Gene: FUBP3

8939
FBP3
far upstream element binding protein 3
protein-coding
9q34.11-q34.12
Ensembl:ENSG00000107164 MIM:603536 Vega:OTTHUMG00000020809 UniprotKB:Q96I24
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.309e-1 (AD)  9.122e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SS180.881
UEVLD0.876
YIPF60.862
SUCO0.862
MYO60.857
DAZAP20.856
ABCD30.854
AGPAT50.853
POFUT10.848
PPFIA10.847

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.661
OR4F29-0.653
EPPIN-0.306
MMP23B-0.213
RAX2-0.212
SULT2B1-0.201
MIP-0.197
CELSR1-0.19
WFDC8-0.185
SPRR2D-0.179

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of FUBP3 mRNA"21354444
D020106AcrylamideAcrylamide results in decreased expression of FUBP3 mRNA28959563
D001280AtrazineAtrazine results in increased expression of FUBP3 mRNA22982499
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased methylation of FUBP3 promoter28329817
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FUBP3 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of FUBP3 mRNA"20382639
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of FUBP3 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of FUBP3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of FUBP3 mRNA25181051
C515564bromovaninbromovanin results in increased expression of FUBP3 protein21419150
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FUBP3 mRNA24982889
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FUBP3 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FUBP3 gene20938992
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FUBP3 mRNA]27941970
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of FUBP3 mRNA27638505
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FUBP3 protein23301498
D005485FlutamideFlutamide results in decreased expression of FUBP3 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FUBP3 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FUBP3 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FUBP3 mRNA23649840
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FUBP3 mRNA25729387
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of FUBP3 mRNA"23246600
C017947sodium arsenitesodium arsenite results in increased expression of FUBP3 mRNA21457566
D012969Sodium FluorideSodium Fluoride results in decreased expression of FUBP3 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FUBP3 mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FUBP3 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of FUBP3 mRNA16140955
D014635Valproic AcidValproic Acid results in decreased methylation of FUBP3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FUBP3 gene25560391
C025643vinclozolinvinclozolin affects the expression of FUBP3 mRNA19015723
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of FUBP3 mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA8940189  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA8940189  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI16713569  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IDA8940189  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0010628positive regulation of gene expression-IDA19087307  
GO:0045893positive regulation of transcription, DNA-templated-IDA8940189  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA8940189  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19087307  
GO:0005634nucleus-NAS8940189  
GO:0005737cytoplasm-IDA19087307  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27134767Genome-wide time-to-event analysis on smoking progression stages in a family-based study. (2016 May)He LBrain Behav