Gene: HERC2

8924
D15F37S1|MRT38|SHEP1|jdf2|p528
HECT and RLD domain containing E3 ubiquitin protein ligase 2
protein-coding
15q13.1
Ensembl:ENSG00000128731 MIM:605837 Vega:OTTHUMG00000129251 UniprotKB:O95714
NG_016355.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.409e-2 (AD)  2.921e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DYNC1H10.96
HERC10.952
HECTD40.95
MAN2A20.949
MTOR0.949
LARP10.949
SUGP20.943
EXOC70.942
KPNA60.94
YEATS20.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.559
OR4F29-0.537
MTRNR2L6-0.428
MTRNR2L9-0.418
MTRNR2L10-0.409
ZNF114-0.382
MYL3-0.373
OR4F16-0.359
CST7-0.356
TFPI2-0.353

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HERC2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HERC2 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of HERC2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of HERC2 gene28458013
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HERC2 mRNA19770486
D000447AldehydesAldehydes results in decreased expression of HERC2 mRNA25014914
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HERC2 mRNA24449571
D001151ArsenicArsenic affects the methylation of HERC2 gene25304211
D001280AtrazineAtrazine results in decreased expression of HERC2 mRNA22378314
D001554BenzeneBenzene results in decreased expression of HERC2 mRNA21843810
D001564Benzo(a)pyreneBenzo(a)pyrene affects the splicing of HERC2 exon26001963
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HERC2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of HERC2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HERC2 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of HERC2 mRNA26079696
D016572CyclosporineCyclosporine results in decreased expression of HERC2 mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of HERC2 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HERC2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HERC2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HERC2 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of HERC2 mRNA28302478
D004026DieldrinDieldrin results in increased expression of HERC2 mRNA23041725
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HERC2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HERC2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HERC2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HERC2 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of HERC2 mRNA24796395
C045463leflunomideleflunomide results in decreased expression of HERC2 mRNA28988120
D008694MethamphetamineMethamphetamine results in increased expression of HERC2 mRNA26307267
C017557nickel subsulfidenickel subsulfide results in increased expression of HERC2 mRNA21086188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of HERC2 mRNA25729387
D052638Particulate MatterParticulate Matter results in increased expression of HERC2 mRNA24769257
C046012pentanalpentanal results in decreased expression of HERC2 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HERC2 mRNA17560707
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of HERC2 mRNA22698814
D011794QuercetinQuercetin results in increased expression of HERC2 mRNA21632981
C009277sodium arsenatesodium arsenate results in increased expression of HERC2 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HERC2 mRNA26290441
D014050TolueneToluene results in decreased expression of HERC2 mRNA28245982
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of HERC2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of HERC2 mRNA25729387
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HERC2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of HERC2 mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of HERC2 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-IDA20304803  
GO:0005085guanyl-nucleotide exchange factor activity-NAS9949213  
GO:0005515protein binding-IPI20023648  20304803  29426014  
GO:0008270zinc ion binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI22508508  
GO:0032183SUMO binding-IDA22508508  
GO ID GO Term Qualifier Evidence PubMed
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0006886intracellular protein transport-NAS9949213  
GO:0006974cellular response to DNA damage stimulus-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IDA22508508  
GO:0007283spermatogenesis-IEA-  
GO:0016567protein ubiquitination-IDA20304803  
GO:0016567protein ubiquitination-IEA-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA20304803  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA20304803  
GO:0005814centriole-IEA-  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1640170Cell CycleTAS
R-HSA-168256Immune SystemTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73894DNA RepairTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25921801Eye color: A potential indicator of alcohol dependence risk in European Americans. (2015 Jul)Sulovari AAm J Med Genet B Neuropsychiatr Genet
27459457Epidemiological Assessments of Skin Outcomes in the Nurses' Health Studies. (2016 Sep)Li WQAm J Public Health