response to epidermal growth factor stimulus-IDA9852145  
GO:0071931positive regulation of transcription involved in G1/S transition of mitotic cell cycle-IMP17068332  
GO:1902742apoptotic process involved in development-ISS-  
GO:1990261pre-mRNA catabolic process-IMP11283611  
GO:2000672negative regulation of motor neuron apoptotic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9852145  11283611  
GO:0005654nucleoplasm-IDA17068332  
GO:0005730nucleolus-IDA9852145  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA9852145  11283611  17068332  
GO:0015030Cajal body-IBA21873635  
GO:0015030Cajal body-IDA11283611  17068332  22422766  
GO:0030424axon-IBA21873635  
GO:0030424axon-ISS-  
GO:0030426growth cone-ISS-  
GO:0032797SMN complex-IDA11283611  
GO:0043025neuronal cell body-ISS-  
GO:0043204perikaryon-ISS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0097504Gemini of coiled bodies-IDA11283611  17068332  22422766  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26405538Association of FURIN and ZPR1 polymorphisms with metabolic syndrome. (2015 Sep)Ueyama CBiomed Rep
27827461Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population. (2016 Nov 9)Lin ESci Rep