Gene: KRIT1

889
CAM|CCM1
KRIT1, ankyrin repeat containing
protein-coding
7q21.2
Ensembl:ENSG00000001631 MIM:604214 Vega:OTTHUMG00000131187 UniprotKB:O00522
NG_012964.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.856e-1 (AD)  1.710e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12704637chr7:92245372 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARFGEF10.951
TRAPPC80.95
HECTD10.949
RALGAPB0.947
TTC370.942
PHF200.941
ZNF6550.94
USO10.939
HERC30.939
GMPS0.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.527
OR4F29-0.496
S100A1-0.35
MTRNR2L10-0.337
MTRNR2L6-0.332
S100A14-0.318
AQP5-0.311
RBP1-0.311
PLA2G5-0.306
MTRNR2L9-0.306

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KRIT1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of KRIT1 mRNA21420995
C014949acetylhydrazineacetylhydrazine results in increased expression of KRIT1 mRNA15282401
D001280AtrazineAtrazine results in decreased expression of KRIT1 mRNA22378314
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of KRIT1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KRIT1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KRIT1 mRNA"19150397|2001819
C044887beta-methylcholinebeta-methylcholine affects the expression of KRIT1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of KRIT1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of KRIT1 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of KRIT1 mRNA20977926
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of KRIT1 mRNA23650126
D002737ChloropreneChloroprene results in increased expression of KRIT1 mRNA23125180
D003042CocaineCocaine results in increased expression of KRIT1 mRNA18000554
D016572CyclosporineCyclosporine results in decreased expression of KRIT1 mRNA25562108
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KRIT1 mRNA22079256
D017313FenretinideFenretinide results in increased expression of KRIT1 mRNA28973697
C029424hydrazinehydrazine results in increased expression of KRIT1 mRNA15282401
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of KRIT1 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased secretion of KRIT1 mRNA21179422
C051890irinotecanirinotecan analog results in decreased expression of KRIT1 mRNA18927307
C544151jinfukangjinfukang results in decreased expression of KRIT1 mRNA27392435
C410337K 7174K 7174 results in increased expression of KRIT1 mRNA24086573
D008727MethotrexateMethotrexate affects the expression of KRIT1 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of KRIT1 mRNA28001369
D008777MethyltestosteroneMethyltestosterone results in increased expression of KRIT1 mRNA29191790
D010416PentachlorophenolPentachlorophenol results in increased expression of KRIT1 mRNA23892564
C046012pentanalpentanal results in decreased expression of KRIT1 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KRIT1 mRNA27153767
D010672PhenytoinPhenytoin results in increased expression of KRIT1 mRNA20345932
C006253pirinixic acidpirinixic acid results in decreased expression of KRIT1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of KRIT1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KRIT1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of KRIT1 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of KRIT1 mRNA19690047
D011794QuercetinQuercetin results in decreased expression of KRIT1 mRNA21632981
C009277sodium arsenatesodium arsenate results in decreased expression of KRIT1 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of KRIT1 mRNA21795629
D013654TaurineTaurine results in increased expression of KRIT1 mRNA16579726
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KRIT1 mRNA21570461|2468072
C009495titanium dioxidetitanium dioxide results in increased expression of KRIT1 mRNA23409001
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KRIT1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16037064  17657516  17916086  20332120  23007647  25814554  
25910212  27027284  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-IDA17916086  
GO:0008017microtubule binding-IDA17916086  
GO:0030695GTPase regulator activity-TAS9285558  
GO:0044877protein-containing complex binding-IDA17916086  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001937negative regulation of endothelial cell proliferation-IMP20616044  
GO:0007264small GTPase mediated signal transduction-TAS9285558  
GO:0010596negative regulation of endothelial cell migration-IMP20616044  
GO:0016525negative regulation of angiogenesis-IMP20616044  
GO:0032092positive regulation of protein binding-IEA-  
GO:0045454cell redox homeostasis-IMP20668652  
GO:0050790regulation of catalytic activity-IEA-  
GO:2000114regulation of establishment of cell polarity-IMP20332120  
GO:2000352negative regulation of endothelial cell apoptotic process-IMP20616044  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005737cytoplasm-IEA-  
GO:0005874microtubule-IDA17916086  
GO:0005886plasma membrane-IDA17916086  
GO:0005911cell-cell junction-IDA20332120  
GO:0032991protein-containing complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24401931Association of cardiovascular risk factors with disease severity in cerebral cavernous malformation type 1 subjects with the common Hispanic mutation. (2014)Choquet HCerebrovasc Dis