Gene: TAX1BP1

8887
CALCOCO3|T6BP|TXBP151
Tax1 binding protein 1
protein-coding
7p15.2
Ensembl:ENSG00000106052 MIM:605326 Vega:OTTHUMG00000023377 UniprotKB:Q86VP1
NG_029523.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.934e-1 (AD)  4.075e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CAPRIN10.973
CCDC470.965
KPNA30.964
CDC5L0.963
RAD23B0.961
API50.958
RAB140.958
CUL30.958
USO10.957
NUDT210.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.697
OR4F29-0.665
MTRNR2L6-0.322
MTRNR2L10-0.318
CSAG1-0.299
MTRNR2L9-0.295
KLRB1-0.275
MTRNR2L3-0.268
KLRK1-0.266
RSPO1-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of TAX1BP1 mRNA19041380
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of TAX1BP1 mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of TAX1BP1 mRNA]"19414516
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TAX1BP1 mRNA"19114083
C0112692,5-hexanedione"2,5-hexanedione results in increased expression of TAX1BP1 mRNA"22952946
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TAX1BP1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TAX1BP1 mRNA"23196670
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of TAX1BP1 mRNA"19561079
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of TAX1BP1 mRNA14583596
D000082AcetaminophenAcetaminophen affects the expression of TAX1BP1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of TAX1BP1 mRNA28959563
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of TAX1BP1 mRNA]"19414516
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TAX1BP1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TAX1BP1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of TAX1BP1 mRNA25929836
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of TAX1BP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of TAX1BP1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TAX1BP1 mRNA20504355
C006780bisphenol Abisphenol A results in increased expression of TAX1BP1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of TAX1BP1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of TAX1BP1 mRNA17553608
C100187chloropicrinchloropicrin results in increased expression of TAX1BP1 mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TAX1BP1 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in increased expression of TAX1BP1 mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of TAX1BP1 mRNA20971185
D003300CopperMT1 affects the reaction [Copper results in increased expression of TAX1BP1 mRNA]16629173
D003300CopperMT2 affects the reaction [Copper results in increased expression of TAX1BP1 mRNA]16629173
D019327Copper SulfateCopper Sulfate results in increased expression of TAX1BP1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of TAX1BP1 mRNA20106945|2556210
D003976DiazinonDiazinon affects the expression of TAX1BP1 mRNA22546817
D002945CisplatinCisplatin results in increased expression of TAX1BP1 mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of TAX1BP1 mRNA28302478
D004147DioxinsDioxins affects the expression of TAX1BP1 mRNA20463971
D005485FlutamideFlutamide results in increased expression of TAX1BP1 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of TAX1BP1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TAX1BP1 mRNA25613284
D007529IsoflavonesIsoflavones results in increased expression of TAX1BP1 mRNA17374662
D007545IsoproterenolIsoproterenol results in increased expression of TAX1BP1 mRNA20003209
C410337K 7174K 7174 results in increased expression of TAX1BP1 mRNA24086573
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of TAX1BP1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TAX1BP1 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in increased expression of TAX1BP1 mRNA19812364
C022838nickel chloridenickel chloride affects the expression of TAX1BP1 mRNA22546817
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of TAX1BP1 mRNA20971185
D019319Okadaic AcidOkadaic Acid results in decreased expression of TAX1BP1 mRNA23561263
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TAX1BP1 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of TAX1BP1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of TAX1BP1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TAX1BP1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TAX1BP1 mRNA]17655762
D010100OxygenOxygen deficiency results in increased expression of TAX1BP1 mRNA22629407|2420500
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of TAX1BP1 mRNA]22629407
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of TAX1BP1 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of TAX1BP1 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TAX1BP1 mRNA]17655762
C006253pirinixic acidpirinixic acid results in increased expression of TAX1BP1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of TAX1BP1 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of TAX1BP1 mRNA23012394
D012715Sesame OilSesame Oil results in increased expression of TAX1BP1 mRNA29191790
D012834SilverSilver results in increased expression of TAX1BP1 mRNA26014281
D020123SirolimusSirolimus results in increased expression of TAX1BP1 mRNA11355896
D013501Surface-Active AgentsSurface-Active Agents results in decreased expression of TAX1BP1 mRNA22467014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TAX1BP1 mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TAX1BP1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TAX1BP1 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TAX1BP1 mRNA25613284
D013849ThimerosalThimerosal results in increased expression of TAX1BP1 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased expression of TAX1BP1 mRNA20920546
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of TAX1BP1 gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TAX1BP1 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of TAX1BP1 mRNA22378314
D014635Valproic AcidValproic Acid results in increased expression of TAX1BP1 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of TAX1BP1 mRNA17963808
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of TAX1BP1 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of TAX1BP1 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TAX1BP1 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TAX1BP1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of TAX1BP1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10920205  11389905  14697242  15231748  15474016  17703191  
18239685  19131965  21765415  21988832  25416956  26871637  
GO:0019900kinase binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0032088negative regulation of NF-kappaB transcription factor activity-ISS-  
GO:0032480negative regulation of type I interferon production-TAS-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-5357905Regulation of TNFR1 signalingTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-75893TNF signalingTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20549079Analysis of the TAX1BP1 gene in head and neck cancer patients. (2010 Mar-Apr)Ruiz MTBraz J Otorhinolaryngol