Gene: CCNA1

8900
CT146
cyclin A1
protein-coding
13q13.3
Ensembl:ENSG00000133101 MIM:604036 Vega:OTTHUMG00000016733 UniprotKB:P78396
NC_000013.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.408e-1 (AD)  4.495e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXL20.944
ELMOD10.942
SLC25A140.935
CRYM0.932
CDK200.93
DLG30.93
SUSD40.93
NSF0.93
BTBD100.929
RGS70.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.585
REST-0.574
ASB4-0.569
MYL3-0.564
MYOM1-0.55
COPZ2-0.548
HEY2-0.545
PARD3B-0.544
RAI14-0.54
RNF135-0.539

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of CCNA1 protein"21354444
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNA1 protein"21391223
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNA1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNA1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNA1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNA1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNA1 mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of CCNA1 mRNA12958197
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CCNA1 protein]20654705
C016601afimoxifeneafimoxifene results in increased expression of CCNA1 mRNA12154049
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCNA1 gene27153756
D006710HomocysteineDNMT1 protein affects the reaction [Homocysteine results in decreased expression of CCNA1 mRNA]17698632
D006710HomocysteineHomocysteine inhibits the reaction [MECP2 protein binds to CCNA1 promoter]17698632
D006710HomocysteineHomocysteine promotes the reaction [HIST3H3 protein modified form binds to CCNA1 promoter]17698632
D006710HomocysteineHomocysteine promotes the reaction [HIST4H4 protein modified form binds to CCNA1 promoter]17698632
D006710HomocysteineHomocysteine results in decreased expression of CCNA1 mRNA17698632
D006710HomocysteineHomocysteine results in decreased methylation of CCNA1 promoter17698632
D001151ArsenicArsenic results in increased expression of CCNA1 mRNA20654705
C006632arsenic trioxidearsenic trioxide results in decreased expression of CCNA1 mRNA15761015
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CCNA1 protein]21621607
D001280AtrazineAtrazine results in increased expression of CCNA1 mRNA22378314
D001285AtropineAtropine results in increased expression of CCNA1 mRNA17390078
D001285Atropine[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA17390078
C426023austenitic steel[Nickel co-treated with austenitic steel analog] results in increased expression of CCNA1 mRNA23638002
D001374AzacitidineAzacitidine inhibits the reaction [MECP2 protein binds to CCNA1 promoter]17698632
D001374AzacitidineAzacitidine promotes the reaction [HIST3H3 protein modified form binds to CCNA1 promoter]17698632
D001374AzacitidineAzacitidine promotes the reaction [HIST4H4 protein modified form binds to CCNA1 promoter]17698632
D001374AzacitidineAzacitidine results in decreased expression of CCNA1 mRNA17698632
C547126AZM551248AZM551248 results in decreased expression of CCNA1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CCNA1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCNA1 mRNA17879257
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of CCNA1 mRNA24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CCNA1 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of CCNA1 mRNA23019147|2309414
D004958EstradiolEstradiol results in increased expression of CCNA1 mRNA12154049|2260985
D004958EstradiolIGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of CCNA1 mRNA]23094148
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of CCNA1 mRNA17404688
C006780bisphenol Abisphenol A affects the expression of CCNA1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CCNA1 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of CCNA1 mRNA27561114
C006780bisphenol Abisphenol A results in increased methylation of CCNA1 gene22258036
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of CCNA1 mRNA22828881
C006780bisphenol Abisphenol A results in decreased expression of CCNA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CCNA1 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CCNA1 mRNA22079614
D002087ButyratesButyrates inhibits the reaction [MECP2 protein binds to CCNA1 promoter]17698632
D002087ButyratesButyrates results in decreased expression of CCNA1 mRNA17698632
D002104CadmiumCadmium results in increased expression of CCNA1 mRNA21120746|2169477
D019256Cadmium ChlorideCadmium Chloride affects the expression of CCNA1 mRNA23941782
D019256Cadmium ChlorideCadmium Chloride affects the expression of CCNA1 protein23941782
D019256Cadmium ChlorideCadmium Chloride affects the reaction [Fluorouracil affects the expression of CCNA1 mRNA]23941782
D019256Cadmium Chloride[Cadmium Chloride co-treated with Fluorouracil] affects the expression of CCNA1 protein23941782
D019256Cadmium ChlorideFluorouracil affects the reaction [Cadmium Chloride affects the expression of CCNA1 mRNA]23941782
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of CCNA1 mRNA18654764
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CCNA1 mRNA24763279
D002737ChloropreneChloroprene results in increased expression of CCNA1 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CCNA1 mRNA21356183
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of CCNA1 mRNA21356183
C074702chromium hexavalent ionAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CCNA1 protein]21621607
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of CCNA1 protein21621607
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of CCNA1 mRNA18654764
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of CCNA1 mRNA21356183
D003300CopperCopper results in decreased expression of CCNA1 mRNA21356183
D016572CyclosporineCyclosporine results in decreased expression of CCNA1 mRNA22147139
C017160cypermethrincypermethrin results in decreased expression of CCNA1 mRNA24810582
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CCNA1 mRNA23640034
C014347decitabinedecitabine affects the expression of CCNA1 mRNA17194187
C014347decitabinedecitabine affects the methylation of CCNA1 promoter17488656
D003976DiazinonDiazinon results in increased methylation of CCNA1 gene22964155
D002945Cisplatin[Cisplatin co-treated with Quercetin] results in increased expression of CCNA1 mRNA27514524
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of CCNA1 mRNA22828881
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CCNA1 mRNA25975992
C014476diethyl maleatediethyl maleate results in decreased expression of CCNA1 mRNA11875189
D002117CalcitriolCalcitriol results in decreased expression of CCNA1 mRNA12875902
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of CCNA1 mRNA16507463
C076221dinophysistoxin 2dinophysistoxin 2 affects the expression of CCNA1 mRNA21512803
D015025ZearalenoneZearalenone results in decreased expression of CCNA1 mRNA24412631
D044950FlavanonesFlavanones results in decreased expression of CCNA1 protein21616090
D005472FluorouracilCadmium Chloride affects the reaction [Fluorouracil affects the expression of CCNA1 mRNA]23941782
D005472Fluorouracil[Cadmium Chloride co-treated with Fluorouracil] affects the expression of CCNA1 protein23941782
D005472FluorouracilFluorouracil affects the expression of CCNA1 mRNA23941782
D005472FluorouracilFluorouracil affects the expression of CCNA1 protein23941782
D005472FluorouracilFluorouracil affects the reaction [Cadmium Chloride affects the expression of CCNA1 mRNA]23941782
C070081fulvestrant[CDK6 affects the susceptibility to fulvestrant] which affects the expression of CCNA1 protein24169358
C039281furanfuran results in increased methylation of CCNA1 gene22079235
D019833GenisteinGenistein affects the expression of CCNA1 mRNA18214933
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CCNA1 mRNA24763279
D006247HarmineHarmine results in increased expression of CCNA1 mRNA25751815
D006247HarmineHarmine results in increased expression of CCNA1 protein25751815
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of CCNA1 mRNA15046208
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CCNA1 mRNA15761015
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of CCNA1 mRNA18654764
D008012LidocaineLidocaine affects the expression of CCNA1 mRNA18931217
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CCNA1 mRNA12057914
D008094LithiumLithium inhibits the reaction [Methamphetamine results in decreased expression of CCNA1 mRNA]19149911
D018021Lithium ChlorideLithium Chloride results in decreased expression of CCNA1 mRNA23527032
D018021Lithium ChlorideLithium Chloride results in increased expression of CCNA1 protein19101580
D008345ManganeseManganese results in increased expression of CCNA1 mRNA26745496
C025340manganese chloridemanganese chloride results in increased expression of CCNA1 mRNA26745496
D008694MethamphetamineLithium inhibits the reaction [Methamphetamine results in decreased expression of CCNA1 mRNA]19149911
D008694MethamphetamineMethamphetamine results in decreased expression of CCNA1 mRNA19149911
D008713MethimazoleMethimazole results in decreased expression of CCNA1 mRNA17403546
D008731MethoxychlorMethoxychlor results in decreased expression of CCNA1 mRNA25048109
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CCNA1 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of CCNA1 mRNA20039754
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CCNA1 mRNA26011545
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of CCNA1 mRNA12634122
D009151Mustard GasMustard Gas results in increased expression of CCNA1 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CCNA1 mRNA"15585362
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CCNA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCNA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCNA1 mRNA"27106021
D009532Nickel[Nickel co-treated with austenitic steel analog] results in increased expression of CCNA1 mRNA23638002
D009532NickelNickel results in increased expression of CCNA1 mRNA24768652|2558310
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CCNA1 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CCNA1 mRNA27935865
D019319Okadaic AcidOkadaic Acid affects the expression of CCNA1 mRNA21512803
C016340o,p'-DDT"o,p'-DDT results in increased expression of CCNA1 mRNA"22609851
D010100OxygenOxygen results in decreased expression of CCNA1 mRNA27103661
D010278Parathion[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA17390078
D010278ParathionParathion results in increased expression of CCNA1 mRNA17390078
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCNA1 mRNA"25510870
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CCNA1 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of CCNA1 mRNA24642059
C494474perchlorateperchlorate results in decreased expression of CCNA1 mRNA17403546
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CCNA1 mRNA23427857
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CCNA1 mRNA27935865
C443641poly(propyleneimine)poly(propyleneimine) analog results in increased expression of CCNA1 mRNA16308212
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CCNA1 mRNA26348139
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CCNA1 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of CCNA1 mRNA17404688
D011441PropylthiouracilPropylthiouracil results in decreased expression of CCNA1 mRNA17403546
D011794Quercetin[Cisplatin co-treated with Quercetin] results in increased expression of CCNA1 mRNA27514524
C059514resveratrolresveratrol results in increased expression of CCNA1 mRNA12154049
C078903seocalcitolseocalcitol results in decreased expression of CCNA1 mRNA12040012
C017947sodium arseniteAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CCNA1 protein]20654705
C017947sodium arsenitesodium arsenite results in decreased expression of CCNA1 protein21642427
C017947sodium arsenitesodium arsenite results in increased expression of CCNA1 mRNA20654705
C017947sodium arsenitesodium arsenite results in increased expression of CCNA1 protein20654705
D053260SootSoot results in increased expression of CCNA1 mRNA22461453|2655175
D010042OuabainOuabain results in decreased expression of CCNA1 mRNA20460749
C003377taxifolintaxifolin results in decreased expression of CCNA1 mRNA17541156
C009495titanium dioxidetitanium dioxide affects the expression of CCNA1 mRNA23557971
D014212TretinoinCCNA1 protein results in increased susceptibility to Tretinoin16517207
D014212TretinoinTretinoin results in decreased expression of CCNA1 mRNA12875902
D014212TretinoinTretinoin results in increased expression of CCNA1 protein16517207
D014212TretinoinTretinoin results in decreased expression of CCNA1 mRNA22498432
C012589trichostatin Atrichostatin A inhibits the reaction [MECP2 protein binds to CCNA1 promoter]17698632
C012589trichostatin Atrichostatin A promotes the reaction [HIST3H3 protein modified form binds to CCNA1 promoter]17698632
C012589trichostatin Atrichostatin A promotes the reaction [HIST4H4 protein modified form binds to CCNA1 promoter]17698632
C012589trichostatin Atrichostatin A results in decreased expression of CCNA1 mRNA17698632
C012589trichostatin Atrichostatin A results in increased expression of CCNA1 mRNA24935251
D014415TunicamycinTunicamycin results in decreased expression of CCNA1 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of CCNA1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CCNA1 mRNA22580532
D014635Valproic AcidValproic Acid results in increased expression of CCNA1 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased expression of CCNA1 protein19101580
D014635Valproic AcidValproic Acid results in increased methylation of CCNA1 gene29154799
D014638VanadatesVanadates results in decreased expression of CCNA1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CCNA1 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of CCNA1 mRNA"23063069
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CCNA1 mRNA27935865
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CCNA1 mRNA18593933
D019287Zinc SulfateZinc Sulfate results in increased expression of CCNA1 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI8756624  15159402  15232106  17353931  25241761  
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity-IBA21873635  
GO:0019901protein kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-TAS-  
GO:0000278mitotic cell cycle-IBA21873635  
GO:0007088regulation of mitotic nuclear division-IBA21873635  
GO:0007141male meiosis I-TAS9843212  
GO:0007283spermatogenesis-TAS9843212  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0016579protein deubiquitination-TAS-  
GO:0045787positive regulation of cell cycle-IBA21873635  
GO:0051301cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS9041194  
GO:0015630microtubule cytoskeleton-IDA-  
GO:0097123cyclin A1-CDK2 complex-IEA-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation
hsa05200Pathways in cancer
hsa05221Acute myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-1538133G0 and Early G1TAS
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesTAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin ATAS
R-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseTAS
R-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointTAS
R-HSA-187577SCF(Skp2)-mediated degradation of p27/p21TAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)TAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453274Mitotic G2-G2/M phasesIEA
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-539107Activation of E2F1 target genes at G1/STAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-6804757Regulation of TP53 DegradationTAS
R-HSA-6806003Regulation of TP53 Expression and DegradationTAS
R-HSA-68911G2 PhaseTAS
R-HSA-68949Orc1 removal from chromatinTAS
R-HSA-69017CDK-mediated phosphorylation and removal of Cdc6TAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69202Cyclin E associated events during G1/S transition TAS
R-HSA-69205G1/S-Specific TranscriptionTAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionTAS
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionIEA
R-HSA-69275G2/M TransitionTAS
R-HSA-69275G2/M TransitionIEA
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-69306DNA ReplicationTAS
R-HSA-69563p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23358896Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics. (2013)Colacino JAPLoS One