Gene: MTMR2

8898
CMT4B|CMT4B1
myotubularin related protein 2
protein-coding
11q21
Ensembl:ENSG00000087053 MIM:603557 Vega:OTTHUMG00000153837 UniprotKB:Q13614
NG_008333.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.673e-1 (AD)  2.405e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCOA70.944
RPS6KC10.939
RUFY30.938
CSE1L0.937
SRPK20.937
LPGAT10.935
CAB390.934
CUL20.931
RAP1GDS10.931
CEP630.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.51
OR4F29-0.504
EYA2-0.372
PLA2G5-0.367
MTRNR2L10-0.364
ACOX2-0.362
LRAT-0.362
PON3-0.357
INHBB-0.353
CSAG1-0.351

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of MTMR2 mRNA19041380
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of MTMR2 mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MTMR2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTMR2 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of MTMR2 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTMR2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MTMR2 gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of MTMR2 mRNA20458559
C006780bisphenol Abisphenol A affects the expression of MTMR2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of MTMR2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of MTMR2 mRNA26079696
D002166CamptothecinMTMR2 mRNA results in decreased susceptibility to Camptothecin25269479
D016572CyclosporineCyclosporine results in increased expression of MTMR2 mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MTMR2 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MTMR2 mRNA21266533
D004237DiuronDiuron results in increased expression of MTMR2 mRNA21551480
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of MTMR2 mRNA"23811387
D005485FlutamideFlutamide results in increased expression of MTMR2 mRNA24136188
C544151jinfukangjinfukang results in decreased expression of MTMR2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MTMR2 mRNA21889194|2290429
D008727MethotrexateMethotrexate affects the expression of MTMR2 mRNA18502557
D009285NaphthoquinonesNaphthoquinones results in increased expression of MTMR2 mRNA23811387
D011441PropylthiouracilPropylthiouracil results in decreased expression of MTMR2 mRNA24780913
D012524SarinSarin results in decreased expression of MTMR2 mRNA19522546
C009277sodium arsenatesodium arsenate results in increased expression of MTMR2 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of MTMR2 mRNA17879257
C016104sodium bichromatesodium bichromate results in increased expression of MTMR2 mRNA22561333
D013629TamoxifenTamoxifen results in increased expression of MTMR2 mRNA15849065
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTMR2 mRNA21570461
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTMR2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MTMR2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MTMR2 mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MTMR2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004438phosphatidylinositol-3-phosphatase activity-IDA12668758  
GO:0004438phosphatidylinositol-3-phosphatase activity-TAS-  
GO:0004725protein tyrosine phosphatase activity-IEA-  
GO:0005515protein binding-IPI12837694  15998640  
GO:0008138protein tyrosine/serine/threonine phosphatase activity-NAS9736772  
GO:0042803protein homodimerization activity-IEA-  
GO:0052629phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity-IDA12668758  
GO:0052629phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002091negative regulation of receptor internalization-ISS-  
GO:0006470protein dephosphorylation-NAS9736772  
GO:0006661phosphatidylinositol biosynthetic process-TAS-  
GO:0031642negative regulation of myelination-IEA-  
GO:0032288myelin assembly-IEA-  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0045806negative regulation of endocytosis-ISS-  
GO:0046855inositol phosphate dephosphorylation-IEA-  
GO:0046856phosphatidylinositol dephosphorylation-IDA12668758  
GO:0048666neuron development-IEA-  
GO:0051262protein tetramerization-IEA-  
GO:0060304regulation of phosphatidylinositol dephosphorylation-IDA16787938  
GO:0090394negative regulation of excitatory postsynaptic potential-ISS-  
GO:0097062dendritic spine maintenance-ISS-  
GO:2000643positive regulation of early endosome to late endosome transport-ISS-  
GO:2000645negative regulation of receptor catabolic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12837694  16787938  
GO:0005737cytoplasm-IDA12837694  
GO:0005774vacuolar membrane-IEA-  
GO:0005829cytosol-IDA12668758  
GO:0005829cytosol-ISS-  
GO:0005829cytosol-TAS-  
GO:0008021synaptic vesicle-ISS-  
GO:0014069postsynaptic density-ISS-  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0031901early endosome membrane-IEA-  
GO:0043197dendritic spine-ISS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-HDA18570454  
GO:0097060synaptic membrane-ISS-  
KEGG ID KEGG Term
hsa00051Fructose and mannose metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1483248Synthesis of PIPs at the ER membraneTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483255PI MetabolismIEA
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-1483257Phospholipid metabolismIEA
R-HSA-1660499Synthesis of PIPs at the plasma membraneIEA
R-HSA-1660516Synthesis of PIPs at the early endosome membraneTAS
R-HSA-1660516Synthesis of PIPs at the early endosome membraneIEA
R-HSA-1660517Synthesis of PIPs at the late endosome membraneTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-556833Metabolism of lipidsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28151741Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides. (2017 May)Mostafavi NEpidemiology