Gene: CACNA1H

8912
CACNA1HB|Cav3.2|ECA6|EIG6|HALD4
calcium voltage-gated channel subunit alpha1 H
protein-coding
16p13.3
Ensembl:ENSG00000196557 MIM:607904 Vega:OTTHUMG00000172992 UniprotKB:O95180
NG_012647.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.765e-1 (AD)  6.307e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
INPP5A0.768
LTBP40.767
CHST150.764
RAP1GAP0.759
CBFA2T30.751
GPR1760.749
TMEM1590.747
EFNB30.746
SLIT30.745
KCNQ20.74

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MBNL3-0.428
NXT2-0.427
YES1-0.422
MYL3-0.42
PARD3B-0.413
ASB4-0.409
COPZ2-0.402
PHEX-0.392
CDKN2C-0.384
BBOX1-0.375

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTransporter
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTransporter
DB00270IsradipineSmall Molecule75695-93-1Approved|InvestigationalTarget
DB00568CinnarizineSmall Molecule298-57-7Approved|InvestigationalTarget
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalTarget
DB01023FelodipineSmall Molecule72509-76-3Approved|InvestigationalTarget
DB01054NitrendipineSmall Molecule39562-70-4Approved|InvestigationalTarget
DB01115NifedipineSmall Molecule21829-25-4ApprovedTarget
DB01118AmiodaroneSmall Molecule1951-25-3Approved|InvestigationalTarget
DB01244BepridilSmall Molecule64706-54-3Approved|WithdrawnTarget
DB01388MibefradilSmall Molecule116644-53-2Investigational|WithdrawnTarget
DB04841FlunarizineSmall Molecule52468-60-7ApprovedTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTarget
DB00421SpironolactoneSmall Molecule52-01-7ApprovedTarget
DB09089TrimebutineSmall Molecule39133-31-8ApprovedTarget
DB09231BenidipineSmall Molecule105979-17-7Approved|InvestigationalTarget
DB09238ManidipineSmall Molecule89226-50-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate results in increased methylation of CACNA1H gene"25445006
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CACNA1H mRNA"29112739
C5112952,2',4,4'-tetrabromodiphenyl ether"ESR1 gene mutant form inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CACNA1H mRNA]"29112739
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]19292980
C0046313-cyanoalanine"3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein]"29129814
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of CACNA1H mRNA21983209
C464485acetamipridacetamiprid results in increased expression of CACNA1H mRNA27782041
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CACNA1H mRNA21298039
D000584AmilorideAmiloride inhibits the reaction [CACNA1H protein results in increased transport of Calcium]9930755
D000584AmilorideAmiloride inhibits the reaction [CACNA1H protein results in increased transport of Calcium]11897840
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CACNA1H mRNA16483693
D001151ArsenicArsenic affects the methylation of CACNA1H gene25304211
D001464BariumCACNA1H mRNA alternative form results in increased transport of Barium11179973
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CACNA1H mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CACNA1H mRNA25566086
C006780bisphenol Abisphenol A results in increased expression of CACNA1H mRNA25958630
C006780bisphenol AESR1 protein affects the reaction [bisphenol A results in increased expression of CACNA1H mRNA]25958630
C006780bisphenol AESR2 protein affects the reaction [bisphenol A results in increased expression of CACNA1H mRNA]25958630
C006780bisphenol Abisphenol A affects the expression of CACNA1H mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1H mRNA25607892
C006780bisphenol Abisphenol A inhibits the reaction [CACNA1H protein results in increased transport of Calcium]24170242
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1H mRNA25607892
C584509C646 compoundC646 compound results in increased expression of CACNA1H mRNA26191083
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CACNA1H mRNA20360939
D002118CalciumAmiloride inhibits the reaction [CACNA1H protein results in increased transport of Calcium]9930755
D002118CalciumCACNA1H protein results in increased transport of Calcium9930755
D002118CalciumMibefradil inhibits the reaction [CACNA1H protein results in increased transport of Calcium]9930755
D002118CalciumNickel inhibits the reaction [CACNA1H protein results in increased transport of Calcium]9930755
D002118CalciumAmiloride inhibits the reaction [CACNA1H protein results in increased transport of Calcium]11897840
D002118CalciumCACNA1H protein results in increased transport of Calcium11897840
D002118CalciumNickel inhibits the reaction [CACNA1H protein results in increased transport of Calcium]11897840
D002118CalciumCACNA1H protein results in increased transport of Calcium11073957
D002118Calciumbisphenol A inhibits the reaction [CACNA1H protein results in increased transport of Calcium]24170242
D002118CalciumCACNA1H protein results in increased transport of Calcium24170242
D002509CephaloridineCephaloridine results in increased expression of CACNA1H mRNA18500788
C018021cobaltous chloridecobaltous chloride results in increased expression of CACNA1H mRNA12679337
D005576ColforsinMibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein]17110049
D005576ColforsinNickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein]17110049
D003471CuprizoneCuprizone results in decreased expression of CACNA1H mRNA26577399
D003520Cyclophosphamide"3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein]"29129814
D003520CyclophosphamideCyclophosphamide results in increased expression of CACNA1H protein29129814
D003520Cyclophosphamide"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein"29129814
D016572CyclosporineCyclosporine results in increased expression of CACNA1H mRNA25562108
D003609DactinomycinDactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA]19292980
D003676DeferoxamineDeferoxamine results in increased expression of CACNA1H mRNA12679337
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CACNA1H mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CACNA1H mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of CACNA1H mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CACNA1H mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of CACNA1H mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CACNA1H mRNA20360939
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1H mRNA25607892
D004997Ethinyl EstradiolESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in increased expression of CACNA1H mRNA]29112739
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CACNA1H mRNA29112739
D005411Flame RetardantsESR1 gene mutant form inhibits the reaction [Flame Retardants results in increased expression of CACNA1H mRNA]29112739
D005411Flame RetardantsFlame Retardants results in increased expression of CACNA1H mRNA29112739
D005473FluoxetineFluoxetine results in decreased expression of CACNA1H mRNA17033635
C020754herbimycinherbimycin results in increased activity of CACNA1H protein18309285
C492448ICG 001ICG 001 results in increased expression of CACNA1H mRNA26191083
C082359imidaclopridimidacloprid results in increased expression of CACNA1H mRNA27782041
D0150561-Methyl-3-isobutylxanthineMibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein]17110049
D0150561-Methyl-3-isobutylxanthineNickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein]17110049
C057531jasplakinolidejasplakinolide results in decreased activity of CACNA1H protein23261645
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CACNA1H mRNA27392435
C045463leflunomideleflunomide results in increased expression of CACNA1H mRNA28988120
C002385linsidominelinsidomine results in increased oxidation of CACNA1H protein28086193
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H mRNA]19791473
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H protein]19791473
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H mRNA]19791473
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H protein]19791473
D020748MibefradilMibefradil inhibits the reaction [CACNA1H protein results in increased transport of Calcium]9930755
D020748MibefradilMibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein]17110049
C028473N-acetyl-4-benzoquinoneimineCACNA1H gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D009532NickelNickel inhibits the reaction [CACNA1H protein results in increased transport of Calcium]9930755
D009532NickelNickel inhibits the reaction [CACNA1H protein results in increased transport of Calcium]11897840
D009532NickelNickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein]17110049
D009532NickelNickel results in decreased activity of CACNA1H protein23261645
D009538NicotineNicotine results in increased expression of CACNA1H mRNA27782041
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein]"29129814
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein"29129814
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1H mRNA25607892
C029341oxophenylarsineoxophenylarsine results in decreased activity of CACNA1H protein18309285
D010100OxygenEPAS1 protein affects the reaction [Oxygen deficiency results in increased expression of CACNA1H mRNA]12679337
D010100OxygenOxygen deficiency results in increased expression of CACNA1H mRNA12679337
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CACNA1H mRNA28511854
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CACNA1H mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of CACNA1H mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of CACNA1H mRNA21228613
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CACNA1H mRNA21427059
C093642SB 203580SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]19292980
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H mRNA]19791473
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H protein]19791473
D019821SimvastatinSimvastatin results in decreased expression of CACNA1H mRNA19791473
D019821SimvastatinSimvastatin results in decreased expression of CACNA1H protein19791473
C017947sodium arsenitesodium arsenite affects the methylation of CACNA1H gene28589171
C084178telmisartan2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]19292980
C084178telmisartanSB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]19292980
C084178telmisartantelmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA]19292980
C084178telmisartantelmisartan results in decreased expression of CACNA1H mRNA19292980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CACNA1H mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CACNA1H mRNA22298810
C005445triphenyl phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of CACNA1H mRNA]"29112739
C005445triphenyl phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of CACNA1H mRNA"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of CACNA1H mRNA]"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of CACNA1H mRNA"29112739
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CACNA1H mRNA29024780
D014317Tritolyl Phosphates"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of CACNA1H mRNA]"29112739
D014317Tritolyl Phosphates"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of CACNA1H mRNA"29112739
C060152tyrphostin 47tyrphostin 47 results in increased activity of CACNA1H protein18309285
D014635Valproic AcidValproic Acid results in increased methylation of CACNA1H gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CACNA1H mRNA19136453|2142705
D014700VerapamilMevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H mRNA]19791473
D014700VerapamilMevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H protein]19791473
D014700VerapamilVerapamil results in decreased expression of CACNA1H mRNA19791473
D014700VerapamilVerapamil results in decreased expression of CACNA1H protein19791473
D015032ZincZinc deficiency results in increased expression of CACNA1H protein29129814
D015032ZincZinc results in decreased activity of CACNA1H protein16410023

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005244voltage-gated ion channel activity-IDA27149520  
GO:0005245voltage-gated calcium channel activity-IBA21873635  
GO:0005261cation channel activity-IBA21873635  
GO:0005515protein binding-IPI27149520  
GO:0008332low voltage-gated calcium channel activity-IBA21873635  
GO:0008332low voltage-gated calcium channel activity-IDA21084288  
GO:0046872metal ion binding-IEA-  
GO:0097110scaffold protein binding-IPI21084288  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS9670923  
GO:0007517muscle organ development-NAS9670923  
GO:0007520myoblast fusion-TAS10861024  
GO:0008016regulation of heart contraction-TAS9670923  
GO:0032342aldosterone biosynthetic process-IMP19342457  
GO:0032870cellular response to hormone stimulus-IEP19342457  
GO:0034651cortisol biosynthetic process-IMP19342457  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0035725sodium ion transmembrane transport-IEA-  
GO:0035865cellular response to potassium ion-IEP19342457  
GO:0042391regulation of membrane potential-IDA21084288  
GO:0045956positive regulation of calcium ion-dependent exocytosis-IBA21873635  
GO:0070509calcium ion import-IBA21873635  
GO:0070509calcium ion import-IDA21084288  
GO:0070588calcium ion transmembrane transport-IEA-  
GO:0086010membrane depolarization during action potential-IBA21873635  
GO:0098662inorganic cation transmembrane transport-IDA27149520  
GO:2000344positive regulation of acrosome reaction-IMP20394732  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA27149520  
GO:0005891voltage-gated calcium channel complex-IEA-  
GO:0016021integral component of membrane-IDA21084288  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-419037NCAM1 interactionsIEA
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29032150Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)Sundararajan TGene