Gene: TOP3B

8940
TOP3B1
DNA topoisomerase III beta
protein-coding
22q11.22
Ensembl:ENSG00000100038 MIM:603582 Vega:OTTHUMG00000167438 UniprotKB:O95985
NC_000022.11
PubMed
0   ANCO-SNPs
ND
2   
2.479e-1 (AD)  2.924e-1 (ND)   (Frontal_Cortex)
5.449e-1 (AD)  2.063e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STK11IP0.874
ZSWIM80.867
SMPD40.854
ATXN2L0.853
DPAGT10.847
PRSS530.844
MAPKBP10.84
CNOT30.837
DNMT10.836
DDX270.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.393
OR4F29-0.358
ENDOU-0.358
KLRC2-0.355
HORMAD2-0.347
TRDN-0.338
IL20RA-0.338
LRAT-0.333
DIO2-0.311
TSPAN12-0.309

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TOP3B mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TOP3B mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TOP3B mRNA"18648102
D020106AcrylamideAcrylamide results in increased expression of TOP3B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TOP3B gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TOP3B mRNA19770486
D003913DextroamphetamineDextroamphetamine results in decreased expression of TOP3B mRNA12558987
D001241AspirinAspirin results in increased expression of TOP3B mRNA11906190
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TOP3B mRNA20106945
C006780bisphenol Abisphenol A results in increased expression of TOP3B mRNA25181051
C584509C646 compoundC646 compound results in increased expression of TOP3B mRNA26191083
D002104CadmiumCadmium results in decreased expression of TOP3B mRNA24067728
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of TOP3B mRNA]20371981
D016572CyclosporineCyclosporine results in increased methylation of TOP3B promoter27989131
C000944dicrotophosdicrotophos results in increased expression of TOP3B mRNA28302478
C024629dimethyl phthalatedimethyl phthalate affects the expression of TOP3B mRNA26924002
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of TOP3B mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TOP3B mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TOP3B mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TOP3B mRNA"20188158
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of TOP3B mRNA16616109
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of TOP3B mRNA25270620
C019536potassium bromatepotassium bromate results in decreased expression of TOP3B mRNA22539617
D018038Sodium SeleniteSodium Selenite results in decreased expression of TOP3B mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TOP3B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TOP3B mRNA19465110
D014635Valproic AcidValproic Acid results in increased methylation of TOP3B gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of TOP3B mRNA19136453

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003916DNA topoisomerase activity-IBA21873635  
GO:0003916DNA topoisomerase activity-TAS9786843  
GO:0003917DNA topoisomerase type I activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006265DNA topological change-IBA21873635  
GO:0007059chromosome segregation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000793condensed chromosome-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS9786843  
KEGG ID KEGG Term
hsa03440Homologous recombination
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28355294Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter. (2017)Hou GXPLoS One
26174813New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder. (2015 Sep)Alemany SAm J Med Genet B Neuropsychiatr Genet