Gene: MBD2

8932
DMTase|NY-CO-41
methyl-CpG binding domain protein 2
protein-coding
18q21.2
Ensembl:ENSG00000134046 MIM:603547 Vega:OTTHUMG00000132705 UniprotKB:Q9UBB5
NG_029550.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.096e-1 (AD)  1.909e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2J10.865
DEK0.855
CDYL0.852
CDV30.847
CUL4A0.845
XRN20.845
CNOT80.844
PRPF4B0.84
CAST0.837
DDX50.834

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.572
OR4F5-0.571
BTBD17-0.322
NXNL1-0.312
ARSF-0.308
HES5-0.277
ADAMTSL5-0.272
PYGM-0.262
WNT7B-0.258
RLBP1-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MBD2 mRNA"25614096
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of MBD2 mRNA17562736
D012436S-AdenosylmethionineS-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein]22558281
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MBD2 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of MBD2 mRNA21298039
D001151ArsenicArsenic affects the methylation of MBD2 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of MBD2 protein22558281
C006632arsenic trioxideS-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein]22558281
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MBD2 mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of MBD2 protein]23395981
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]20631324
D004958Estradiolresveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]]20631324
D004958Estradiol[Testosterone co-treated with Estradiol] promotes the reaction [bisphenol A results in increased expression of MBD2 mRNA]22109888
D004958Estradiol[Testosterone co-treated with Estradiol] promotes the reaction [estradiol-17 beta-benzoate results in increased expression of MBD2 mRNA]22109888
C053541bicalutamidebicalutamide results in increased expression of MBD2 mRNA16631469
C006780bisphenol Abisphenol A affects the expression of MBD2 mRNA27120497
C006780bisphenol Abisphenol A results in increased expression of MBD2 mRNA22109888|2518105
C006780bisphenol A[Testosterone co-treated with Estradiol] promotes the reaction [bisphenol A results in increased expression of MBD2 mRNA]22109888
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBD2 mRNA28628672
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of MBD2 mRNA24763279
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MBD2 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MBD2 gene20938992
C014347decitabine[decitabine co-treated with trichostatin A] inhibits the reaction [MBD2 protein binds to CLDN3 promoter]17986852
C014347decitabinedecitabine inhibits the reaction [MBD2 protein binds to BUB1B promoter]17464181
C014347decitabinedecitabine inhibits the reaction [MBD2 protein binds to CLDN3 promoter]17986852
C014347decitabinedecitabine results in decreased activity of MBD2 protein19221000
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBD2 mRNA28628672
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MBD2 mRNA25280772
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MBD2 mRNA24316720
C118739entinostatentinostat results in increased expression of MBD2 mRNA27188386
C010452estradiol-17 beta-benzoateestradiol-17 beta-benzoate results in increased expression of MBD2 mRNA22109888
C010452estradiol-17 beta-benzoate[Testosterone co-treated with Estradiol] promotes the reaction [estradiol-17 beta-benzoate results in increased expression of MBD2 mRNA]22109888
D000431Ethanolbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of MBD2 protein]23395981
D000431EthanolEthanol results in decreased expression of MBD2 mRNA23395981
D000431EthanolEthanol results in decreased expression of MBD2 protein23395981
D000431EthanolEthanol results in increased degradation of MBD2 protein23395981
D018120FinasterideFinasteride results in increased expression of MBD2 mRNA24136188
D005485FlutamideFlutamide results in increased expression of MBD2 mRNA24136188
D005492Folic AcidFolic Acid affects the expression of MBD2 mRNA17311948
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MBD2 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of MBD2 mRNA21745553
D005557FormaldehydeFormaldehyde results in increased expression of MBD2 protein21745553
C056933fumonisin B1fumonisin B1 results in increased expression of and results in increased activity of MBD2 protein24280379
D019833GenisteinGenistein results in decreased activity of MBD2 protein19221000
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of MBD2 mRNA24763279
C031927hydroquinonehydroquinone results in decreased expression of MBD2 mRNA22245671
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBD2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBD2 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MBD2 mRNA23086925
C042720mercuric bromidemercuric bromide results in increased expression of MBD2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MBD2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MBD2 mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MBD2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MBD2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MBD2 mRNA"25554681
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of MBD2 mRNA28973697
D010634PhenobarbitalPhenobarbital affects the expression of MBD2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MBD2 mRNA26272509
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in decreased expression of MBD2 protein19459041
C059514resveratrolresveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]]20631324
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [MBD2 protein binds to BRCA1 promoter]]22197621
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MBD2 mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in increased expression of MBD2 mRNA25351596
D013467SulindacSulindac results in decreased expression of MBD2 mRNA24136188
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of MBD2 mRNA"26680231
D013739Testosterone[Testosterone co-treated with Estradiol] promotes the reaction [bisphenol A results in increased expression of MBD2 mRNA]22109888
D013739Testosterone[Testosterone co-treated with Estradiol] promotes the reaction [estradiol-17 beta-benzoate results in increased expression of MBD2 mRNA]22109888
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MBD2 mRNA18495758
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]20631324
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]]20631324
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [MBD2 protein binds to BRCA1 promoter]]22197621
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [MBD2 protein binds to BRCA1 promoter]20631324
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [MBD2 protein binds to BRCA1 promoter]22197621
D013849ThimerosalThimerosal results in decreased expression of MBD2 mRNA27188386
D014212TretinoinTretinoin results in increased expression of MBD2 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MBD2 gene27618143
C012589trichostatin A[decitabine co-treated with trichostatin A] inhibits the reaction [MBD2 protein binds to CLDN3 promoter]17986852
C012589trichostatin Atrichostatin A results in increased expression of MBD2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MBD2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of MBD2 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased expression of MBD2 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MBD2 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of MBD2 mRNA20829426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA bindingcontributes_toHDA16217013  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingcontributes_toHDA16217013  
GO:0003696satellite DNA binding-TAS9774669  
GO:0003729mRNA binding-IEA-  
GO:0005515protein binding-IPI12183469  16415179  21258344  23752268  25753662  26496610  
27593931  
GO:0008327methyl-CpG binding-IBA21873635  
GO:0008327methyl-CpG binding-IDA21029866  24307175  
GO:0008327methyl-CpG binding-NAS10441743  
GO:0019904protein domain specific binding-IPI11984006  
GO:0031492nucleosomal DNA bindingcontributes_toHDA16217013  
GO:0035197siRNA binding-IEA-  
GO:0070742C2H2 zinc finger domain binding-IPI11553631  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000183chromatin silencing at rDNA-TAS-  
GO:0006346methylation-dependent chromatin silencing-IBA21873635  
GO:0006346methylation-dependent chromatin silencing-IGI23770133  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007507heart development-IEA-  
GO:0007568aging-IEA-  
GO:0009612response to mechanical stimulus-IEA-  
GO:0030177positive regulation of Wnt signaling pathway-IEA-  
GO:0031667response to nutrient levels-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0034622cellular protein-containing complex assembly-IEA-  
GO:0035563positive regulation of chromatin binding-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0042711maternal behavior-IEA-  
GO:0043044ATP-dependent chromatin remodeling-HDA16217013  
GO:0044030regulation of DNA methylation-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-NAS10441743  
GO:0048568embryonic organ development-IEA-  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complex-IEA-  
GO:0000790nuclear chromatin-HDA16217013  
GO:0000790nuclear chromatin-IDA23770133  
GO:0000792heterochromatin-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11553631  
GO:0005634nucleus-NAS10441743  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0032991protein-containing complex-HDA16217013  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-427413NoRC negatively regulates rRNA expressionTAS
R-HSA-5250941Negative epigenetic regulation of rRNA expressionTAS
R-HSA-73728RNA Polymerase I Promoter OpeningTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15112265Methyl-CpG-binding domain 2: a protective role in bladder carcinoma. (2004 May 1)Zhu YCancer