Gene: TIMELESS

8914
TIM|TIM1|hTIM
timeless circadian regulator
protein-coding
12q13.3
Ensembl:ENSG00000111602 MIM:603887 Vega:OTTHUMG00000170600 UniprotKB:Q9UNS1
NC_000012.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.468e-1 (AD)  2.706e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMC1A0.768
FKBP150.751
ELK40.75
ZNF2340.741
RNF2130.724
IQGAP10.724
NUP2050.721
POLD10.721
PHACTR40.72
MYO9B0.719

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.372
OR4F5-0.333
OR4F29-0.325
HES5-0.27
ARSF-0.268
REN-0.26
PLA2G5-0.255
ROPN1B-0.25
PNMT-0.249
C9orf24-0.247

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TIMELESS mRNA"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIMELESS mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TIMELESS mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIMELESS mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIMELESS mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIMELESS mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIMELESS mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TIMELESS mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMELESS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMELESS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMELESS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMELESS mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TIMELESS mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of TIMELESS mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TIMELESS mRNA19770486
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of TIMELESS mRNA"22863853
C006632arsenic trioxidearsenic trioxide results in decreased expression of TIMELESS mRNA20458559
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TIMELESS mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TIMELESS mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TIMELESS mRNA20713471|2222880
D004958EstradiolEstradiol results in increased expression of TIMELESS mRNA15223131|1916744
C006780bisphenol Abisphenol A results in decreased methylation of TIMELESS promoter27312807
C006780bisphenol Abisphenol A affects the expression of TIMELESS mRNA25181051
C584509C646 compoundC646 compound results in increased expression of TIMELESS mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of TIMELESS promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TIMELESS mRNA17484886
D002509CephaloridineCephaloridine results in increased expression of TIMELESS mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TIMELESS gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of TIMELESS mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TIMELESS mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of TIMELESS mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of TIMELESS mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of TIMELESS mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of TIMELESS mRNA25562108
D000069439DasatinibDasatinib results in decreased expression of TIMELESS mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TIMELESS mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TIMELESS mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TIMELESS mRNA27392435
D002945CisplatinCisplatin results in increased expression of TIMELESS mRNA27594783
D004041Dietary FatsDietary Fats results in decreased expression of TIMELESS mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TIMELESS mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIMELESS mRNA17942748
C007738fluoranthene[fluoranthene co-treated with pyrene] results in decreased expression of TIMELESS mRNA20117838
D005472FluorouracilTIMELESS protein affects the susceptibility to Fluorouracil15548681
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TIMELESS gene20938992
C070081fulvestrant[fulvestrant co-treated with Sirolimus] results in decreased expression of TIMELESS mRNA19016759
C070081fulvestrantfulvestrant results in decreased expression of TIMELESS mRNA19016759
C039281furanfuran results in increased expression of TIMELESS mRNA25539665
D017313FenretinideFenretinide results in increased expression of TIMELESS mRNA28973697
C492448ICG 001ICG 001 results in increased expression of TIMELESS mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TIMELESS mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TIMELESS mRNA27392435
C544151jinfukangjinfukang results in increased expression of TIMELESS mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TIMELESS gene20938992
C028577monobutyl phthalatemonobutyl phthalate affects the expression of TIMELESS mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TIMELESS mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TIMELESS mRNA"25554681
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of TIMELESS mRNA17616710
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TIMELESS mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of TIMELESS mRNA26516004
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIMELESS mRNA"25510870
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of TIMELESS mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of TIMELESS mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of TIMELESS mRNA19136022|2309116
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMELESS mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TIMELESS mRNA26272509
C006253pirinixic acidpirinixic acid affects the expression of TIMELESS mRNA19136022
C006253pirinixic acidpirinixic acid results in increased expression of TIMELESS mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of TIMELESS mRNA]17950772
C006253pirinixic acidpirinixic acid results in increased expression of TIMELESS mRNA12832660|1916217
D010936Plant ExtractsPlant Extracts results in increased expression of TIMELESS mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TIMELESS mRNA22698814
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TIMELESS mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of TIMELESS mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of TIMELESS mRNA20726854
D011441PropylthiouracilPropylthiouracil results in increased expression of TIMELESS mRNA24780913
C030984pyrene[fluoranthene co-treated with pyrene] results in decreased expression of TIMELESS mRNA20117838
D011794QuercetinQuercetin results in increased expression of TIMELESS mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of TIMELESS mRNA19167446
C059514resveratrolresveratrol results in increased expression of TIMELESS mRNA19167446
D020123Sirolimus[fulvestrant co-treated with Sirolimus] results in decreased expression of TIMELESS mRNA19016759
D012999SomanSoman results in increased expression of TIMELESS mRNA19281266
D053260SootSoot results in increased expression of TIMELESS mRNA22461453
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of TIMELESS mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TIMELESS mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIMELESS mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TIMELESS promoter]19654925
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TIMELESS mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of TIMELESS mRNA22378314
C009495titanium dioxidetitanium dioxide results in increased expression of TIMELESS mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TIMELESS mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TIMELESS mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TIMELESS mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TIMELESS mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TIMELESS mRNA19140230
D014520UrethaneUrethane results in decreased expression of TIMELESS mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMELESS mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TIMELESS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TIMELESS mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TIMELESS gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of TIMELESS mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IBA21873635  
GO:0005515protein binding-IPI15798197  17102137  20124417  
GO:0042803protein homodimerization activity-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000076DNA replication checkpoint-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0002009morphogenesis of an epithelium-ISS-  
GO:0006281DNA repair-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006974cellular response to DNA damage stimulus-IMP23797032  
GO:0006974cellular response to DNA damage stimulus-ISS-  
GO:0007623circadian rhythm-ISS-  
GO:0009582detection of abiotic stimulus-TAS9856466  
GO:0030324lung development-IEA-  
GO:0042127regulation of cell proliferationNOTIMP17102137  
GO:0042752regulation of circadian rhythm-IMP23418588  
GO:0043111replication fork arrest-IBA21873635  
GO:0044770cell cycle phase transition-IMP17102137  
GO:0045892negative regulation of transcription, DNA-templated-IDA9856465  
GO:0048478replication fork protection-IBA21873635  
GO:0048754branching morphogenesis of an epithelial tube-IEA-  
GO:0051301cell division-IEA-  
GO:0072711cellular response to hydroxyurea-IMP23797032  
GO:0072719cellular response to cisplatin-IMP23797032  
GO:1904976cellular response to bleomycin-IMP23797032  
GO:2000781positive regulation of double-strand break repair-IMP23797032  
GO ID GO Term Qualifier Evidence PubMed
GO:0000228nuclear chromosome-IBA21873635  
GO:0000790nuclear chromatin-IBA21873635  
GO:0000790nuclear chromatin-IDA17102137  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IC9856465  
GO:0005634nucleus-IDA17102137  
GO:0005654nucleoplasm-TAS-  
GO:0031298replication fork protection complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
1569432Timeless epidemiology or history cannot be ignored. (1992 Apr)Gunning-Schepers LJJ Clin Epidemiol
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One