Gene: PHOX2B

8929
CCHS|NBLST2|NBPhox|PMX2B
paired like homeobox 2b
protein-coding
4p13
Ensembl:ENSG00000109132 MIM:603851 Vega:OTTHUMG00000099379 UniprotKB:Q99453
NG_008243.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.540e-1 (AD)  8.330e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BAGE20.779
OR52A10.729
OR2AP10.719
DAOA0.717
OR5K10.715
TCHHL10.713
OR2B20.713
OR1S20.71
SPATA31D10.71
CRISP10.708

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTSR2-0.202
HHATL-0.2
GALR3-0.199
GPT-0.197
NUDT8-0.193
HIST1H4C-0.191
C16orf89-0.186
GPR143-0.186
CHRDL1-0.185
HPSE2-0.185

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of PHOX2B mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PHOX2B gene27153756
C015001arsenitearsenite results in increased methylation of PHOX2B promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PHOX2B mRNA22316170
C044887beta-methylcholinebeta-methylcholine affects the expression of PHOX2B mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of PHOX2B mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of PHOX2B mRNA25181051
D003300CopperCopper deficiency results in increased expression of PHOX2B mRNA26033743
C014347decitabinedecitabine results in decreased methylation of PHOX2B promoter17690560
C014347decitabinedecitabine results in increased expression of PHOX2B mRNA17690560
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PHOX2B mRNA26924002
C118739entinostatentinostat results in decreased expression of PHOX2B mRNA27188386
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PHOX2B protein23430699
D008628MercuryMercury results in increased expression of PHOX2B mRNA16823088
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PHOX2B mRNA"20188158
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHOX2B mRNA24058054
D014118Toxins, Biological"Toxins, Biological affects the expression of PHOX2B mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of PHOX2B mRNA23724009
D014212TretinoinTretinoin results in increased expression of PHOX2B mRNA21934132
D014635Valproic AcidValproic Acid affects the expression of PHOX2B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PHOX2B mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of PHOX2B gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PHOX2B gene25560391
C111237vorinostatvorinostat results in decreased expression of PHOX2B mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA16280598  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA16144830  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA16144830  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-ISS-  
GO:0002087regulation of respiratory gaseous exchange by neurological system process-ISS-  
GO:0003357noradrenergic neuron differentiation-IC19573018  
GO:0003357noradrenergic neuron differentiation-ISS-  
GO:0003358noradrenergic neuron development-ISS-  
GO:0003360brainstem development-IEP12640453  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0010001glial cell differentiation-ISS-  
GO:0010468regulation of gene expression-ISS-  
GO:0010971positive regulation of G2/M transition of mitotic cell cycle-ISS-  
GO:0021533cell differentiation in hindbrain-ISS-  
GO:0021723medullary reticular formation development-ISS-  
GO:0021934hindbrain tangential cell migration-ISS-  
GO:0035914skeletal muscle cell differentiation-IEA-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16144830  16280598  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP19573018  
GO:0048483autonomic nervous system development-IMP12640453  
GO:0048484enteric nervous system development-IEP12640453  
GO:0048485sympathetic nervous system development-ISS-  
GO:0048486parasympathetic nervous system development-ISS-  
GO:0048839inner ear development-ISS-  
GO:0048894efferent axon development in a lateral line nerve-ISS-  
GO:0060541respiratory system development-ISS-  
GO:0061452retrotrapezoid nucleus neuron differentiation-ISS-  
GO:0061549sympathetic ganglion development-ISS-  
GO:0071157negative regulation of cell cycle arrest-ISS-  
GO:0071542dopaminergic neuron differentiation-IC19573018  
GO:0071542dopaminergic neuron differentiation-ISS-  
GO:0071773cellular response to BMP stimulus-ISS-  
GO:1901166neural crest cell migration involved in autonomic nervous system development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA16280598  
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21206965IL23R, NOD2/CARD15, ATG16L1 and PHOX2B polymorphisms in a group of patients with Crohn's disease and correlation with sub-phenotypes. (2011 Mar)Lauriola MInt J Mol Med