Gene: CCND2

894
KIAK0002|MPPH3
cyclin D2
protein-coding
12p13.32
Ensembl:ENSG00000118971 MIM:123833 Vega:OTTHUMG00000168123 UniprotKB:P30279
NG_034254.1
PubMed
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.682e-1 (AD)  3.297e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CMIP0.878
UBE2V10.875
TERF20.872
LASP10.862
MAST20.862
PRKACA0.861
ARRB20.859
FAM222B0.858
PACS10.857
HARS0.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.654
OR4F29-0.585
SH2D1A-0.343
CTNNA3-0.327
ASB4-0.297
ANXA13-0.289
TRPV5-0.276
HEY2-0.274
TNFRSF13B-0.273
CLEC4E-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0449851',2'-dihydrorotenone"1',2'-dihydrorotenone results in decreased expression of CCND2 mRNA"24615755
C0449851',2'-dihydrorotenone"1',2'-dihydrorotenone results in decreased expression of CCND2 protein"24615755
C0741531,4-phenylenebis(methylene)selenocyanate"1,4-phenylenebis(methylene)selenocyanate results in decreased expression of CCND2 mRNA"12844480
C4779411,4-phenylenebis(methylene)selenocyanate, glutathione conjugate"1,4-phenylenebis(methylene)selenocyanate, glutathione conjugate results in decreased expression of CCND2 mRNA"12844480
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 results in decreased expression of CCND2 mRNA12649303
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 results in decreased expression of CCND2 protein12649303
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCND2 mRNA"25510870
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of CCND2 protein"15525693
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCND2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCND2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCND2 mRNA"25510870
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 mRNA]15778701
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]15778701
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased methylation of CCND2 promoter14745455
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CCND2 mRNA14745455
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]15778701
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND2 protein15601625
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCND2 mRNA"25510870
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCND2 mRNA"15059925
C487689(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid"(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid results in decreased expression of CCND2 protein"16546985
C1202752-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CCND2 protein11468187
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCND2 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCND2 mRNA"27188386
C4943564-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Ethanol results in decreased expression of CCND2 mRNA]"21878650
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CCND2 protein15607904
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide results in increased expression of CCND2 mRNA20829426
C5139355-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide"5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide results in decreased expression of CCND2 mRNA"17537993
C5139355-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide"5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide results in decreased expression of CCND2 protein"17537993
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCND2 mRNA"27188386
C0428349,10-anthraquinone"9,10-anthraquinone analog results in decreased expression of CCND2 protein"26915975
C072876A 771726A 771726 results in decreased expression of CCND2 protein19174558
C542662AC 93253AC 93253 results in increased expression of CCND2 mRNA25912555
D000082AcetaminophenAcetaminophen results in decreased expression of CCND2 mRNA22230336
D000082AcetaminophenAcetaminophen results in increased expression of CCND2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CCND2 mRNA17562736
D000086AcetazolamideAcetazolamide results in increased expression of CCND2 mRNA19274763
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Methoxychlor results in decreased expression of CCND2 mRNA]19615393
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]26332274
D020106AcrylamideAcrylamide affects the expression of CCND2 mRNA28959563
D000181AcrylonitrileAcetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]26332274
D000181AcrylonitrileAcrylonitrile results in increased expression of CCND2 mRNA26332274
D000181Acrylonitrilealpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]26332274
D000181AcrylonitrilePlant Extracts inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]26332274
C058956acteosideacteoside results in decreased expression of CCND2 protein17634406
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CCND2 mRNA19770486
C000188alachloralachlor results in increased expression of CCND2 mRNA12419858
D000447AldehydesAldehydes results in increased expression of CCND2 mRNA25014914
C000607033alpha-terthienylmethanolalpha-terthienylmethanol results in increased expression of CCND2 protein28506552
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]26332274
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CCND2 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CCND2 protein16483693
C023650anilineaniline results in increased expression of CCND2 mRNA21070798
C023650anilineaniline results in increased expression of CCND2 protein21070798
D001151ArsenicArsenic results in increased expression of CCND2 mRNA19945496
D001151ArsenicArsenic results in decreased expression of CCND2 mRNA19654921
C006632arsenic trioxidearsenic trioxide results in increased expression of CCND2 mRNA15073043
C015001arsenitearsenite results in increased expression of CCND2 mRNA18191166
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in increased expression of CCND2 mRNA17639512
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CCND2 protein]21621607
D001280AtrazineAtrazine inhibits the reaction [FSHB protein results in increased expression of CCND2 mRNA]25253736
D001280AtrazineAtrazine results in decreased expression of CCND2 mRNA26923738
D001374AzacitidineAzacitidine affects the methylation of CCND2 promoter17016690
D001374Azacitidine[Azacitidine affects the methylation of CCND2 promoter] which affects the expression of CCND2 mRNA17016690|1701669
C487081belinostatbelinostat results in decreased expression of CCND2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCND2 mRNA"27188386
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CCND2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CCND2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CCND2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCND2 mRNA25690898
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CCND2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCND2 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCND2 mRNA"20382639
D001599BerberineBerberine results in decreased expression of CCND2 protein16505103
D004958Estradiol[Estradiol co-treated with IGF1R mutant form] results in increased expression of CCND2 mRNA23094148
D004958EstradiolEstradiol results in increased expression of CCND2 mRNA23019147
D004958EstradiolEstradiol inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CCND2 mRNA]19874833
D004958EstradiolEstradiol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CCND2 mRNA]19874833
D004958EstradiolEstradiol results in increased expression of CCND2 mRNA11861973
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CCND2 mRNA]11861973
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of CCND2 mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of CCND228729173
C006780bisphenol Abisphenol A results in decreased expression of CCND2 mRNA26363213
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCND2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of CCND2 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of CCND2 mRNA18958704
D000069286BortezomibBortezomib results in decreased expression of CCND2 mRNA20977926
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CCND2 mRNA22079614
C073829Bupleuran 2IIcBupleuran 2IIc results in increased expression of CCND2 protein14556967
C027561butylbenzyl phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CCND2 mRNA28013214
C018475butyraldehydebutyraldehyde results in increased expression of CCND2 mRNA26079696
D002087ButyratesButyrates results in decreased expression of CCND2 mRNA26559563
D002087ButyratesButyrates results in decreased expression of CCND2 protein26559563
D002101Cacodylic AcidCacodylic Acid affects the expression of CCND2 mRNA17720352
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CCND2 mRNA18804290
D000074262Canola OilCanola Oil metabolite results in decreased expression of CCND2 mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CCND2 protein12629582
D000068579CelecoxibCelecoxib results in decreased expression of CCND2 mRNA19428934
D000068579CelecoxibCelecoxib results in decreased expression of CCND2 protein19428934
C100187chloropicrinchloropicrin results in decreased expression of CCND2 mRNA26352163|2847649
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CCND2 mRNA20350560
D002794CholineCholine results in increased expression of CCND2 mRNA16014740
D002794CholineCholine results in increased expression of CCND2 mRNA16014740
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CCND2 mRNA28472532
C074702chromium hexavalent ionAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CCND2 protein]21621607
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of CCND2 protein21621607
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CCND2 mRNA27858113
C019304ciprofibrateciprofibrate results in decreased expression of CCND2 mRNA12649303
C019304ciprofibrateciprofibrate results in decreased expression of CCND2 protein12649303
D002994ClofibrateClofibrate results in decreased expression of CCND2 mRNA12649303
D002994ClofibrateClofibrate results in decreased expression of CCND2 protein12649303
C018021cobaltous chloridecobaltous chloride results in decreased expression of CCND2 mRNA19320972
D003300Copper[Thiosemicarbazones binds to Copper] which results in decreased expression of CCND2 protein20931265
D019327Copper SulfateCopper Sulfate results in increased expression of CCND2 mRNA21595052
D003345CorticosteroneCorticosterone results in decreased expression of CCND2 mRNA15755911
D003345CorticosteroneCorticosterone results in decreased expression of CCND2 protein15755911
C477330CP-654577CP-654577 results in decreased expression of CCND2 protein12907618
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of CCND2 protein17209053
D003471CuprizoneCuprizone affects the expression of CCND2 mRNA26577399
D003484CyanamideCyanamide inhibits the reaction [CGA protein results in increased expression of CCND2 mRNA]22285649
C000541cyclopaminecyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]27481074
C000541cyclopaminecyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]]27481074
D003520CyclophosphamideCyclophosphamide results in increased expression of CCND2 mRNA21041162
D016572CyclosporineCyclosporine results in decreased expression of CCND2 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of CCND2 mRNA20106945
C017160cypermethrincypermethrin results in decreased expression of CCND2 mRNA24810582
C017160cypermethrincypermethrin results in increased expression of CCND2 mRNA22528246
D003634DDTDDT results in decreased expression of CCND2 mRNA25014179
C014347decitabinedecitabine results in increased expression of CCND2 mRNA27915011
D003676DeferoxamineDeferoxamine results in decreased expression of CCND2 protein11468187
D003907DexamethasoneDexamethasone results in decreased expression of CCND2 mRNA19428934
D003907DexamethasoneDexamethasone results in decreased expression of CCND2 protein19428934
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCND2 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of CCND2 mRNA21041162
D003907DexamethasoneDexamethasone results in decreased expression of CCND2 mRNA14618091
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone affects the expression of CCND2 protein"21750178
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CCND2 mRNA17361019|2126653
D003993Dibutyl Phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CCND2 mRNA28013214
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CCND2 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with Quercetin] results in increased expression of CCND2 mRNA27514524
D002945CisplatinCisplatin results in decreased expression of CCND2 mRNA27594783
D019259LamivudineLamivudine results in decreased expression of CCND2 mRNA15784690
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of CCND2 mRNA15784690
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of CCND2 mRNA17490981
C020283diethanolaminediethanolamine results in increased expression of CCND2 mRNA16014740
C020283diethanolaminediethanolamine results in increased expression of CCND2 mRNA16014740
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CCND2 mRNA19874833
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CCND2 mRNA25701202
D004051Diethylhexyl Phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CCND2 mRNA28013214
D004051Diethylhexyl PhthalateEstradiol inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CCND2 mRNA]19874833
C007379diethyl phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CCND2 mRNA28013214
D002117CalcitriolCalcitriol results in decreased expression of CCND2 mRNA15951637|1600243
C025605diisobutyl phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CCND2 mRNA28013214
C012125diisononyl phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CCND2 mRNA28013214
D004221DisulfiramDisulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]22285649
D004317DoxorubicinCCND2 protein affects the susceptibility to Doxorubicin16928833
D004317DoxorubicinDoxorubicin results in decreased expression of CCND2 mRNA21040762
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of CCND2 mRNA21040762
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of CCND2 protein"15456542
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CCND2 mRNA"23811387
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of CCND2 mRNA12655031
D000431Ethanol"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Ethanol results in decreased expression of CCND2 mRNA]"21878650
D000431EthanolEthanol results in decreased expression of CCND2 mRNA21878650
D000431EthanolLithium inhibits the reaction [Ethanol results in decreased expression of CCND2 mRNA]21878650
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CCND2 mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CCND2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CCND2 mRNA17942748|2409603
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CCND2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CCND2 mRNA12655037|1755790
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in increased expression of CCND2 mRNA15659706
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in increased expression of CCND2 protein15659706
D000068338EverolimusEverolimus results in decreased expression of CCND2 protein16033851
D000068338Everolimus[letrozole co-treated with Everolimus] results in decreased expression of CCND2 protein16033851
D015025ZearalenoneZearalenone results in decreased expression of CCND2 mRNA28965971
D015025ZearalenoneZearalenone results in decreased expression of CCND2 mRNA17557909
C540355fenamidonefenamidone results in increased expression of CCND2 mRNA27029645
D005472FluorouracilCCND2 protein affects the susceptibility to Fluorouracil15352031
D005472FluorouracilFluorouracil results in increased expression of CCND2 protein15352031
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of CCND2 mRNA]15016801
D005472FluorouracilFluorouracil results in decreased expression of CCND2 mRNA19272435
D005485FlutamideFlutamide results in increased expression of CCND2 protein15659706
D005557FormaldehydeFormaldehyde results in decreased expression of CCND2 mRNA23649840
C007789fucoidanfucoidan results in decreased expression of CCND2 protein16201850
C039281furanfuran results in increased expression of CCND2 mRNA22079235
C001277geldanamycingeldanamycin results in increased expression of CCND2 mRNA26705709
D019833GenisteinGenistein results in increased expression of CCND2 mRNA23019147|2686566
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of CCND2 mRNA21782745
D005947Glucosecyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]27481074
D005947Glucosecyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]]27481074
D005947Glucose[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA27481074
D005947Glucosepolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]27481074
D006064Gonadotropins, Equine"[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in decreased expression of CCND2 mRNA"20724799
C500810GW8510GW8510 results in increased expression of CCND2 mRNA22242153
C538724HhAntag691HhAntag691 results in decreased expression of CCND2 mRNA24973920
D017313FenretinideFenretinide results in decreased expression of CCND2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CCND2 protein21179406
D006918HydroxyureaHydroxyurea results in increased expression of CCND2 protein11468187
C492448ICG 001ICG 001 results in increased expression of CCND2 mRNA26191083
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of CCND2 mRNA21536647
C016517indole-3-carbinolindole-3-carbinol affects the expression of CCND2 mRNA21396975
D007213IndomethacinIndomethacin results in decreased expression of CCND2 mRNA19428934
D007213IndomethacinIndomethacin results in decreased expression of CCND2 protein19428934
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCND2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCND2 mRNA28628672
C040920isoliquiritigeninisoliquiritigenin results in decreased expression of CCND2 mRNA27702603
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CCND2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CCND2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to CCND2 enhancer alternative form]23582323
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CCND2 mRNA25961927|2664458
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CCND2 mRNA24973920
C500368labedipinedilol Alabedipinedilol A results in decreased expression of CCND2 protein19056458
C067431letrozole[letrozole co-treated with Everolimus] results in decreased expression of CCND2 protein16033851
C067431letrozoleletrozole results in decreased expression of CCND2 protein16033851
C523615levistolide Alevistolide A inhibits the reaction [PDGFB protein results in increased expression of CCND2 protein]17520522
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCND2 mRNA22185406
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCND2 mRNA]22185406
D008070Lipopolysaccharides"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CCND2 mRNA]"22185406
D008094LithiumLithium inhibits the reaction [Ethanol results in decreased expression of CCND2 mRNA]21878650
D008687MetforminMetformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein]16760380
D008687MetforminMetformin results in decreased expression of CCND2 protein16760380
D008727MethotrexateMethotrexate results in increased expression of CCND2 mRNA21678067
D008731MethoxychlorAcetylcysteine inhibits the reaction [Methoxychlor results in decreased expression of CCND2 mRNA]19615393
D008731MethoxychlorMethoxychlor affects the expression of CCND2 protein19615393
D008731MethoxychlorMethoxychlor metabolite results in increased expression of CCND2 protein15525693
D008731MethoxychlorMethoxychlor results in decreased expression of CCND2 mRNA19615393
D008731MethoxychlorMethoxychlor results in increased expression of CCND2 mRNA20829426
D008731MethoxychlorMethoxychlor results in increased expression of CCND2 protein15525693
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of CCND2 mRNA21782745
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CCND2 mRNA18804290
C002950methylformamidemethylformamide analog results in decreased expression of CCND2 mRNA17040096
C002950methylformamidemethylformamide results in decreased expression of CCND2 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CCND2 mRNA26272509|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CCND2 mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCND2 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCND2 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCND2 mRNA]"20230807
C016599mono-(2-ethylhexyl)phthalateEstradiol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CCND2 mRNA]19874833
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of CCND2 mRNA19874833
C028577monobutyl phthalatemonobutyl phthalate affects the expression of CCND2 mRNA19162170
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of CCND2 mRNA20886546
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of CCND2 mRNA20024957
D009151Mustard GasMustard Gas results in increased expression of CCND2 mRNA12884408
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CCND2 mRNA"29244179
D009285NaphthoquinonesNaphthoquinones results in increased expression of CCND2 mRNA23811387
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of CCND2 mRNA19812364
D009532NickelNickel results in increased expression of CCND2 mRNA25583101
C022838nickel chloridenickel chloride results in decreased expression of CCND2 mRNA17312168
D009534NiclosamideNiclosamide results in increased expression of CCND2 mRNA22576131
D009538NicotineNicotine results in decreased expression of CCND2 protein15231866
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCND2 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCND2 mRNA]"20230807
C025589ochratoxin Aochratoxin A results in decreased expression of CCND2 mRNA21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of CCND2 mRNA]21703336
C507134ON 01910ON 01910 results in decreased expression of CCND2 protein19198627
C016340o,p'-DDT"o,p'-DDT results in decreased expression of CCND2 mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in decreased expression of CCND2 mRNA"24096037
D009966OrphenadrineOrphenadrine affects the expression of CCND2 mRNA23665939
D010100OxygenOxygen affects the reaction [AHR protein results in decreased expression of CCND2 mRNA]27103661
D010100Oxygencyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]27481074
D010100Oxygencyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]]27481074
D010100OxygenOxygen deficiency affects the methylation of CCND2 promoter24205000
D010100Oxygen[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA27481074
D010100OxygenOxygen deficiency results in increased expression of CCND2 mRNA24205000
D010100Oxygenpolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]27481074
C500026palbociclib[CDKN2A gene mutant form results in increased expression of CCND2 protein] which results in increased susceptibility to palbociclib24098593
D010269ParaquatParaquat results in decreased expression of CCND2 mRNA28619522
D010269ParaquatParaquat results in decreased expression of CCND2 mRNA17935786
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CCND2 mRNA"25510870
C046012pentanalpentanal results in increased expression of CCND2 mRNA26079696
C539933pevonedistatpevonedistat affects the expression of CCND2 mRNA24634471
D010634PhenobarbitalPhenobarbital affects the expression of CCND2 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of CCND2 mRNA23091169
D010656PhenylephrinePhenylephrine results in increased expression of CCND2 protein12163013
D010795Phthalic AcidsPhthalic Acids results in increased expression of CCND2 mRNA21061450
D010852PicrotoxinPicrotoxin results in decreased expression of CCND2 mRNA15170462
C008922piperinepiperine inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]25655587
C006253pirinixic acidpirinixic acid results in decreased expression of CCND2 mRNA17426115
D010936Plant ExtractsPlant Extracts inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]26332274
C058229polydatincyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]]27481074
C058229polydatinpolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]27481074
D059808PolyphenolsPolyphenols results in increased expression of CCND2 mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CCND2 mRNA26348139
C005556propionaldehydepropionaldehyde results in increased expression of CCND2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CCND2 mRNA24780913
D015237DinoprostDinoprost results in decreased expression of CCND2 mRNA11517196
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CCND2 mRNA27029645
D011748PyrogallolPyrogallol results in increased expression of CCND2 mRNA20362636
D011794Quercetin[Cisplatin co-treated with Quercetin] results in increased expression of CCND2 mRNA27514524
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in increased expression of CCND2 mRNA17639512
D011794QuercetinQuercetin results in decreased expression of CCND2 mRNA14715546
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCND2 mRNA]22185406
D011794QuercetinQuercetin results in decreased expression of CCND2 mRNA22185406
C052785rebamipiderebamipide results in increased expression of CCND2 mRNA18299717
C059514resveratrolresveratrol results in decreased expression of CCND2 protein18347188
C059514resveratrolresveratrol results in decreased expression of CCND2 mRNA11588890
C059514resveratrolresveratrol results in decreased expression of CCND2 protein15122319
D019438RitonavirRitonavir results in decreased expression of CCND2 mRNA16174765|1938611
C089730rosiglitazonerosiglitazone results in decreased expression of CCND2 protein20210794
C010327salinomycinsalinomycin results in decreased expression of CCND2 mRNA19682730
D012643SeleniumSelenium deficiency results in decreased expression of CCND2 mRNA11925459
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CCND2 mRNA23806026
D012834SilverSilver results in increased expression of CCND2 mRNA28959546
D012839SimazineSimazine results in decreased expression of CCND2 mRNA25461544
D020123Sirolimus[Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]15778701
D020123SirolimusSirolimus inhibits the reaction [IL2 protein results in increased expression of CCND2 mRNA]15778701
D020123SirolimusSirolimus results in decreased expression of CCND2 protein15070696
D020123SirolimusSirolimus inhibits the reaction [FSHB protein results in increased expression of CCND2 mRNA]17510244
C497103SK-7041SK-7041 results in increased expression of CCND2 protein16009488
D012906SmokeSmoke affects the expression of CCND2 mRNA23693141
C017947sodium arsenitesodium arsenite results in decreased expression of CCND2 mRNA12377979|2088654
C017947sodium arsenitesodium arsenite results in increased expression of CCND2 mRNA11241755
C016104sodium bichromatesodium bichromate results in increased expression of CCND2 mRNA12325037
D018038Sodium SeleniteSodium Selenite results in decreased expression of CCND2 mRNA16705456
C471405sorafenibsorafenib results in decreased expression of CCND2 protein19001435
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of CCND2 mRNA16214533
D014284TriiodothyronineTriiodothyronine results in increased expression of CCND2 mRNA17399805
D013629TamoxifenTamoxifen affects the expression of CCND2 mRNA17555576
D013739TestosteroneDisulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]22285649
D013739Testosterone[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA22285649
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CCND2 mRNA26988606
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CCND2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CCND2 mRNA]11861973
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CCND2 mRNA15667827
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCND2 mRNA19770486|2104116
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in decreased expression of CCND2 mRNA"20724799
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [CCND2 protein binds to CDK4 protein]12387751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of and results in increased localization of CCND2 protein12387751
D013849ThimerosalThimerosal results in decreased expression of CCND2 mRNA27188386
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in decreased expression of CCND2 protein20931265
D013974ThyroxineThyroxine results in increased expression of CCND2 mRNA17403546
C475928THRX 165724THRX 165724 results in decreased expression of CCND2 mRNA17537993
C475928THRX 165724THRX 165724 results in decreased expression of CCND2 protein17537993
C009495titanium dioxidetitanium dioxide results in decreased expression of CCND2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of CCND2 gene26756918
C082097tocotrienol, delta"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CCND2 mRNA]"22185406
C082097tocotrienol, delta"tocotrienol, delta results in increased expression of CCND2 mRNA"22185406
D014212TretinoinTretinoin results in increased expression of CCND2 mRNA16024653|2193413
D014212TretinoinTretinoin results in increased expression of CCND2 protein20507312
D014212TretinoinTretinoin results in increased expression of CCND2 mRNA20488242
C012589trichostatin Atrichostatin A results in decreased expression of CCND2 mRNA26272509|2655956
C012589trichostatin Atrichostatin A results in increased expression of CCND2 protein16009488
C001899triptolidetriptolide results in increased expression of CCND2 mRNA23639586
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CCND2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CCND2 mRNA12649303
C057693troglitazonetroglitazone results in decreased expression of CCND2 protein12649303
D014635Valproic AcidValproic Acid affects the expression of CCND2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CCND2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of CCND2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of CCND2 protein15379904
C025643vinclozolinvinclozolin affects the expression of CCND2 mRNA19015723
D014801Vitamin AVitamin A deficiency results in decreased expression of CCND2 mRNA12163651
D014810Vitamin EVitamin E results in increased expression of CCND2 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of CCND2 mRNA27188386
C009687wortmanninwortmannin results in decreased methylation of CCND2 promoter14745455
C009687wortmanninwortmannin results in increased expression of CCND2 mRNA14745455
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of CCND2 mRNA15784690
D015215ZidovudineZidovudine results in decreased expression of CCND2 mRNA15784690
D015032ZincZinc results in decreased expression of CCND2 mRNA17074742
D019287Zinc SulfateZinc Sulfate results in decreased expression of CCND2 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI11896535  16182291  16189514  16765349  23455922  23602568  
25241761  25416956  25910212  26871637  27107012  
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity-IBA21873635  
GO:0019901protein kinase binding-IBA21873635  
GO:0019901protein kinase binding-IPI8114739  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0000278mitotic cell cycle-IBA21873635  
GO:0001934positive regulation of protein phosphorylation-IDA8114739  
GO:0007049cell cycle-IEA-  
GO:0007088regulation of mitotic nuclear division-IBA21873635  
GO:0007616long-term memory-IEA-  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IMP24130168  
GO:0008344adult locomotory behavior-IEA-  
GO:0043066negative regulation of apoptotic process-IMP24130168  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IDA8114739  
GO:0045787positive regulation of cell cycle-IBA21873635  
GO:0051301cell division-IEA-  
GO:0071481cellular response to X-ray-IEA-  
GO:1900087positive regulation of G1/S transition of mitotic cell cycle-IBA21873635  
GO:1900087positive regulation of G1/S transition of mitotic cell cycle-IMP24130168  
GO ID GO Term Qualifier Evidence PubMed
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IBA21873635  
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IDA8114739  18827403  
GO:0000785chromatin-IDA18827403  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA18827403  
GO:0005654nucleoplasm-IDA-  
GO:0005730nucleolus-IDA18827403  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA18827403  
GO:0031965nuclear membrane-IDA18827403  
GO:0097129cyclin D2-CDK4 complex-IEA-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04310Wnt signaling pathway
hsa04510Focal adhesion
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8934593Regulation of RUNX1 Expression and ActivityTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21878650miR-497 and miR-302b regulate ethanol-induced neuronal cell death through BCL2 protein and cyclin D2. (2011 Oct 28)Yadav SJ Biol Chem
26671626Sources of polycyclic aromatic hydrocarbons are associated with gene-specific promoter methylation in women with breast cancer. (2016 Feb)White AJEnviron Res
29197760Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors. (2018 Feb)Callahan CLEnviron Res
19861513Association between lifestyle factors and CpG island methylation in a cancer-free population. (2009 Nov)Brait MCancer Epidemiol Biomarkers Prev
18349282DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. (2008 Mar)Feng QCancer Epidemiol Biomarkers Prev