Gene: NAE1

8883
A-116A10.1|APPBP1|HPP1|ula-1
NEDD8 activating enzyme E1 subunit 1
protein-coding
16q22.1
Ensembl:ENSG00000159593 MIM:603385 Vega:OTTHUMG00000137513 UniprotKB:Q13564
NC_000016.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.841e-1 (AD)  7.147e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs422945chr16:66832730 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs363175chr16:66821744 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ORC30.938
SCFD10.936
EXOC10.934
PSMC20.926
PWP10.926
GLT8D10.925
TAF90.921
PRKAG10.92
NUP1330.92
WBP40.919

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.665
OR4F29-0.625
MTRNR2L6-0.34
MTRNR2L9-0.334
MTRNR2L10-0.307
MTRNR2L2-0.258
MTRNR2L8-0.252
C8orf74-0.251
NKX6-1-0.24
EVC2-0.239

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of NAE1 mRNA"19162173
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NAE1 mRNA"21346803
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of NAE1 mRNA"19936915
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NAE1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NAE1 mRNA19770486|2222880
C006780bisphenol Abisphenol A affects the expression of NAE1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of NAE1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of NAE1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NAE1 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of NAE1 promoter22457795
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NAE1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NAE1 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of NAE1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of NAE1 mRNA19549813
C009160cyclonitecyclonite results in decreased expression of NAE1 mRNA25559034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NAE1 mRNA]27941970
C000944dicrotophosdicrotophos results in decreased expression of NAE1 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of NAE1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NAE1 mRNA]19850644
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of NAE1 mRNA21318169
D004147DioxinsDioxins affects the expression of NAE1 mRNA20463971
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NAE1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NAE1 mRNA16954407
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NAE1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NAE1 mRNA17557909
D018120FinasterideFinasteride results in increased expression of NAE1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of NAE1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NAE1 gene20938992
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of NAE1 mRNA20044591
C016517indole-3-carbinolindole-3-carbinol affects the expression of NAE1 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of NAE1 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NAE1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NAE1 mRNA23458150
C051752nefazodonenefazodone results in increased expression of NAE1 mRNA24136188
D010416PentachlorophenolPentachlorophenol results in increased expression of NAE1 mRNA23892564
D010936Plant ExtractsPlant Extracts results in increased expression of NAE1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NAE1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NAE1 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of NAE1 mRNA19162173
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NAE1 mRNA18495758
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NAE1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NAE1 mRNA17942748|1946511
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of NAE1 mRNA25613284
D013876ThiophenesThiophenes analog promotes the reaction [Tretinoin results in decreased expression of NAE1 mRNA]16140955
D014212TretinoinThiophenes analog promotes the reaction [Tretinoin results in decreased expression of NAE1 mRNA]16140955
D014212TretinoinTretinoin results in decreased expression of NAE1 mRNA16140955
C012589trichostatin Atrichostatin A results in increased expression of NAE1 mRNA15901671
D014501UraniumUranium affects the expression of NAE1 mRNA15672453
D017974Uranium CompoundsUranium Compounds results in decreased expression of NAE1 mRNA19654044
C005460uranyl acetateuranyl acetate affects the expression of NAE1 mRNA15672453
D014635Valproic AcidValproic Acid results in increased expression of NAE1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of NAE1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NAE1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of NAE1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI8626687  10722740  12694406  14557245  15361859  
GO:0019781NEDD8 activating enzyme activity-IBA21873635  
GO:0019781NEDD8 activating enzyme activitycontributes_toIDA12740388  
GO:0031625ubiquitin protein ligase binding-IPI18627766  
GO:0046982protein heterodimerization activity-IPI12740388  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS8626687  
GO:0033314mitotic DNA replication checkpoint-IDA10722740  
GO:0042981regulation of apoptotic process-IDA14557245  
GO:0042981regulation of apoptotic process-IMP10722740  
GO:0043523regulation of neuron apoptotic process-IDA10722740  
GO:0043687post-translational protein modification-TAS-  
GO:0045116protein neddylation-IBA21873635  
GO:0045116protein neddylation-IDA10207026  12740388  
GO:0045116protein neddylation-IEA-  
GO:0051402neuron apoptotic process-IDA14557245  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS8626687  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
hsa05010Alzheimer's disease
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal