Gene: TRIM4

89122
RNF87
tripartite motif containing 4
protein-coding
7q22.1
Ensembl:ENSG00000146833 Vega:OTTHUMG00000156648 UniprotKB:Q9C037
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
8.421e-1 (AD)  2.602e-1 (ND)   (Frontal_Cortex)
4.747e-1 (AD)  4.436e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNAI30.864
G3BP10.853
PPIL40.836
DNAJC30.835
DERL20.834
SMAD40.833
AFF10.821
MTA20.817
MCMBP0.816
TMEM430.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.556
OR4F29-0.534
CRH-0.304
NKX2-8-0.25
NMU-0.235
ZNRF4-0.218
MYCNOS-0.215
CYP1A1-0.212
ZSCAN1-0.21
HCRTR1-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TRIM4 mRNA26238291
C044887beta-methylcholinebeta-methylcholine affects the expression of TRIM4 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TRIM4 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRIM4 mRNA28628672
C584509C646 compoundC646 compound results in increased expression of TRIM4 mRNA26191083
D019327Copper SulfateCopper Sulfate results in decreased expression of TRIM4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TRIM4 mRNA25562108
C014347decitabinedecitabine affects the expression of TRIM4 mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TRIM4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRIM4 mRNA28628672
D002945CisplatinCisplatin affects the expression of TRIM4 mRNA23300844
D002945CisplatinCisplatin results in increased expression of TRIM4 mRNA19561079
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TRIM4 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of TRIM4 mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TRIM4 mRNA20044591
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TRIM4 protein18951874
C492448ICG 001ICG 001 results in increased expression of TRIM4 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TRIM4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRIM4 mRNA28628672
C051890irinotecanirinotecan analog results in increased expression of TRIM4 mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TRIM4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRIM4 mRNA28628672
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TRIM4 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TRIM4 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TRIM4 mRNA23649840
D011794QuercetinQuercetin results in increased expression of TRIM4 mRNA21632981
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TRIM4 mRNA26378955
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TRIM4 protein18951874
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TRIM4 mRNA"26179874

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-IEA-  
GO:0016740transferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016567protein ubiquitination-IEA-  
GO:0045087innate immune response-IEA-  
GO:0070206protein trimerization-IDA17156811  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA17156811  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26200269Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung. (2015 Aug)Shim HSJ Thorac Oncol