Gene: SGCE

8910
DYT11|ESG|epsilon-SG
sarcoglycan epsilon
protein-coding
7q21.3
Ensembl:ENSG00000127990 MIM:604149 Vega:OTTHUMG00000022828 UniprotKB:O43556
NG_008893.2
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.292e-3 (AD)  3.860e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16492735chr7:94286208SGCEPromoter6.249e-5Alcohol use disorders26763658
cg26997085chr7:94286110SGCEPromoter3.721e-4Alcohol use disorders26763658
cg22579075chr7:94250352SGCE9.000e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM590.922
PPP1R80.914
EMC70.899
SNAPIN0.893
COQ50.892
PCNA0.888
LMBRD10.884
METAP20.882
ADIPOR10.877
TMED100.877

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.783
OR4F29-0.747
MROH9-0.216
C8orf74-0.21
FER1L6-0.196
KRT73-0.196
HMHB1-0.19
OR6C74-0.19
KRTAP3-2-0.184
MTRNR2L3-0.183

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of SGCE mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SGCE mRNA24449571
D001151ArsenicArsenic affects the methylation of SGCE gene25304211
C006780bisphenol Abisphenol A affects the expression of SGCE mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SGCE mRNA28196854
C006780bisphenol Abisphenol A results in increased expression of SGCE mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SGCE gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SGCE mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SGCE mRNA17484886
D019327Copper SulfateCopper Sulfate results in decreased expression of SGCE mRNA19549813
D003520CyclophosphamideSGCE protein affects the susceptibility to Cyclophosphamide16217747
D016572CyclosporineCyclosporine results in decreased expression of SGCE mRNA25562108|2798913
C000944dicrotophosdicrotophos results in decreased expression of SGCE mRNA28302478
D005472FluorouracilSGCE protein affects the susceptibility to Fluorouracil16217747
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of SGCE mRNA22634610
D017313FenretinideFenretinide results in decreased expression of SGCE mRNA28973697
D008727MethotrexateSGCE protein affects the susceptibility to Methotrexate16217747
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SGCE mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SGCE mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of SGCE mRNA25729387
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SGCE mRNA27935865
C009277sodium arsenatesodium arsenate results in increased expression of SGCE mRNA21795629
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SGCE mRNA25729387
D019772TopotecanTopotecan results in increased expression of SGCE mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of SGCE mRNA"19682533
D014212TretinoinTretinoin results in increased expression of SGCE mRNA16236135|1660451
C012589trichostatin Atrichostatin A results in decreased expression of SGCE mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SGCE mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of SGCE mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SGCE mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of SGCE gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SGCE gene25560391
C111237vorinostatvorinostat results in decreased expression of SGCE mRNA20060208

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007160cell-matrix adhesion-TAS9405466  
GO:0007517muscle organ development-TAS9405466  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-ISS-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-ISS-  
GO:0005887integral component of plasma membrane-TAS9475163  
GO:0016010dystrophin-associated glycoprotein complex-IDA17993586  
GO:0016012sarcoglycan complex-IEA-  
GO:0032590dendrite membrane-ISS-  
GO:0042383sarcolemma-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26783545Psychiatric disorders, myoclonus dystonia and SGCE: an international study. (2016 Jan)Peall KJAnn Clin Transl Neurol
23365103SGCE mutations cause psychiatric disorders: clinical and genetic characterization. (2013 Jan)Peall KJBrain
22677950Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. (2012 Jul)Liu YEpigenetics
17296918Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers. (2007 Feb 13)Hess CWNeurology