Gene: MBD4

8930
MED1
methyl-CpG binding domain 4, DNA glycosylase
protein-coding
3q21.3
Ensembl:ENSG00000129071 MIM:603574 Vega:OTTHUMG00000159463 UniprotKB:O95243
NG_033106.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.334e-1 (AD)  5.475e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IBTK0.9
HNRNPDL0.9
RBMX0.895
USP160.887
GOLGA50.886
RARS20.885
NAP1L10.884
NFX10.878
RNF140.878
DIMT10.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.636
OR4F5-0.603
MTRNR2L6-0.282
MTRNR2L10-0.281
EYA2-0.278
ADAMTSL5-0.268
MTRNR2L9-0.268
FOXJ1-0.266
SALL3-0.26
WNT7B-0.259

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0182893,N(4)-ethenocytosine"MBD4 protein affects the glycosylation of 3,N(4)-ethenocytosine"11056019
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MBD4 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of MBD4 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MBD4 gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of MBD4 mRNA20458559
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MBD4 mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MBD4 mRNA"26238291
D004958EstradiolEstradiol promotes the reaction [sodium arsenite results in decreased expression of MBD4 protein]22952798
D004958EstradiolEstradiol results in decreased expression of MBD4 mRNA22952798
D004958EstradiolEstradiol results in decreased expression of MBD4 protein22952798
D004958Estradiolsodium arsenite promotes the reaction [Estradiol results in decreased expression of MBD4 mRNA]22952798
D004958Estradiolsodium arsenite promotes the reaction [Estradiol results in decreased expression of MBD4 protein]22952798
D000069286BortezomibBortezomib results in increased expression of MBD4 mRNA20977926
C584509C646 compoundC646 compound results in increased expression of MBD4 mRNA26191083
D019327Copper SulfateCopper Sulfate results in increased expression of MBD4 mRNA19549813
C017160cypermethrincypermethrin results in increased expression of MBD4 mRNA21142847
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of MBD4 mRNA23914054
D003703DemecolcineDemecolcine results in decreased expression of MBD4 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MBD4 mRNA21266533
D002945CisplatinCisplatin results in increased expression of MBD4 mRNA19561079
C000944dicrotophosdicrotophos results in decreased expression of MBD4 mRNA28302478
C010452estradiol-17 beta-benzoateestradiol-17 beta-benzoate results in increased expression of MBD4 mRNA22109888
D005472FluorouracilMBD4 protein results in increased metabolism of Fluorouracil16885370
D017313FenretinideFenretinide results in increased expression of MBD4 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MBD4 mRNA21179406
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of MBD4 mRNA27655674
C492448ICG 001ICG 001 results in increased expression of MBD4 mRNA26191083
D007065IdoxuridineMBD4 protein affects the susceptibility to Idoxuridine16885370
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MBD4 mRNA25613284
C410337K 7174K 7174 results in increased expression of MBD4 mRNA24086573
C045463leflunomideleflunomide results in decreased expression of MBD4 mRNA28988120
D008627Mercuric Chloride"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD4 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MBD4 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MBD4 mRNA"25554681
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MBD4 mRNA19710929
D011794QuercetinQuercetin results in decreased expression of MBD4 mRNA21632981
D011794QuercetinQuercetin results in decreased expression of MBD4 mRNA17103110
C547185riccardin Driccardin D results in increased expression of MBD4 mRNA24069304
D012643SeleniumSelenium results in decreased expression of MBD4 mRNA19244175
C017947sodium arseniteEstradiol promotes the reaction [sodium arsenite results in decreased expression of MBD4 protein]22952798
C017947sodium arsenitesodium arsenite affects the expression of MBD4 mRNA22952798
C017947sodium arsenitesodium arsenite affects the methylation of MBD4 gene28589171
C017947sodium arsenitesodium arsenite promotes the reaction [Estradiol results in decreased expression of MBD4 mRNA]22952798
C017947sodium arsenitesodium arsenite promotes the reaction [Estradiol results in decreased expression of MBD4 protein]22952798
C017947sodium arsenitesodium arsenite results in decreased expression of MBD4 protein22952798
D018038Sodium SeleniteSodium Selenite results in decreased expression of MBD4 mRNA23274088
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of MBD4 mRNA20189893
C004648testosterone enanthatetestosterone enanthate affects the expression of MBD4 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MBD4 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MBD4 mRNA25613284
D019772TopotecanMBD4 protein affects the susceptibility to Topotecan16217747
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MBD4 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of MBD4 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of MBD4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MBD4 mRNA29154799
D014750VincristineVincristine results in decreased expression of MBD4 mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of MBD4 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IBA21873635  
GO:0003696satellite DNA binding-TAS9774669  
GO:0004520endodeoxyribonuclease activity-TAS10097147  
GO:0005515protein binding-IPI12702765  
GO:0008263pyrimidine-specific mismatch base pair DNA N-glycosylase activity-IDA14614141  
GO:0019104DNA N-glycosylase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-TAS10097147  
GO:0009314response to radiation-IBA21873635  
GO:0032355response to estradiol-IEA-  
GO:0045008depyrimidination-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS9774669  
GO:0005654nucleoplasm-TAS-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-110328Recognition and association of DNA glycosylase with site containing an affected pyrimidineTAS
R-HSA-110329Cleavage of the damaged pyrimidine TAS
R-HSA-110357Displacement of DNA glycosylase by APEX1TAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73928DepyrimidinationTAS
R-HSA-73929Base-Excision Repair, AP Site FormationTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18495292Tagging single nucleotide polymorphisms in MBD4 are associated with risk of lung cancer in a Chinese population. (2008 Dec)Miao RLung Cancer